Mean platelet volume as an indicator of severity of hypertensive retinopathy in hypertensive subjects

Background: Hypertensive retinopathy (HR) represents the ophthalmic findings of end-organ damage secondary to systemic arterial hypertension. Platelets play a crucial role in the pathogenesis of atherosclerotic complications, contributing to thrombus formation or apposition after plaque rupture. The aim of our study was to investigate whether Mean platelet volume (MPV) is associated with the severity of hypertensive retinopathy in hypertensive patients.Methods: This cross-sectional study was conducted in Department of Medicine of SAMC and PGI, Indore. Total 250 adult hypertensive patients (BP >140/90 mm Hg or taking antihypertensive drugs) recruited for the study.Results: Of the 250 subjects, 158 (63.2%) were male and 92 (36.8%) were female. Elevated MPV >11.5 femtoliter was observed in 84 cases (33.6%). There was statistically significant relationship between the grade of retinopathy and elevated MPV in hypertensive subjects. (r = 0.52, P <0.001).Conclusions: We described a relation between MPV and HR (probably first time in Indian patients). Measurement of MPV is easy to establish and therefore might serve as a valuable predictor of a worse outcome in microvascular complications.

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Mean Platelet Volume (MPV) as an indicator of disease activity and severity in lupus

F1000Research ◽

10.12688/f1000research.10763.3 ◽

2017 ◽

Vol 6 ◽

pp. 126 ◽

Cited By ~ 3

Author(s):

Abidullah Khan ◽

Iqbal Haider ◽

Maimoona Ayub ◽

Salman Khan

Keyword(s):

Disease Activity ◽

Lupus Erythematosus ◽

Mean Platelet Volume ◽

Activity Index ◽

Disease Activity Index ◽

Sampling Technique ◽

Cross Sectional Study ◽

Strong Positive Correlation ◽

Platelet Volume ◽

Cross Sectional

Background: Amongst the different clinical and laboratory parameters used to monitor disease activity in systemic lupus erythematosus (SLE), mean platelet volume (MPV) is a novel biomarker. Although MPV has been studied in other rheumatological conditions like rheumatoid arthritis, its role in adult SLE needs to be defined, especially in Pakistan. Methods: The aim of this study was to evaluate the role of MPV as a biomarker of disease activity in SLE. Fifty patients were recruited through a consecutive non-probability sampling technique for this cross-sectional study. On the basis of their SLE disease activity index (SLEDAI) score of greater or lesser than 5, these 50 participants were divided into two equal groups respectively;25 patients with active SLE, and another 25 participants with stable, inactive lupus. MPV was measured in each group and compared using SPSS version 16. MPV was also correlated with SLEDAI and erythrocyte sedimentation rate (ESR). Independent sample t-test and Spearman’s rho and Pearson’s correlation tests were applied. Sensitivity and specificity of MPV were checked through ROC analysis. Results: The MPV of patients with active SLE (n=25, mean [M]=7.12, SD=1.01) was numerically lower than those in the inactive-SLE group (n=25, M= 10.12, SD=0.97), and this was statistically significant ( P<0.001). MPV had an inverse relationship with both ESR (r=-0.93, P<0.001) and SLEDAI (rs= -0.89, P<0.001). However, there was a strong positive correlation between ESR and SLEDAI (rs=0.90, P<0.001). For MPV, a cutoff value of less than 8.5fl had a sensitivity of 92% and a specificity of 100% ( P< 0.001). Conclusions: Higher disease activity in SLE is associated with a correspondingly low MPV.

