scholarly journals ROLE OF MICHELIA CHAMPACA IN MEMORY ENHANCEMENT AND ACUTE NOISE STRESSED MALE WISTAR ALBINO RATS

2018 ◽  
Vol 10 (2) ◽  
pp. 129
Author(s):  
Malathi S. ◽  
Vidyashree . ◽  
Ravindran Rajan
Keyword(s):  
Acute Stress ◽  
Corticosterone Level ◽  
Acetylcholinesterase Activity ◽  
Plasma Corticosterone ◽  
Albino Rats ◽  
Memory Enhancement ◽  
Wistar Albino Rats ◽  
The Brain ◽  
Michelia Champaca

Objective: To identify the memory enhancing role of Michelia champaca in acute noise stressed animals. Methods: Male Wistar albino rats were used in this study. Animals were exposed to noise for 4 h before testing for memory. Thereafter, the plasma corticosterone level and acetylcholinesterase activity were estimated in the discrete regions of the brain, and the memory related behavior were assessed by eight arm radial maze.Results: Our results showed that Michelia champaca enhances the memory activity and decreases the corticosterone concentrations in acute noise stress animals treated with M. champaca. Moreover, it also decreased brain acetylcholinesterase activity when compared with the acute stress group (p<0.05). Furthermore, behavioral tests indicate that working memory, is enhanced by acute stress and decreases the error levels in all the parameters studied in the behavior aspects when compared to control animals.Conclusion: These findings suggest that Michelia champaca enhances the memory in albino rats and might be useful therapeutically for cognitive related dysfunctions. This could be due to the presence of memory boosting compounds and its antistressor and anti-acetylcholinesterase activity, thereby reduces the levels of serum corticosterone and inhibition of cholinesterase enzyme significantly.

scholarly journals RESTORATION OF MEMORY AND ACETYLCHOLINESTERASE ACTIVITY BY MICHELIA CHAMPACA IN CHRONICALLY NOISE STRESSED WISTAR ALBINO RATS

2016 ◽  
Vol 9 (6) ◽  
pp. 210
Author(s):  
Malathi S
Keyword(s):  
Memory Impairment ◽  
Corticosterone Level ◽  
Brain Homogenate ◽  
Acetylcholinesterase Activity ◽  
Plasma Corticosterone ◽  
Albino Rats ◽  
Memory Decline ◽  
Noise Stress ◽  
Wistar Albino Rats ◽  
Michelia Champaca

ABSTRACTObjective:The ability of an organism to adapt to aversive stressful situations or life challenging circumstances is very crucial to its state of health and survival. However, breakdown in adaptation due to persistent uncontrollable stress, leads to impairment of bodily functions and onset of a variety of pathological disorders especially memory decline. This study was designed to evaluate the effect of Michelia champaca(M.champaca) a potent antioxidant on chronic noise stress induced memory impairment in rats. Methods: Male wistar albino rats were used in this study. Animals were exposed to noise for 30 consecutive days (4hrs/day) before testing for memory. Thereafter, the plasma corticosterone level and acetylcholinesterase activity were estimated in the three discrete regions of the brain homogenate using spectrophotometer. Result:Our results showed that M.champaca prevented memory impairment and suppressed corticosterone concentrations induced by chronic noise stress. Moreover it also decreased brain acetylcholinesterase activity when compared with chronic stress group (p < 0.05). Conclusions:These findings suggest that M.champaca attenuates memory deficits induced by chronic noise stress in albino rats and may be useful therapeutically for stress-related cognitive dysfunctions. The reduction in the levels of serum corticosterone and inhibition of cholinesterase enzyme might be contributing significantly to the positive effect of M.champaca on memory in rats exposed to chronic noise stress.Keywords: M.champaca, memory, corticosterone, chronic noise stress, acetylcholinesterase activity, Eight-arm radial maze.

The protective role of ferulic acid on sepsis-induced oxidative damage in Wistar albino rats

2014 ◽  
Vol 38 (3) ◽  
pp. 774-782 ◽  
Author(s):  
Merve Bacanlı ◽  
Sevtap Aydın ◽  
Gökçe Taner ◽  
Hatice Gül Göktaş ◽  
Tolga Şahin ◽  
...  
Keyword(s):  
Oxidative Damage ◽  
Ferulic Acid ◽  
Protective Role ◽  
Albino Rats ◽  
Wistar Albino Rats

Effects of erdosteine on cyclosporin-A-induced nephrotoxicity

2011 ◽  
Vol 31 (6) ◽  
pp. 565-573 ◽  
Author(s):  
M Tutanc ◽  
V Arica ◽  
N Yılmaz ◽  
A Nacar ◽  
I Zararsiz ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Cyclosporin A ◽  
Protective Role ◽  
Control Group ◽  
Albino Rats ◽  
Protective Mechanism ◽  
Antioxidant Parameters ◽  
Group 2 ◽  
Wistar Albino Rats

