Significantly longer Covid-19 incubation times for the elderly from a case study of 136 patients throughout China (Preprint)

2020 ◽  
Author(s):  
Richard Lieu
Keyword(s):  
Incubation Time ◽  
Age Groups ◽  
The Elderly ◽  
Individual Case ◽  
Age Group ◽  
Log Normal ◽  
Case Data ◽  
Larger Sample ◽  
Two Age Groups

BACKGROUND Incubation time distributed of Covid-19 is information needed as a matter of urgency for all age groups. OBJECTIVE To infer Covid-19 incubation time distribution from a large sample. METHODS Based on individual case data published online by 21 cities of China, we investigated a total of 136 COVID-19 patients who traveled to Hubei from 21 cities of China between January 5 and January 31, 2020, remained there for 48 hours or less, and returned to these cities with onset of symptoms between January 10 and February 6, 2020. Among these patients, 110 were found to be aged 15 – 64, 22 aged 65 – 86, and 4 aged under 15. RESULTS The differential incubation time histogram of the two age groups 15 – 64 and 65 – 86 are adequately fitted by the log normal model. For the 15 - 64 age group, the median incubation time of 7.00 + 1.10 - 0.90 days (uncertainties are 95 % CL) is broadly consistent with previous literature. For the 65-86 age group, the median is 10.9 + 2.7 -2.0 days is statistically significantly longer. Moreover, for this group, the 95 % confidence contour indicates the data cannot constrain the upper bound of the log normal parameters µ, σ by failing to close there; this is because the sample has a maximum incubation time of 17 days, beyond which we ran out of data even though the histogram has not yet peaked. CONCLUSIONS Thus the incubation time for the 65-86 age group is much longer than the 10 – 14 days of the main adult group. Only a much larger sample can clinch this number further.

scholarly journals Significantly longer Covid-19 incubation times for the elderly, from a case study of 136 patients throughout China

2020 ◽  
Author(s):  
Ally Bi-Zhu Jiang ◽  
Richard Lieu ◽  
Siobhan Quenby
Keyword(s):  
Incubation Time ◽  
Age Groups ◽  
The Elderly ◽  
Individual Case ◽  
Age Group ◽  
Log Normal ◽  
Case Data ◽  
Larger Sample ◽  
Two Age Groups

AbstractObjectiveTo infer Covid-19 incubation time distribution from a large sample.MethodBased on individual case data published online by 21 cities of China, we investigated a total of 136 COVID-19 patients who traveled to Hubei from 21 cities of China between January 5 and January 31, 2020, remained there for 48 hours or less, and returned to these cities with onset of symptoms between January 10 and February 6, 2020. Among these patients, 110 were found to be aged 15 – 64, 22 aged 65 – 86, and 4 aged under 15.FindingsThe differential incubation time histogram of the two age groups 15 – 64 and 65 – 86 are adequately fitted by the log normal model. For the 15 - 64 age group, the median incubation time of days (uncertainties are 95 −0.90 % CL) is broadly consistent with previous literature. For the 65-86 age group, the median is days is statistically significantly longer. Moreover, for −2.0 this group, the 95 % confidence contour indicates the data cannot constrain the upper bound of the log normal parameters µ, σ by failing to close there; this is because the sample has a maximum incubation time of 17 days, beyond which we ran out of data even though the histogram has not yet peaked. Thus there is the potential of a much longer incubation time for the 65-86 age group than 10 – 14 days. Only a much larger sample can settle this.

scholarly journals Pancreatic Surgery in the Older Population: A Single Institution’s Experience over Two Decades

2016 ◽  
Vol 2016 ◽  
pp. 1-6 ◽  
Author(s):  
Bhaumik Brahmbhatt ◽  
Abhishek Bhurwal ◽  
Frank J. Lukens ◽  
Mauricia A. Buchanan ◽  
John A. Stauffer ◽  
...  
Keyword(s):  
Pancreatic Resection ◽  
Care Center ◽  
Tertiary Care ◽  
Age Groups ◽  
The Elderly ◽  
Age Group ◽  
Pancreatic Resections ◽  
Increased Risk ◽  
Younger Patient ◽  
Two Age Groups

