scholarly journals Clinical characteristics of outpatients and inpatients with COVID-19 in Bushehr: a report from the south of Iran

2021 ◽  
Author(s):  
Mohsen Keshavarz ◽  
Ahmad Tavakoli ◽  
Sareh Zanganeh ◽  
Mohammad Javad Mousavi ◽  
Katayoun Vahdat ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Renal Failure ◽  
Lactate Dehydrogenase ◽  
Elderly Patients ◽  
Clinical Characteristics ◽  
Clinical Laboratory ◽  
Imaging Features ◽  
Severe Renal Failure ◽  
Erythrocyte Sedimentation ◽  
Increased Risk

Aim: To investigate clinical, laboratory and imaging features of COVID-19 patients in Bushehr, a southern province of Iran. Materials & methods: A total of 148 COVID-19 patients were enrolled. The patients were categorized into four groups including inpatients, outpatients, elderly and nonelderly. Clinical, laboratory and computed tomography characteristics were analyzed and compared. Results: Levels of erythrocyte sedimentation rate, CRP, lactate dehydrogenase and aspartate aminotransferas among inpatients were higher than outpatients. There were significant differences in the levels of creatinine and blood urine nitrogen between elderly and nonelderly patients. The incidence of ground-glass opacities in inpatients was significantly higher than in outpatients. Conclusion: COVID-19 is associated with more severe renal failure in elderly patients. Elderly patients with underlying conditions are at increased risk of severe progression of COVID-19.

scholarly journals Clinical, Laboratory, and Imaging Features of 148 Patients with COVID-19 in Bushehr: A Report from the South of Iran

2020 ◽  
Author(s):  
Mohsen Keshavarz ◽  
Ahmad Tavakoli ◽  
Sareh Zanganeh ◽  
Mohammad Javad Mousavi ◽  
Katayoun Vahdat ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Elderly Patients ◽  
Clinical Characteristics ◽  
Clinical Laboratory ◽  
Imaging Features ◽  
Ministry Of Health ◽  
Laboratory Findings ◽  
Southern Province ◽  
Increased Risk

Aim: To investigate clinical characteristics, laboratory findings, and imaging features of patients confirmed with COVID-19 in Bushehr, a southern province of Iran. Method: During April 29th to May 30th 2020, a total of 148 patients confirmed with COVID-19 infection were admitted to three hospitals in Bushehr province, assigned by the Iranian Ministry of Health. Results: The most common coexisting disease was type 2 diabetes. Levels of ESR, CRP, LDH, and AST among inpatients were higher than the outpatients (P<0.05). There were significant differences in the levels of creatinine and BUN between elderly and non-elderly patients (P<0.05). Conclusion: Patients with comorbidities and elderly patients are at increased risk of severe progression of COVID-19.

scholarly journals LENALIDOMIDE IN COMBINATION WITH DEXAMETHASONE IN ELDERLY PATIENTS WITH ADVANCED, RELAPSED OR REFRACTORY MULTIPLE MYELOMA AND RENAL FAILURE

2013 ◽  
Vol 5 (1) ◽  
pp. e2013037 ◽  
Author(s):  
Patrizia Tosi
Keyword(s):  
Multiple Myeloma ◽  
Renal Failure ◽  
Elderly Patients ◽  
Hematological Toxicity ◽  
Severe Renal Failure ◽  
Minor Response ◽  
Median Response ◽  
Refractory Multiple Myeloma ◽  
First Choice ◽  
Grade Iii

  Salvage therapy of elderly patients with advanced, relapsed and refractory multiple myeloma (MM) is often limited by poor marrow reserve and multi-organ impairment. In particular, renal failure occurs in up to 50% of such patients, an this can potentially limit the therapeutic options. Both thalidomide and bortezomib have proven effective in these patients, with an acceptable toxicity, while, in clinical practice, lenalidomide is generally not considered a first-choice drug for MM patients with renal failure as early reports showed an increased hematological toxicity unless appropriate dose reduction is applied. Aim of this study was a retrospective evaluation of the efficacy of the combination Lenalidomide +Dexamethasone in a population of elderly MM patients treated in 5 Italian Centers. The study included 20 consecutive MM patients (9 M, 11 F, median age 76.5 years) with relapsed (N= 6) or refractory (N=13) MM and moderate to severe renal failure, defined as creatinine clearance (Cr Cl) < 50ml/min. Four patients were undergoing hemodyalisis at study entry. 85 % of the patients had been previously treated with bortezomib-containing regimens. Lenalidomide dose was adjusted according to renal function and patients clinical conditions Median treatment duration was 16 months (1-22), therapy was interrupted after 1 21-day cycle in 2 patients. Grade III-IV neutropenia was observed in 7 patients (35%) ; grade III-IV non hematological toxicity was recorded in 3 cases (28%). A > partial response was observed in 8 patients (40%), 1 of whom obtained a VGPR; 4 additional patients achieved a minor response. Median response duration was 16 months (range 2-19+ months). A complete and partial renal response was obtained in 4 and 3 patients, respectively, all of them were responsive to Lenalidomide-dexamethasone According to our data, LEN+DEX has shown efficacy and acceptable toxicity in this population of elderly patients with advanced MM and renal failure

scholarly journals Referral of elderly patients with severe renal failure: questionnaire survey of physicians

