scholarly journals SYNTHESIS, BIOLOGICAL STUDY, DNA INTERACTION OF MANNICH BASE METAL COMPLEXES DERIVED FROM BENZAMIDE

2021 ◽  
pp. 60-64
Author(s):  
SIVAKAMI SUDHASANKAR
Keyword(s):  
Metal Complexes ◽  
Mannich Base ◽  
Dna Interaction ◽  
Mannich Bases ◽  
Molar Conductance ◽  
Biological Study ◽  
Spectral Studies ◽  
Mass Spectral ◽  
Calf Thymus ◽  
Uv Visible

Objective: Coordination compounds occur widely in nature and they comprise a large share of current inorganic research. The Mannich reaction is a classic method for the preparation of Mannich bases, namely, β amino compounds, which are heterocyclic. Methods: A novel Mannich base of N-((3,4-dimethoxyphenyl)(2,5-dioxopyrrolidin-1-yl) methyl)benzamide and its coordination complexes with transition metals Mn and Co have been synthesized and characterized by elemental analysis, molar conductance, magnetic susceptibility measurements, UV-Visible, IR, NMR, and Mass spectral studies. Results: Based on the magnetic moment and UV-Visible spectral data, octahedral geometries were assigned for the metal complexes. The metal complexes were screened for antifungal activity. Conclusion: the metal complexes have shown good activity than the ligand. The binding of selected metal complexes with calf thymus DNA was investigated. It is found that the cobalt (II) metal complex of the ligand showed efficient DNA binding ability.

scholarly journals Synthesis, Characterization and Biological Evaluation of Schiff Base Transition Metal Complexes Derived from 4-Nitrobenzene-1,2-diamine and 5-Chloroisatin

2020 ◽  
Vol 32 (9) ◽  
pp. 2324-2328
Author(s):  
NETRA PAL SINGH ◽  
KAUSHAL KUMAR ◽  
GAJENDRA KUMAR ◽  
ANUROOP KUMAR
Keyword(s):  
Schiff Base ◽  
Transition Metal ◽  
Metal Complexes ◽  
Transition Metal Complexes ◽  
Magnetic Moments ◽  
Biological Evaluation ◽  
Molar Conductance ◽  
Spectral Studies ◽  
Mass Spectral ◽  
Bacteria And Fungi

A series of transition metal complexes of the type [MLX2], where M = Mn(II), Fe(II), Co(II), Ni(II), X = Cl–/CH3COO– and L = Schiff base derived from 4-nitrobenzene-1,2-diamine and 5-chloroisatin have been synthesized and characterized by elemental analysis, molar conductance, IR, UV-visible, magnetic moments measurement, 1H & 13C NMR and mass spectral studies. On the basis of physico-chemical studies and spectral evaluation, an octahedral geometry have been proposed for all metal(II) complexes. The antimicrobial activity of ligand and its metal complexes have been additionally screened against bacteria and fungi. Metal(II) complexes show good activity as compared to ligand towards studied microorganisms and also metal complexes checked for their catalytic properties for benzoylation of phenol.

scholarly journals Bioactive Metal Complexes of Schiff Base Derived from 2,3-Dioxobutane, Ethane-1,2-diamine and 4-Chloro-2-formylphenol: Spectral Studies and in vitro Antimicrobial Activity

2021 ◽  
Vol 33 (12) ◽  
pp. 3063-3069
Author(s):  
Abhay Nanda Srivastva ◽  
Sayanwita Panja ◽  
Netra Pal Singh ◽  
Chandra Kiran Shriwastaw
Keyword(s):  
Schiff Base ◽  
Metal Complexes ◽  
Magnetic Moment ◽  
Metal Ion ◽  
Molar Conductance ◽  
Spectral Studies ◽  
Coordination Behaviour ◽  
Uv Visible ◽  
Iron Chromium

A novel series of trivalent coordination complexes was synthesized by the reaction between a chloride/ acetate salt of iron, chromium, cobalt or manganese ions and NNNNOO type persuasive Schiff base ligand synthesized from 2,3-dioxobutane, ethane-1,2-diamine and 4-chloro-2-formylphenol. Synthesized compounds were characterized by using elemental analysis, molar conductance, magnetic moment, IR, UV-visible, 1H NMR, 13C NMR and ESI-MS spectral analyses. IR and NMR spectra favoured hexadentate coordination behaviour of ligand. Electronic spectra and magnetic moment data reveal Oh geometry with distortion around the metal ion in complexes. The molar conductance values show 1:1 electrolytic nature of complexes. Biological potentiality of the ligand and its metal complexes were tested in vitro against two bacterial and two fungal strains; Bacillus subtilis, Escherichia coli and Aspirgillus niger, Aspirgillus flavus, respectively.

