Bioactive Compounds and Distinctive Pharmacological Activity Guided Review of Aegle marmelos: A Miraculous Plant of Indigenous Medicine System

2020 ◽  
Vol 16 (7) ◽  
pp. 965-977
Author(s):  
Sourav Ghosh ◽  
Arvind Kumar ◽  
Neetu Sachan ◽  
Phool Chandra
Keyword(s):  
Bioactive Compounds ◽  
New Drugs ◽  
Therapeutic Effects ◽  
Human Beings ◽  
Indigenous Medicine ◽  
Aegle Marmelos ◽  
Pharmacological Activities ◽  
Wide Range ◽  
Ethnobotanical Uses ◽  
Different Parts

Background: It is always thought that traditional herbal drugs are safe, effective and economical and are used worldwide for healing purposes. Aegle marmelos, belonging to family Rutaceae, is an important medicinal plant of the indigenous medicine system in India. Despite the study on ethnobotanical uses and the presence of bioactive compounds, there was only a handful of research on A. marmelos. The therapeutic use of bioactive compounds is not explored properly. Objective: The objective of this study is to provide comprehensive data on the botanical description, ethnobotany, isolated bioactive compounds and their therapeutic effects according to the pharmacology of A. marmelos and its future prospects for further scientific investigation for the development of effective bioactive compounds. Methods: Literature searches were performed in various databases, such as PubMed, SciFinder and Google Scholar, for peer-reviewed research literature pertaining to the bioactive compounds present and distinctive pharmacological activities of A. marmelos. Results: The literature review indicates that different parts of A. marmelos possess various ethnobotanical uses. A large number of bioactive compounds isolated from different parts of the plant were reviewed which mainly belong to alkaloids, terpenoids, steroids, coumarins, flavonoids and carbohydrate in nature. The plant also possesses a wide range of pharmacological activities, such as antidiarrheal, antimicrobial, anticancer, hepatoprotective, antifertility, anti-inflammatory, wound healing, radioprotective, hypoglycemic and cardioprotective activity. Conclusion: It is clearly proven that different parts of A. marmelos possess numerous therapeutic effects for treating various ailments of human beings. As the scientists anticipated to develop new drugs from natural sources, investigation of modern drugs from A. marmelos should be emphasized. Still, extensive research studies are required on A. marmelos as it is the most important plant of the indigenous medicine system in India. Therefore, this review could be used as a good source of information for researchers who wish to proceed their exploration of A. marmelos.

scholarly journals PLANT PROFILE, PHYTOCHEMISTRY AND PHARMACOLOGY OF SPATHODEA CAMPANULATA P. BEAUVAIS (AFRICAN TULIP TREE): A REVIEW

2018 ◽  
Vol 10 (5) ◽  
pp. 1 ◽  
Author(s):  
Anita S. Wagh ◽  
Santosh R. Butle
Keyword(s):  
Web Of Science ◽  
Relevant Information ◽  
Stem Bark ◽  
Human Beings ◽  
Pharmacological Activities ◽  
Traditional System ◽  
Wide Range ◽  
Ancient Times ◽  
Important Medicinal Plant ◽  
Different Parts

Plants have been used as one of the important source for treating various diseases of human beings since ancient times. Numbers of plants are mentioned in different traditional system of medicine, among them Spathodea campanulata P. Beauvais is one of the important medicinal plant. Different parts of Spathodea campanulata such as flowers, leaves, stem, bark and roots have been reported for possessing anti-inflammatory, analgesic, cytotoxic, anti-diabetic and anticonvulsant activity. Phytochemical screening shows the presence of various secondary metabolites like alkaloids, tannins, flavonoids, glycosides and sterols. Relevant information and literature on Spathodea campanulata from electronic databases such as Academic Journals, Google, Google Scholar, Science Direct, PubMed and Web of Science were collected and analyzed. Available literatures evidently show that Spathodea campanulata possess a wide range of pharmacological activities that could be explained by the presence of variety of phytochemicals. The aim of the present review to provide detailed information regarding geographical distribution, phytochemicals and pharmacological properties of this plant.

