No obvious association exists between mean platelet volume and hypertension subtypes

2021 ◽  
Author(s):  
Tingwei Li ◽  
Zhaowei Meng ◽  
Wenjuan Zhang ◽  
Yongle Li ◽  
Xuefang Yu ◽  
...  
Keyword(s):  
Mean Platelet Volume ◽  
Protective Factor ◽  
Blood Parameters ◽  
Cross Sectional Study ◽  
Continuous Variable ◽  
Platelet Volume ◽  
Cross Sectional ◽  
Diastolic Hypertension ◽  
Obvious Association ◽  
The Mean

Aims: To determine the association between mean platelet volume (MPV) and hypertension subtypes. Participants & results: 44,281 Chinese individuals were enrolled in this cross-sectional study. The mean blood pressure decreased with increasing MPV in females (p = 0.001) and increased MPV seemed to be a potential protective factor for isolated diastolic hypertension in models 1 and 2. The OR (CI) was 0.878 (0.789–0.976) for model 1 and 0.880 (0.789–0.981) for model 2 in males and 0.646 (0.495–0.841) for model 1 and 0.657 (0.503–0.858) for model 2 in females, when MPV was analyzed as a categorical variable. The OR (CI) was 0.947 (0.911–0.985) for Model 1 and 0.947 (0.910–0.985) for Model 2 in males, and 0.886 (0.807–0.973) for Model 1 and 0.892 (0.813–0.978) for Model 2 in females when MPV was analyzed as a continuous variable. However, the statistical difference of OR disappeared when we added blood-related covariates in Model 3. Conclusion: No obvious association exists between MPV and hypertension subtypes. Other blood parameters might have a greater impact on hypertension subtypes.

scholarly journals AGREGASI TROMBOSIT DAN MEAN PLATELET VOLUME DENGAN SINDROM METABOLIK TERKAIT KEGEMUKAN

2018 ◽  
Vol 21 (2) ◽  
pp. 130
Author(s):  
Nindia Sugih Arto ◽  
Adi Koesoema Aman ◽  
Dharma Lindarto
Keyword(s):  
Cardiovascular Disease ◽  
Metabolic Syndrome ◽  
Platelet Aggregation ◽  
Mean Platelet Volume ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Platelet Volume ◽  
Cross Sectional ◽  
The Metabolic Syndrome ◽  
The Mean

The hyperactivity of platelet had been seen in patients with metabolic syndrome which can be caused by several factors, such as:insulin resistance, obesity, dyslipidemia and hypertension. The hyperactivity of platelet leads to its aggregation that can be increased therisk of cardiovascular disease. This study is aimed to know the platelet aggregation and mean platelet volume in patients with metabolicsyndrome and obesity by determination 30 patients were choosen for this cross sectional study, those whom attended to the laboratoryand policlinic at H. Adam Malik Medan Hospital, between May 2013 until August 2013. The diagnosis used of metabolic syndromecriteria established by the International Diabetic Federation 2005. From the 30 patients with 15 metabolic syndrome and 15 obesity,four patients were excluded because of their tryglyceride were more than 200 mg/dL. There is no significant differences between theplatelet aggregation with the agonist adenosin difosfat (ADP) in patient with metabolic syndrome and obesity. And there is no significantdifferences of the mean platelet volume values between the metabolic syndrome (9.6±0.93) and the obesity group (9.73±0.74), with pvalue 0.846. Based on this study there is no significant differences between the platelet aggregation and the Mean Platelet Volume values(MPV) in the metabolic syndrome and the obese group

Evaluation of Mean Platelet Volume (MPV) in Pre-Eclamptic and Normotensive Women in 3rd Trimester of Gestation

2021 ◽  
Vol 15 (6) ◽  
pp. 2119-2121
Author(s):  
Salza Zainab ◽  
Armish Saeed ◽  
Shazia Awan ◽  
Sehrish Raja ◽  
Faiza Khanum ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Mean Platelet Volume ◽  
Complete Blood Count ◽  
Cost Effective ◽  
Cross Sectional Study ◽  
P Value ◽  
Platelet Volume ◽  
Cross Sectional ◽  
The Mean ◽  
Automated Hematology Analyzer

