scholarly journals Robust Feature Engineering for Parkinson Disease Diagnosis: New Machine Learning Techniques (Preprint)

2019 ◽  
Author(s):  
Max Wang ◽  
Wenbo Ge ◽  
Deborah Apthorp ◽  
Hanna Suominen

BACKGROUND Parkinson disease (PD) is a common neurodegenerative disorder that affects between 7 and 10 million people worldwide. No objective test for PD currently exists, and studies suggest misdiagnosis rates of up to 34%. Machine learning (ML) presents an opportunity to improve diagnosis; however, the size and nature of data sets make it difficult to generalize the performance of ML models to real-world applications. OBJECTIVE This study aims to consolidate prior work and introduce new techniques in feature engineering and ML for diagnosis based on vowel phonation. Additional features and ML techniques were introduced, showing major performance improvements on the large mPower vocal phonation data set. METHODS We used 1600 randomly selected /aa/ phonation samples from the entire data set to derive rules for filtering out faulty samples from the data set. The application of these rules, along with a joint age-gender balancing filter, results in a data set of 511 PD patients and 511 controls. We calculated features on a 1.5-second window of audio, beginning at the 1-second mark, for a support vector machine. This was evaluated with 10-fold cross-validation (CV), with stratification for balancing the number of patients and controls for each CV fold. RESULTS We showed that the features used in prior literature do not perform well when extrapolated to the much larger mPower data set. Owing to the natural variation in speech, the separation of patients and controls is not as simple as previously believed. We presented significant performance improvements using additional novel features (with 88.6% certainty, derived from a Bayesian correlated t test) in separating patients and controls, with accuracy exceeding 58%. CONCLUSIONS The results are promising, showing the potential for ML in detecting symptoms imperceptible to a neurologist.

10.2196/13611 ◽  
2020 ◽  
Vol 5 (1) ◽  
pp. e13611
Author(s):  
Max Wang ◽  
Wenbo Ge ◽  
Deborah Apthorp ◽  
Hanna Suominen

Background Parkinson disease (PD) is a common neurodegenerative disorder that affects between 7 and 10 million people worldwide. No objective test for PD currently exists, and studies suggest misdiagnosis rates of up to 34%. Machine learning (ML) presents an opportunity to improve diagnosis; however, the size and nature of data sets make it difficult to generalize the performance of ML models to real-world applications. Objective This study aims to consolidate prior work and introduce new techniques in feature engineering and ML for diagnosis based on vowel phonation. Additional features and ML techniques were introduced, showing major performance improvements on the large mPower vocal phonation data set. Methods We used 1600 randomly selected /aa/ phonation samples from the entire data set to derive rules for filtering out faulty samples from the data set. The application of these rules, along with a joint age-gender balancing filter, results in a data set of 511 PD patients and 511 controls. We calculated features on a 1.5-second window of audio, beginning at the 1-second mark, for a support vector machine. This was evaluated with 10-fold cross-validation (CV), with stratification for balancing the number of patients and controls for each CV fold. Results We showed that the features used in prior literature do not perform well when extrapolated to the much larger mPower data set. Owing to the natural variation in speech, the separation of patients and controls is not as simple as previously believed. We presented significant performance improvements using additional novel features (with 88.6% certainty, derived from a Bayesian correlated t test) in separating patients and controls, with accuracy exceeding 58%. Conclusions The results are promising, showing the potential for ML in detecting symptoms imperceptible to a neurologist.