Bioprospecting Cryptogams as Potential Source of Unique Biodynamic Phytochemicals with Diverse Pharmaceutical Applications

2016 ◽  
Vol 1 (1) ◽  
Author(s):  
Brahma N. Singh ◽  
Garima Pandey ◽  
Prateeksha ◽  
J. Kumar
Keyword(s):  
Secondary Metabolites ◽  
Higher Plants ◽  
New Drugs ◽  
Terrestrial Plants ◽  
Pharmacological Activities ◽  
Therapeutic Drugs ◽  
Potential Source ◽  
Therapeutic Value ◽  
Wide Range ◽  
Novel Structures

With the advent of green pharmaceuticals, the secondary metabolites derived from plants have provided numerous leads for the development of a wide range of therapeutic drugs; however the discovery of new drugs with novel structures has declined in the past few years. Cryptogams including lichens, bryophytes, and pteridophytes represent a group of small terrestrial plants that remain relatively untouched in the drug discovery process though some have been used as ethnomedicines by various tribes worldwide. Studies of their secondary metabolites are recent but reveal unique secondary metabolites which are not synthesized by higher plants. These compounds can have the potential to develop more potential herbal drugs for prevention and treatment of diseases The present article . deals with the secondary metabolites and pharmacological activities of cryptogams with an objective to bring them forth as potential source of biodynamic compounds of therapeutic value.

scholarly journals ETHNOBOTANICAL, PHYTOCHEMICAL, AND PHARMACOLOGICAL PROPERTIES OF NEPENTHES SPECIES: A REVIEW

2017 ◽  
Vol 10 (11) ◽  
pp. 16 ◽  
Author(s):  
Shuaibu Babaji Sanusi ◽  
Mohd Fadzelly Abu Bakar ◽  
Maryati Mohamed ◽  
Siti Fatimah Sabran ◽  
Muhammad Murtala Mainasara
Keyword(s):  
Folk Medicine ◽  
Therapeutic Agents ◽  
Bioactive Components ◽  
Pharmacological Activities ◽  
Crude Extracts ◽  
Gastrointestinal Discomfort ◽  
Wide Range ◽  
Long Time ◽  
Phytochemical Compounds ◽  
Ethnobotanical Uses

The genus Nepenthes (Nepenthaceae) has been utilized in folk medicine for a long time in India and Southeast Asia countries. They are used in the treatment of leprosy, cholera, night blindness, gastrointestinal discomfort, dysentery, stomachache, and bed-wetting among others. This review highlights the ethnobotanical uses, phytochemicals, and pharmacological activities of both crude extracts and pure bioactive compounds of Nepenthes spp. The phytochemical compounds isolated from Nepenthes species include flavonoids, terpenoids, tannins, alkaloids, and steroids among other phytochemicals. A wide range of pharmacological activities was exhibited by the crude extracts and pure bioactive components such as antibacterial, antifungal, antimalarial antioxidant, antidiabetic, antiosteoporotic, anti-inflammatory, cytotoxicity, and hypolipidemic activities. This review revealed that many active compounds are present in Nepenthes spp. However, many pharmacological screenings such as anticancer, antiviral, wound healing, antihelminthic, antidiarrheal properties, among others have not been carried out yet. Therefore, more biological investigations and phytochemical screenings are required to fully explore the genus Nepenthes which may lead to development of new therapeutic agents.  

scholarly journals A Review on Ethnopharmacological Applications, Pharmacological Activities, and Bioactive Compounds ofMangifera indica(Mango)

2017 ◽  
Vol 2017 ◽  
pp. 1-24 ◽  
Author(s):  
Meran Keshawa Ediriweera ◽  
Kamani Hemamala Tennekoon ◽  
Sameera Ranganath Samarakoon
Keyword(s):  
Amino Acids ◽  
Bioactive Compounds ◽  
Mangifera Indica ◽  
Fruit Peel ◽  
Pharmacological Activities ◽  
Phytochemical Constituents ◽  
Pharmacological Potential ◽  
Diverse Plant ◽  
Different Parts ◽  
Comprehensive Study