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THE CORRELATION BETWEEN THE MEAN PLATELET VOLUME VALUES WITH THROMBOCYTE AGGREGATION IN NEPHROPATHY DIABETIC PATIENTS

INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY ◽

10.24293/ijcpml.v25i1.1510 ◽

2019 ◽

Vol 25 (1) ◽

pp. 79

Author(s):

Agus Sunardi ◽

Nadjwa Zamalek Dalimoenthe ◽

Coriejati Rita ◽

Adhi Kristianto Sugianli

Keyword(s):

Diabetic Nephropathy ◽

Platelet Aggregation ◽

Mean Platelet Volume ◽

Cross Sectional Study ◽

Endothelial Damage ◽

Diabetic Patients ◽

Platelet Volume ◽

Cross Sectional ◽

Positive Correlation ◽

Chronic Hyperglycemia

Diabetic nephropathy is the most important cause of end-stage renal failure. Chronic hyperglycemia will cause glomerular endothelial damage, and this damage will stimulate hemostasis activation including platelets so that platelet aggregation will increase. The increase of platelet aggregation will increase platelet consumption, which further stimulates thrombopoiesis which will lead to immature platelets of large size to be released into the circulation. This research aimed to determine the positive correlation between MPV with platelet aggregation in patients with diabetic nephropathy. This study was an analytic observational study with a cross-sectional study design. The research was conducted in the Dr. Hasan Sadikin Hospital Bandung from July 2016 to October 2017. A total of 52 subjects who met the inclusion criteria were included in the study. Mean platelet volume and platelet aggregation were performed with venous examination with EDTA and sodium citrate 3.2% anticoagulants. The result of platelet aggregation examination showing platelet hyper-aggregation was found in 44.2% of subjects, 50% normal-aggregation, 5.8% hypo-aggregation. While the median value of MPV in this study was 9.2 fL with the range of 8.00 – 11.80 fL. A positive correlation was found between MPV value with platelet aggregation with r= 0.067, p= 0.634. The conclusion was that there was no correlation between MPV values with platelet aggregation in diabetic nephropathy patients. This small and insignificant r-value might be due to several factors that also affect platelet aggregation in diabetic nephropathy patients, requiring further investigation.

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AGREGASI TROMBOSIT DAN MEAN PLATELET VOLUME DENGAN SINDROM METABOLIK TERKAIT KEGEMUKAN

INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY ◽

10.24293/ijcpml.v21i2.1095 ◽

2018 ◽

Vol 21 (2) ◽

pp. 130

Author(s):

Nindia Sugih Arto ◽

Adi Koesoema Aman ◽

Dharma Lindarto

Keyword(s):

Cardiovascular Disease ◽

Metabolic Syndrome ◽

Platelet Aggregation ◽

Mean Platelet Volume ◽

Cross Sectional Study ◽

Sectional Study ◽

Platelet Volume ◽

Cross Sectional ◽

The Metabolic Syndrome ◽

The Mean

The hyperactivity of platelet had been seen in patients with metabolic syndrome which can be caused by several factors, such as:insulin resistance, obesity, dyslipidemia and hypertension. The hyperactivity of platelet leads to its aggregation that can be increased therisk of cardiovascular disease. This study is aimed to know the platelet aggregation and mean platelet volume in patients with metabolicsyndrome and obesity by determination 30 patients were choosen for this cross sectional study, those whom attended to the laboratoryand policlinic at H. Adam Malik Medan Hospital, between May 2013 until August 2013. The diagnosis used of metabolic syndromecriteria established by the International Diabetic Federation 2005. From the 30 patients with 15 metabolic syndrome and 15 obesity,four patients were excluded because of their tryglyceride were more than 200 mg/dL. There is no significant differences between theplatelet aggregation with the agonist adenosin difosfat (ADP) in patient with metabolic syndrome and obesity. And there is no significantdifferences of the mean platelet volume values between the metabolic syndrome (9.6±0.93) and the obesity group (9.73±0.74), with pvalue 0.846. Based on this study there is no significant differences between the platelet aggregation and the Mean Platelet Volume values(MPV) in the metabolic syndrome and the obese group

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Mean Platelet Volume (MPV) as an indicator of disease activity and severity in lupus

F1000Research ◽

10.12688/f1000research.10763.2 ◽

2017 ◽

Vol 6 ◽

pp. 126 ◽

Cited By ~ 5

Author(s):

Abidullah Khan ◽

Iqbal Haider ◽

Maimoona Ayub ◽

Salman Khan

Keyword(s):

