scholarly journals Correlation between Ascites and Total Lymphocyte Count with Occurrence of Hepatic Encephalopathy in Liver Cirrhosis Patients

2021 ◽  
Vol 31 (4) ◽  
pp. 3
Author(s):  
Ratna Adelia Pravitasari
Keyword(s):  
Liver Cirrhosis ◽  
Portal Hypertension ◽  
Hepatic Encephalopathy ◽  
Inflammatory Response ◽  
Physical Examination ◽  
Lymphocyte Count ◽  
Retrospective Cohort ◽  
Total Lymphocyte Count ◽  
Systemic Inflammatory Response ◽  
Total Lymphocyte

Hepatic encephalopathy (HE) is brain dysfunction manifested as a broad spectrum of neuropsychiatric abnormalities caused by hepatic insufficiency or portosystemic shunting due to portal hypertension. Portal hypertension in liver cirrhosis also causes ascites, as the most common clinical manifestation. Further, immune dysfunction, one of which is decreased total lymphocyte count (TLC), happens at liver cirrhosis, which triggers the systemic inflammatory response. This systemic inflammatory response plays a role in HE. Objective of this study is to know the correlation between ascites and TLC with occurence of HE in liver cirrhosis patient. This study was conducted by retrospective cohort design in Saiful Anwar Hospital. Determination of sample amount at this study used total sampling method. Hepatic encephalopathy diagnosis was based on West Haven Criteria. Ascites was determined by physical examination and/or abdominal ultasonography. Total lymphocyte count data was taken from medical record, with complete blood count examination used XS-800i hematology analyzer machine. Data were analyzed using a logistic regression test, with p&lt;0.05 was considered significant and Confidence Interval (CI) 95%. Seventy-eight liver cirrhosis patients were observed using a retrospective cohort method regarding the HE occurrence, and physical examination for ascites and laboratory examination were performed. The statistical analysis result of the correlation between ascites and HE is significant with an odds ratio of 5.108 and CI of 1.36-19.25. On the other hand, TLC has no significant correlation with the occurrence of HE. Based on this analysis result, it is concluded that ascites has a correlation with HE, but TLC does not.<p> </p>

scholarly journals Hubungan Kadar Limfosit Total dengan Prognosis Penyakit pada Penderita Sirosis Hati di Bagian Penyakit Dalam RSUP Dr. M. Djamil Padang Tahun 2011

2013 ◽  
Vol 2 (2) ◽  
pp. 98
Author(s):  
Vyola Regina ◽  
Arnelis Arnelis ◽  
Zulkarnain Edward
Keyword(s):  
Liver Cirrhosis ◽  
Lymphocyte Count ◽  
Total Lymphocyte Count ◽  
Chi Square ◽  
A Value ◽  
Total Lymphocyte ◽  
Fibrotic Process ◽  
End Stage ◽  
Relationship Of ◽  
Normal Architecture