Objective: To determine the mean platelet volume (MPV) in pre-eclamptic and normotensive women presenting in 3rd trimester of pregnancy. Study Design: Descriptive Cross-sectional study. Place and Duration: Department of Obstetrics & Gynecology, Multan Medical and Dental College/Ibn-e-Sina Hospital, Multan during from 29-May-2019 to 28-Nov-2019. Methodology: 246 pregnant females were included in this study. Patients were assessed for pre-eclampsia those who were history of blood pressure >140 mmHg and 90 mmHg diastolic as seen on examination on three consecutive readings. Data of maternal hemogram taken at presentation was recording using an automated hematology analyzer. mean platelet volume (MPV) was recorded at completion of 36th week of gestation. Results: Mean age of patients included in this study was 34.22±5.02 years. Mean body mass index (BMI) of patients was 24.58±4.65 kg/m2. Mean parity was 2.63±0.78. Mean blood pressure of patients was 128.37±15.06 mmHg. The mean platelet volume in patients with normotensive pregnancy was 9.27±1.31 fL versus 12.49±1.51 fL in patients pre-eclampsia. This difference was statistically significant with p-value of <0.0001. Conclusion: As a biomarker for preeclampsia severity, MPV is a valuable tool. In a clinical context, MPV is regularly acquired during a complete blood count, making it a potentially cost-effective prediction tool for evaluating pre-eclampsia Keywords: Pregnancy, Pre-eclampsia, Mean Platelet Volume (MPV)

scholarly journals Mean Platelet Volume (MPV) as an indicator of  disease activity and severity in lupus

F1000Research ◽  
2017 ◽  
Vol 6 ◽  
pp. 126 ◽  
Author(s):  
Abidullah Khan ◽  
Iqbal Haider ◽  
Maimoona Ayub ◽  
Salman Khan
Keyword(s):  
Disease Activity ◽  
Lupus Erythematosus ◽  
Mean Platelet Volume ◽  
Activity Index ◽  
Disease Activity Index ◽  
Sampling Technique ◽  
Cross Sectional Study ◽  
Strong Positive Correlation ◽  
Platelet Volume ◽  
Cross Sectional

Background: Amongst the different clinical and laboratory parameters used to monitor disease activity in systemic lupus erythematosus (SLE), mean platelet volume (MPV) is a novel biomarker. Although MPV has been studied in other rheumatological conditions like rheumatoid arthritis, its role in adult SLE needs to be defined, especially in Pakistan. Methods: The aim of this study was to evaluate the role of MPV as a biomarker of disease activity in SLE. Fifty patients were recruited through a consecutive non-probability sampling technique for this cross-sectional study.  On the basis of their SLE disease activity index (SLEDAI) score of greater or lesser than 5, these 50 participants were divided into two equal groups respectively;25 patients with active SLE, and another 25 participants with stable, inactive lupus. MPV was measured in each group and compared using SPSS version 16. MPV was also correlated with SLEDAI and erythrocyte sedimentation rate (ESR). Independent sample t-test and Spearman’s rho and Pearson’s correlation tests were applied. Sensitivity and specificity of MPV were checked through ROC analysis.    Results: The MPV of patients with active SLE (n=25, mean [M]=7.12, SD=1.01) was numerically lower than those in the inactive-SLE group (n=25, M= 10.12, SD=0.97), and this was statistically significant ( P<0.001). MPV had an inverse relationship with both ESR (r=-0.93, P<0.001) and SLEDAI (rs= -0.89, P<0.001). However, there was a strong positive correlation between ESR and SLEDAI (rs=0.90, P<0.001). For MPV, a cutoff value of less than 8.5fl had a sensitivity of 92% and a specificity of 100% ( P< 0.001).  Conclusions: Higher disease activity in SLE is associated with a correspondingly low MPV.

