scholarly journals Kualitas Hidup Pasien Kanker Rawat Jalan yang Menjalani Kemoterapi di RSUD Kota Yogyakarta

2021 ◽  
Vol 17 (2) ◽  
Author(s):  
Ratna R. ◽  
Woro Supadmi ◽  
Endang Yuniarti
Keyword(s):  
Cross Sectional ◽  
Eortc Qlq C30 ◽  
Eortc Qlq

Kualitas hidup merupakan kondisi dimana pasien memiliki kesejahteraan secara fisik, psikologis dan sosial serta mampu mengoptimalkan potensinya dalam kehidupan dan aktivitasnya sehari-hari. Jenis kanker dan kemoterapi yang diberikan dapat mempengaruhi kualitas hidup pasien kanker secara keseluruhan. Penelitian ini bertujuan untuk mengetahui gambaran kualitas hidup pasien kanker dengan menggunakan kuesioner EORTC QLQ-C30 dan menganalisis hubungan karakteristik demografi pasien, jenis kanker dan stadium kanker serta regimen kemoterapi dengan kualitas hidup pasien kanker. Penelitian ini merupakan penelitian observasional menggunakan desain cross sectional dengan subyek semua pasien kanker yang sedang menjalani kemoterapi di RSUD Kota Yogyakarta dan memenuhi kriteria inklusi selama bulan September-Oktober 2020. Data yang diperoleh dianalisis secara univariat menggunakan distribusi frekuensi dan dianalisis statistik dengan uji korelasi Spearman. Hasil penelitian menunjukkan skor rata-rata kualitas hidup pada skala status kesehatan global adalah 61,03±14,07. Domain tertinggi pada skala fungsional adalah fungsi sosial dengan skor rata-rata 92,40±17,14 dan kehilangan nafsu makan merupakan domain tertinggi pada skala gejala dengan skor rata-rata 52,94±28,93. Hasil analisis statistik menunjukkan bahwa terdapat hubungan yang signifikan antara karakteristik demografi pasien kanker (usia dan jenis kelamin) dengan kualitas hidup pada skala status kesehatan global (p < 0,05), sedangkan untuk jenis kanker, stadium, regimen dan siklus kemoterapi tidak terdapat hubungan yang signifikan dengan kualitas hidup pada status kesehatan global (p > 0,05). 

scholarly journals Psychometric validation of the Moroccan version of the EORTC QLQ-C30 in colorectal Cancer patients: cross-sectional study and systematic literature review

BMC Cancer ◽  
2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Yacir El Alami ◽  
Hajar Essangri ◽  
Mohammed Anass Majbar ◽  
Saber Boutayeb ◽  
Said Benamr ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Colorectal Cancer ◽  
Discriminant Validity ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Related Quality ◽  
Eortc Qlq C30 ◽  
Eortc Qlq ◽  
Colorectal Cancer Patients

Abstract Background Health-related quality of life is mainly impacted by colorectal cancer which justified the major importance addressed to the development and validation of assessment questionnaires. We aimed to assess the validity and reliability of the Moroccan Arabic Dialectal version of the European Organization for Research and Treatment of Cancer (EORTC) Quality of Life Core Questionnaire (QLQ-C30) in patients with colorectal cancer. Methods We conducted a cross-sectional study using the Moroccan version of the EORTC QLQ-C30 on colorectal cancer patients from the National Oncology Institute of Rabat, in the period from February 2015 to June 2017. The QLQ-C30 was administered to 120 patients. Statistical analysis included reliability, convergent, and discriminant validity as well as known-groups comparisons. Results In total, 120 patients with colorectal cancer were included in the study with 38 (32%) patients diagnosed with colon cancers. Eighty-two patients (68%) had rectal cancer, among which 29 (24%) patients with a stoma. The mean age of diagnosis was 54 years (+/− 13.3). The reliability and validity of the Arabic dialectal Moroccan version of the EORTC QLQ-C30 were satisfactory. [Cronbach’s alpha (α =0.74)]. All items accomplished the criteria for convergent and discriminant validity except for question number 5, which did not complete the minimum required correlation with its own scale (physical functioning). Patients with rectal cancer presented with bad Global health status and quality of life (GHS/QOL), emotional functioning as well as higher fatigue symptoms compared to patients with colon cancer. The difference between patients with and without stoma was significant for diarrhea and financial difficulty. Conclusions The Moroccan Arabic Dialectal version of the QLQ-C30 is a valid and reliable measure of health-related quality of life (HRQOL) in patients with colorectal cancer.

