scholarly journals A ROLE FOR PHALERIA MACROCARPA (SCHEFF) BOERL. EXTRACTS IN THE MANAGEMENT OF WOMEN’S PATHOLOGICAL CONDITIONS: A RESEARCH REVIEW

2017 ◽  
Vol 9 (3) ◽  
pp. 7 ◽  
Author(s):  
Raymond Rubianto Tjandrawinata ◽  
Hanna Christabel Rouli
Keyword(s):  
Research Review ◽  
Fruit Extract ◽  
Breast And Cervical Cancer ◽  
Pathological Conditions ◽  
Cell Progression ◽  
Cervical Cancer Cells ◽  
Apoptosis Inducer ◽  
Anti Oxidant ◽  
Phaleria Macrocarpa ◽  
Preclinical And Clinical Studies

Phaleria macrocarpa (Scheff) Boerl is a medicinal plant that originates from West Papua, Indonesia. The fruit of this plant is known to contain numerous different compounds that produce different bioactivities. Many of these bioactivities are related to women pathological conditions. The purpose of this review is to evaluate the effect of P. macrocarpa fruit extract in the management of these conditions. Different studies have proven that P. macrocarpa extract helps regulate hormone imbalance in women with problems relating to their menstruation cycle, especially during premenstrual syndrome. It helps alleviate symptoms of primary dysmenorrhea and endometriosis through its bioactivity as anti-inflammation, apoptosis inducer, anti-angiogenic and anti-oxidant agent. P. macrocarpa fruit extract also showed selective anti-proliferative, anti-inflammatory, and anti-angiogenic activity on breast and cervical cancer cells. It regulates cancer cell progression through numerous different pathways, making it highly favourable to be developed as a cancer treatment, whether as a single treatment or as an adjunct therapy. In conclusion, P. macrocarpa extract has great potential to be developed into treatments for women’s pathological conditions. However, further study, both preclinical and clinical studies are needed to ascertain its use in women to be effective and safe.

scholarly journals Antioxidant Effects of Schisandra chinensis Fruits and Their Active Constituents

Antioxidants ◽  
2021 ◽  
Vol 10 (4) ◽  
pp. 620
Author(s):  
Dalia M. Kopustinskiene ◽  
Jurga Bernatoniene
Keyword(s):  
Alternative Medicine ◽  
Bioactive Compounds ◽  
Antioxidant Activities ◽  
Polyphenolic Compounds ◽  
Schisandra Chinensis ◽  
Aging Effects ◽  
Fruit Extract ◽  
Active Constituents ◽  
Pathological Conditions ◽  
Antioxidant Effects

Schisandra chinensis Turcz. (Baill.) fruits, their extracts, and bioactive compounds are used in alternative medicine as adaptogens and ergogens protecting against numerous neurological, cardiovascular, gastrointestinal, liver, and skin disorders. S. chinensis fruit extracts and their active compounds are potent antioxidants and mitoprotectors exerting anti-inflammatory, antiviral, anticancer, and anti-aging effects. S. chinensis polyphenolic compounds—flavonoids, phenolic acids and the major constituents dibenzocyclooctadiene lignans are responsible for the S. chinensis antioxidant activities. This review will focus on the direct and indirect antioxidant effects of S. chinensis fruit extract and its bioactive compounds in the cells during normal and pathological conditions.

scholarly journals Radiation enhancing effects of sanazole and gemcitabine in hypoxic breast and cervical cancer cells in vitro

2015 ◽  
Vol 3 ◽  
pp. 236-240
Author(s):  
Yue-Can Zeng ◽  
Rong Wu ◽  
Yu-Ping Xiao ◽  
Yan Xin ◽  
Feng Chi ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Cancer Cells ◽  
Breast And Cervical Cancer ◽  
Cervical Cancer Cells

Anti-oxidant and Anti-microbial Activities of Flavonoids from the Fruit Extract of Dacryodes edulis

