scholarly journals Hypoxic Status Is Associated With The Intensity Of Hypoxia Inducible Factor (Hif)-1α Expression In A Premature Placenta

2021 ◽  
Vol 17 (1) ◽  
pp. 1-11
Author(s):  
Kartini Edwin
Keyword(s):  
Confidence Interval ◽  
Premature Birth ◽  
Odds Ratio ◽  
Critical Role ◽  
Hypoxia Inducible Factor ◽  
Biological Materials ◽  
P Value ◽  
Live Births ◽  
Infant Morbidity ◽  
The Relationship

Prematurity refers to live births before 37 weeks of gestation and associated with infant morbidity/mortality. Activation of HIF during the final pregnancy phase is believed to play a critical role in the pathogenesis of premature birth and other pregnancy disorders. This study aimed to analyze the relationship between hypoxicstatus and the intensity of HIF-1α expression in a premature placenta.Stored biological materials premature placenta (paraffin blocks) was used in this study. Thirtyone samples of placental hypoxia (H) and 28 samples of premature placental non-hypoxia (N) as controls, were selected non-random consecutively. Subsequently, immunohistochemistry was performed to analyze HIF-1α expression. TheChi-square testwas used to analyze the data and a p-value <0.05 was considered statistically significant.Moderate to strong intensity of HIF-1α expressionwas observed in 58% of hypoxic placenta samples, whereas most of non-hypoxic placental samples(86%) did not expressed or expressed weaklyHIF-1α.There was a significant correlation between the intensity of HIF-1α expression and placental hypoxia (p <0.05) and Odds Ratio (OR) value was 8.31 with a 95% confidence interval (2.32-29.77). The conclusion shows that hypoxic status is associated with intensity of hypoxia inducible factor (HIF)-1α expression in a premature placenta.

Is there a relationship between gestational diabetes and postpartum depression?

2020 ◽  
Vol 16 ◽  
Author(s):  
Salman Khazaei ◽  
Erfan Ayubi ◽  
Saeid Bashirian ◽  
Ronak Hamzehei ◽  
Ensiyeh Jenabi
Keyword(s):  
Gestational Diabetes ◽  
Postpartum Depression ◽  
Odds Ratio ◽  
Depression Scale ◽  
Binary Logistic Regression ◽  
Cross Sectional Study ◽  
University Education ◽  
P Value ◽  
Cross Sectional ◽  
The Relationship

Background: The relationship between gestational diabetes and postpartum depression (PPD) is poorly understood and seldom studied. Objective: In an effort to explore this issue, the present study investigated the relationship between gestational diabetes and PPD. Methods: The present cross-sectional study was performed with 342 women who were referred to four urban health centers of Hamadan city, west of Iran. We used convenience sampling as a method to recruit women in each health center. We used a researcher-made checklist for gathering data on socio-demographic characteristics and potential risk factors of PPD. The Persian validated version of the Edinburgh Postnatal Depression Scale (EPDS) was used to assess PPD. Univariate and multivariable binary logistic regression was applied to estimate the odds ratio (OR) (95% confidence interval [CI]). Results: Gestational diabetes was identified as the most important risk factor for PPD with OR (95% CI) of 2.19 (1.11, 4.31); P-value=0.02 after adjusting for other variables. Moreover, the adjusted odds ratio showed that PPD among lesseducated women (primary school) was 3.5 times higher compared to women with a university education (OR=3.54, 95% CI: 1.27, 9.84; P-value=0.01). Conclusion: Our findings suggested that PPD is more likely among women with gestational diabetes and those who were less educated. Interventional and educational activities for reducing the risk of PPD can be targeted for use with this population.

scholarly journals Hispanic/Latino Ethnic Identity and Diabetes: An Examination of Underlying Acculturation Processes and the Hispanic/Latino Health Advantage

