scholarly journals STUDY OF DRUG-DRUG INTERACTION IN THE INPATIENTS OF A TERTIARY CARE HOSPITAL AT CALICUT

2018 ◽  
Vol 11 (9) ◽  
pp. 162
Author(s):  
Greeshma K George ◽  
Siraj Sundaran ◽  
Ashar Ali Cp ◽  
Mubeena Km ◽  
Thansiya Ph ◽  
...  
Keyword(s):  
Drug Interactions ◽  
Health Care Professionals ◽  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Close Monitoring ◽  
Care Hospital ◽  
Potential Drug ◽  
High Prevalence ◽  
Medication Chart ◽  
Pharmacokinetic Drug

Objective: The study was conducted to monitor the potential drug-drug interactions in the prescriptions of inpatients in a tertiary care hospital based on the mechanism and severity.Methods: This prospective observational study was conducted by collecting the prescriptions containing two or more drugs. The interactions were checked using an interaction checker and were categorized into pharmacokinetic and pharmacodynamic interactions on the basis of mechanism of action and severity based on the risks or consequences of the interactions.Result: Among 150 randomly collected prescriptions, 123 (82%) prescriptions had 396 drug-drug interactions. The pharmacodynamic drug interactions (77.27%) were more common when compared to pharmacokinetic drug interactions (22.73%). There was high prevalence of drug-drug interactions among the patients above the age of 60 years (56.09%). The moderate drug-drug interactions (81.81%) were found to be more when compared to the major (10.61%) and minor (7.58%) interactions. The neurology department prescriptions were observed to have more number of drug-drug interactions (26.01%).Conclusion: A systematic approach and close monitoring of the medication chart is necessary to identify the potential drug-drug interactions. The clinicians and other health-care professionals at the study site require an awareness program in regard to identification and management of drug-drug interactions. Clinical pharmacist can play an important role in the monitoring and management of drug-drug interactions.

scholarly journals A STUDY ON POTENTIAL DRUG-DRUG INTERACTIONS AMONG PATIENTS ADMITTED UNDER DEPARTMENT OF MEDICINE IN A TERTIARY CARE HOSPITAL IN INDIA

2021 ◽  
Vol 10 (1) ◽  
pp. 29-32
Author(s):  
Sanjib Bandyopadhyay ◽  
Kaushik Mitra ◽  
Dipankar Bhaumik ◽  
Saibal Das
Keyword(s):  
Drug Interactions ◽  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Cross Sectional Study ◽  
Controlled Study ◽  
Care Hospital ◽  
Potential Drug ◽  
Sectional Study ◽  
Cross Sectional ◽  
Different Types

Objective: This study was conducted to evaluate the potential drug-drug interactions (pDDIs) among patients admitted in a tertiary care hospital in India. Methods: This was anobservational and cross sectional study for 3 months. All the patients admitted in the general ward under Department of Medicine. Pre-structured proforma and patient’s charts were be used for data collection on the 2nd day of admission. For drug interactions, online ‘Medscape Drug Interaction Checker’ was used. Results: A total of 61 charts were screened. A total of 304 drugs with 57 different types were admitted to these patients (including all dosage forms and routes). The total number of pDDIs were 217, of them 69 were minor, 130 were significant and 18 were serious (including repetitions in different patients). There were 13 unique serious pDDIs. Conclusion: The incidence of pDDIs in our study was high. Controlled study to evaluate whether good clinical management of DDIs can reduce drug-related morbidity or mortality is needed. Keywords:Potential drug-drug interactions (pDDIs), adverse drug reactions (ADRs), poly-medication, hospitalization, pharmacokinetic and pharmacodynamics interactions.

scholarly journals A prospective observational study to evaluate potential drug-drug interactions in patients admitted in intensive care unit, at BRIMS tertiary care hospital in Bidar, India

2018 ◽  
Vol 7 (4) ◽  
pp. 655 ◽  
Author(s):  
Shailander Singh ◽  
Swetha K.
Keyword(s):  
Observational Study ◽  
Drug Interactions ◽  
Prospective Observational Study ◽  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Care Hospital ◽  
Potential Drug ◽  
Icu Patients ◽  
Study Population ◽  
Type C

Background: Drug interaction occurs when presence of one drug affects the activity of another when, both are co-administered. 6-30% of adverse events (AEs) with significant hospitalizations or death are by drug-drug interactions(DDI). There is increased possibility to prevent the potential drug-drug interactions (pDDIs), if their prevalence and pattern are determined accurately before their occurrence. Hence this study aimed to evaluate the prevalence of pDDIs in ICU patients at BRIMS tertiary care hospital, Bidar.Methods: This prospective observational study included 30 patients admitted in ICU of BRIMS hospital for >24hrs of either gender, aged >18yrs. The study was conducted for a period of 3 months. Data was collected from the case records of patients on the predesigned proforma. Potential drug-drug interactions were classified based on their severity and the risk of Potential drug-drug interactions was estimated by Lexicomp, inc.version; 3.0.1.drug interact android mobile application.Results: Out of 35 patients admitted in the ICU, 30 cases were included in the study. The mean age of study population was 56.3years. The study population was exposed to a total of 330 medicines during the hospital stay with an average of 11.7 drugs per patient. The prevalence of pDDI was 93.3% (28) with an average of 9.75 pDDI per patient. According to Lexicomp drug interact android mobile application majority (63%) of pDDI were found to be moderate in their severity, 67% belonged to type C risk.Conclusions: The study showed higher prevalence of pDDI among ICU patients due to the complexity of the pharmacotherapies administered.

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