2018 ◽  
Vol 34 (3) ◽  
pp. 569-581 ◽  
Author(s):  
Sujata Rani ◽  
Parteek Kumar

Abstract In this article, an innovative approach to perform the sentiment analysis (SA) has been presented. The proposed system handles the issues of Romanized or abbreviated text and spelling variations in the text to perform the sentiment analysis. The training data set of 3,000 movie reviews and tweets has been manually labeled by native speakers of Hindi in three classes, i.e. positive, negative, and neutral. The system uses WEKA (Waikato Environment for Knowledge Analysis) tool to convert these string data into numerical matrices and applies three machine learning techniques, i.e. Naive Bayes (NB), J48, and support vector machine (SVM). The proposed system has been tested on 100 movie reviews and tweets, and it has been observed that SVM has performed best in comparison to other classifiers, and it has an accuracy of 68% for movie reviews and 82% in case of tweets. The results of the proposed system are very promising and can be used in emerging applications like SA of product reviews and social media analysis. Additionally, the proposed system can be used in other cultural/social benefits like predicting/fighting human riots.


Author(s):  
Hesham M. Al-Ammal

Detection of anomalies in a given data set is a vital step in several applications in cybersecurity; including intrusion detection, fraud, and social network analysis. Many of these techniques detect anomalies by examining graph-based data. Analyzing graphs makes it possible to capture relationships, communities, as well as anomalies. The advantage of using graphs is that many real-life situations can be easily modeled by a graph that captures their structure and inter-dependencies. Although anomaly detection in graphs dates back to the 1990s, recent advances in research utilized machine learning methods for anomaly detection over graphs. This chapter will concentrate on static graphs (both labeled and unlabeled), and the chapter summarizes some of these recent studies in machine learning for anomaly detection in graphs. This includes methods such as support vector machines, neural networks, generative neural networks, and deep learning methods. The chapter will reflect the success and challenges of using these methods in the context of graph-based anomaly detection.


2019 ◽  
Vol 11 (16) ◽  
pp. 1943 ◽  
Author(s):  
Omid Rahmati ◽  
Saleh Yousefi ◽  
Zahra Kalantari ◽  
Evelyn Uuemaa ◽  
Teimur Teimurian ◽  
...  

Mountainous areas are highly prone to a variety of nature-triggered disasters, which often cause disabling harm, death, destruction, and damage. In this work, an attempt was made to develop an accurate multi-hazard exposure map for a mountainous area (Asara watershed, Iran), based on state-of-the art machine learning techniques. Hazard modeling for avalanches, rockfalls, and floods was performed using three state-of-the-art models—support vector machine (SVM), boosted regression tree (BRT), and generalized additive model (GAM). Topo-hydrological and geo-environmental factors were used as predictors in the models. A flood dataset (n = 133 flood events) was applied, which had been prepared using Sentinel-1-based processing and ground-based information. In addition, snow avalanche (n = 58) and rockfall (n = 101) data sets were used. The data set of each hazard type was randomly divided to two groups: Training (70%) and validation (30%). Model performance was evaluated by the true skill score (TSS) and the area under receiver operating characteristic curve (AUC) criteria. Using an exposure map, the multi-hazard map was converted into a multi-hazard exposure map. According to both validation methods, the SVM model showed the highest accuracy for avalanches (AUC = 92.4%, TSS = 0.72) and rockfalls (AUC = 93.7%, TSS = 0.81), while BRT demonstrated the best performance for flood hazards (AUC = 94.2%, TSS = 0.80). Overall, multi-hazard exposure modeling revealed that valleys and areas close to the Chalous Road, one of the most important roads in Iran, were associated with high and very high levels of risk. The proposed multi-hazard exposure framework can be helpful in supporting decision making on mountain social-ecological systems facing multiple hazards.


2021 ◽  
Vol 2021 ◽  
pp. 1-13
Author(s):  
O. Obulesu ◽  
Suresh Kallam ◽  
Gaurav Dhiman ◽  
Rizwan Patan ◽  
Ramana Kadiyala ◽  
...  