Mangifera indica(family Anacardiaceae), commonly known as mango, is a pharmacologically, ethnomedically, and phytochemically diverse plant. Various parts ofM. indicatree have been used in traditional medicine for the treatment of different ailments, and a number of bioactive phytochemical constituents ofM. indicahave been reported, namely, polyphenols, terpenes, sterols, carotenoids, vitamins, and amino acids, and so forth. Several studies have proven the pharmacological potential of different parts of mango trees such as leaves, bark, fruit peel and flesh, roots, and flowers as anticancer, anti-inflammatory, antidiabetic, antioxidant, antibacterial, antifungal, anthelmintic, gastroprotective, hepatoprotective, immunomodulatory, antiplasmodial, and antihyperlipemic. In the present review, a comprehensive study on ethnopharmacological applications, pharmacological activities, and bioactive compounds ofM. indicahas been described.

scholarly journals A comprehensive review on ethnobotanical applications and pharmacological activities of Acampe praemorsa (Roxb.) Blatt. & McCann (Orchidaceae)

2019 ◽  
Vol 9 (1) ◽  
pp. 331-336 ◽  
Author(s):  
S Vibha ◽  
Sushmitha S Hebbar ◽  
S.N. Mahalakshmi ◽  
T.R. Prashith Kekuda
Keyword(s):  
Eye Diseases ◽  
Wide Spread ◽  
Pharmacological Activities ◽  
Promising Candidate ◽  
Orchid Species ◽  
Comprehensive Review ◽  
Ethnobotanical Uses ◽  
Pharmacological Potential ◽  
Major Emphasis ◽  
Different Parts

Orchidaceae is one of the two largest families in angiosperms. Orchids are popular owing to the most beautiful flowers they produce and due to their wide spread ethnobotanical importance. In this review, ethnobotanical uses and pharmacological activities of A. praemorsa is discussed by referring flora, journals, and search engines such as Google scholar, ScienceDirect and Pubmed. Ethnobotanical investigations have revealed the potential therapeutic roles of different parts of A. praemorsa. The orchid is used traditionally by for treating ailments such as stomachache, earache, backache, wounds, neuralgia, rheumatism, eye diseases, sciatica, cough and fracture. A. praemorsa is investigated for various pharmacological activities. Studies have revealed the potential of A. praemorsa to exhibit a range of bioactivities such as anticancer, antibacterial, antifungal, antioxidant and anti-inflammatory activities. In conclusion, A. praemorsa is an extensively used epiphytic orchid for medicinal purposes in several parts of the India and other countries. Major emphasis has to be given in order to conserve this medicinally important orchid species. A. praemorsa can be a promising candidate in terms of its pharmacological potential. Keywords: Orchids, Orchidaceae, Acampe praemorsa, Ethnobotanical, Pharmacological

A review on phytochemical and therapeutic potential of Iris germanica

2021 ◽  
Author(s):  
Bahareh Sadat Yousefsani ◽  
Motahareh Boozari ◽  
Kobra Shirani ◽  
Amirhossein Jamshidi ◽  
Majid Dadmehr
Keyword(s):  
Bioactive Compounds ◽  
Therapeutic Potential ◽  
Experimental Studies ◽  
Therapeutic Effects ◽  
Pharmacological Activities ◽  
Pharmacological Studies ◽  
Iris Germanica ◽  
Safety Studies ◽  
History Of ◽  
Therapeutic Activities