Disease Activity ◽

Lupus Erythematosus ◽

Mean Platelet Volume ◽

Activity Index ◽

Disease Activity Index ◽

Sampling Technique ◽

Cross Sectional Study ◽

Strong Positive Correlation ◽

Platelet Volume ◽

Cross Sectional

Background: Amongst the different clinical and laboratory parameters used to monitor disease activity in systemic lupus erythematosus (SLE), mean platelet volume (MPV) is a novel biomarker. Although MPV has been studied in other rheumatological conditions like rheumatoid arthritis, its role in adult SLE needs to be defined, especially in Pakistan. Methods: The aim of this study was to evaluate the role of MPV as a biomarker of disease activity in SLE. Fifty patients were recruited through a consecutive non-probability sampling technique for this cross-sectional study. On the basis of their SLE disease activity index (SLEDAI) score of greater or lesser than 5, these 50 participants were divided into two equal groups respectively;25 patients with active SLE, and another 25 participants with stable, inactive lupus. MPV was measured in each group and compared using SPSS version 16. MPV was also correlated with SLEDAI and erythrocyte sedimentation rate (ESR). Independent sample t-test and Pearson’s correlation tests were applied. Sensitivity and specificity of MPV were checked through ROC analysis. Results: The MPV of patients with active SLE (n=25, mean [M]=7.12, SD=1.01) was numerically lower than those in the inactive-SLE group (n=25, M= 10.12, SD=0.97), and this was statistically significant (P<0.001). MPV had an inverse relationship with both ESR (r=-0.93, P<0.001) and SLEDAI (r= -0.94, P<0.001). However, there was a strong positive correlation between ESR and SLEDAI (r=0.95, P<0.001). For MPV, a cutoff value of less than 8.5fl had a sensitivity of 92% and a specificity of 100% (P< 0.001). Conclusions: Higher disease activity in SLE is associated with a correspondingly low MPV.

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No obvious association exists between mean platelet volume and hypertension subtypes

Biomarkers in Medicine ◽

10.2217/bmm-2020-0305 ◽

2021 ◽

Author(s):

Tingwei Li ◽

Zhaowei Meng ◽

Wenjuan Zhang ◽

Yongle Li ◽

Xuefang Yu ◽

...

Keyword(s):

Mean Platelet Volume ◽

Protective Factor ◽

Blood Parameters ◽

Cross Sectional Study ◽

Continuous Variable ◽

Platelet Volume ◽

Cross Sectional ◽

Diastolic Hypertension ◽

Obvious Association ◽

The Mean

Aims: To determine the association between mean platelet volume (MPV) and hypertension subtypes. Participants & results: 44,281 Chinese individuals were enrolled in this cross-sectional study. The mean blood pressure decreased with increasing MPV in females (p = 0.001) and increased MPV seemed to be a potential protective factor for isolated diastolic hypertension in models 1 and 2. The OR (CI) was 0.878 (0.789–0.976) for model 1 and 0.880 (0.789–0.981) for model 2 in males and 0.646 (0.495–0.841) for model 1 and 0.657 (0.503–0.858) for model 2 in females, when MPV was analyzed as a categorical variable. The OR (CI) was 0.947 (0.911–0.985) for Model 1 and 0.947 (0.910–0.985) for Model 2 in males, and 0.886 (0.807–0.973) for Model 1 and 0.892 (0.813–0.978) for Model 2 in females when MPV was analyzed as a continuous variable. However, the statistical difference of OR disappeared when we added blood-related covariates in Model 3. Conclusion: No obvious association exists between MPV and hypertension subtypes. Other blood parameters might have a greater impact on hypertension subtypes.

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Mean Platelet Volume in Patients of Psoriasis in a Tertiary Care Hospital

10.53350/pjmhs2115103122 ◽

2021 ◽

Vol 15 (10) ◽

pp. 3122-3125

Author(s):

Bushra Muzaffar Khan ◽

Nida Yaqoob ◽

Najia Ahmed ◽

Ayesha Anwar ◽

Moizza Tahir ◽

...

