scholarly journals ANTICANCER POTENTIAL OF α-MANGOSTIN

2017 ◽  
Vol 10 (12) ◽  
pp. 440 ◽  
Author(s):  
Muchtaridi Muchtaridi ◽  
Cindy Aprillianie Wijaya
Keyword(s):  
Chemical Compounds ◽  
Cancer Drug ◽  
Garcinia Mangostana ◽  
Pharmacological Activities ◽  
Tropical Fruit ◽  
Cancer Drug Discovery ◽  
Anticancer Properties ◽  
Xanthone Derivatives ◽  
East Region ◽  
Apoptotic Activity

Objective: Mangosteen (Garcinia mangostana Linn.) is a tropical fruit originated from South East region. Mangosteen exhibiting a variety of pharmacological activities and is often used for traditional medicine. There are numerous chemical compounds contained in the pericarp of the mangosteen fruit. One of them is xanthone derivative which in some studies shows antioxidant and anticancer activity by preventing free radical and damaging cells. One of the xanthone derivatives that have the strongest anticancer properties is α-mangostin.Methods: Anticancer potential of α-mangostin was reviewed from available literature.Results: The α-mangostin shows anti-proliferative and apoptotic activity by suppressing the formation of carcinogenic compounds in various cancer cells. This review will summarize the anticancer properties of α-mangostin that may be exploited for effective cancer prevention.Conclusion: Development of α-mangostin as a chemopreventive compound can provide new opportunities for effective cancer drug discovery. α-mangostin is useful as a complementary or alternative medicine and a chemopreventive tool against cancer.

scholarly journals Nanoformulations of α-Mangostin for Cancer Drug Delivery System

Pharmaceutics ◽  
2021 ◽  
Vol 13 (12) ◽  
pp. 1993
Author(s):  
Lisna Meylina ◽  
Muchtaridi Muchtaridi ◽  
I Made Joni ◽  
Ahmed Fouad Abdelwahab Mohammed ◽  
Nasrul Wathoni
Keyword(s):  
Drug Delivery ◽  
Cellular Uptake ◽  
Polymeric Nanoparticles ◽  
Cancer Drug ◽  
Garcinia Mangostana ◽  
Active Constituent ◽  
Anticancer Efficacy ◽  
Anticancer Properties ◽  
Cancer Drug Delivery

Natural compounds are emerging as effective agents for the treatment of malignant diseases. The active constituent of α-mangostin from the pericarp of Garcinia mangostana L. has earned significant interest as a plant base compound with anticancer properties. Despite α-mangostin’s superior properties as an anticancer agent, its applications are limited due to its poor solubility and physicochemical stability, rapid systemic clearance, and low cellular uptake. Our review aimed to summarize and discuss the nanoparticle formulations of α-mangostin for cancer drug delivery systems from published papers recorded in Scopus, PubMed, and Google Scholar. We investigated various types of α-mangostin nanoformulations to improve its anticancer efficacy by improving bioavailability, cellular uptake, and localization to specific areas These nanoformulations include nanofibers, lipid carrier nanostructures, solid lipid nanoparticles, polymeric nanoparticles, nanomicelles, liposomes, and gold nanoparticles. Notably, polymeric nanoparticles and nanomicelles can increase the accumulation of α-mangostin into tumors and inhibit tumor growth in vivo. In addition, polymeric nanoparticles with the addition of target ligands can increase the cellular uptake of α-mangostin. In conclusion, nanoformulations of α-mangostin are a promising tool to enhance the cellular uptake, accumulation in cancer cells, and the efficacy of α-mangostin as a candidate for anticancer drugs.

scholarly journals Chemical Compounds and Pharmacological Activities of Mangosteen (Garcinia mangostana L.) – Updated Review

2021 ◽  
Vol 12 (2) ◽  
pp. 2503-2516
Keyword(s):  
Research Field ◽  
In Vivo Studies ◽  
Future Research ◽  
Drug Candidate ◽  
Garcinia Mangostana ◽  
Pharmacological Activities ◽  
Tropical Fruit ◽  
Wide Range