scholarly journals Quality of life among ovarian cancer survivors in Haji Adam Malik General Hospital Medan, Indonesia

2020 ◽  
Vol 11 (2) ◽  
pp. 133-139
Author(s):  
Kristivani Br Ginting ◽  
Muhammad Rizki Yaznil ◽  
M. Oky Prabudi ◽  
Lili Rahmawati
Keyword(s):  
Quality Of Life ◽  
Ovarian Cancer ◽  
Cancer Survivors ◽  
General Hospital ◽  
Detection Methods ◽  
Cross Sectional ◽  
Eortc Qlq C30 ◽  
C 30 ◽  
Eortc Qlq

Latar belakang: Kanker ovarium memiliki angka mortalitas yang cukup tinggi dikarenakan gejalanya yang tidak spesifik, sering ditemukan pada stadium lanjut, dan belum adanya metode deteksi dini yang sudah terbukti. Untuk menilai keberhasilan terapi penyintas kanker ovarium, tidak hanya dinilai dari aspek klinis tetapi juga dinilai dari kualitas hidup penyintas kanker ovarium yang penilaiannya berdasarkan skala fungsional dan skala gejala dalam kuesioner EORTC QLQ C30 dan EORTC QLQ OV28. Metode: Penelitian ini menggunakan desain penelitian cross sectional, menggunakan data primer dari hasil wawancara dengan kuesioner EORTC QLQ C30 dan EORTC QLQ OV28 serta data sekunder yang berasal dari rekam medik di RSUP Haji Adam Malik Medan tahun 2017 - 2018. Sampel penelitian dipilih dengan metode total sampling dari seluruh data rekam medik yang memenuhi kriteria penelitian.   Hasil: Hasil penelitian ini didapatkan kualitas hidup global penyintas kanker ovarium 89.36% adalah baik, dan 10.64% adalah sedang serta tidak ada yang memiliki kualitas hidup buruk. Namun, didapatkan adanya gangguan pada skala fungsional berupa: fungsi emosional, fungsi kognitif, fungsi seksual, dan sikap terhadap penyakit, serta adanya permasalahan pada skala gejala berupa: kelelahan, nyeri, neuropati perifer, dan gejala menopause. Didapatkan juga tidak ada hubungan karakteristik usia, jenis histopatologis, stadium, lama terapi dengan kualitas hidup penyintas kanker ovarium, namun terdapat hubungan antara jenis terapi dengan kualitas hidup penyintas kanker ovarium. Kesimpulan: Kualitas hidup penyintas kanker ovarium secara global adalah baik. Kata Kunci: Kualitas Hidup, Penyintas Kanker Ovarium, EORTC QLQ C-30, EORTC QLQ     OV-28   Abstract Background: Ovarian cancer has a high mortality rate due to nonspecific symptoms, often found at an advanced stage, and also the absence of proven early detection methods. To assess the success of ovarian cancer survivors therapy, it is not only assessed from the clinical aspect but also from the quality of life of ovarian cancer survivors which is based on the functional and symptom scale in the EORTC QLQ C30 and EORTC QLQ OV28 questionnaires.  Methods: This study used a cross-sectional study design, using primary data from interviews with the survivors based on the questionnaire EORTC QLQ C30 and EORTC QLQ OV28 as well as secondary data derived from medical records at Haji Adam Malik General Hospital Medan in 2017 - 2018. The research sample was used with a total sampling method from all medical record data that fulfill the research criteria.  Result: The quality of life of ovarian cancer survivors is generally good (89.36%), meanwhile the rest is moderate (10.64%) without the poor quality of life. However, there are disorders on the functional scale in the form of emotional function, cognitive function, sexual function, and attitude toward disease. Likewise on the scale of symptoms, there are problems including: fatigue, pain, peripheral neuropathy, and menopausal symptoms.  Conclusion: The quality of life of ovarian cancer survivors globally is good. Keywords: Quality of Life, Ovarian Cancer Survivors, EORTC QLQ C-30, EORTC QLQ OV-28  

scholarly journals Health-Related Quality of Life Among Rural Chinese Patients With Upper Gastrointestinal Diseases at Different Pathological Stages: A Cross-Sectional Study