Variations of blood cells in prediction of gestational diabetes mellitus

2014 ◽  
Vol 0 (0) ◽  
Author(s):  
Hongling Yang ◽  
Chunyan Zhu ◽  
Qinling Ma ◽  
Yan Long ◽  
Zhou Cheng
Keyword(s):  
Diabetes Mellitus ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Blood Parameters ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Mean Cell Volume ◽  
Cell Parameters ◽  
The Mean ◽  
Laboratory Information Systems

AbstractThis study aims to evaluate the value of increasing inflammation in predicting gestational diabetes mellitus (GDM).Subjects in this cross-sectional study included 302 GDM and 310 normal pregnancies before 20 weeks. Sociodemographic and pregnancy characteristics as well as blood parameters were acquired by maternal health booklet, medical records and laboratory information systems. Blood cell parameters were compared between the two groups by independent sampleWomen with GDM had significantly higher neutrophil (NEU), lymphocyte (LYM), platelet (PLT) and erythrocyte (RBC) counts, and were positively correlated with GDM. NEU (odds ratios, OR, 1.22) and LYM (OR, 2.01) were independently associated with the development of GDM (P<0.001). The OR of the mean platelet volume (MPV) and mean cell volume (MCV) were 0.84 and 0.92, respectively (P<0.01 for both). The efficiency of Fisher’s equations in correctly classifying cases of GDM from 4 to 20 weeks of gestation was 70.06%.Maternal WBC, RBC, and PLT counts are important correlates of GDM. Increased volume of RBC and PLT might protect pregnant women from development of GDM.

scholarly journals THE CORRELATION BETWEEN THE MEAN PLATELET VOLUME VALUES WITH THROMBOCYTE AGGREGATION IN NEPHROPATHY DIABETIC PATIENTS

2019 ◽  
Vol 25 (1) ◽  
pp. 79
Author(s):  
Agus Sunardi ◽  
Nadjwa Zamalek Dalimoenthe ◽  
Coriejati Rita ◽  
Adhi Kristianto Sugianli
Keyword(s):  
Diabetic Nephropathy ◽  
Platelet Aggregation ◽  
Mean Platelet Volume ◽  
Cross Sectional Study ◽  
Endothelial Damage ◽  
Diabetic Patients ◽  
Platelet Volume ◽  
Cross Sectional ◽  
Positive Correlation ◽  
Chronic Hyperglycemia

     Diabetic nephropathy is the most important cause of end-stage renal failure. Chronic hyperglycemia will cause glomerular endothelial damage, and this damage will stimulate hemostasis activation including platelets so that platelet aggregation will increase. The increase of platelet aggregation will increase platelet consumption, which further stimulates thrombopoiesis which will lead to immature platelets of large size to be released into the circulation. This research aimed to determine the positive correlation between MPV with platelet aggregation in patients with diabetic nephropathy. This study was an analytic observational study with a cross-sectional study design. The research was conducted in the Dr. Hasan Sadikin Hospital Bandung from July 2016 to October 2017. A total of 52 subjects who met the inclusion criteria were included in the study. Mean platelet volume and platelet aggregation were performed with venous examination with EDTA and sodium citrate 3.2% anticoagulants. The result of platelet aggregation examination showing platelet hyper-aggregation was found in 44.2% of subjects, 50% normal-aggregation, 5.8% hypo-aggregation. While the median value of MPV in this study was 9.2 fL with the range of 8.00 – 11.80 fL. A positive correlation was found  between MPV value with platelet aggregation with r= 0.067, p= 0.634. The conclusion was that there was no correlation between MPV values with platelet aggregation in diabetic nephropathy patients. This small and insignificant r-value might be due to several factors that also affect platelet aggregation in diabetic nephropathy patients, requiring further investigation.

scholarly journals Mean Platelet Volume (MPV) as an indicator of  disease activity and severity in lupus