Mangosteen (Garcinia mangostana L.) is a tropical fruit belonging to Guttiferae (syn. Clusiaceae) family. Research on mangosteen has been widely conducted. Also, numerous in vitro and in vivo studies related to mangosteen have been published, indicating its significance and potential usefulness in the research field. This review was constructed by collecting and analyzing more than 50 research articles to explore the phytochemical contents and the medicinal benefits of mangosteen. A significant level of xanthones greatly contributes to the extensive pharmacological activities of mangosteen. Apart from xanthones, mangosteen also contained benzophenones, flavonoids, and anthocyanins. Mangosteen had a wide range of pharmacological effects, including antioxidant, anti-acne, anti-aging, anti-hyperpigmentation, antibacterial, antidiabetic, anti-obesity, anti-inflammatory, antimalarial, antiparasitic, and antitumor. Additionally, mangosteen has shown an advantageous activity toward pathological conditions such as Alzheimer's, bipolar disorder, schizophrenia, neuropathic pain, and pulmonary fibrosis. This literature review indicated that xanthone in mangosteen had potential and promising to be developed as a drug candidate. More extensive explorations, especially in pharmacokinetic, pharmacodynamic, and xanthone targeting effects, are widely open to be carried out for future research.

scholarly journals 7-epi-Clusianone, a Multi-Targeting Natural Product with Potential Chemotherapeutic, Immune-Modulating, and Anti-Angiogenic Properties

Molecules ◽  
2019 ◽  
Vol 24 (23) ◽  
pp. 4415 ◽  
Author(s):  
Wesley F. Taylor ◽  
Maria Yanez ◽  
Sara E. Moghadam ◽  
Mahdi Moridi Farimani ◽  
Sara Soroury ◽  
...  
Keyword(s):  
Cancer Cell ◽  
Targeted Therapies ◽  
Acquired Resistance ◽  
Cell Types ◽  
Treatment Modalities ◽  
Cancer Drug ◽  
Cancer Drug Discovery ◽  
Anticancer Properties ◽  
Immune Therapies ◽  
Cancer Types

Targeted therapies have changed the treatment of cancer, giving new hope to many patients in recent years. The shortcomings of targeted therapies including acquired resistance, limited susceptible patients, high cost, and high toxicities, have led to the necessity of combining these therapies with other targeted or chemotherapeutic treatments. Natural products are uniquely capable of synergizing with targeted and non-targeted anticancer regimens due to their ability to affect multiple cellular pathways simultaneously. Compounds which provide an additive effect to the often combined immune therapies and cytotoxic chemotherapies, are exceedingly rare. These compounds would however provide a strengthening bridge between the two treatment modalities, increasing their effectiveness and improving patient prognoses. In this study, 7-epi-clusianone was investigated for its anticancer properties. While previous studies have suggested clusianone and its conformational isomers, including 7-epi-clusianone, are chemotherapeutic, few cancer types have been demonstrated to exhibit sensitivity to these compounds and little is known about the mechanism. In this study, 7-epi-clusianone was shown to inhibit the growth of 60 cancer cell types and induce significant cell death in 25 cancer cell lines, while simultaneously modulating the immune system, inhibiting angiogenesis, and inhibiting cancer cell invasion, making it a promising lead compound for cancer drug discovery.

Scaffold Repurposing of Old Drugs Towards New Cancer Drug Discovery

2016 ◽  
Vol 16 (19) ◽  
pp. 2107-2114 ◽  
Author(s):  
Haijun Chen ◽  
Jianlei Wu ◽  
Yu Gao ◽  
Haiying Chen ◽  
Jia Zhou
Keyword(s):  
Drug Discovery ◽  
Cancer Drug ◽  
Cancer Drug Discovery ◽  
Old Drugs

Natural Sesquiterpene Lactones in the Prevention and Treatment of Inflammatory Disorders and cancer: A Systematic Study of this Emerging Therapeutic Approach based on Chemical and Pharmacological Aspect