scholarly journals Magnetic and Spectroscopic Studies of the Synthesized Metal Complexes of Bis(Pyridine-2-carbo) Hydrazide and Their Antimicrobial Studies

2012 ◽  
Vol 9 (4) ◽  
pp. 1835-1842 ◽  
Author(s):  
Netra Pal Singh ◽  
Anu ◽  
Jagvir Singh
Keyword(s):  
Staphylococcus Aureus ◽  
Metal Complexes ◽  
Magnetic Moments ◽  
Bacterial Species ◽  
Spectroscopic Studies ◽  
Fungal Species ◽  
Molar Conductance ◽  
Spectral Studies ◽  
Mass Spectral ◽  
Antimicrobial Studies

Cobalt(II), Nickel(II), Copper(II) and Manganese(II) complexes, having the general composition {M(L)2X2}, have been synthesized [where L= bis(pyridine-2-carbo) hydrazide(L), and X = Cl–]. All the Metal complexes reported here have been characterized by elemental analysis, molar conductance, magnetic moments, IR, electronic and mass spectral studies. All the complexes were found to have magnetic moments corresponding to unpaired electrons. The possible geometries of the complexes were assigned on the basis of electronic and infrared spectral studies. On the basis of molar conductance values the complexes show 1:2 electrolytic nature. Newly synthesized ligand and its Metal complexes have been screened againstStaphylococcus aureus(ATCC 25923),Staphylococcus aureus(ATCC 3160) bacterial species andCandida albicans(227) and Staphylococcus cereviscae (361) fungal species.

scholarly journals Transition Metal Complexes of Omeprazole An Anti-Ulcerative Drug

2017 ◽  
Vol 36 (3) ◽  
pp. 31 ◽  
Author(s):  
Suman Malik ◽  
Supriya Das ◽  
Bharti Jain
Keyword(s):  
Magnetic Susceptibility ◽  
Metal Complexes ◽  
Analytical Data ◽  
Molar Conductance ◽  
Spectral Studies ◽  
X Ray Diffraction ◽  
Antibacterial And Antifungal Activities ◽  
Metal Ratio ◽  
Uv Visible ◽  
Antibacterial And Antifungal

Omeprazole (OME) is a proton pump inhibitor (PPI). PPI’s have enabled to improve the treatment of various acidpeptic disorders. OME is a weak base and it can form several complexes with transition and non-transitions metal ions. In the present paper, we are describing series of trantion metal complexes of omeprazole i.e.,5-methoxy-2[(4methoxy-3,5dimethyl-2-pyridinyl)methylsulfinyl]–1H–benzimidazole with CuII, MnII, CoII, NiII, FeII, ZnII and HgII. These complexes were characterized by elemental analysis, molar conductance, IR, NMR, magnetic susceptibility, UV-visible spectral studies, ESR, SEM and X-ray diffraction. Based on the above studies, the ligand behaves as bidentate O, N donor and forms coordinate bonds through C=N and S=O groups .The complexes were found to non-electrolytic in nature on the basis of low values of molar conductance . Analytical data and stochiometry suggest ligand metal ratio of 2:1 for all the complexes. Electronic Spectra and Magnetic susceptibility measurements reveal octahedral geometry for Mn(II),Co(II), Ni(II),Fe(II) and Cu(II) complexes and tetrahedral for Hg(II) and Zn(II) complexes. Ligands and their metal complexes have been screened for their antibacterial and antifungal activities against bacteria Pseudomonas, Staphylococcus Aureus and fungi Aspergillus niger and A. flavous.

scholarly journals Synthesis, Characterization and Antimicrobial Studies of N1-[(1E)-1-(2-Hydroxyphenyl) ethylidene]-2-oxo-2H-chromene-3-carbohydrazide and its Metal Complexes

2009 ◽  
Vol 6 (3) ◽  
pp. 615-624 ◽  
Author(s):  
K. Siddappa ◽  
K. Mallikarjun ◽  
Tukaram Reddy ◽  
M. Mallikarjun ◽  
C. V. Reddy ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Magnetic Susceptibility ◽  
Schiff Base ◽  
Metal Complexes ◽  
Molar Conductance ◽  
Tetrahedral Geometry ◽  
H Nmr ◽  
Antimicrobial Studies ◽  
Mononuclear Complexes ◽  
Uv Visible