F1000Research ◽  
2017 ◽  
Vol 6 ◽  
pp. 126 ◽  
Author(s):  
Abidullah Khan ◽  
Iqbal Haider ◽  
Maimoona Ayub ◽  
Salman Khan
Keyword(s):  
Disease Activity ◽  
Lupus Erythematosus ◽  
Mean Platelet Volume ◽  
Activity Index ◽  
Disease Activity Index ◽  
Sampling Technique ◽  
Cross Sectional Study ◽  
Strong Positive Correlation ◽  
Platelet Volume ◽  
Cross Sectional

Background: Amongst the different clinical and laboratory parameters used to monitor disease activity in systemic lupus erythematosus (SLE), mean platelet volume (MPV) is a novel biomarker. Although MPV has been studied in other rheumatological conditions like rheumatoid arthritis, its role in adult SLE needs to be defined, especially in Pakistan. Methods: The aim of this study was to evaluate the role of MPV as a biomarker of disease activity in SLE. Fifty patients were recruited through a consecutive non-probability sampling technique for this cross-sectional study.  On the basis of their SLE disease activity index (SLEDAI) score of greater or lesser than 5, these 50 participants were divided into two equal groups respectively;25 patients with active SLE, and another 25 participants with stable, inactive lupus. MPV was measured in each group and compared using SPSS version 16. MPV was also correlated with SLEDAI and erythrocyte sedimentation rate (ESR). Independent sample t-test and Pearson’s correlation tests were applied. Sensitivity and specificity of MPV were checked through ROC analysis.   Results: The MPV of patients with active SLE (n=25, mean [M]=7.12, SD=1.01) was numerically lower than those in the inactive-SLE group (n=25, M= 10.12, SD=0.97), and this was statistically significant (P<0.001). MPV had an inverse relationship with both ESR (r=-0.93, P<0.001) and SLEDAI (r= -0.94, P<0.001). However, there was a strong positive correlation between ESR and SLEDAI (r=0.95, P<0.001). For MPV, a cutoff value of less than 8.5fl had a sensitivity of 92% and a specificity of 100% (P< 0.001). Conclusions: Higher disease activity in SLE is associated with a correspondingly low MPV.

scholarly journals Elevated Serum Total Bilirubin Concentrations Are Negatively Associated with Diabetic Retinopathy among the Chinese Northeastern Population

2018 ◽  
Vol 2018 ◽  
pp. 1-6 ◽  
Author(s):  
Dan Zhang ◽  
Wei Zhang ◽  
Shi Jin ◽  
Wei Wang ◽  
Dan Guo ◽  
...  
Keyword(s):  
Diabetic Retinopathy ◽  
Total Bilirubin ◽  
Elevated Serum ◽  
Cross Sectional Study ◽  
Continuous Variable ◽  
Serum Total Bilirubin ◽  
Cross Sectional ◽  
Total Bilirubin Concentration ◽  
The Mean

Objective. To evaluate the association between serum total bilirubin concentration (STBC) and diabetic retinopathy (DR) among the Chinese northeastern population. Methods. A cross-sectional study was conducted in Liaoning between January 2015 and May 2017. Results. A total of 742 subjects (419 men and 323 women) with type 2 diabetes mellitus (DM) who visited an ophthalmic clinic were included in this study. The mean age of the subjects was 59.55 ± 10.63 years, and 43.5% of the subjects were women. The mean of DM duration was 11.01 ± 7.35 years. STBC were negatively correlated with DM duration, urea nitrogen, serum creatinine, uric acid, and urine microalbumin. After adjusting for confounding factors, as a continuous variable, STBC was inversely associated with the risk of DR in total subjects (OR: 0.95, 95% CI: 0.93–0.99). When STBC was used as a tertiary variable, compared with the first tertile, the OR in the third tertile was 0.37 (95% CI: 0.22–0.64) in total subjects. Conclusion. Our results demonstrate that a significant negative association was found between STBC and DR. STBC might be an early clinical marker for predicting the occurrence of DR.

