scholarly journals Physiology of magnesium metabolism and the use of magnesium in intensive care (literature review with the results of own observations, part 1)

2021 ◽  
Vol 17 (5) ◽  
pp. 56-67
Author(s):  
S.V. Kursov ◽  
V.V. Nikonov ◽  
O.V. Biletskyi ◽  
O.I. Fedets ◽  
V.O. Homenko
Keyword(s):  
Intensive Care ◽  
Human Body ◽  
Clinical Medicine ◽  
Magnesium Deficiency ◽  
Biological Fluids ◽  
The Body ◽  
Large Size ◽  
Water Compartment ◽  
Water Space

The first part of the review presents data on the content of magnesium in organs and tissues of the human body, the role of magnesium in the implementation of multiple functions, and the peculiarities of its intake and excretion from the body. A significant part of the review is devoted to methods for determining the concentration of magnesium in biological fluids of the human body. The advantages, disadvantages and limitations of various methods are presented. The most common methods for studying the concentration of magnesium in biological fluids of the body, which are used in clinical medicine all over the world, are photometric methods with dyes. The role of the fraction of ionized magnesium in the body, the content of which is determined electrochemically, is still uncertain. Cellular magnesium studies are extremely complex and time-consuming. Cells of different organs and tissues normally contain very different amounts of magnesium. It is not possible to judge about the presence of magnesium deficiency in the body by its concentration in plasma or serum. To detect a decrease in the tissue content of magnesium, tests with magnesium load and the subsequent observation of the rate of its excretion from the body are used. The causes for the development of hypomagnesemia are extremely numerous. The main of them are: any severe stress, restriction of magnesium intake into the body, an increase in its losses through the gastrointestinal tract and the kidneys in various pathological conditions. The formation of hypomagnesemia is facilitated by therapy with numerous medications, which are very widely used in clinical practice, and especially in the intensive care. Studies on the distribution of magnesium in the body after its intravenous administration have shown that, despite the large size of hydrated magnesium ions, they can not only paradoxically quickly spread in the extracellular water space, but most likely are also able to quickly penetrate through cell membranes, spreading in the intracellular water compartment.

scholarly journals Physiology of magnesium metabolism and the use of magnesium in intensive care (literature review with the results of personal observations, part 3)

2021 ◽  
Vol 17 (8) ◽  
pp. 33-46
Author(s):  
S.V. Kursov ◽  
V.V. Nikonov ◽  
O.V. Biletskyi ◽  
Ye.I. Kinoshenko ◽  
S.M. Skoroplit
Keyword(s):  
Intensive Care ◽  
Mitral Valve ◽  
Mitral Valve Prolapse ◽  
Magnesium Deficiency ◽  
Ventricular Tachyarrhythmia ◽  
Myocardial Damage ◽  
The Body ◽  
Magnesium Metabolism ◽  
Results Of Treatment

In this review, we presented the results of experimental and clinical studies that most convincingly demonstrate the role of magnesium metabolism disorders in the development of myocardial damage, fatal arrhythmias, and arterial hypertension. We also highlighted the diagnosis of latent magnesium deficiency in the body and the role of magnesium deficiency in the pathogenesis of cardiomyopathy, congestive heart failure, and mitral valve prolapse. Oral Mg supplementation helps to reduce mean arterial pressure, peripheral vascular resistance, and the frequency of isolated and burst ventricular extrasystoles and attacks of unstable ventricular tachyarrhythmia. The researchers found that many patients with severe mitral valve prolapse had low serum Mg levels, and Mg supplementation was associated with improved patient outcomes. Monitoring the status of magnesium metabolism in the body is ne-cessary not only in intensive care and in the hospital as a whole but is also relevant in outpatient practice. The cost of magnesia therapy is quite low, but at the same time, regular intake of magnesium preparations or dietary supplements, containing mainly magnesium, can significantly improve the results of treatment of many diseases and prevent the development of complications that are dangerous for the body.