AbstrakSirosis hati adalah stadium akhir dari penyakit hati kronik berupa proses fibrosis difus yang ditandai dengan perubahan arsitektur normal hati menjadi bentuk nodulus abnormal. Pada penderita sirosis hati ini sering terjadi penyakit infeksi akibat adanya imunosupresi. Hitung kadar limfosit total dapat digunakan untuk menentukan status imunitas penderita sirosis hati. Tujuan penelitian ini adalah mengetahui kadar limfosit total penderita sirosis hati. Jenis penelitian ini adalah deskriptif analitik. Populasi penelitian adalah penderita sebagai sirosis hati yang dirawat di Bagian Penyakit Dalam RSUP Dr. M. Djamil Padang pada tahun 2011. Sampel diambil dari populasi yang memenuhi kriteria inklusi dan eksklusi. Data diolah menggunakan uji Chi-square. Dari hasil penelitian didapatkan bahwa sebanyak 83,1% penderita sirosis hati memiliki kadar limfosit total yang rendah. Terdapat hubungan kadar limfosit total dengan berat ringannya penyakit sirosis hati dengan p<0,05. Sebanyak 49,2% infeksi ditemukan pada penderita sirosis hati. Kematian pada penderita sirosis hati akibat penyakit infeksi ditemukan 52,9%.Kata kunci: kadar limfosit total, sirosis hatiAbstractLiver Cirrhosis is the end stage of chronic liver disease in the form of a diffuse fibrotic process characterized by changes in the normal architecture of the liver to abnormal nodules. In patients with liver cirrhosis is common infections due to immunosuppression. The total lymphocyte count can be used to determine the immune status of patients with liver cirrhosis. The purpose of this study was to determine total lymphocyte count of liver cirrhosis patients. This research design is descriptive analytic. The population is the liver cirrhosis patients as treated in the Internal Medicine Dr. M. Djamil Padang in 2011. Samples were taken from the population that meet the inclusion and exclusion criteria. The data processed by Chi-square test.The results of this study indicated that as many as 83,1% of cirrhosis patients have a low total lymphocyte count. There is a relationship of total lymphocyte levels with severity of liver cirrhosis with a value of p<0,05. The infections found 49.2% of cirrhosis patients. Mortality in cirrhosis patients due to infection was found 52,9%Keywords:total lymphocyte count, liver cirrhosi

Correlation between total and CD4 lymphocyte counts in HIV infection: not making the good an enemy of the not so perfect

1996 ◽  
Vol 7 (6) ◽  
pp. 422-428 ◽  
Author(s):  
E J Beck ◽  
E J Kupek ◽  
M M Gompels ◽  
A J Pinching
Keyword(s):  
T Cell ◽  
Hiv Infection ◽  
Lymphocyte Count ◽  
Cell Subset ◽  
Total Lymphocyte Count ◽  
Aids Patients ◽  
T Cell Subset ◽  
Total Lymphocyte ◽  
Asymptomatic Patients ◽  
Cd4 Lymphocyte

The aim of this study was to assess the correlation and average cost of total lymphocyte count compared with CD4 count as a broad estimate of immunosuppression in HIV-1 infected individuals. Spearman's partial rank correlation were calculated between total lymphocyte count, absolute CD4 count and CD4 per cent stratified by stage of HIV-1 infection for routinely collected samples. Data were collected prospectively from a T cell-subset register combined with clinical data obtained retrospectively from case notes of HIV-infected patients managed at St Mary's Hospital, London 1982-1991. Costing data were obtained through a survey of the departments of haematology and immunology 1989 90 prices . The correlation between 1534 paired absolute lymphocyte count and CD4 lymphocyte count was found to be high R 0.76 . When analysed by stage of HIV infection, the correlation increased from R 0.64 for asymptomatic patients, to R 0.72 for patients with symptomatic non-AIDS HIV infection and R 0.73 for AIDS patients. Correlations between absolute lymphocyte count and CD4 per cent were considerably weaker: R 0.41 all paired counts; R 0.32 for asymptomatic patients; R 0.25 for symptomatic non-AIDS patients; R 0.32 for AIDS patients. Average cost was 8 per full blood count compared with 38 per T-cell subset analysis. The high correlation between total and CD4 lymphocyte counts, especially for patients with symptomatic HIV disease, demonstrates the suitability of the use of total lymphocyte count in the absence of CD4 counts. Given the considerably lower prices of total lymphocyte counts compared with T-cell subset analysis, this is particularly relevant for developing countries.