Aim: In cyclosporin-A (CsA)-induced toxicity, oxidative stress has been implicated as a potential responsible mechanism. Therefore, we aimed to investigate the protective role of erdosteine against CsA-induced nephrotoxicity in terms of tissue oxidant/antioxidant parameters and light microscopy in rats. Materials and methods: Wistar albino rats were randomly separated into four groups. Group 1 rats treated with sodium chloride served as the control, group 2 rats were treated with CsA, group 3 with CsA plus erdosteine, and group 4 with erdosteine alone. Animals were killed and blood samples were analyzed for blood urea nitrogen (BUN), serum creatinine (Cr), uric acid (UA), total protein (TP), and albumin (ALB) levels. Kidney sections were analyzed for malondialdehyde (MDA) and nitric oxide (NO) levels and superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-Px) activities, as well as for histopathological changes. Results: In the CsA group, MDA, GSH-Px, BUN, and Cr levels were increased. The TP and ALB levels were decreased. These changes had been improved by erdosteine administration. Other biochemical parameters did not show any significant change. Conclusion: These results indicate that erdosteine produces a protective mechanism against CsA-induced nephrotoxicity and suggest a role of oxidative stress in pathogenesis.

scholarly journals CHRONIC UNPREDICTABLE STRESS-INDUCED BEHAVIORAL AND ELECTROPHYSIOLOGICAL ALTERATIONS AND ITS AMELIORATIVE EFFECT BY MYRICETIN MICROEMULSION

2018 ◽  
Vol 11 (3) ◽  
pp. 124
Author(s):  
Sakthivel G ◽  
Deva Karunya M ◽  
Prajisha P ◽  
Keerthipriya Cs ◽  
Ravindran R
Keyword(s):  
Decision Making ◽  
Corticosterone Level ◽  
Treated Group ◽  
Plasma Corticosterone ◽  
Albino Rats ◽  
Chronic Unpredictable Stress ◽  
Behavioral Alterations ◽  
Object Recognition Test ◽  
Open Field Behavior ◽  
Brain Wave

 Objective: The present study is designed to investigate the effects of chronic unpredictable stress (CUS) on electrophysiological and behavioral alterations in male Wistar albino rats and its ameliorating effect by myricetin-microemulsion (MYR-ME).Materials and Methods: Adult Wistar male albino rats were exposed to CUS for 21 days and treated with MYR-ME (10 mg/kg) for 21 days by oral administration. All the experimental animals were tested for anxiety and cognitive behavior by open-field behavior, light/dark test, eight-arm radial maze, spontaneous alteration T-maze, novel object recognition test, plasma corticosterone level, and electrophysiological activity.Results: The rats which were exposed to CUS showed memory impairment, increased anxiety, decreased novel explorations, deleterious effect on decision-making, increased corticosterone level, increased brain wave frequency and amplitude, and also heart rate. Whereas, CUS with MYR-ME-treated group showed a protective effect against CUS-induced behavioral alterations, electrophysiological activity, and corticosterone levels, which is characterized by the enhancement of cognitive function, decreased anxiety and improved decision-making, novel exploration, decreased corticosterone, and electrophysiological activity.Conclusion: From the present study, it is shown that MYR-ME may act as a potential anxiolytic and nootropic compound against CUS-induced alterations.

Role of Diosmin in protection against the oxidative stress induced damage by gamma-radiation in Wistar albino rats

2020 ◽  
Vol 113 ◽  
pp. 104622 ◽  
Author(s):  
Shahenda Mahgoub ◽  
Anas O. Sallam ◽  
Hazem K.A. Sarhan ◽  
Amal A.A. Ammar ◽  
Sameh H. Soror
Keyword(s):  
Oxidative Stress ◽  
Gamma Radiation ◽  
Albino Rats ◽  
Wistar Albino Rats

scholarly journals ROLE OF OCIMUM CANUM IN PREVENTION OF REPERFUSION-INDUCED RENAL ISCHEMIA IN WISTAR ALBINO RATS

2012 ◽  
Vol 3 (7) ◽  
Author(s):  
Saiprasanna Behera ◽  
S M Babu ◽  
Y Roja Ramani ◽  
Prasanta Kumar Choudhury ◽  
Sudeep Kumar Patra
Keyword(s):  
Renal Ischemia ◽  
Albino Rats ◽  
Wistar Albino Rats

Carbaryl-induced elevation of corticosterone level and cholinergic mechanism

1983 ◽  
Vol 3 (10) ◽  
pp. 973-977 ◽  
Author(s):  
S. K. Ray ◽  
M. K. Poddar
Keyword(s):  
Single Dose ◽  
Adrenal Gland ◽  
Rat Brain ◽  
Corticosterone Level ◽  
Acetylcholinesterase Activity ◽  
Plasma Corticosterone ◽  
Significant Rise ◽  
Atropine Sulphate ◽  
Transaminase Activity ◽  
Cholinergic Mechanism

Administration of a single dose (200 mg/kg, p.o.) of carbaryl to rats produced a significant rise in adrenal and plasma corticosterone levels and an increase of tyrosine α-ketoglutarate transaminase activity in the liver cytosot. Synaptosomal acetylcholinesterase activity of the hypothalamic and the striatal regions of rat brain was decreased by carbaryl treatment under similar conditions. Pretreatment (0.5 h) with atropine sulphate (10 mg/kg, i.p.) failed to counteract the carbaryl-induced elevation of adrenal and plasma corticosterone levels and hence the liver tyrosine α-ketoglutarate transaminase activity. Present results suggest that the carbaryl-induced rise in the corticosterone level in the adrenal gland and plasma is not due to a cholinergic mechanism.

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