The essential role of nesfatin-1 as a biological signal on the body systems

2021 ◽  
pp. 113-118
Keyword(s):  
Metabolic Disorders ◽  
Clinical Medicine ◽  
The Body ◽  
World Population ◽  
Peripheral Tissues ◽  
Future Studies ◽  
Body Organ ◽  
Regulate Food Intake ◽  
System Today

Nesfatin-1is first described in 2006 as an anorectic peptide and regulate food intake. In following years, the studies demonstrated the presence of nesfatin-1 in central and various peripheral tissues. Thus, nesfatin-1 popularity increasing widely in clinical medicine, especially in cardiology, neurology, reproduction, metabolic disorders, psychiatric disorders, gastrointestinal system. Today, the main point concerning nesfatin-1 action in body organ and systems is concentrate its biological signals effects. Thus the increasing knowledge in these area will be highlighted for future studies especially in serious health problem all over the world population.

scholarly journals Molecular Politics, Wearables, and the Aretaic Shift in Biopolitical Governance

2020 ◽  
Vol 37 (3) ◽  
pp. 71-96
Author(s):  
Peter Lindner
Keyword(s):  
Human Body ◽  
Common Ground ◽  
New Technologies ◽  
Expert Knowledge ◽  
The Body ◽  
Life Itself ◽  
The Common ◽  
The Individual ◽  
Individual Body

Since the publication of Nikolas Rose’s ‘The Politics of Life Itself’ (2001) there has been vivid discussion about how biopolitical governance has changed over the last decades. This article uses what Rose terms ‘molecular politics’, a new socio-technical grip on the human body, as a contrasting background to ask anew his question ‘What, then, of biopolitics today?’ – albeit focusing not on advances in genetics, microbiology, and pharmaceutics, as he does, but on the rapid proliferation of wearables and other sensor-software gadgets. In both cases, new technologies providing information about the individual body are the common ground for governance and optimization, yet for the latter, the target is habits of moving, eating and drinking, sleeping, working and relaxing. The resulting profound differences are carved out along four lines: ‘somatic identities’ and a modified understanding of the body; the role of ‘expert knowledge’ compared to that of networks of peers and self-experimentation; the ‘types of intervention’ by which new technologies become effective in our everyday life; and the ‘post-discipline character’ of molecular biopolitics. It is argued that, taken together, these differences indicate a remarkable shift which could be termed aretaic: its focus is not ‘life itself’ but ‘life as it is lived’, and its modality are new everyday socio-technical entanglements and their more-than-human rationalities of (self-)governance.

The Key Role of Headrest Optimization in Driver Comfort

2019 ◽  
Vol 24 (3) ◽  
pp. 592-599
Author(s):  
Hamid Gheibollahi ◽  
Masoud Masih-Tehrani ◽  
Mohammadmehdi Niroobakhsh
Keyword(s):  
Human Body ◽  
The Body ◽  
Human Body Model ◽  
Sitting Posture ◽  
Conventional Vehicle ◽  
Body Model ◽  
Basic Model ◽  
Proposed Model ◽  
Stiffness And Damping

In this study, adding a headrest to the conventional vehicle driver seat is investigated to improve the driver comfort and decrease the driver damages. For this purpose, a conventional biomechanical human body model of wholebody vibrations is provided and modified by adding a head degree of freedom to the body model and a headrest to the seat model. The basic model is in the sitting posture, lumped parameters and has nine DOFs for the human body, on contrary to the proposed model which has ten DOFs. The new human body DOF is the twisting motion of the head and neck. This new DOF is generated because of headrest adding to the driver’s seat. To determine the head discomforts, the Seat to Head (STH) indexes are studied in two directions: horizontal and vertical. The Genetic Algorithm (GA) is used to optimize the STH in different directions. The optimization variables are stiffness and damping parameters of the driver’s seat which are 12 for the basic model and are 16 for a new seat. The integer programming is used for time reduction. The results show that new seat (equipped by headrest) has very better STH in both directions.

scholarly journals Microbiocenosis Of Open Cavities Of The Body

2021 ◽  
Vol 03 (07) ◽  
pp. 1-45
Author(s):  
Ziyaeva E.R. ◽  
Keyword(s):  
Environmental Pollution ◽  
Human Body ◽  
Human Life ◽  
The Body ◽  
Chemotherapeutic Drugs ◽  
Topical Problem ◽  
Normal Microflora ◽  
Open Cavities