Objectives. Surgery is the most effective treatment for pancreatic cancer. However, present literature varies on outcomes of curative pancreatic resection in the elderly. The objective of the study was to evaluate age as an independent risk factor for 90-day mortality and complications after pancreatic resection. Methods. Nine hundred twenty-nine consecutive patients underwent 934 pancreatic resections between March 1995 and July 2014 in a tertiary care center. Primary analyses focused on outcomes in terms of 90-day mortality and postoperative complications after pancreatic resection in these two age groups. Results. Even though patients aged 75 years or older had significantly more postoperative morbidities compared with the younger patient group, the age group was not associated with increased risk of 90-day mortality after pancreatic resection. Discussion. The study suggests that age alone should not preclude patients from undergoing curative pancreatic resection.

The changing face of cancer in the elderly—Only a demographic change?

2006 ◽  
Vol 24 (18_suppl) ◽  
pp. 18597-18597
Author(s):  
Y. Rottenberg ◽  
T. Peretz
Keyword(s):  
Breast Cancer ◽  
Prostate Cancer ◽  
Lung Cancer ◽  
Older Women ◽  
Age Groups ◽  
The Elderly ◽  
Age Group ◽  
Industrial Countries ◽  
Cancer Burden ◽  
Two Age Groups

18597 Background: In industrial countries, the cancer burden of the elderly is high and is increased. One reason is longer life expectancy. Increasing age standardized rates of cancer in this age group compared to younger groups may also explain this phenomenon. Methods: Two age groups were examined, above and below 65 years. Each age group was further divided into men and women. The age standardized rates for all cancers combined among the Jewish population in Israel were identified through the Israel Cancer Registry during the years 1973–2002. In addition, lung and colorectal cancers according to sexes, prostate cancer in men and breast cancer in women were examined. Results: Between the first 5 years of the study (1973–1977) and the last 5 years (1998–2002) the age standardized rates for all cancers combined were raised by about one third in the two age groups. In males, the overall change was higher in the older group (42% in men aged 65 years and older compared to 31% in men younger than 65). However, the rise in the younger group was more prominent in females (42% in women younger than 65 years compared to 33 % in women aged 65 and older). The most outstanding increase was in prostate cancer in men, but mainly in the younger group (176% in the older group and 368% in the younger group) followed by breast cancer in women, more prominent in the older group (64% in the older group and 50% in the younger group). In both sexes, more noticeable increases were noted in the older groups in colorectal cancer and in lung cancer. Between the years 1993–1997 and 1998–2002 shifts towards stabilization and even a decrease was noted in some of the cancers that were examined. In men aged 65 years and older rates for all cancers combined were decreased by 2.5%, among the specific tumors and a decrease was noted in lung cancer (6.7%) and prostate cancer (5.8%). The rates for all cancers combined among the older women were slightly decreasing (2.0%). No decrease was noted in the specific tumors in this group. Among the younger groups in both sexes, no decrease (defined >0.5%) was noted. Conclusions: These data argue against the hypothesis that the overall change in the cancer burden in the aged could be also explained by differences changes in the risk of developing cancer between these two age groups. No significant financial relationships to disclose.

scholarly journals The Older, the More Forgiving? Characteristics of Forgiveness of Chinese Older Adults

2021 ◽  
Vol 12 ◽  
Author(s):  
Linjin Tao ◽  
Tingting Zhu ◽  
Yanglu Min ◽  
Mingxia Ji
Keyword(s):  
Older Adults ◽  
Age Groups ◽  
The Elderly ◽  
Age Group ◽  
Implicit Measures ◽  
Chinese Older Adults ◽  
Significant Difference ◽  
Single Category ◽  
The Difference ◽  
Two Age Groups