A new complexes of the type ML, MʹL and M″L [where M=Cu(II), Co(II), Ni(II) and Mn(II), Mʹ=Fe(III) and M″=Zn(II), Cd(II) and Hg(II) and L=N1-[(1E)-1-(2-hydroxyphenyl)ethylidene]-2-oxo-2H-chromene- 3-carbohydrazide (HL)] Schiff base have been synthesized and characterized by elemental analysis, magnetic susceptibility, molar conductance, IR,1H NMR, UV-Visible and ESR data. The studies indicate the HL acts as doubly monodentate bridge for metal ions and form mononuclear complexes. The complexes Ni(II), Co(II), Cu(II) Mn(II) and Fe(III) complexes are found to be octahedral, where as Zn(II), Cd(II) and Hg(II) complexes are four coordinated with tetrahedral geometry. The synthesized ligand and its metal complexes were screened for their antimicrobial activity.

scholarly journals Biological Study of Transition Metal Complexes with Adenine Ligand

Proceedings ◽  
2019 ◽  
Vol 41 (1) ◽  
pp. 77 ◽  
Author(s):  
Hamad M. I. Hasan ◽  
Aaza I. Yahiya ◽  
Safaa S. Hassan ◽  
Mabrouk M. Salama
Keyword(s):  
Metal Complexes ◽  
Molar Conductance ◽  
Molar Ratio ◽  
Biological Study ◽  
Ratio Method ◽  
Spectroscopic Techniques ◽  
Stoichiometric Ratio ◽  
Metal Contents ◽  
Molar Ratio Method

Adenine complexes were prepared with some of the first series transition metals in a stoichiometric ratio of 1: 2 (Mn+: L), where Mn+ = Mn2+, Fe3+, Co2+, Ni2+, Cu2+, Zn2+, and Cd2+ ions. The Complexes were characterized by the physicochemical and spectroscopic techniques as electric conductivity, metal contents, IR, UV–Visible, and molar conductance techniques. The stoichiometric ratios of the synthesized complexes were confirmed by using molar ratio method. The dissociation constant of adenine ligand was determined spectrophotometrically. Solvent effect on the electronic spectra of the adenine ligand was examined using solvents with different polarities. The biological activity of adenine ligand and its metal complexes were tested in vitro against some selected species of fungi and bacteria. The results showed a satisfactory spectrum against the tested organisms.

scholarly journals Physico-chemical characterization and biological screening of metal complexes with Cyanex 301

1970 ◽  
Vol 34 (2) ◽  
pp. 153-161 ◽  
Author(s):  
Tarun Kumar Pal ◽  
Md Ashraful Alam ◽  
Suchitra Rani Paul
Keyword(s):  
Metal Complexes ◽  
Magnetic Measurements ◽  
Chemical Characterization ◽  
Molar Conductance ◽  
Spectral Studies ◽  
Antibacterial And Antifungal Activities ◽  
Physico Chemical ◽  
Dithiophosphinic Acid ◽  
Cyanex 301 ◽  
Antibacterial And Antifungal

New metal complexes of Mg(II), VO(II), Mn(II), Fe(III), Co(II), Ni(II), Cu(II) and Pd(II) with cyanex 301(L) i.e., bis(2,4,4-trimethylpentyl) dithiophosphinic acid were synthesized. The complexes have been characterized by elemental analysis, molar conductivity, molecular mass determination, magnetic measurements, infrared and electronic spectral studies. The prepared metal complexes have the compositions: 2. [MgL2].H2O, 3. [VOL2], 4. K[MnL3].H2O, 5. [FeL3], 6. K[CoL3].H2O, 7. K[NiL3], 8. K[CuL3] and 9. [PdL2]. The complexes 2, 3 and 9 are assumed to have tetrahedral, square pyramidal and square planar geometries, respectively but the complexes 4 - 8 are octahedral based on experimental data. From magnetic measurements the complexes 2 and 9 are found to be diamagnetic and others are paramagnetic. Measured molar conductance showed that the complexes 2, 3, 5 and 9 are non-electrolytes and rest are electrolytes. Besides, some complexes have shown good antibacterial and antifungal activities. Key words: Cyanex 301; Antibacterial; Antifungal; DMSO; Bis (2, 4, 4-trimethylpentyl) dithiophosphinic acid DOI: 10.3329/jbas.v34i2.6859Journal of Bangladesh Academy of Sciences, Vol. 34, No. 2, 153-161, 2010

scholarly journals THE METAL COMPLEXES OF NOVEL SCHIFF BASE CONTAINING ISATIN: CHARACTERIZATION, ANTIMICROBIAL, ANTIOXIDANT AND CATALYTIC ACTIVITY STUDY