Mean Platelet Volume in Patients of Psoriasis in a Tertiary Care Hospital

2021 ◽  
Vol 15 (10) ◽  
pp. 3122-3125
Author(s):  
Bushra Muzaffar Khan ◽  
Nida Yaqoob ◽  
Najia Ahmed ◽  
Ayesha Anwar ◽  
Moizza Tahir ◽  
...  
Keyword(s):  
Mean Platelet Volume ◽  
Cross Sectional Study ◽  
Complete Analysis ◽  
Military Hospital ◽  
Ethical Review ◽  
Care Hospital ◽  
Sectional Study ◽  
Platelet Volume ◽  
Cross Sectional ◽  
Dermatology Department

Objective: To determine mean platelet volume in patients of psoriasis Study Design: Cross sectional study Place and duration of study: Dermatology Department, Pak Emirates Military Hospital Rawalpindi from August 2017 to January 2018. Methodology: Approval from the hospital ethical review committee was taken and a total of 100 patients were enrolled by non-probability consecutive sampling. After an informed written consent, name, gender, age, hospital record number, and phone number of each individual were noted. At the time of enrollment, all the individuals were subjected to complete blood count, bleeding time, fasting blood sugar, fasting lipid profile, renal and liver function tests. Patients with abnormal parameters were excluded from the study. A two ml venous blood sample was drawn from each patient and sent in CP bottle to the laboratory of Armed Forces Institute of Pathology for blood complete analysis by hematology analyzer machine. Data analysis was done using SPSS version 22. Results: In this study mean age was 40 ± 10.40 years. 54% patients were male and 46% patients were female. Mean platelet volume in patients presenting with psoriasis was 9.10fL with SD ± 2.12. Conclusion: Our study concludes that the mean platelet volume in patients presenting with psoriasis was 9.10fL with SD ± 2.12 which is in the normal range. Therefore, mean platelet volume is not affected by psoriasis. Key words: Mean platelet volume, psoriasis, severity, cross-sectional study

Platelet Count and Mean Platelet Volume in Hypertensive Patients: A Cross Sectional Study

2017 ◽  
Vol 6 (3 (part-2)) ◽  
pp. 693--695
Author(s):  
Harish S. Permi ◽  
◽  
Kishan Prasad H.L. ◽  
Sanjana D.S. ◽  
Jayaprakash Shetty K ◽  
...  
Keyword(s):  
Platelet Count ◽  
Mean Platelet Volume ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Platelet Volume ◽  
Cross Sectional ◽  
Hypertensive Patients

scholarly journals Mean platelet volume as an indicator of severity of hypertensive retinopathy in hypertensive subjects

2017 ◽  
Vol 5 (4) ◽  
pp. 1471
Author(s):  
Vishal Yadav ◽  
Pragya Jain ◽  
Abhishek Singhai ◽  
Rajesh Kumar Jha
Keyword(s):  
Mean Platelet Volume ◽  
Antihypertensive Drugs ◽  
Plaque Rupture ◽  
Thrombus Formation ◽  
Microvascular Complications ◽  
Organ Damage ◽  
Cross Sectional Study ◽  
Hypertensive Retinopathy ◽  
Platelet Volume ◽  
Cross Sectional

Background: Hypertensive retinopathy (HR) represents the ophthalmic findings of end-organ damage secondary to systemic arterial hypertension. Platelets play a crucial role in the pathogenesis of atherosclerotic complications, contributing to thrombus formation or apposition after plaque rupture. The aim of our study was to investigate whether Mean platelet volume (MPV) is associated with the severity of hypertensive retinopathy in hypertensive patients.Methods: This cross-sectional study was conducted in Department of Medicine of SAMC and PGI, Indore. Total 250 adult hypertensive patients (BP >140/90 mm Hg or taking antihypertensive drugs) recruited for the study.Results: Of the 250 subjects, 158 (63.2%) were male and 92 (36.8%) were female. Elevated MPV >11.5 femtoliter was observed in 84 cases (33.6%). There was statistically significant relationship between the grade of retinopathy and elevated MPV in hypertensive subjects. (r = 0.52, P <0.001).Conclusions: We described a relation between MPV and HR (probably first time in Indian patients). Measurement of MPV is easy to establish and therefore might serve as a valuable predictor of a worse outcome in microvascular complications.

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