2021 ◽  
Vol 48 (3) ◽  
pp. 285-294
Author(s):  
Jeannie B. Concha ◽  
Kristen Kelly ◽  
Briana Mezuk
Keyword(s):  
Ethnic Identity ◽  
Confidence Interval ◽  
Health Outcomes ◽  
Physical Health ◽  
Odds Ratio ◽  
Well Being ◽  
The United States ◽  
Diabetes Prevalence ◽  
Physical Health Outcomes ◽  
The Relationship

Background. Hispanics/Latinos in the United States experience both a health advantage and disadvantage in developing diabetes. Ethnic identity, a predictor of psychological well-being, has not been widely applied to physical health outcomes. The objective of this study is to apply what is known regarding ethnic identity and psychological health to physical health outcomes (diabetes) and to explore the moderating effect of education as a possible underlying mechanism of the Hispanic Health Advantage/Disadvantage. Specifically, this study examines (a) the association between ethnic identity and diabetes prevalence among adult Hispanics/Latinos and (b) determines whether education modifies this relationship. Method. Data come from the nationally representative adult U.S. household study, National Latino and Asian American Study (NLAAS), collected in 2001 to 2003 ( N = 1,746). Multiple logistic regression was conducted to examine the relationship between ethnic identity, education, and their interaction with likelihood of diabetes. Results. Hispanics/Latinos with high ethnic identity have a higher odds of reporting diabetes among those with 13 to 15 years of education (odds ratio: 1.84; 95% confidence interval: 1.16–2.92) and a lower odds among those with 16+ years of education (odds ratio: 0.53; 95% confidence interval: 0.34–0.84). Ethnic identity is associated with diabetes prevalence and the relationship is moderated by educational attainment. Conclusion. Given the growth, diversity, and diabetes disparities among Hispanics/Latinos, our buffering and exacerbating findings exemplify the complexity and fluidity of theory in understanding psychological/behavioral processes. The findings highlight the importance of designing targeted health interventions that take into account the diverse psychosocial and educational experiences of Hispanics/Latinos.

scholarly journals Epidemiological study on the relationship among menopausal condition, bone fragility, and knee osteoarthritis

2020 ◽  
Author(s):  
Eiji Sasaki ◽  
Daisuke Chiba ◽  
Seiya Ota ◽  
Yuka Kimura ◽  
Shizuka Sasaki ◽  
...  
Keyword(s):  
Regression Analysis ◽  
Knee Osteoarthritis ◽  
Epidemiological Study ◽  
Odds Ratio ◽  
Weight Bearing ◽  
Predictive Marker ◽  
P Value ◽  
Mineral Density ◽  
High Turnover ◽  
The Relationship

Abstract Background: Knee osteoarthritis (KOA) occurs more often in middle-aged females. While this age-group experiences comorbid osteoporosis with menopause, its influence on KOA has not been clarified. This epidemiological study aimed to investigate the relationship between menopausal conditions, bone mineral density (BMD), and KOA. Methods: A total of 518 female volunteers who participated in the Iwaki cohort study were enrolled and divided into groups (pre- and post-menopause). Antimullerian hormone (AMH) was measured as a predictive marker for menopause in the pre-menopausal subjects. Weight-bearing anterior-posterior knee radiographs were classified by Kellgren-Lawrence grade, and grade ≥ 2 was defined as definitive KOA (DKOA). Early KOA (EKOA) was defined by Luyten’s criteria, and BMD was measured at a distal radius. The relationship between menopausal condition, BMD, and KOA was analyzed by ROC and regression analysis. Results: Fifty-two participants (10.0%) were diagnosed with EKOA and 204 (39.4%) with DKOA. A total of 393 (75.9%) females began menopause, and the prevalence of DKOA was up to 48.1% and >12.0% in pre-menopause females (p < 0.001, Odds ratio: 6.79). From the ROC analysis in pre-menopausal females, cut-off value of AMH for detecting EKOA was 0.08 ng/ml (AUC: 0.712, p5%CI: 0.527 to 0.897, p-value: 0.025, Odds ratio: 8.28). Regression analysis showed that lower AMH was related to EKOA (p=0.035, Odds ratio: 5.55) and DKOA (p=0.032, Odds 1.59), and lower BMD and high turnover bone metabolism were correlated with DKOA. Conclusions: KOA increased after menopause and was correlated with lower BMD. Furthermore, reduction in AMH was a valuable biomarker for the detection of EKOA.