2020 ◽  
Author(s):  
Tingting Qin ◽  
Yuchen Shao ◽  
Nan Zhang ◽  
Jialin Wang ◽  
Nengliang Yao ◽  
...  
Keyword(s):  
Chinese Patients ◽  
Pathological Stage ◽  
Cross Sectional ◽  
Upper Gi ◽  
Significant Difference ◽  
Related Quality ◽  
Eortc Qlq C30 ◽  
Health Related ◽  
Eortc Qlq

Abstract Objective: The aim of this study was to compare the health-related quality of life (HR-QoL) among rural Chinese patients with upper gastrointestinal (GI) diseases at different pathological stages and to determine the factors influencing HR-QoL in this population.Methods: A cross-sectional survey was conducted in two counties in Shandong province in China from July to September 2018. Demographic and clinical characteristics were collected, and HR-QoL of patients was assessed using a set of questionnaires, including the EORTC QLQ-C30 (V3.0), the QLQ-OES18 and the QLQ-STO22. Multivariate analysis of variance (MANOVA) and Kruskal–Wallis test were used to compare the HR-QoL of patients of different pathological stage subgroups, and multivariate regression analyses were used to determine influencing factors.Results: A total of 406 patients were included in this study. The mean scores for patients with upper GI diseases were 74.88 (SD=19.15), 8.04 (SD=16.17) and 8.64 (SD=16.96) for the global QoL scale of EORTC QLQ-C30, QLQ-OES18 and QLQ-STO22, respectively. There was no significant difference in most of the scales between the precancerous and early stage groups, but a significant difference in HR-QoL between the precancerous and advanced groups as well as between early and advanced groups. Residence area, age, education level and pathological stage were the significant factors influencing HR-QoL scores, controlling for other variables.Conclusions: The overall HR-QoL of patients with advanced upper GI cancer needs to be managed as a component of cancer care. Measures should be taken to routinely identify patient symptoms so that follow-up care can alleviate patient symptom burden. Tailored treatment and care for patients with upper GI diseases of different age, educational level and pathological stage may be needed to help improve HR-QoL.

scholarly journals Functional health and symptoms in Spain before and during the COVID-19 pandemic

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Jens Lehmann ◽  
Bernhard Holzner ◽  
Johannes M. Giesinger ◽  
Andrew Bottomley ◽  
Shaad Ansari ◽  
...  
Keyword(s):  
General Population ◽  
Symptom Burden ◽  
Functional Health ◽  
Cross Sectional ◽  
Social Distancing ◽  
Global Quality ◽  
Global Quality Of Life ◽  
Eortc Qlq C30 ◽  
Eortc Qlq ◽  
The Impact

Abstract Background The impact of the coronavirus disease (COVID-19) pandemic on wellbeing and health has so far been studied using mostly cross-sectional designs. To place recent findings into context, we compared symptoms and functional health status in two independent samples assessed before and during the COVID-19 pandemic. Methods Participants were recruited via an online panel using quota sampling. We assessed symptoms, functional health, and global quality of life with the EORTC QLQ-C30 in two general population samples in Spain (collected in July 2019 and April 2020). We also assessed several COVID-19 related variables, such as adherence to social distancing. Results Data from N = 1010 participants before the pandemic (mean age 47.1 years, 50.5% female) were compared with data from N = 504 participants during the pandemic (mean age 47.1 years, 50.8% female). Participants during the pandemic (vs. before the pandemic) reported lower role functioning and emotional functioning, as well as less symptom burden. A lower degree of social distancing was associated with better functional health and lower symptom burden. Conclusion Our findings indicate an impact of the COVID-19 pandemic on functional health and symptom burden in the Spanish general population. The comparison of before and during the pandemic can be used to benchmark results raised only during the pandemic.

scholarly journals Penilaian kualitas hidup penderita karsinoma nasofaring berdasarkan Karnofsky Scale, EORTC QLQ-C30 dan EORTC QLQ-H & N35