Serum albumin and total lymphocyte count as predictors of outcome in hip fractures

2010 ◽  
Vol 29 (1) ◽  
pp. 89-93 ◽  
Author(s):  
Brendan J. O'Daly ◽  
James C. Walsh ◽  
John F. Quinlan ◽  
Gavin A. Falk ◽  
Robert Stapleton ◽  
...  
Keyword(s):  
Serum Albumin ◽  
Hip Fractures ◽  
Lymphocyte Count ◽  
Total Lymphocyte Count ◽  
Predictors Of Outcome ◽  
Total Lymphocyte

scholarly journals Perbandingan Efek Pemberian Emulsi Kedelai dan Emulsi Tempe Terhadap Hitung Limfosit Total pada Tikus Putih yang Telah Diberi Prednison

2017 ◽  
Vol 5 (1) ◽  
pp. 56
Author(s):  
Rizka Bekti Nurcahyani ◽  
Imelda T Pardede ◽  
Huriatul Masdar
Keyword(s):  
Lymphocyte Count ◽  
Total Lymphocyte Count ◽  
Distilled Water ◽  
Adequate Nutrition ◽  
White Rats ◽  
Total Lymphocyte ◽  
Significant Difference ◽  
Group A ◽  
Group B

Adequate nutrition is one of important factors in immunodeficiency repairment. Soybean and tempeh contains proteins,zinc, ferrum, vitamins and isoflavon. Fermentation in tempeh makes it having better nutrients digestion and absorptionthan soybean. The objective of this study was to compare the effects of soy and tempeh emulsions on total lymphocytecount in rats treated with prednisone. The test was done on 24 male white rats divided into four groups. Group A wasgiven distilled water and group B, C and D had prednisone 2.5 mg/day for 6 days. After that, group A and B werecontinued having distilled water while groups C or D was fed with soy or tempeh emulsion 0.71 mL/day for 10 days,respectively. The results shown that soy and tempeh emulsion could increase total lymphocyte count significantly (p <0,05) but there was no significant difference of total lymphocyte count between soy and tempeh emulsion groups (p >0,05).

scholarly journals CORRELATION OF MONOCYTE COUNT, MLR AND NLCR WITH PRESEPSIN LEVEL IN SIRS (Hubungan Jumlah Monosit, MLR dan NLCR dengan Kadar Presepsin pada SIRS)

2018 ◽  
Vol 22 (3) ◽  
pp. 212
Author(s):  
Nurmalia PS ◽  
N. Suci W ◽  
Imam BW
Keyword(s):  
Systemic Inflammatory Response Syndrome ◽  
Inflammatory Response ◽  
Enzyme Immunoassay ◽  
Lymphocyte Count ◽  
Systemic Inflammatory Response ◽  
Monocyte Count ◽  
Lymphocyte Ratio ◽  
Count Ratio ◽  
Hematology Analyzer ◽  
Chemiluminescent Enzyme Immunoassay

Systemic Inflammatory Response Syndrome (SIRS) mempunyai kebahayaan tinggi terjadi sepsis dan kematian. Nilai jumlahkeseluruhan leukosit merupakan salah satu peramal pasien SIRS dengan bakteriemia. Pemeriksaan jumlah monosit, angka bandinglimfosit Monocyte-Lymphocyte Ratio (MLR), Neutrophil-Lymphocyte Count Ratio (NLCR) dapat diketahui dengan pemeriksaan leukosit.Presepsin telah diteliti untuk mencerminkan kondisi sepsis. Penelitian ini bertujuan untuk mengetahui keberadaan hubungan jumlahmonosit, MLR dan NLCR dengan presepsin di SIRS lewat pembuktian. Ada 34 pasien SIRS di ICU RSUP Dr. Kariadi, diambil secaraberturutan antara selama bulan Januari−Februari 2014. Pemeriksaan darah rutin dengan hematology analyzer. MLR dan NLCR dihitung secara manual. Kadar presepsin ditentukan dengan metode Chemiluminescent Enzyme Immunoassay (CLEIA). Uji kenasabanPearson untuk hubungan MLR dan NLCR dengan presepsin. Uji kenasaban Spearman untuk jumlah monosit dengan presepsin. Kadarpresepsin subjek penelitian 286–15687 pg/mL. Terdapat 23(67,8%) subjek yang mempunyai jumlah monosit dalam rentang nilai rujukan.24(70,6%) dan memiliki jumlah neutrofil absolut lebih besar dari rentang nilai rujukan, sedangkan 21(61,8%) mempunyai jumlahlimfosit absolut dalam rentang nilai rujukan. Hubungan jumlah monosit dengan presepsin mempunyai nilai r= -0,204; p=0,247;yang terkait MLR dengan presepsin r=0,163; p=0,358; sedangkan NLCR dengan presepsin r=0,345; p=0,046. Didasari telitian ini,dapat disimpulkan tidak terdapat hubungan bermakna antara jumlah monosit dan MLR dengan presepsin, selain itu didapatkan pulahubungan positif berarti antara NLCR dan presepsin di SIRS.