Keyword(s):

Mean Platelet Volume ◽

Cross Sectional Study ◽

Complete Analysis ◽

Military Hospital ◽

Ethical Review ◽

Care Hospital ◽

Sectional Study ◽

Platelet Volume ◽

Cross Sectional ◽

Dermatology Department

Objective: To determine mean platelet volume in patients of psoriasis Study Design: Cross sectional study Place and duration of study: Dermatology Department, Pak Emirates Military Hospital Rawalpindi from August 2017 to January 2018. Methodology: Approval from the hospital ethical review committee was taken and a total of 100 patients were enrolled by non-probability consecutive sampling. After an informed written consent, name, gender, age, hospital record number, and phone number of each individual were noted. At the time of enrollment, all the individuals were subjected to complete blood count, bleeding time, fasting blood sugar, fasting lipid profile, renal and liver function tests. Patients with abnormal parameters were excluded from the study. A two ml venous blood sample was drawn from each patient and sent in CP bottle to the laboratory of Armed Forces Institute of Pathology for blood complete analysis by hematology analyzer machine. Data analysis was done using SPSS version 22. Results: In this study mean age was 40 ± 10.40 years. 54% patients were male and 46% patients were female. Mean platelet volume in patients presenting with psoriasis was 9.10fL with SD ± 2.12. Conclusion: Our study concludes that the mean platelet volume in patients presenting with psoriasis was 9.10fL with SD ± 2.12 which is in the normal range. Therefore, mean platelet volume is not affected by psoriasis. Key words: Mean platelet volume, psoriasis, severity, cross-sectional study

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Platelet Count and Mean Platelet Volume in Hypertensive Patients: A Cross Sectional Study

Indian Journal of Pathology Research and Practice ◽

10.21088/ijprp.2278.148x.6317.31 ◽

2017 ◽

Vol 6 (3 (part-2)) ◽

pp. 693--695

Author(s):

Harish S. Permi ◽

◽

Kishan Prasad H.L. ◽

Sanjana D.S. ◽

Jayaprakash Shetty K ◽

...

Keyword(s):

Platelet Count ◽

Mean Platelet Volume ◽

Cross Sectional Study ◽

Sectional Study ◽

Platelet Volume ◽

Cross Sectional ◽

Hypertensive Patients

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Mean Platelet Volume and Splenomegaly as Useful Markers of Subclinical Activity in Egyptian Children with Familial Mediterranean Fever: A Cross-Sectional Study

International Journal of Chronic Diseases ◽

10.1155/2015/152616 ◽

2015 ◽

Vol 2015 ◽

pp. 1-6

Author(s):

Huda Marzouk ◽

Hala M. Lotfy ◽

Yomna Farag ◽

L. A. Rashed ◽

Kamal El-Garf

Keyword(s):

Familial Mediterranean Fever ◽

Mean Platelet Volume ◽

Abdominal Ultrasound ◽

Cross Sectional Study ◽

Sectional Study ◽

Platelet Volume ◽

Laboratory Practice ◽

Cross Sectional ◽

Egyptian Children ◽

Mediterranean Fever

Objective. To study whether mean platelet volume (MPV) and splenomegaly could be used as subclinical inflammatory markers in children with familial Mediterranean fever (FMF) at the attack-free period.Patients and Methods. The study included ninety-seven children with FMF. MPV was carried out within 4 hours of blood sampling according to standard laboratory practice. Splenomegaly was determined by abdominal ultrasound (USG).Results. High MPV was detected in 84.45% of our studied patients and was significantly higher in FMF patients with splenomegaly than in patients without splenomegaly. There was a statistically significant correlation between MPV and splenic span (P=0.045).Conclusion. Elevated MPV and its significant correlation with splenic span in FMF children during the attack-free periods support the use of MPV and splenomegaly as useful markers of the subclinical inflammation in FMF patients at the attack-free period.