2014 ◽  
Vol 43 (2) ◽  
pp. 110
Author(s):  
Dewi Kurniawati ◽  
Frederik George Kuhuwael ◽  
Abdul Qadar Punagi
Keyword(s):  
Quality Of Life ◽  
Karnofsky Performance Scale ◽  
Life Questionnaire ◽  
Cross Sectional ◽  
European Organization ◽  
Quality Of Life Questionnaire ◽  
Eortc Qlq C30 ◽  
Eortc Qlq ◽  
Performance Scale

Latar belakang: Karsinoma nasofaring (KNF) berpengaruh terhadap kualitas hidup penderita, baik dari kankernya sendiri, maupun pengobatan serta efek sampingnya. Penilaian kualitas hidup penderita KNF dapat secara unidimensional menggunakan parameter status tampilan Karnofsky Performance Scale (Karnofsky PS) atau multidimensional memakai parameter European Organization For Research and Treatment of Cancer Quality of Life Questionnaire C30 (EORTC QLQ-C30) dan European Organization For Research And Treatment Of Cancer Head and Neck Cancer Quality of Life Questionnaire (EORTC QLQ-H&N35).Tujuan: Menilai kesesuaian hasil skor Karnofsky PS, EORTC QLQ-C30 dan EORTC QLQ-H&N35 dalam menilai kualitas hidup penderita KNF dengan menentukan korelasi antar parameter dan menentukan estimasi skor Karnofsky PS menggunakan skor EORTC QLQ-C30 dan skor EORTC QLQ-H&N35. Menganalisis hubungan antar parameter menurut stadium.Metode: Penelitian adalah observasional analitik dengan pedekatan cross sectional. Populasinya semua kasus KNF yang berobat ke Bagian THT-KL, Rumah Sakit Wahidin Sudirohusodo, Makassar. Sampel sebanyak 48 orang dipilih secara purposive. Penilaian kualitas hidup menggunakan parameter Karnofsky PS, EORTC QLQ-C30 dan EORTC QLQ-H&N35. Hasil: Didapati kesesuaian hasil skor dari ketiga parameter, ditandai adanya korelasi bermakna antara skor Karnofsky PS, skor EORTC QLQ-C30 dan skor EORTC QLQ-H&N35. Semakin tinggi skor Karnofsky PS, akan semakin rendah skor EORTC QLQ-C30 dan skor EORTC QLQ-H&N35 maka kualitas hidup penderita KNF semakin baik. Skor EORTC QLQ-C30 dan skor EORTC QLQ-H&N35 dapat mengestimasi skor Karnofsky PS. Terdapat hubungan bermakna antara Karnofsky PS, EORTC QLQ-C30 dan EORTC QLQ-H&N35 menurut stadium (p<0,05). Kesimpulan: DEORTC QLQ-C30 dan EORTC QLQ-H&N35 dapat melengkapi Karnofsky PS dalam penilaian kualitas hidup penderita kanker kepala leher terutama KNF. Kata kunci: Kualitas hidup, KNF, Karnofsky PS, EORTC QLQ-C30, EORTC QLQ-H&N3.

Transfusion Dependence and Low Hemoglobin Have the Greatest Impact On Quality of Life (QOL) in MDS Patients - a Tertiary Care Cross Sectional and Longitudinal Study.

Blood ◽  
2009 ◽  
Vol 114 (22) ◽  
pp. 2500-2500 ◽  
Author(s):  
Rena Buckstein ◽  
Shabbir Alibhai ◽  
Adam Lam ◽  
Liying Zhang ◽  
Alex Mamedov ◽  
...  
Keyword(s):  
Health Status ◽  
Global Health ◽  
Social Functioning ◽  
Linear Regression Analysis ◽  
Iron Chelation ◽  
Global Health Status ◽  
Cross Sectional ◽  
Eortc Qlq C30 ◽  
Clinically Significant ◽  
Eortc Qlq

