scholarly journals NATURAL PERMEATION ENHANCER FOR TRANSDERMAL DRUG DELIVERY SYSTEM AND PERMEATION EVALUATION: A REVIEW

2017 ◽  
Vol 10 (9) ◽  
pp. 5 ◽  
Author(s):  
Asha Das ◽  
Abdul Baquee Ahmed
Keyword(s):  
Drug Delivery ◽  
Transdermal Drug Delivery ◽  
Drug Level ◽  
Systemic Circulation ◽  
Self Administration ◽  
Permeation Enhancers ◽  
Transdermal Drug Delivery System ◽  
Natural Type ◽  
Physical Type ◽  
Pass Metabolism

The transdermal drug delivery route is evolving as a potential route due to its advantages of bypassing the hepatic first pass metabolism, decreased side effects and gastrointestinal effects, improve patience compliance as it is a pain-free self-administration for patients, etc. The major setback appearing in this route is the difficulty of the drugs to penetrate through the skin as the stratum corneum (outermost layer of the skin) forms a protective barrier for the underlying tissues from the outer environment. A transdermally delivered drug can only show its action when it can cross the transdermal barrier to reach the systemic circulation and for helping on doing that the penetration enhancer are the agents which increase the permeability of the skin which on return maintains the drug level in the blood. Permeation enhancers can be of a chemical type, natural type, and physical type. The present review describes the natural permeation enhancers can be which be employed for transdermal permeation of drugs. 

scholarly journals Formulation and evalution of Transdermal patches of torasemide

2015 ◽  
Vol 1 (1) ◽  
pp. 38 ◽  
Author(s):  
Rajesh Asija ◽  
Avinash Gupta ◽  
Bhagwan Swaroop Maheshwari
Keyword(s):  
Drug Delivery ◽  
Transdermal Drug Delivery ◽  
Systemic Circulation ◽  
Topical Drug Delivery ◽  
Intravenous Therapy ◽  
Transdermal Drug Delivery System ◽  
First Pass Metabolism ◽  
First Pass ◽  
Gastric Emptying Time ◽  
Pass Metabolism

The main advantage of Transdermal drug delivery system is to bypass the first pass metabolism, avertance of the risk and annoyance of intravenous therapy and of the varied conditions of absorption, like pH changes, gastric emptying time and presence of enzyme. The Transdermal drug delivery scheme is generally used where the others system of drug administration fails or it is mainly used in edema associates congestive heart failure. The transdermal drug delivery has advantage to deliver medicines via skin to systemic circulation at a predetermined rate and maintain therapeutic concentration for prolong period of time. This review describes the assorted formulation aspects, a variety of excipients, evaluation tests, challenges and drugs explored in the pasture of topical drug delivery.

An Insight into delivery of drug through The Skin: Transdermal Drug Delivery system

2021 ◽  
pp. 4-12
Author(s):  
Lakshmi Usha Ayalasomayajula ◽  
M. Kusuma Kumari ◽  
Radha Rani Earle
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Transdermal Drug Delivery ◽  
Drug Delivery Systems ◽  
Dosage Forms ◽  
Transdermal Drug Delivery System ◽  
First Pass Metabolism ◽  
First Pass ◽  
Pass Metabolism

In the recent days about 75% of the drugs taken orally are does not show the desired therapeutic effect. Oral conventional dosage forms have several disadvantages such as poor bioavailability due to hepatic first pass metabolism and tendency to produce rapid blood level spikes (Both high and low). Thus, rapid drug levels in the plasma leads to a need of high and/or frequent dosing, which can be both uneconomical and inconvenient. To overcome such disadvantages transdermal drug delivery system was developed. TDDS is such a delivery system which has been explored extensively over the last two decades, with therapeutic success. Transdermal drug delivery systems (TDDS) are the drug delivery systems which involves transportation of drug to epidermal and dermal tissues of the skin for local therapeutic action while major fraction of the drug is transported into the systemic blood circulation. Topical administration of therapeutic agents offers vast advantages over conventional oral and invasive methods of drug delivery. Some of the advantages of transdermal drug delivery include limitation of hepatic first pass metabolism, enhancement of therapeutic efficiency and maintenance of steady state plasma level concentration of the drug. This study includes a brief overview of TDDS, its advantages over conventional dosage forms, drug delivery routes across human skin, permeation enhancers, and classification, formulation, methods of preparation and evaluation of transdermal patches.