This study explores the characteristics of forgiveness in the aging cohorts, which is regarded to be associated with healthy outcomes. Data were drawn from a sample of 308 older adults (aged from 60 to 98 years) who completed the forgiveness questionnaire: forgiving others of The Heartland Forgiveness Scale (HFS) to examine explicit forgiveness, and among the participants, 44 older adults were administrated on the variant single category of implicit association test (SC-IAT) to examine the implicit forgiveness. The results revealed that (1) there is no correlation between explicit forgiveness and implicit forgiveness of older adults. (2) The result of explicit forgiveness is relatively high while that of implicit forgiveness is relatively low. (3) There was no significant correlation between explicit forgiveness and age, but there was significant difference between age groups, as forgiveness tendency of the elderly had a trough in the age group of 70–79 and then rebounded. (4) Implicit forgiveness was significantly correlated with age, and the difference between age groups was marginal. The forgiveness tendency of the elderly over 80 years old was significantly higher than that of the other two age groups. (5) Gender differences are found in both explicit and implicit forgiveness. The findings indicated that (1) explicit and implicit measures in this study have assessed independent and complementary aspects of forgiveness tendency in older adults. (2) Implicit forgiveness falls behind explicit forgiveness, and true internal forgiveness is difficult and rare in older adults according to data analysis. (3) The trend of explicit forgiveness with age is not obvious, because explicit forgiveness in the middle old age group presents an inflection point. However, implicit forgiveness increases slowly with age. (4) Women excel men in scores obtained with both explicit and implicit measures for forgiveness.

scholarly journals Estimating the early impact of immunization against COVID-19 on deaths among elderly people in Brazil: analyses of secondary data on vaccine coverage and mortality

2021 ◽  
Author(s):  
Cesar Victora ◽  
Marcia C Castro ◽  
Susie Gurzenda ◽  
Aluisio J D Barros
Keyword(s):  
Vaccination Coverage ◽  
Health Workers ◽  
Vaccine Coverage ◽  
Age Groups ◽  
Secondary Data ◽  
The Elderly ◽  
Mortality Rates ◽  
Age Group ◽  
Rate Ratios ◽  
Two Age Groups

ABSTRACTBackgroundImmunization against COVID-19 in Brazil started in January 2021, with health workers and the elderly as the priority groups. We assessed whether there was an impact of immunizations on the mortality of individuals aged 80+ years.MethodsBy April 22, 2021, 147,454 COVID-19 deaths had been reported to the Brazilian Mortality Information System. Denominators for mortality rates were calculated by correcting population estimates for all-cause deaths reported in 2020. Proportionate mortality at ages 80+ and 90+ years relative to deaths at all ages were calculated, and mortality rate ratios compared these two age groups with individuals aged 0-79 years. Vaccine coverage data were obtained from the Ministry of Health vaccination monitoring website. All results were tabulated by two-week periods from epidemiological weeks 1-14, 2021.FindingsAs the P.1 variant spread throughout Brazil, the total number of deaths increased over time starting in epidemiological week 9 of 2021. The proportion of all deaths occurring at ages 80+ years was over 25% in weeks 1-6 and declined rapidly to 13.1% in weeks 13-14. Mortality rates were over 13 times higher in the 80+ years age group compared to that of 0-79 year olds up to week 6, and declined to 6.9 times in weeks 13-14. Coronavac accounted for 77.3% and AstraZeneca for 15.9% of all doses administered. Vaccination coverage (first dose) increased rapidly among individuals aged 80+ years, reaching 49.1% in weeks 5-6 and over 90% after week 9.InterpretationRapid scaling up of vaccination coverage among elderly Brazilians was associated with an important decline in relative mortality compared to younger individuals, in a setting where the P.1 variant predominates. Had mortality rates among the elderly remained proportionate to what was observed up to week 6, an estimated additional 13,824 deaths would have been expected up to week 14.

scholarly journals Hip fractures among the elderly in Kyoto, Japan: a 10-year study

2021 ◽  
Vol 16 (1) ◽  
Author(s):  
Maki Asada ◽  
Motoyuki Horii ◽  
Kazuya Ikoma ◽  
Tsuyoshi Goto ◽  
Naoki Okubo ◽  
...  
Keyword(s):  
Hip Fracture ◽  
Femoral Neck ◽  
Incidence Rate ◽  
Acute Care ◽  
Hip Fractures ◽  
Age Groups ◽  
The Elderly ◽  
Femoral Neck Fractures ◽  
Age Group ◽  
Trochanteric Fractures