Abstract Abstract 2500 Poster Board II-477 Background: There are few prospective longitudinal data evaluating QOL in MDS, a disease characterized by chronic anemia and transfusion dependence in many patients. Furthermore, the effects of various drug therapies on QOL are little known but essential for cost-effectiveness studies. We have been conducting prospective assessments of QOL in all consenting patients registered in our MDS clinic using the instruments EORTC QLQ-C30, FACT-An/Fatigue, EQ5D and a global fatigue scale. We present cross-sectional results in the first 93 patients evaluated prospectively over 14.7 months. Methods: We analyzed QOL according to age, hemoglobin, IPSS risk group, transfusion dependence (Y/N), drug therapy and ferritin. Changes in QOL in the 64 (67%) patients with repeat assessments at a median time of 3 months were also examined. We examined the correlation between QOL scores using Spearman's correlation coefficient. We compared raw scores for clinically significant differences between MDS patients and normative data. Clinically significant (CS) score differences were considered 10 points for the EORTC, 7 for the FACT-An, and 4 for the FACT-Fatigue. Statistical significance (SS) using p<0.05 was determined using logistic and linear regression analysis to compare QOL scores adjusting for up to 3 additional confounding variables and non-parametric tests were used to compare risk groups (e.g., ferritin > 1000 vs. =< 1000 ug/L) on QOL scores without adjustment for confounders. Results: The median age was 71 y, with 59% males. Of the 89 patients with measurable IPSS scores, 84% fell into low/low intermediate risk categories and 7% had del 5q abnormality. 40% were transfusion dependent, 20% were receiving lenalidomide, 21% iron chelation and 21% growth factors. 50% had a Hgb of <100 g/L at time of study and the median ferritin was 837 ug/L. Comparing MDS QOL scores with normative scores from the general population, we observed SS and CS differences in the following 9 scales: worse physical, role, emotional, cognitive and social functioning; worse global QOL; increased fatigue, nausea, vomiting and pain on the QLQ-C30 function and symptoms scales; and increased fatigue on the FACT-Fatigue subscale. By linear regression analysis of QOL scores, transfusion dependence and Hgb level < 100 were the most powerful and independent predictors for impaired global health status (p=.03 and .01) but transfusion dependence was the most significant predictor of global fatigue (p=.012), impaired physical functioning (p=.002), impaired social functioning (p=.001), global health status (p=.03), and financial problems (p=.001). Increasing age was independently predictive of impaired physical functioning and appetite loss. QOL scores did not differ significantly between patients on or off lenalidomide, growth factors or iron chelation however, patients on lenalidomide who were transfusion independent had CS improved physical, emotional and social functioning and global health status /QOL compared with those who remained transfusion dependent. Eleven of 63 patients who had repeated QOL assessments increased their Hgb to >100 g/L and demonstrated increased global health status QOL (p=.03). Finally, the visual analogue scores (derived) from the single-item global fatigue and the EQ-5D health state scales correlated very strongly with virtually every symptom and functional domain of the QLQ-C30 as did the FACT-An and EQ-5D. The UK converted EQ-5D summary state utilities /self-reported scores and EORTC QLQ-C30 global health scores are in the table below. Conclusions: Most domains of QOL are impaired and symptoms of fatigue and dyspnea are increased in MDS and most dependent on transfusion dependence and Hgb, particularly if the Hgb is <100 g/L. Simple numerical rating scales for global health and fatigue may be convenient screening tools to employ in the clinic for QOL assessment. Utility scores derived from longitudinal QOL data in MDS patients treated with different agents are both feasible and essential to calculate QALYs in this era of cost constraints and pharmaco-economic modeling. Disclosures: No relevant conflicts of interest to declare.

scholarly journals Association between spirituality and quality of life of women with breast cancer undergoing radiotherapy

2021 ◽  
Vol 55 ◽  
Author(s):  
Mayara Lindner Brandão ◽  
Thais Zilles Fritsch ◽  
Thayla Rafaella Pasa Toebe ◽  
Eliane Goldberg Rabin
Keyword(s):  
Breast Cancer ◽  
Quality Of Life ◽  
Predominantly White ◽  
Pearson Correlation ◽  
Statistical Significance ◽  
Porto Alegre ◽  
Cross Sectional ◽  
Eortc Qlq C30 ◽  
Eortc Qlq