The article is devoted to a review of the topical problem of our time “Microbiocenosis of open cavities of the body and its role in the occurrence of many diseases of the human body ”. It has now been proven that the normal microflora of the human body plays a huge role in the normal course of life processes. The slightest violation of the composition of microorganisms leads to various irreversible defects in the normal course of human life, which are associated with the functions of the microbiocenosis and which no medicine can replace. The concept of microbiocenosis appeared in the 70s of the last century, although the first stone in this direction was put by Louis Pasteur, who proved the role of a microorganism in the process of fermentation and digestion. Many scientists contributed to the leap forward development of this science, which was forced due to errors in the use of antibiotics and chemotherapeutic drugs. Yes, indeed, the path of development of the science of biocenoses is closely related to the misuse of drugs, which often leads to dysbiosis. In addition, environmental pollution due to the uncontrollable development of urbanization plays a huge role in the development of dysbiotic processes.Therefore, with the aim of acquainting readers with the concept of biocenoses, certain pathways of pathogenetic links in the development of various diseases in violation of the composition of the normal microflora of the human body, we set ourselves the task of conducting a partial review of the achievement of the science of biocenoses of open cavities of the body.

scholarly journals Battle between plants as antioxidants with free radicals in human body

2020 ◽  
Vol 9 (3) ◽  
pp. 191-199 ◽  
Author(s):  
Fatemeh Jamshidi-kia ◽  
Joko Priyanto Wibowo ◽  
Mostafa Elachouri ◽  
Rohollah Masumi ◽  
Alizamen Salehifard-Jouneghani ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Free Radicals ◽  
Human Body ◽  
Defense Mechanisms ◽  
Natural Antioxidants ◽  
Redox Status ◽  
The Body ◽  
Antioxidant Agents ◽  
Endogenous Antioxidants

Free radicals are constructed by natural physiological activities in the human cells as well as in the environment. They may be produced as a result of diet, smoking, exercise, inflammation, exposure to sunlight, air pollutants, stress, alcohol and drugs. Imbalanced redox status may lead to cellular oxidative stress, which can damage the cells of the body, resulting in an incidence of various diseases. If the endogenous antioxidants do not stop the production of reactive metabolites, they will be needed to bring about a balance in redox status. Natural antioxidants, for example plants, play an important part in this context. This paper seeks to report the available evidence about oxidative stress and the application of plants as antioxidant agents to fight free radicals in the human body. For this purpose, to better understand oxidative stress, the principles of free radical production, the role of free radicals in diseases, antioxidant defense mechanisms, and the role of herbs and diet in oxidative stress are discussed.

scholarly journals Hyperammonemia in clinical practice: analysis of own clinical observations

2020 ◽  
Vol 4 (38) ◽  
pp. 23-26
Author(s):  
Z. M. Galeeva ◽  
O. F. Galiullin ◽  
E. G. Yeziukova ◽  
R. G. Tukhbatullina
Keyword(s):  
Clinical Practice ◽  
Drug Therapy ◽  
Human Body ◽  
Scientific Data ◽  
The Body ◽  
Mechanism Of Formation ◽  
Practice Analysis ◽  
Clinical Observations ◽  
The Brain

The article presents scientific data on the role of ammonia in the human body, examines in detail the mechanism of formation and utilization of ammonia in the body. The questions of etiology and separate forms of pathogenesis of hyperammonemia, and its influence on the processes of fibrosis in the liver and the role of stellate liver cells in it are highlighted separately. The data on the influence of hyperammonemia on cognitive functions of the brain with the development of encephalopathy are presented, which is of great importance in clinical practice, during medical examination. The data of own observations are given, the questions of drug therapy are highlighted.

Mimi Nichter, Fat talk: What girls and their parents say about dieting. Cambridge, MA: Harvard University Press, 2000. Pp. xi, 263. Hb $22.95.