Abstract Objectives Iris germanica L. is a medicinal plant, which has a long history of uses, mainly in medieval Persia and many places worldwide for the management of a wide variety of diseases. In this study, we aimed to review ethnopharmacological applications in addition to phytochemical and pharmacological properties of I. germanica. Key findings Ethnomedical uses of I. germanica have been reported from many countries such as China, Pakistan, India, Iran and Turkey. The medicinal part of I. germanica is the rhizome and the roots. Based on phytochemical investigations, different bioactive compounds, including flavonoids, triterpenes, sterols, phenolics, ceramides and benzoquinones, have been identified in its medicinal parts. Current pharmacological studies represent that the plant possesses several biological and therapeutic effects, including neuroprotective, hypoglycaemic, hypolipidaemic, antimicrobial, antioxidant, antiproliferative, anti-inflammatory, antiplasmodial, antifungal, immunomodulatory, cytotoxic and antimutagenic effects. Summary Although the majority of preclinical studies reported various pharmacological activities of this plant, however, sufficient clinical trials are not currently available. Therefore, to draw a definitive conclusion about the efficacy and therapeutic activities of I. germanica and its bioactive compounds, further clinical and experimental studies are required. Moreover, it is necessary to focus on the pharmacokinetic and safety studies on the extracts of I. germanica.

scholarly journals Natural Product Repertoire of the Genus Amphimedon

Marine Drugs ◽  
2018 ◽  
Vol 17 (1) ◽  
pp. 19 ◽  
Author(s):  
Nourhan Shady ◽  
Mostafa Fouad ◽  
Mohamed Salah Kamel ◽  
Tanja Schirmeister ◽  
Usama Abdelmohsen
Keyword(s):  
Secondary Metabolites ◽  
Natural Product ◽  
Bioactive Compounds ◽  
Biological Activities ◽  
Marine Sponges ◽  
Rich Source ◽  
Undescribed Species ◽  
Pharmacological Activities ◽  
Wide Range ◽  
Complete Survey

Marine sponges are a very attractive and rich source in the production of novel bioactive compounds. The sponges exhibit a wide range of pharmacological activities. The genus Amphimedon consists of various species, such as viridis, compressa, complanata, and terpenensis, along with a handful of undescribed species. The Amphimedon genus is a rich source of secondary metabolites containing diverse chemical classes, including alkaloids, ceramides, cerebrososides, and terpenes, with various valuable biological activities. This review covers the literature from January 1983 until January 2018 and provides a complete survey of all the compounds isolated from the genus Amphimedon and the associated microbiota, along with their corresponding biological activities, whenever applicable.

Pleistocene Images outside Europe.

1991 ◽  
Vol 57 (01) ◽  
pp. 91-102 ◽  
Author(s):  
Paul G. Bahn
Keyword(s):  
Late Pleistocene ◽  
Ice Age ◽  
Central Basin ◽  
Human Beings ◽  
Artistic Activity ◽  
Wide Range ◽  
Dating Methods ◽  
The World ◽  
Widespread Phenomenon ◽  
Different Parts

At first sight it may seem a pointless exercise to produce a survey of late Pleistocene ‘artistic activity’ around the world, but there are two specific aims involved here: first, to show that human beings in different parts of the world were producing ‘art’ at roughly the same time, i.e. from about 40,000 BC onward, and particularly at the end of the Pleistocene, from about 12,0000 BC, and second, to show that the well known Ice Age art of Europe is no longer unique, but part of a far more widespread phenomenon (Bahn 1987; Bahn and Vertut 1988, 26–32). The European art remains supreme in its quantity and its ‘quality’ (i.e. its realism and its wide range of techniques), but that situation may well alter in the next decade or two as new discoveries are made elsewhere and new dating methods are refined and extended.Ironically, the first clue to Pleistocene art outside Europe was found as long ago as 1870, only a few years after Edouard Lartet's and Henry Christy's discoveries in southern France were authenticated. Unfortunately, the object in question was badly published, and dis-appeared from 1895 until its rediscovery in 1956, and consequently very few works on Pleistocene art mention it. This mineralized sacrum of an extinct fossil camelid was found at Tequixquiac in the northern part of the central basin of Mexico. The bone is carved and engraved (two nostrils have been cut into the end) so as to represent the head of a pig-like or dog-like animal (pl. 18a). The circumstances of its discovery are unclear, but it is thought to be from a late Pleistocene bone bed, and to be at least 11,000 or 12,000 years old (Aveleyra 1965; Messmacher 1981,94). At present it is on exhibit in Mexico's National Museum of Anthropology.