BMJ ◽  
1996 ◽  
Vol 313 (7055) ◽  
pp. 466-466 ◽  
Author(s):  
R G Parry ◽  
A Crowe ◽  
J M Stevens ◽  
J C Mason ◽  
P Roderick
Keyword(s):  
Renal Failure ◽  
Elderly Patients ◽  
Questionnaire Survey ◽  
Severe Renal Failure

scholarly journals Clinical characteristics and cardiovascular implications of the dead patients for COVID-19

2021 ◽  
Vol 19 ◽  
pp. 205873922098625
Author(s):  
Katia Falasca ◽  
Claudio Ucciferri ◽  
Alessandro Brandimarte ◽  
Antonio Auricchio ◽  
Michela Pontolillo ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Clinical Characteristics ◽  
Clinical Symptoms ◽  
Radiological Finding ◽  
Case Fatality ◽  
Outcome Data ◽  
Qtc Interval ◽  
Increased Risk ◽  
Treatment Measures ◽  
Novel Coronavirus

Coronavirus Disease 2019 (COVID-19) caused by 2019 novel coronavirus (named SARS-CoV-2), has become a global pandemic. Aged population with cardiovascular diseases is usually more susceptible to SARS-CoV-2 infection with an increased risk of severe complications and elevated case-fatality rate. Despite of several researches about COVID-19, cardiovascular implications related to this infection still remain largely unclear. The aim of this study is to evaluate the clinical characteristics of dead patients with COVID-19. We enrolled all patients with more than 50 years of age with laboratory confirmed COVID-19, admitted to infectious clinical diseases PO SS Annunziata of Chieti (Italy) from March 2020 to April 2020 who died during hospitalization. Demographics, underlying comorbidities, clinical symptoms and signs, laboratory results, computed tomography of the chest, treatment measures, and outcome data were collected. We enrolled eight patients, the age was 82 ± 9.7 years, four female and four male. All patients had comorbidity, such as hypertension (7 [87.5%]), diabetes (1 [12.5%]), and heart disease (6 [75%]). Common symptoms included fever [8 (100%)], dry cough (1[12.56%]), and dyspnea (3 [37.5%]). All patients [8 (100%)] showed local and/or bilateral patchy shadowing on chest computed tomography that is the typical radiological finding in COVID-19. Lymphopenia was observed in seven patients (87.5%). All patients showed elevated troponin and prolongation of the QTc interval ( p < 0.05). In this study we demonstrated that in SARS-CoV-2 infection, the deaths occurred in the non-ICU population with more than 50 years are related to cardiac causes. In our cases elongation of QTc and alteration in troponin are present in all patients who died and could represent a data to better stratify the population at risk. More detailed research on cardiovascular involvement in COVID-19 patients with sudden deaths showed a predictive role of troponin and QTc elongation.

Platelet Function and the Bleeding Time in Progressive Renal Failure

1988 ◽  
Vol 60 (01) ◽  
pp. 083-087 ◽  
Author(s):  
M P Gordge ◽  
R W Faint ◽  
P B Rylance ◽  
G H Neild
Keyword(s):  
Renal Failure ◽  
Platelet Aggregation ◽  
Platelet Function ◽  
Bleeding Time ◽  
C Reactive Protein ◽  
Severe Renal Failure ◽  
Reactive Protein ◽  
Thromboxane Production ◽  
Von Willebrand ◽  
Willebrand Factor

SummaryBleeding time and platelet function tests were performed on 31 patients with progressive chronic renal failure (CRF) due to non-immunological (urological) causes, and compared with 22 healthy controls. Patients were classified as mild (plasma creatinine <300 μmol/l), moderate (300-600 μmol/l) or severe renal failure (>600 μmol/l). Bleeding time was rarely prolonged in mild and moderate CRF and mean bleeding time significantly elevated only in severe CRF (p <0.005). Haematocrit was the only index which correlated with bleeding time (r = -0.40). Platelet counts, collagen stimulated thromboxane generation, and platelet aggregation responses to ADP, collagen and ristocetin were all either normal or increased in all three CRF groups, but thromboxane production in clotting blood was reduced. Plasma fibrinogen, C reactive protein and von Willebrand factor (vWF) were elevated in proportion to CRF. We found no evidence that defects in platelet aggregation or platelet interaction with vWF prolong the bleeding time in patients with progressive CRF.

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