Cancer is a complicated worldwide health issue with an increasing death rate in recent years. With the swift blooming of the high throughput technology and several machine learning methods that have unfolded in recent years, progress in cancer disease diagnosis has been made based on subset features, providing awareness of the efficient and precise disease diagnosis. Hence, progressive machine learning techniques that can, fortunately, differentiate lung cancer patients from healthy persons are of great concern. This paper proposes a novel Wilcoxon Signed-Rank Gain Preprocessing combined with Generative Deep Learning called Wilcoxon Signed Generative Deep Learning (WS-GDL) method for lung cancer disease diagnosis. Firstly, test significance analysis and information gain eliminate redundant and irrelevant attributes and extract many informative and significant attributes. Then, using a generator function, the Generative Deep Learning method is used to learn the deep features. Finally, a minimax game (i.e., minimizing error with maximum accuracy) is proposed to diagnose the disease. Numerical experiments on the Thoracic Surgery Data Set are used to test the WS-GDL method's disease diagnosis performance. The WS-GDL approach may create relevant and significant attributes and adaptively diagnose the disease by selecting optimal learning model parameters. Quantitative experimental results show that the WS-GDL method achieves better diagnosis performance and higher computing efficiency in computational time, computational complexity, and false-positive rate compared to state-of-the-art approaches.


2021 ◽  
Author(s):  
Jeniffer Luz ◽  
Scenio De Araujo ◽  
Caio Abreu ◽  
Juvenal Silva Neto ◽  
Carlos Gulo

Since the beginning of the COVID-19 outbreak, the scientific communityhas been making efforts in several areas, either by seekingvaccines or improving the early diagnosis of the disease to contributeto the fight against the SARS-CoV-2 virus. The use of X-rayimaging exams becomes an ally in early diagnosis and has been thesubject of research by the medical image processing and analysiscommunity. Although the diagnosis of diseases by image is a consolidatedresearch theme, the proposed approach aims to: a) applystate-of-the-art machine learning techniques in X-ray images forthe COVID-19 diagnosis; b) identify COVID-19 features in imagingexamination; c) to develop an Artificial Intelligence model toreduce the disease diagnosis time; in addition to demonstrating thepotential of the Artificial Intelligence area as an incentive for theformation of critical mass and encouraging research in machinelearning and processing and analysis of medical images in the Stateof Mato Grosso, in Brazil. Initial results were obtained from experimentscarried out with the SVM (Support Vector Machine) classifier,induced on a publicly available image dataset from Kaggle repository.Six attributes suggested by Haralick, calculated on the graylevel co-occurrence matrix, were used to represent the images. Theprediction model was able to achieve 82.5% accuracy in recognizingthe disease. The next stage of the studies includes the study of deeplearning models.


The prediction of price for a vehicle has been more popular in research area, and it needs predominant effort and information about the experts of this particular field. The number of different attributes is measured and also it has been considerable to predict the result in more reliable and accurate. To find the price of used vehicles a well defined model has been developed with the help of three machine learning techniques such as Artificial Neural Network, Support Vector Machine and Random Forest. These techniques were used not on the individual items but for the whole group of data items. This data group has been taken from some web portal and that same has been used for the prediction. The data must be collected using web scraper that was written in PHP programming language. Distinct machine learning algorithms of varying performances had been compared to get the best result of the given data set. The final prediction model was integrated into Java application


2021 ◽  
Vol 8 (1) ◽  
pp. 28
Author(s):  
S. L. Ávila ◽  
H. M. Schaberle ◽  
S. Youssef ◽  
F. S. Pacheco ◽  
C. A. Penz

The health of a rotating electric machine can be evaluated by monitoring electrical and mechanical parameters. As more information is available, it easier can become the diagnosis of the machine operational condition. We built a laboratory test bench to study rotor unbalance issues according to ISO standards. Using the electric stator current harmonic analysis, this paper presents a comparison study among Support-Vector Machines, Decision Tree classifies, and One-vs-One strategy to identify rotor unbalance kind and severity problem – a nonlinear multiclass task. Moreover, we propose a methodology to update the classifier for dealing better with changes produced by environmental variations and natural machinery usage. The adaptative update means to update the training data set with an amount of recent data, saving the entire original historical data. It is relevant for engineering maintenance. Our results show that the current signature analysis is appropriate to identify the type and severity of the rotor unbalance problem. Moreover, we show that machine learning techniques can be effective for an industrial application.