2002 ◽  
Vol 31 (5) ◽  
pp. 811-815
Author(s):  
Mary Bucholtz
Keyword(s):  
Human Body ◽  
Harvard University ◽  
The Body ◽  
Fat Talk ◽  
Teenage Girls ◽  
Wide Range ◽  
Medical Anthropologist ◽  
The Relationship ◽  
Equal Interest

The relationship between language and the body has become an increasingly prominent area of research within linguistics and related disciplines. Some investigators of this question have examined how facts about the human body are encoded in linguistic structure, while others have explored the use of the body as a communicative resource in interaction. Surprisingly little, however, has been written about the role of language in constructing the body as a social object. In Fat talk, Mimi Nichter, a medical anthropologist, addresses this issue by examining the discourse of dieting among American teenage girls. Although language itself is not the center of the analysis, Nichter draws on a wide range of sociolinguistic research to investigate how the body is constructed through talk – a question that will be of equal interest to scholars of language, culture, and society.

scholarly journals “Encores me frissonne et tremble le coeur dedans sa capsule”: Rabelais’s Anatomy of Emotion and the Soul

2017 ◽  
Vol 39 (3) ◽  
pp. 33-58
Author(s):  
Emmanuelle Lacore-Martin
Keyword(s):  
Human Body ◽  
Natural Philosophy ◽  
Ancient Philosophy ◽  
The Body ◽  
Christian Faith ◽  
Animal Spirits ◽  
Philosophie Naturelle ◽  
The Relationship ◽  
Shed Light

This article examines the role of anatomical references in the representation of emotion and argues that they constitute textual markers of the Rabelaisian view of the relationship between the body and the soul, and the nature of the soul itself. By analyzing the ancient models of natural philosophy and medicine on which Rabelais draws—Galen, in particular—and by contextualizing Rabelais’s thinking within contemporary debates on the faculties of the soul, the article aims to shed light on his representation of the intersection between material and immaterial processes within the human body. Instead of trying to reconcile potentially contradictory aspects of these ancient models with the Christian faith, Rabelais’s prose is informed by an intuitive understanding of ancient philosophy. His exploitation of the Galenic concept of the animal spirits gives us invaluable insights into the influence of materialist representations of the soul on Rabelais’s thinking. Cet article étudie le rôle des références anatomiques dans la représentation rabelaisienne de l’émotion et propose d’y voir les marqueurs textuels de la façon dont Rabelais conçoit les rapports entre l’âme et le corps, et la nature de l’âme elle-même. En analysant les modèles anciens de la philosophie naturelle et de la médecine — Galien en particulier — dont Rabelais s’inspire et en situant sa pensée dans le contexte des débats contemporains sur les facultés de l’âme, l’article vise à éclairer la façon dont Rabelais représente l’intersection à l’intérieur du corps humain des processus matériels et immatériels. Sans chercher à réconcilier avec la foi chrétienne certains aspects de ces anciens modèles qui peuvent être en contradiction avec elle, la prose rabelaisienne porte la marque d’une compréhension intuitive de la philosophie ancienne. En particulier, l’exploitation de la conception galénique des esprits animaux donne de précieux aperçus concernant l’influence des représentations matérialistes de l’âme sur la pensée de Rabelais.

scholarly journals The Driving Lesson as a Socio-Technical Situation. A Case Study on the Interaction between Learner Driver, Driving Instructor, and the Motor Car

2021 ◽  
Vol 17 (2) ◽  
pp. 6-21
Author(s):  
Alexander Schmidl
Keyword(s):  
Detailed Analysis ◽  
Human Body ◽  
Technical Information ◽  
Theoretical Background ◽  
The Body ◽  
Driver Assistance ◽  
Driver Assistance Systems ◽  
Assistance Systems

A micro-sociological examination of the driving lesson raises the following question: How is the interaction between learner driver and driving instructor structured in this technical setting, and what meaning can be ascribed in this threefold constellation to the vehicle with its various technical elements? This case study examines the orientation patterns which exist between the learner driver, the driving instructor, and the car, which together constitute a socio-technical triangle, and what actions the learner driver needs to learn to enable them to drive the car safely. The theoretical background to the study is provided by interactionist theories, which have been broadened to include a greater sensitivity for the body and technology, and a sociological reading of postphenomenology. Using a method based on this theoretical background and informed by workplace studies, this study observed and made audiovisual recordings of driving lessons. This approach made it possible to undertake a detailed analysis of the situations, reveal how the human body interacts with technology, and how a person’s attention responds to technical information. In these situations, the driving instructor takes on the role of the translator by mediating between various situational definitions—one’s own, that of the inexperienced learner driver, other motorists, and the driver assistance systems in the car. The driving instructor represents the driving school as an institution that is responsible for creating an intersubjectively arranged understanding of how to deal with technology and socio-technical situations.

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