scholarly journals Anthocyanins: Promising Natural Products with Diverse Pharmacological Activities

Molecules ◽  
2021 ◽  
Vol 26 (13) ◽  
pp. 3807
Author(s):  
Jiaqi Liu ◽  
Hongbing Zhou ◽  
Li Song ◽  
Zhanjun Yang ◽  
Min Qiu ◽  
...  
Keyword(s):  
Natural Products ◽  
Research Progress ◽  
Therapeutic Effects ◽  
Anticancer Effect ◽  
Pharmacological Activities ◽  
Pharmacological Agents ◽  
Wide Range ◽  
Health Promoting ◽  
Disease Impact ◽  
Antioxidant Effects

Anthocyanins are natural products that give color to plants. As natural plant pigments, anthocyanins also have a series of health-promoting benefits. Many researchers have proved that anthocyanins have therapeutic effects on diseases, such as circulatory, nervous, endocrine, digestive, sensory, urinary and immune systems. Additionally, a large number of studies have reported that anthocyanins have an anticancer effect through a wide range of anti-inflammatory and antioxidant effects. The anti-disease impact and mechanism of anthocyanins are diverse, so they have high research value. This review summarizes the research progress of anthocyanins on the pharmacological agents of different diseases to provide references for subsequent research.

scholarly journals Ethnomedicinal Uses, Phytochemistry and Pharmacological Activities of Pittosporum floribundum Wight. & Arn. – A Review

2020 ◽  
pp. 48-55
Author(s):  
Kishangiri Kirtigiri Gunsai ◽  
Abhay Jayprakash Gandhi ◽  
Rabinarayan Acharya ◽  
V. J. Shukla
Keyword(s):  
Methanolic Extract ◽  
Stem Bark ◽  
Extensive Literature ◽  
Phytochemical Screening ◽  
Pharmacological Activities ◽  
Medicinal Uses ◽  
Anti Oxidant ◽  
Ethnobotanical Uses ◽  
Ethnomedicinal Uses ◽  
Different Parts

Objectives: Pittosporum floribundum Wight & Arn. (Pittosporaceae) has been associated with many therapeutic claims, especially for its ethnomedicinal and economical uses. In this review, an extensive literature survey was carried out to compile information available about its medicinal uses, phytochemistry and pharmacological properties. Materials and Methods: Ethnobotanical uses of P. floribundum reported in available books on ethnobotany and ethnomedicinal research articles have been compiled. The obtained data are arranged in a tabular form, enlisting its local names, their area of presence and parts used. Therapeutic indications, external or internal dosage form and usage of the drug are also noted. Results and Discussion: It was found that stem bark, leaves, and root of P. floribundum are used to combat itching, rheumatism, leprosy, sprain, eczema, arthritis, diabetes, chest pain and antidote for snake bite. Bark has maximum applications in leprosy, and sprain. The extracts of the different parts were subjected to phytochemical screening for the presence of phytoconstituents such as alkaloids, flavonoids, phenols, lignins, anthroquinones, steroids, tannins, saponins, fixed oils and glycosides. Studies have shown that the methanolic extract of bark having promising antifungal, antibacterial, anti-inflammatory, antioxidant, hepatoprotective, neuropharmacological and behaviour activities. Conclusion: P. floribundum has multifaceted uses in varied aspects thus underlining its significance. Reported claimed anti-bacterial and anti-oxidant activities can be further strengthened through pharmacological and clinical studies to establish the ethnic claims like leprosy, sprain, bruises, sciatica, pulmonary affection and phthisis.

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