2020 ◽  
Vol 17 (9) ◽  
pp. 1102-1116
Author(s):  
Sudip Kumar Mandal ◽  
Utsab Debnath ◽  
Amresh Kumar ◽  
Sabu Thomas ◽  
Subhash Chandra Mandal ◽  
...  
Keyword(s):  
Drug Discovery ◽  
Biological Activities ◽  
Sesquiterpene Lactones ◽  
Structural Diversity ◽  
Cancer Drug ◽  
Cancer Drug Discovery ◽  
Anti Cancer ◽  
Drug Discovery Program ◽  
Anti Inflammatory ◽  
Family Based

Background and Introduction: Sesquiterpene lactones are a class of secondary metabolite that contains sesquiterpenoids and lactone ring as pharmacophore moiety. A large group of bioactive secondary metabolites such as phytopharmaceuticals belong to this category. From the Asteraceae family-based medicinal plants, more than 5,000 sesquiterpene lactones have been reported so far. Sesquiterpene lactone-based pharmacophore moieties hold promise for broad-spectrum biological activities against cancer, inflammation, parasitic, bacterial, fungal, viral infection and other functional disorders. Moreover, these moiety based phytocompounds have been highlighted with a new dimension in the natural drug discovery program worldwide after the 2015 Medicine Nobel Prize achieved by the Artemisinin researchers. Objective: These bitter substances often contain an α, β-unsaturated-γ-lactone as a major structural backbone, which in recent studies has been explored to be associated with anti-tumor, cytotoxic, and anti-inflammatory action. Recently, the use of sesquiterpene lactones as phytomedicine has been increased. This study will review the prospect of sesquiterpene lactones against inflammation and cancer. Methods: Hence, we emphasized on the different features of this moiety by incorporating its structural diversity on biological activities to explore structure-activity relationships (SAR) against inflammation and cancer. Results: How the dual mode of action such as anti-inflammatory and anti-cancer has been exhibitedby these phytopharmaceuticals will be forecasted in this study. Furthermore, the correlation of anti-inflammatory and anti-cancer activity executed by the sesquiterpene lactones for fruitful phytotherapy will also be revealed in the present review in the milieu of pharmacophore activity relation and pharmacodynamics study as well. Conclusion: So, these metabolites are paramount in phytopharmacological aspects. The present discussion on the future prospect of this moiety based on the reported literature could be a guide for anti-inflammatory and anti-cancer drug discovery programs for the upcoming researchers.

Multi-Targeting Anticancer Agents: Rational Approaches, Synthetic Routes and Structure Activity Relationship

2019 ◽  
Vol 19 (7) ◽  
pp. 842-874 ◽  
Author(s):  
Harbinder Singh ◽  
Nihar Kinarivala ◽  
Sahil Sharma
Keyword(s):  
Anticancer Agents ◽  
Cancer Drug ◽  
Design And Synthesis ◽  
Cancer Drug Discovery ◽  
Dual Targeting ◽  
Structure Activity ◽  
Anti Cancer ◽  
Dual Inhibitors ◽  
Recent Trends ◽  
Synthetic Routes

We live in a world with complex diseases such as cancer which cannot be cured with one-compound one-target based therapeutic paradigm. This could be due to the involvement of multiple pathogenic mechanisms. One-compound-various-targets stratagem has become a prevailing research topic in anti-cancer drug discovery. The simultaneous interruption of two or more targets has improved the therapeutic efficacy as compared to the specific targeted based therapy. In this review, six types of dual targeting agents along with some interesting strategies used for their design and synthesis are discussed. Their pharmacology with various types of the molecular interactions within their specific targets has also been described. This assemblage will reveal the recent trends and insights in front of the scientific community working in dual inhibitors and help them in designing the next generation of multi-targeted anti-cancer agents.

Quinoxaline Nucleus: A Promising Scaffold in Anti-cancer Drug Discovery

2016 ◽  
Vol 16 (10) ◽  
pp. 1339-1352 ◽  
Author(s):  
Alessandra C. Pinheiro ◽  
Thais C. Mendonça Nogueira ◽  
Marcus V.N. de Souza
Keyword(s):  
Drug Discovery ◽  
Cancer Drug ◽  
Cancer Drug Discovery ◽  
Anti Cancer
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