Phytomedicine ◽  
2020 ◽  
pp. 131-137
Author(s):  
R. O. Omosimua ◽  
B. D. Macham ◽  
A. Onanuga ◽  
B. T. Thomas ◽  
C. O. Ugbomor ◽  
...  
Keyword(s):  
Microbial Activities ◽  
Fruit Extract ◽  
Anti Oxidant ◽  
Dacryodes Edulis

scholarly journals Effects of jujube fruit extract on peripheral blood mononuclear cell proliferation, cytokine productions and intracellular hydrogen peroxide level

2017 ◽  
Vol 15 (8) ◽  
pp. 561-568
Author(s):  
Sahapat BARUSRUX ◽  
Preeyaporn Plaimee PHIBOONCHAIYANAN ◽  
Munthipha KHAMPHIO ◽  
Natthida WEERAPREEYAKUL ◽  
Sirithon SIRIAMORNPUN
Keyword(s):  
Peripheral Blood Mononuclear Cell ◽  
Mononuclear Cell ◽  
Peripheral Blood ◽  
Enzyme Linked Immunosorbent Assay ◽  
Fruit Extract ◽  
Peripheral Blood Mononuclear ◽  
Jujube Fruit ◽  
Th1 Cytokine ◽  
Anti Oxidant ◽  
H2o2 Level

Background: Ziziphus genus (jujube) is a fruit, which is commonly found and used in Eastern traditional medicine for various conditions. Immunomodulation and anti-oxidant activities of jujube fruit extract are reported. This study aimed to observe immunomodulation effects of green (unripe) and ripe jujube fruit extract on peripheral blood mononuclear cell (PBMC) proliferation by carboxyfluorescein diacetate (CFSE) fluorescence, cytokine profiling by enzyme-linked immunosorbent assay (ELISA), and intracellular H2O2 level by dichlorodihydrofluorescein diacetate (DCFH-DA) fluorescence. Results: Treatments of PBMC with both green and ripe pulp extracts resulted in non-significant increases, about 1.01 - 1.15 times, in PBMC proliferation compared to the untreated group (p > 0.05). The pro-inflammatory cytokine (IL-1β) and regulatory Th2 cytokine (IL-10) levels were significantly higher in PBMC treated with ripe jujube fruit extract than in the cells stimulated with green jujube extract (p < 0.05). Th1 cytokine (IFN-γ) level was not significantly different between the ripe and green jujube extract. A higher percentage of intracellular H2O2 reduction was observed in PBMC treated with the green pulp extract compared to the ripe pulp extract (p < 0.05). Conclusions: This study provides practical information about an effect of jujube staging on some cytokine inductions. The reduction of intracellular oxidative stress seems to involve these cytokine induction phenomena.

scholarly journals Phaleria macrocarpa Fruit Extract Inhibits NF-ĸB Activation and Apoptosis Induction on HeLa Cells

2017 ◽  
Vol 8 (1) ◽  
pp. 9
Author(s):  
Meirizky Zulharini S. ◽  
Amalia Miranda ◽  
Lina Permatasari ◽  
Hilyatul Fadliyah ◽  
Riris Istighfari Jenie
Keyword(s):  
Transcription Factor ◽  
Molecular Docking ◽  
Mtt Assay ◽  
Apoptosis Induction ◽  
Double Staining ◽  
Fruit Extract ◽  
Apoptosis Inhibition ◽  
Ic50 Value ◽  
Anticancer Mechanism ◽  
Phaleria Macrocarpa

NF-κB is a transcription factor and if activated, it induces apoptosis inhibition. Phalerin from Phaleria macrocarpa fruits expected to inhibit NF-κB activation. This research is to investigate anticancer mechanism of Phaleria macrocarpa fruits extracts (EBMD) in NF-κB pathway. Molecular docking assay was performed to determine phalerin affinity to IKK. Cytotoxic activity was observed by MTT assay. Double staining was performed to determine the apoptotic cells. Docking score of phalerin to IKK is -60. The IC50 value of EBMD is 629 μg/mL. Apoptosis profile shows (shown that) many cells undergoing apoptosis after treatment. Thus, EBMD potentially inhibits activation of NF-κB pathway and triggers apoptosis on HeLa cells.Keywords : NF-κB, Phaleria macrocarpa, sel HeLa, Bcl-2, IKK, molecular docking