Evaluation of Transdermal Patches of Valproic Acid

2020 ◽  
Vol 8 (3) ◽  
pp. 238-245
Author(s):  
Sudhir Singh ◽  
Anand Singh ◽  
Anil Bhandari ◽  
Satish Kumar Sharma ◽  
Sumer Singh ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Valproic Acid ◽  
Transdermal Drug Delivery ◽  
Dosage Form ◽  
Controlled Drug Delivery ◽  
Systemic Circulation ◽  
Transdermal Drug Delivery System ◽  
New Approach ◽  
Manic Disorder ◽  
Transdermal Patches

Conventional System of Medication that requires multi dose therapy are having many problems. The controlled drug delivery is a newer approach is to deliver drug into systemic circulation. As Valproic Acid is a drug to control the manic disorder so it is necessary to maintain the concentration of drug in systemic circulation continuously. So a new approach known as transdermal drug delivery system is adopted to avoid the various drawbacks of oral and other conventional dosage form.  

scholarly journals A Review on Chemical Permeation Enhancers used in the Formulation of Transdermal Drug Delivery System

2021 ◽  
pp. 429-437
Author(s):  
. Shivani ◽  
Ritika Puri
Keyword(s):  
Drug Delivery ◽  
Transdermal Drug Delivery ◽  
Free Water ◽  
Skin Barrier ◽  
Skin Penetration ◽  
Penetration Enhancers ◽  
Permeation Enhancers ◽  
Transdermal Drug Delivery System ◽  
Chemical Permeation Enhancers ◽  
Chemical Permeation

Skin penetration enhancement technology is a rapidly evolving area that will greatly increase the quantity of transdermal drug delivery medications. Penetration enhancers are used to facilitate the movement of drugs through the skin barrier. Numerous methods exist for extending partition enhancement. The enhancers' contact with the polar head of the lipid groups is the potential means for increasing the penetration. Penetration enhancers improve the amount of free water molecules between the bilayer, leading to an improvement of the polar drug diffusion cross section. This article focuses on the different compounds assessed for improving penetration activity like sulphoxides, azones, pyrrolidones, alcohols and alkanols, glycols, surfactants and terpenes.

scholarly journals AN OVERVIEW OF TRANSDERMAL DELIVERY SYSTEM

2017 ◽  
Vol 10 (10) ◽  
pp. 36 ◽  
Author(s):  
Reshmi Jayaprakash ◽  
Jahnara Hameed ◽  
Anupriya Anupriya
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Transdermal Drug Delivery ◽  
Dosage Form ◽  
Systemic Circulation ◽  
Oral Dosage ◽  
Transdermal Drug Delivery System ◽  
Different Types ◽  
Conventional Dosage

Recently, most widely using conventional dosage form such as tablet, capsules, and injections but due to some case we are preferable to choose transdermal drug delivery system (TDDS) because conventional oral dosage form undergo first pass metabolism. In TDDS, skin is the effective medium for the penetration of drug into systemic circulation. This system required very low dose for the effective result or action. One of the major disadvantages of TDDS is penetration rate is very low through the stratum corneum. Nowadays, different types of skin penetration enhancement techniques are used for increasing the penetration. These types of techniques can be also increase the bioavailability. The patients have more preferable to choose this type of drug delivery system because it has more advantages than conventional dosage form. This article is discuses about the anatomy and physiology of skin and its drug penetration capacity, polymers used in transdermal drug delivery and different types of TDDS.

Transdermal Drug Delivery System

2017 ◽  
Vol 9 (1) ◽  
Author(s):  
Syeda Ayesha Fathima ◽  
Shireen Begum ◽  
Syeda Saniya Fatima
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Transdermal Drug Delivery ◽  
Systemic Circulation ◽  
Dosage Forms ◽  
Transdermal Drug Delivery System ◽  
Novel Drug Delivery System ◽  
Novel Drug ◽  
Conventional Dosage

Conventional dosage forms which require multidose therapy have many problems and complications. Design of a conventional dosage forms should be such that it delivers right amount of drug in right manner to the target site. The encouragement in development of novel drug delivery system is apart from therapeutic efficacy is its cause. Redesigning the unit and means is a difficult task and profitable task so a controlled released drug delivery system, a novel drug delivery system evolves which facilitates the release of drug at predetermined rate. Controlled drug delivery can be achieved by transdermal drug delivery system which can deliver the drug through skin to the systemic circulation at a predetermine rate over a prolonged period of time.