ABSTRACT Objective: To verify whether there is an association between spirituality/religiosity and quality of life of women with breast cancer undergoing radiotherapy. Method: Cross-sectional, quantitative study performed between May and July 2019 in an Oncology Hospital of Porto Alegre state, Brazil. A sociodemographic questionnaire and the instruments EORTC-QLQ-C30 and WHOQOL-SRPB were applied. The data were verified through Shapiro-Wilk test, Pearson correlation coefficient, and Spearman. Results: The sample comprised 108 women with a mean age of 56, predominantly white, married, and with incomplete primary education. A positive correlation between “Overall quality of life score” with all facets of spirituality, as well as a negative correlation for the symptoms “Fatigue”, “Insomnia”, and “Diarrhea” with some aspects of spirituality, such as “Faith”, were observed. Conclusion: The statistical significance of the correlation has positively associated spirituality/religiosity and quality of life in women with breast cancer undergoing radiotherapy. Understanding spirituality as a preponderant factor in quality of life contributes to positive nursing care interference, with individualized orientation and care to each woman.

scholarly journals Quality of Life of Cancer Patients Receiving Chemotherapy

2020 ◽  
Vol 11 (3) ◽  
pp. 3813-3818
Author(s):  
Thenmozhi P ◽  
Simeon I
Keyword(s):  
Quality Of Life ◽  
Cancer Patients ◽  
Sampling Technique ◽  
Demographic Variables ◽  
Symptom Scale ◽  
Cross Sectional ◽  
Eortc Qlq C30 ◽  
Eortc Qlq ◽  
The Mind

Quality of life is a significant part of patient care among cancer patients. Toxicities and adverse impacts of chemotherapy influence personal satisfaction in disease patients, and it likewise makes challenges in satisfying family and social jobs. Hence the study aimed to assess the quality of life of cancer patients receiving chemotherapy. Cross-sectional research design was employed with 50 samples which matched the inclusion criteria were selected by convenience sampling technique. Demographic variables data were collected by using a structured questionnaire followed by assessing the quality of life by using the EORTC QLQ-C30 questionnaire. The findings of the study revealed the highest median value in the cognitive functioning, social functioning, role functioning and also in physical functioning compared symptom scale and in which the lowest score in the symptoms of nausea & vomiting, loss of craving, fatigue, diarrhea and constipation and face many challenges related to finance. Based on findings, further studies can be conducted to correlate the quality of life with clinical assessment and focus on the mind-body exercise such as yoga, meditation and physical therapy like exercise, massage to enhance the quality of life and to complete the entire cycle of chemotherapy.

Is there a difference in quality of life, comparing summer and winter, in patients who have undergone total laryngectomy?

2007 ◽  
Vol 122 (9) ◽  
pp. 967-971
Author(s):  
F C Van Wyk ◽  
F Vaz ◽  
M Harries ◽  
J Weighill
Keyword(s):  
Quality Of Life ◽  
Total Laryngectomy ◽  
Cross Sectional Study ◽  
Short Term ◽  
Cross Sectional ◽  
European Organization ◽  
Eortc Qlq C30 ◽  
Eortc Qlq ◽  
The Impact

AbstractIntroduction:Several studies have implied that patients' quality of life stabilises six months after undergoing total laryngectomy. However, these studies may well have overlooked persistent short term variations in patients' quality of life. The aim of this study was to assess the impact of seasonal change (i.e. summervswinter) on the quality of life of patients following total laryngectomy.Methods:A prospective, cross-sectional study of recurrence-free laryngectomy patients was performed, using the European Organization for Research and Treatment of Cancer (version three) QLQ-C30 questionnaires (EORTC QLQ-C30), during January 2004 (i.e. winter), August 2004 (summer) and January 2005 (winter).Results:Thirty-six patients were entered into the study. The response rate was 70.3 per cent. Patient's time elapsed since surgery varied from six months to 12 years. In all questionnaire domains, responses seemed remarkably consistent over time.Conclusion:No statistically significant differences were found between summer and winter scores in all the domains analysed by the EORTC QLQ-C30.

Hubungan respons terapi dengan kualitas hidup penderita karsinoma nasofaring WHO tipe III setelah terapi

2016 ◽  
Vol 46 (2) ◽  
pp. 135
Author(s):  
Deviana Deviana ◽  
Pudji Rahaju ◽  
Iriana Maharani
Keyword(s):  
Quality Of Life ◽  
Nasopharyngeal Carcinoma ◽  
Treatment Response ◽  
High Quality ◽  
Cross Sectional ◽  
Type Iii ◽  
Eortc Qlq C30 ◽  
Positive Treatment ◽  
Eortc Qlq