Silver nanoparticles: green synthesis using Phoenix dactylifera fruit extract, characterization, and anti-oxidant and anti-microbial activities

2018 ◽  
Vol 8 (3) ◽  
pp. 407-415 ◽  
Author(s):  
Anas Ejaz Shaikh ◽  
Kshitij Vasant Satardekar ◽  
Rummana Rehman Khan ◽  
Nanda Amit Tarte ◽  
Siddhivinayak Satyasandha Barve
Keyword(s):  
Silver Nanoparticles ◽  
Green Synthesis ◽  
Phoenix Dactylifera ◽  
Microbial Activities ◽  
Fruit Extract ◽  
Anti Oxidant

scholarly journals Impact of Melatonin on Skeletal Muscle and Exercise

Cells ◽  
2020 ◽  
Vol 9 (2) ◽  
pp. 288 ◽  
Author(s):  
Alessandra Stacchiotti ◽  
Gaia Favero ◽  
Luigi Fabrizio Rodella
Keyword(s):  
Quality Of Life ◽  
Skeletal Muscle ◽  
Human Aging ◽  
Muscle Disorders ◽  
Age Related ◽  
Anti Oxidant ◽  
Therapeutic Tools ◽  
Skeletal Muscle Disorders ◽  
Preclinical And Clinical Studies

Skeletal muscle disorders are dramatically increasing with human aging with enormous sanitary costs and impact on the quality of life. Preventive and therapeutic tools to limit onset and progression of muscle frailty include nutrition and physical training. Melatonin, the indole produced at nighttime in pineal and extra-pineal sites in mammalians, has recognized anti-aging, anti-inflammatory, and anti-oxidant properties. Mitochondria are the favorite target of melatonin, which maintains them efficiently, scavenging free radicals and reducing oxidative damage. Here, we discuss the most recent evidence of dietary melatonin efficacy in age-related skeletal muscle disorders in cellular, preclinical, and clinical studies. Furthermore, we analyze the emerging impact of melatonin on physical activity. Finally, we consider the newest evidence of the gut–muscle axis and the influence of exercise and probably melatonin on the microbiota. In our opinion, this review reinforces the relevance of melatonin as a safe nutraceutical that limits skeletal muscle frailty and prolongs physical performance.

Effect of Hippophae rhamnoides extract on Cisplatin-induced ototoxicity in Guinea Pigs

2017 ◽  
Author(s):  
Ertugrul Erhan ◽  
Renad Mammadov ◽  
Durdu Altuner ◽  
Ferda Cimen ◽  
Nezahat Kurt ◽  
...  
Keyword(s):  
Gene Expression ◽  
Guinea Pigs ◽  
Cost Effective ◽  
Hippophae Rhamnoides ◽  
Fruit Extract ◽  
Hippophaë Rhamnoides ◽  
Anti Oxidant ◽  
Histopathological Results ◽  
Fat Soluble Vitamins ◽  
Gene Expression Levels

No previous studies have examined the effect of Hippophae rhamnoides fruit extract (HRE), which contains both water and fat soluble vitamins, on cisplatin-induced ototoxicity. Therefore, the aim of the study was to investigate the effects of HRE on cisplatin-induced ototoxicity in Guinea pigs and to evaluate the biochemical, gene expression and histopathological changes associated with cisplatin use. Experimental animals were divided into three groups: healthy (HG), HRE+cisplatin (HRC) and cisplatin control (CCG) groups. Biochemical, gene expression and histopathological examinations were carried on the removed inner ear tissues. In the HRC group, the oxidant parameter was lower and the anti-oxidant parameter was higher than in the CCG. These results are supported by gene expression levels and histopathological results. The use of HRE against cisplatin-induced oxidative ototoxicity may be easier, more cost effective and more beneficial than the use of vitamins alone or in combination with each other.

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