Abstract Summary In Kyoto Prefecture, Japan, the number of hip fractures increased during 2013–2017 compared to 2008–2012. However, the estimated overall incidence rate increased only in femoral neck fractures in men aged ≥75 and women aged ≥85. Purpose The incidence rate of hip fractures in Japan has plateaued or decreased. We investigated the annual hip fracture occurrences in Kyoto Prefecture, Japan, from 2008 to 2017. Methods Patients aged 65 years and above who sustained hip fractures between 2008 and 2017 and were treated at one of the participating 11 hospitals were included. The total number of beds in these institutions was 3701, accounting for 21.5% of the 17,242 acute-care beds in Kyoto Prefecture. The change in incidence rate was estimated utilizing the population according to the national census conducted in 2010 and 2015. Results The total number of hip fractures was 10,060, with 47.5% femoral neck fractures and 52.5% trochanteric fractures. A decrease in number was seen only in trochanteric fractures in the group of 75- to 84-year-old women. The population-adjusted numbers of femoral neck fractures showed a significant increase in all age groups in men, whereas in women, there was an increase in femoral neck fractures in the ≥85 group and trochanteric fractures in the age group 65–74, and a decrease in trochanteric fractures in the age group 75–84. The estimated change in incidence rate showed an increase in femoral neck fractures in men aged ≥75 and women aged ≥85. Conclusion In Kyoto Prefecture, the number of hip fractures increased in the second half of the study period (2013–2017) compared to the first half (2008–2012). However, the incidence rate had not increased, except in femoral neck fractures in men aged ≥75 and women aged ≥85.

scholarly journals "It Is Not Good For Man To Be Alone" The Struggle against Loneliness in Old Age: Basic Assumptions for an Integrative Operational Concept –The Israeli Case

2017 ◽  
Vol 6 (1) ◽  
pp. 82
Author(s):  
Avi Bitzur ◽  
Eran Fisher
Keyword(s):  
Old Age ◽  
Local Level ◽  
Age Groups ◽  
The Elderly ◽  
Dominant Factor ◽  
Comprehensive Plan ◽  
Limited Scale ◽  
Operational Concept

The widespread expression saying that "loneliness is the No. 1 enemy of old age" has, in the 21st century, becomes obvious and banal now that suicide rates among the elderly in many countries and in Israel, the case study for this paper, is higher than among other age groups in those countries.Loneliness itself, its ramifications, consequences, and implications on the lives of the elderly have made it a dominant factor in terms of its potential damage.Old age and loneliness have been the subjects of many different definitions, studies and theories, but despite the quantity and quality of these attempts worldwide, and particularly in Israeli research, there is a conspicuous lack of any comprehensive plan that would address the implications and destructive effects of the loneliness experienced by the elderly. Many limited-scale programs exist on a local level, but they fail to address the clear need to eradicate menacing loneliness.The authors of this essay plan to outline basic principles for designing an operational concept for a national plan to combat the consequences and effects of depression among the elderly, using Israel as an example.This paper will begin with a review of the definitions and literature on the phenomenon of depression, and a review of the literature dealing with the unhealthy connection between old age and depression. We will then review various programs worldwide that deal with the phenomenon of loneliness and old age; continue to present data on the effects of loneliness on elderly Israelis; present various Israeli programs and projects that attempt to deal with this phenomenon; and conclude by detailing the proposed principles for a comprehensive operational approach that maps out this painful phenomenon in Israel and proposes a plan of action on how to best deal with it.