Latar belakang: Hasil terapi penderita kanker umumnya dinilai dari angka kelangsungan hidup dan angka kontrol penyakit secara lokal/regional. Penilaian ini dilakukan oleh dokter dan tidak menunjukkan bagaimana kepuasan penderita terhadap hasil terapi. Di Indonesia, karsinoma nasofaring (KNF) menempati peringkat keempat keganasan tertinggi, dengan tipe terbanyak adalah KNF WHO tipe III. Penilaian kualitas hidup penting dilakukan karena penyakit dan terapi KNF dapat mempengaruhi beberapa fungsi penting kehidupan (makan, komunikasi, dan hubungan sosial). Belum pernah dilaporkan penelitian mengenai kualitas hidup penderita KNF setelah terapi di Indonesia. Tujuan: Mengetahui hubungan antara respons terapi dengan kualitas hidup penderita KNF WHO tipe III setelah radioterapi atau kemoradioterapi. Metode: Penelitian observasional analitik dengan pendekatan cross-sectional. Dinilai respons terapi dan kualitas hidup 8 subyek dari kelompok radioterapi, dan 8 subyek dari kelompok kemoradioterapi, dengan waktu evaluasi minimal 3 bulan setelah terapi. Penilaian respons terapi berdasarkan hasil pemeriksaan terakhir: biopsi nasofaring, foto Rontgen toraks, ultrasonografi abdomen,biopsi aspirasi jarum halus kelenjar getah bening leher (jika ada indikasi), dan foto Rontgen torakolumbal (jika ada indikasi). Penilaian kualitas hidup menggunakan kuesioner EORTC QLQ-C30 dan EORTC QLQ-H&N35. Hasil: Tidak didapati perbedaan respons terapi antara kelompok radioterapi dan kemoradioterapi. Seluruh subyek memiliki respons terapi positif (tidak didapati tumor menetap, kambuh secara lokal dan regional, dan metastasis jauh). Penderita dengan respons terapi positif memiliki kualitas hidup tinggi. Uji perbedaan kualitas hidup menunjukkan perbedaan bermakna hanya dalam hal fungsi emosi (p=0,031). Kesimpulan: Penderita KNF WHO tipe III dengan respons terapi positif memiliki kualitas hidup tinggi. Tidak didapati perbedaan respons terapi antara kelompok radioterapi dengan kemoradioterapi. Penderita yang mendapatkan kemoradioterapi memiliki kualitas hidup lebih tinggi dalam hal fungsi emosi.Kata kunci: Karsinoma nasofaring, radioterapi, kemoradioterapi, respons terapi, kualitas hidupABSTRACT Introduction: The endpoint of medical care for cancer patients usually focused on the survival rate and locoregional control rate. These endpoints were assessed by doctor and not the patient’s satisfaction rate to treatment outcome. In Indonesia, nasopharyngeal carcinoma (NPC) is the fourth most common cancer, especially NPC type III WHO. Assessment of quality of life is important because both the disease and the therapy of NPC could affect several important functions in life (eating, communication, and social relationships). There was no study reported about quality of life of NPC patients after therapy in Indonesia. Purpose: To assess the relationship between treatment response and quality of life of NPC WHO type III patients after radiotherapy or chemoradiotherapy. Method: Analytic observational study with cross-sectional design assessed treatment response and quality of life in 8 subjects of radiotherapy group and 8 subjects of chemoradiotherapy group with minimal evaluation time 3 months after therapy. Treatment response was assessed by the latest examination result of nasopharyngeal biopsy, thorax plain photo, abdomen ultrasonography, fine needle aspiration biopsy of neck mass (if indicated), and thoracolumbal plain photo (if indicated). Quality of life was assessed by EORTC QLQ-C30 and EORTC QLQ-H&N35 questionnaire. Result: There was no treatment response difference between radiotherapy and chemoradiotherapy group. All subjects had positive treatment response (no cancer remained, no locoregional recurrence, and no distant metastasis). Subjects with positive treatment response had high quality of life. Statistical analysis on the quality of life only showed a marked difference in emotional function (p=0.031). Conclusion: NPC WHO type III patients with positive treatment response had high quality of life. There was no treatment response difference between radiotherapy and chemoradiotherapy subjects. Patients treated with chemoradiotherapy had a better quality of life in emotional function.Keywords: Nasopharyngeal carcinoma, radiotherapy, chemoradiotherapy, treatment response, quality of life

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