2019 ◽  
Vol 18 (27) ◽  
pp. 2347-2354 ◽  
Author(s):  
Juan Alberto Castillo-Garit ◽  
Naivi Flores-Balmaseda ◽  
Orlando Álvarez ◽  
Hai Pham-The ◽  
Virginia Pérez-Doñate ◽  
...  

Leishmaniasis is a poverty-related disease endemic in 98 countries worldwide, with morbidity and mortality increasing daily. All currently used first-line and second-line drugs for the treatment of leishmaniasis exhibit several drawbacks including toxicity, high costs and route of administration. Consequently, the development of new treatments for leishmaniasis is a priority in the field of neglected tropical diseases. The aim of this work is to develop computational models those allow the identification of new chemical compounds with potential anti-leishmanial activity. A data set of 116 organic chemicals, assayed against promastigotes of Leishmania amazonensis, is used to develop the theoretical models. The cutoff value to consider a compound as active one was IC50≤1.5μM. For this study, we employed Dragon software to calculate the molecular descriptors and WEKA to obtain machine learning (ML) models. All ML models showed accuracy values between 82% and 91%, for the training set. The models developed with k-nearest neighbors and classification trees showed sensitivity values of 97% and 100%, respectively; while the models developed with artificial neural networks and support vector machine showed specificity values of 94% and 92%, respectively. In order to validate our models, an external test-set was evaluated with good behavior for all models. A virtual screening was performed and 156 compounds were identified as potential anti-leishmanial by all the ML models. This investigation highlights the merits of ML-based techniques as an alternative to other more traditional methods to find new chemical compounds with anti-leishmanial activity.


2020 ◽  
Author(s):  
Mazin Mohammed ◽  
Karrar Hameed Abdulkareem ◽  
Mashael S. Maashi ◽  
Salama A. Mostafa A. Mostafa ◽  
Abdullah Baz ◽  
...  

BACKGROUND In most recent times, global concern has been caused by a coronavirus (COVID19), which is considered a global health threat due to its rapid spread across the globe. Machine learning (ML) is a computational method that can be used to automatically learn from experience and improve the accuracy of predictions. OBJECTIVE In this study, the use of machine learning has been applied to Coronavirus dataset of 50 X-ray images to enable the development of directions and detection modalities with risk causes.The dataset contains a wide range of samples of COVID-19 cases alongside SARS, MERS, and ARDS. The experiment was carried out using a total of 50 X-ray images, out of which 25 images were that of positive COVIDE-19 cases, while the other 25 were normal cases. METHODS An orange tool has been used for data manipulation. To be able to classify patients as carriers of Coronavirus and non-Coronavirus carriers, this tool has been employed in developing and analysing seven types of predictive models. Models such as , artificial neural network (ANN), support vector machine (SVM), linear kernel and radial basis function (RBF), k-nearest neighbour (k-NN), Decision Tree (DT), and CN2 rule inducer were used in this study.Furthermore, the standard InceptionV3 model has been used for feature extraction target. RESULTS The various machine learning techniques that have been trained on coronavirus disease 2019 (COVID-19) dataset with improved ML techniques parameters. The data set was divided into two parts, which are training and testing. The model was trained using 70% of the dataset, while the remaining 30% was used to test the model. The results show that the improved SVM achieved a F1 of 97% and an accuracy of 98%. CONCLUSIONS :. In this study, seven models have been developed to aid the detection of coronavirus. In such cases, the learning performance can be improved through knowledge transfer, whereby time-consuming data labelling efforts are not required.the evaluations of all the models are done in terms of different parameters. it can be concluded that all the models performed well, but the SVM demonstrated the best result for accuracy metric. Future work will compare classical approaches with deep learning ones and try to obtain better results. CLINICALTRIAL None


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