2019 ◽  
pp. 206-210
Author(s):  
VAIRALAKSHMI M ◽  
PRINCESS R ◽  
JOHNSON RAJA S
Keyword(s):  
Catalytic Activity ◽  
Metal Complexes ◽  
1H Nmr ◽  
Metal Ion ◽  
Analytical Data ◽  
Free Ligand ◽  
Molar Conductance ◽  
Diffusion Method ◽  
Spectral Studies ◽  
Standard Drug

Objectives: The aim of our work was to synthesize novel mixed ligand-metal complexes and evaluation of antimicrobial, antioxidant assay, and analysis of catalytic oxidation of cyclohexane. Methods: The complexes were characterized by means of various physicochemical techniques such as elemental analysis, molar conductance, magnetic susceptibility, infrared (IR), electronic absorption, 1H NMR (proton magnetic resonance), and mass spectral studies. The antimicrobial screening study was done by disc diffusion method. The catalytic activity of the complexes was observed in the oxidation of cyclohexane using eco-friendly hydrogen peroxide as oxidant. Results: On comparing the 1H NMR and IR spectral data of free ligand and its complexes, it was found to be azomethine (CH=N) proton which is formed in the free ligand. During complexation, the azomethine proton is coordinated to the metal ion and the phenolic oxygen is coordinated to the metal ion by deprotonation. The analytical data and mass spectra of the ligand and the complexes confirm the stoichiometry of metal complexes as being of the (MLY)Cl type and the metal to ligand ratio is 1:1. The antimicrobial, antioxidant, and catalytic potential were evaluated and the result shows the better activity of the complexes than the ligand. Conclusion: It was found to be copper(II) and zinc(II) complexes which are effective against all the bacteria when compared to standard drug streptomycin. Copper(II) complex was found to be effective antibacterial agent against Aspergillus niger and Aspergillus flavus in comparison to the standard drug Nystatin. The zinc complex exhibited good catalytic activity.

scholarly journals Synthesis and Spectral Studies of Some Bioactive Transition Metal Complexes of [bis-2-(4-Fluorophenyl)prop-2-enaln]ethane-1,2-diamine

2019 ◽  
Vol 31 (10) ◽  
pp. 2357-2360
Author(s):  
Jagvir Singh ◽  
Anuradha ◽  
Pradeep Kumar ◽  
Mordhwaj ◽  
Ravi Kumar
Keyword(s):  
Staphylococcus Aureus ◽  
Metal Complexes ◽  
Antimicrobial Properties ◽  
Analysis Data ◽  
Antimicrobial Activities ◽  
Spectral Studies ◽  
Elemental Analysis Data ◽  
Chloride Complexes ◽  
Elemental Analyses ◽  
Uv Visible

Co(II), Ni(II) and Cu(II) metal complexes of a novel Schiff base ligand (SBL) derived from condensation of 2-(4-fluorophenyl)prop-2-enaln and ethane-1,2-diamine were synthesized. All the complexes were characterized by elemental analyses, IR, UV-visible spectroscopy, magnetic susceptibility and conductance measurements and 1H NMR. From the elemental analysis data, 1:1 [M]:[ligand] metal chloride complexes are formed having the general composition [M(SBL)Cl2] and [Cu(SBL)] Cl2, [where M = Co(II), Ni(II) and SBL= {bis-2-(4-fluorophenyl)prop-2-enaln}ethane-1,2-diamine]. The result showed that the ligand is coordinated to the metal ions in a neutral tetradentate manner with ON donor sites and the nature of metal-ligand bonding can range from covalent to ionic. Antimicrobial activities of the newly synthesized chemical compounds were evaluated against Staphylococcus aureus (ATCC 25923), Staphylococcus aureus (ATCC 3160), Cabdida albicans (ATCC 227) and Staphylococcus cereviscae (ATCC 361) species and found that metal complexes exhibited more antimicrobial properties so they are more potential and significant than the ligand.

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