scholarly journals Low serum albumin and total lymphocyte count as predictors of 30 day hospital readmission in patients 65 years of age or older

2015 ◽  
Author(s):  
Robert Robinson
Keyword(s):  
Risk Factor ◽  
Serum Albumin ◽  
Hospital Readmission ◽  
Lymphocyte Count ◽  
Protein Energy Malnutrition ◽  
Total Lymphocyte Count ◽  
Total Lymphocyte ◽  
Protein Energy ◽  
Patients At Risk ◽  
Low Serum

Introduction: Hospital readmission within 30 days of discharge is a target for health care cost savings through the medicare Value Based Purchasing initiative. Because of this focus, hospitals and health systems are investing considerable resources into the identification of patients at risk of hospital readmission and designing interventions to reduce the rate of hospital readmission. Malnutrition is a known risk factor for hospital readmission. Materials and Methods: All medical patients 65 years of age or older discharged from Memorial Medical Center from January 1, 2012 to March 31, 2012 who had a determination of serum albumin level and total lymphocyte count on hospital admission were studied retrospectively. Admission serum albumin levels and total lymphocyte counts were used to classify the nutritional status of all patients in the study. Patients with a serum albumin less than 3.5 grams/dL and/or a TLC less than 1,500 cells per mm3 were classified as having protein energy malnutrition. The primary outcome investigated in this study was hospital readmission for any reason within 30 days of discharge. Results: The study population included 1,683 hospital discharges with an average age of 79 years. The majority of the patients were female (55.9%) and had a DRG weight of 1.22 (0.68). 219 patients (13%) were readmitted within 30 days of hospital discharge. Protein energy malnutrition was common in this population. Low albumin was found in 973 (58%) patients and a low TLC was found in 1,152 (68%) patients. Low albumin and low TLC was found in 709 (42%) of patients. Kaplan-Meier analysis shows any laboratory evidence of PEM is a significant (p < 0.001) predictor of hospital readmission. Low serum albumin (p < 0.001) and TLC (p = 0.018) show similar trends. Cox proportional-hazards regression analysis showed low serum albumin (Hazard Ratio 3.27, 95% CI: 2.30-4.63) and higher DRG weight (Hazard Ratio 1.19, 95% CI: 1.03-1.38) to be significant independent predictors of hospital readmission within 30 days. Discussion: This study investigated the relationship of PEM to the rate of hospital readmission within 30 days of discharge in patients 65 years of age or older. These results indicate that laboratory markers of PEM can identify patients at risk of hospital readmission within 30 days of discharge. This risk determination is simple and identifies a potentially modifiable risk factor for readmission: protein energy malnutrition.

scholarly journals Utility of total lymphocyte count as a surrogate marker for CD4 counts in HIV-1 infected children in Kenya

2011 ◽  
Vol 11 (1) ◽  
Author(s):  
Nyawira Githinji ◽  
Elizabeth Maleche-Obimbo ◽  
Moses Nderitu ◽  
Dalton C Wamalwa ◽  
Dorothy Mbori-Ngacha
Keyword(s):  
Lymphocyte Count ◽  
Surrogate Marker ◽  
Total Lymphocyte Count ◽  
Cd4 Counts ◽  
Total Lymphocyte ◽  
Hiv 1
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