Noise-Limited Detection in Young and Old Observers

1997 ◽  
Vol 84 (3) ◽  
pp. 829-830 ◽  
Author(s):  
Filippo Speranza ◽  
Giampaolo Moraglia ◽  
Bruce A. Schneider
Keyword(s):  
Additive Noise ◽  
Age Groups ◽  
Internal Noise ◽  
The Elderly ◽  
Visual Noise ◽  
Processing Efficiency ◽  
Limited Bandwidth ◽  
Lower Performance ◽  
A Current ◽  
Two Age Groups

11 young ( M age = 24.3 yr.) and 11 old ( M age = 67.4 yr.) observers attempted to detect signals of limited bandwidth in visual noise. The older observers did not perform as well as the young ones. We considered whether, as suggested by a current hypothesis, these differences could be attributed to higher internal additive noise in the elderly observers. The results suggested that internal noise did not differ across the two age groups and that the lower performance of the older observers stemmed instead from reduced processing efficiency.

scholarly journals Dynamic Smile Visualization and Quantification in different age groups

2016 ◽  
Vol 06 (04) ◽  
pp. 32-38
Author(s):  
Harshitha V. ◽  
M.S. Ravi ◽  
Reshma Raveendran ◽  
Raed Saeed ◽  
Kiran Kumar C.
Keyword(s):  
Age Groups ◽  
T Test ◽  
Age Group ◽  
Chi Square ◽  
Video Clips ◽  
Younger Age ◽  
Chi Square Test ◽  
Buccal Corridor ◽  
Paired T Test ◽  
Two Age Groups

Abstract Aims and Objectives: To assess the posed and dynamic smile and to compare the various attributes of smile in frontal, oblique and sagittal dimensions, in two different age groups (10- 15years and 18-25 years). Materials and Methods: The posed and dynamic smile parameters were measured using digital video clips in 80 subjects of two different age groups (10-15years and 18-25 years). Total of 15 parameters were studied in 3 planes of space. The data was analysed using student`s t-test to compare smile parameters across the age groups, paired t-test was used to analyse the parameters of posed and unposed smile within the same age group and chi-square test was performed for the discrete data. Results: The present study revealed significant differences in dynamic smile parameters between the two age groups. The parameters like Philtrum height and Smile index are more in older age group whereas the buccal corridor was more in younger age group. Significant differences were also recorded in various parameters in both the groups when the posted smile is compared with that of the dynamic smile. Conclusion: In both the age groups, the dynamic and posed smile attributes are significantly different, except for buccal corridor and interlabial gap.

Character introductions in oral narratives of Swedish–German bilingual preschoolers

2020 ◽  
pp. 014272371989744
Author(s):  
Josefin Lindgren ◽  
Valerie Reichardt ◽  
Ute Bohnacker
Keyword(s):  
Language Proficiency ◽  
Language Skills ◽  
Age Groups ◽  
Age Group ◽  
Morphological Form ◽  
Information Status ◽  
Significant Difference ◽  
Old Swedish ◽  
As Effects ◽  
Two Age Groups

Closely related Swedish and German both mark information status of referents morphologically, though little is known about its acquisition. This study investigates character introductions in the narratives of 4- and 6-year-old Swedish–German bilinguals ( N = 40) in both languages, elicited with MAIN Cat/Dog. We analyse effects of age group, language and animacy (human vs nonhuman characters) on the type of referring expression (indefinite NP and pronoun), as well as effects of language proficiency and exposure on the use of indefinite NPs for each language. We also explore which syntactic constructions indefinite NPs occur in. A significant difference was found between the two age groups, but not between languages. No effect was found of language skills or exposure. Four-year-olds used more pronouns and a lower proportion of indefinite NPs than 6-year-olds. Pronouns were more frequent for the human character than for nonhuman animate characters. Whilst animacy (humanness) promoted the use of pronouns, it did not affect the choice of morphological form for lexical NPs (indefinite/definite). The age groups differed in how indefinite NPs were used. Four-year-olds produced fewer narrative presentations (where a character is introduced as part of a typical story opening, e.g. Once upon a time there was a cat) than 6-year-olds, and more labellings (with only an NP, or a clausal predicative, e.g. That’s a cat). Qualitative analyses suggest that the children’s indefinite NPs in labelling constructions can be both referential (when setting the narrative scene), and type-denoting (when naming referents in individual pictures). Whilst the children’s abilities to introduce story characters develop measurably from 4 to 6 years in Swedish and German, appropriateness of character introductions not only depends on whether an indefinite NP is chosen, but also on the syntactic construction this indefinite NP is used in.

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