A Smart and Potential approach for Transdermal Drug Delivery using Microneedles: A Review

2021 ◽  
Vol 11 (2) ◽  
pp. 113-120
Author(s):  
Neha Sharma ◽  
Tarun Kumar Sharma ◽  
Vinay Pandit ◽  
M. S Ashawat
Keyword(s):  
Drug Delivery ◽  
Stratum Corneum ◽  
Drug Delivery System ◽  
Delivery System ◽  
Transdermal Drug Delivery ◽  
Systemic Circulation ◽  
Transdermal Drug Delivery System ◽  
Drug Molecules ◽  
Transdermal Drug Delivery Systems ◽  
Materials Used

Transdermal drug delivery system used to transport the drug across the skin deep into systemic circulation. The main advantages of Transdermal drug delivery system improved patient compliance, sustained release, avoidance of gastric irritation, as well as elimination of pre-systemic first-pass effect. But most of therapeutic agents is limited due to thickness of stratum corneum, which act as a barrier for the delivery of various drug molecules and only few molecules are able to reach the action site. Microneedles are the new form of delivery system, which are used to increase the delivery of drug through this route and overcoming the number of problems related to conventional drug delivery system the main aim of this review to focus on new innovation in transdermal drug delivery systems. In the microneedle drug delivery system, the skin is temporarily broken, that creating micron size pathways that deliver the sufficient amount of drug directly into the stratum corneum from which the drug can directly go into the systemic circulation. In this review, we describe different type of microneedles can be solid, coated, dissolving and biodegradable microneedles and their method of fabrication. Microneedles can be manufactured in different forms like hollow, solid, and dissolving. Also describe materials used for fabrication, fabrication techniques, methodology of drug delivery such as Poke and patch, Coat and poke, Poke and release, Poke and flow and evaluation parameters.

scholarly journals Review on Transdermal drug delivery system

2021 ◽  
pp. 236-240
Author(s):  
Lakshmi savithri S ◽  
Geethika Reddy B ◽  
Sushanth Sekhar K ◽  
Durga G ◽  
Srilekha Y ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Transdermal Drug Delivery ◽  
Oral Route ◽  
Permeation Enhancers ◽  
Transdermal Drug Delivery System ◽  
Non Invasive ◽  
Application Techniques ◽  
Invasive Method

Transdermal drug delivery system offers best way of drug delivery through skin than compared to oral route of administration by overcoming side-effects.Drug delivery is done through adhesion of transdermal patches to skin surface.Novel application techniques have been employed for better therapeutic response for various drug in treatment of several disease using dermal route of administration.This is best non-invasive method of drug delivery by reducing frequency of administration to achieve complete action of action of drug with maximum benefits to patients .These patches are formulated using various permeation enhancers that are compatible to skins surface .The dermal route of delivery is best suited for therapy to patient for certain diseases.

scholarly journals CHEMICAL PENETRATION ENHANCERS FOR TRANSDERMAL DRUG DELIVERY SYSTEM

2018 ◽  
Vol 8 (5-s) ◽  
pp. 62-66 ◽  
Author(s):  
Anupriya Kapoor ◽  
Shashi Kiran Mishra ◽  
Dharmesh Kumar Verma ◽  
Prashant Pandey
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Transdermal Drug Delivery ◽  
Systemic Circulation ◽  
Oral Route ◽  
Penetration Enhancer ◽  
Penetration Enhancers ◽  
Transdermal Drug Delivery System ◽  
Transdermal Patches

In present scenario more than 70% of the drugs that are taken by oral route are found to be less effective as desired, to overcome this constraint Transdermal drug delivery system has emerged as an innovative area of research, this system helps in delivering the drugs and macromolecules through skin into systemic circulation. At present, the worldwide market of Transdermal patch has reached 2 billion pounds. Many drugs like Estrogen, Progestrone, Nitroglycerine, Clonodine etc. are fabricated in form of Transdermal patches due to its ability to deliver the drug in non-invasive manner and also to overcome the problems associated with oral route. Although the Transdermal patches deliver the drug at predetermined rate1, the partitioning of drug from the system to the skin and then penetration through different layers of skin can be altered by adding penetration enhancers that can be physical or chemical in nature. This article deals with the role of different chemicals that can be used as penetration enhancer. Keywords: Penetration enhancer, Layer of skin, Fatty alcohol and glycol

Sign in / Sign up

Export Citation Format

Share Document