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STUDY OF MEAN PLATELET VOLUME IN ISCHEMIC STROKE

10.36106/ijsr/9501930 ◽

2021 ◽

pp. 51-52

Author(s):

Pawan Kumar ◽

Khushboo Agarwal ◽

Ravi Kumar Bansal

Keyword(s):

Ischemic Stroke ◽

Mean Platelet Volume ◽

Tertiary Care ◽

Cost Effective ◽

Cross Sectional Study ◽

Care Hospital ◽

Platelet Volume ◽

Cross Sectional ◽

Severe Stroke ◽

Medical College

Background: Mean platelet volume, as well as platelet count, are an index of haemostasis and its dysfunction i.e. thrombosis. Aim of this study is to investigate the association between mean platelet volume (MPV) & acute ischemic stroke. Methods: This retrospective cross-sectional study included 200 patients admitted to the emergency & general opd (medicine & pediatric) of a tertiary care hospital in JLN Medical College Ajmer from Aug jan 2020 to Nov 2020. The data were evaluated according to MPV levels, National Institutes of Health Stroke Scale (NIHSS) scores. The patients were divided into groups based on MPV level ≤7.5, 7.6-10.0,10.1-12.5,≥12.6. Results: In our study, a signicant association was found between severity of stroke (according to NIHSS criteria) and MPV in male and female populations (p<0.0001 and p<0.0001 respectively). A signicant difference was found between MPV values of all 3 categories ie patients of severe stroke had higher value of MPV than those of mild and moderate stroke and patients of moderate stroke had higher values than those of mild stroke. Conclusion: This is a simple and cost effective test which can be easily done at any primary care centre and can serve as a useful marker to differentiate ischemic stroke from hemorrhagic stroke.

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Sex-Dependent Performance of the Neutrophil-to-Lymphocyte, Monocyte-to-Lymphocyte, Platelet-to-Lymphocyte and Mean Platelet Volume-to-Platelet Ratios in Predicting Covid-19 Severity.

10.21203/rs.3.rs-597523/v1 ◽

2021 ◽

Author(s):

Martha Fors ◽

Santiago Ballaz ◽

Hégira Ramírez ◽

Francisco Mora ◽

Mary Pulgar ◽

...

Keyword(s):

Immune Responses ◽

Mean Platelet Volume ◽

Area Under The Curve ◽

Cross Sectional Study ◽

Rt Pcr ◽

Platelet Volume ◽

Cross Sectional ◽

Lymphocyte Ratio ◽

Lymphocyte To Monocyte Ratio ◽

Polymerase Chain

Abstract Background The neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), lymphocyte-to-monocyte ratio (LMR) and mean platelet volume-to-platelet ratio (MPR) are combined hematology tests useful for the assessment of COVID-19 severity, but different cut-off values have been reported. Sex can significantly impact immune responses and the course of COVID-19, so these combined hematology tests should be differentiated by gender. Purpose The aim of this study was to evaluate sex differences in the contribution of the NLR, PLR, MLR and MPR to severity and mortality using a sample of COVID-19 patients infected with SARS-CoV-2 from Quito (Ecuador). Methods This single center observational cross-sectional study included 3280 subjects with COVID-19 disease admitted in the IESS Hospital from Quito. Subjects over 18 years old having a positive result in the real time reverse transcriptase polymerase chain reaction (RT-PCR) test for SARS-CoV-2. Confirmed COVID-19 cases were categorized as Severe (PaO2 < 60 mmHg) and Non-Severe (PaO2 ≥ 60 mmHg). Area under the curve, sensibility and specificity were calculated for these ratios to identify optimal cut-offs according to gender to predict severity and mortality in COVID-19 subjects. Results Covid-19 mortality rate among men was double that in women. Severe and non-surviving patients had a higher NLR and MLR, and a lower MPR. A higher PLR was also associated with severity, but not with mortality. The means of NLR, MLR, and PLR in men were significantly higher, yet MPR levels were lower than in women. In men, these ratios had lower cut-offs than in women (NLR: 2.42 vs. 3.31, MLR: 0.24 vs. 0.35 and PLR: 83.9 vs. 151.9). The sensitivity of NLR, MLR and PLR to predict severity was better in men (69%-77%), while their specificity enhanced in women compared to men (70%-76% vs. 23%-48%). Conclusion High NLR, MLR, PLR and low MPR levels were related to COVID-19 severity with different performance in men and women.

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