scholarly journals Latrine availability and associated factors among Religious institution in Northern Ethiopia, 2018

2019 ◽  
Author(s):  
Mulugeta Woldu Abrha ◽  
Kiros Demoz Ghebremedhin ◽  
Tesfay Teklemariam Weldeslasie
Keyword(s):  
Confidence Interval ◽  
Odds Ratio ◽  
Associated Factors ◽  
P Value ◽  
Northern Ethiopia ◽  
Religious Institutions ◽  
Religious Institution ◽  
Tigray Region ◽  
Availability Analysis ◽  
Sanitation And Hygiene

Abstract Background Religious institutions found at the community, not only uphold belief and cultural values but also as a force for positive change and development. Improved sanitation and hygiene is crucial in these institutions to decrease preventable infections due to unsanitary conditions. However, there are no studies among religious institution on availability of latrine. So this study was conducted to assess the latrine availability and associated factors among religious institution in Tigray Region, Ethiopia.Method Institution based cross – sectional study design was conducted in Tigray Region, Northern Ethiopia. Multi-stage sampling was used to sample 385 religious institutions. Data was collected using pre tested, structured questionnaire and observation checklist. Logistic regression was fitted and odds ratio with 95% confidence interval (CI) with p-value less than 0.05 was used to determine the predictors of latrine availability. Analysis was carried out using SPSS 20 TM - software package.Results In this study latrine availability was 32.8%. And was significantly affected by currently saved money towards having a latrine (Adjusted Odds ratio (AOR): 0.32, 95% confidence interval (CI) [0.25, 0.42]), any messages seen, heard or received on sanitation and hygiene (AOR: 0.43, 95% CI [0.38, 0.51]) and place where messages seen, heard, received (AOR: 2.95, 95% CI [1.11, 5.55]).Conclusion Availability of latrine was very low when compared to the national target of 100% among the religious institution and was affected by the currently saved money towards having a latrine, any messages seen, heard or received on sanitation and hygiene and place where the messages receive. Information regarding latrine availability should be provided to the community visiting religious institutions through available channels and practical models promotion.

scholarly journals Utilization of MCH handbooks and attitudes of pregnant women regarding pregnancy and childbirth complications

2019 ◽  
Vol 27 (2) ◽  
pp. 71
Author(s):  
Dian Irawati ◽  
Agustin Dwi Syalfina
Keyword(s):  
Pregnant Women ◽  
P Value ◽  
Chi Square ◽  
Cross Sectional ◽  
Live Births ◽  
Pregnancy And Childbirth ◽  
Independent Variable ◽  
The Right ◽  
Chi Square Analysis ◽  
The Relationship

Objectives: Maternal Mortality Rate (MMR) is closely related to maternal care. MMR in Indonesia based on the 2015 IDHS is 359 per 100,000 live births. By increasing the utilization of MCH handbooks, MMR would be decline. Therefore, this research investigated the relationship between of the utilization of MCH handbooks and attitudes pregnant women regarding pregnancy and childbirth complications.Materials and Methods: We conducted a cross sectional research with 54 pregnant women during March - June 2018 at the Sooko Health Center, Mojokerto. The independent variable was the utilization of MCH handbooks and the dependent variable was the attitude of pregnan women regarding pregnancy and childbirth complications. Data analysis included descriptive and bivariate analysis.Results: The results showed that 79.6% of respondents used the MCH handbook well. The results of the chi square analysis test showed a p value of 0.027 (<0.05).Conclusion: MCH handbook utilization effected the attitude of pregnant women regarding the complication of pregnancy and childbirth. Pregnant women who read and utilize MCH handbook would be have better alertness about the risk of complication so they would make the right decision for their pregnancy.

scholarly journals Relationship Between Unbound Bilirubin Levels and Acute Bilirubin Encephalopathy in Exchange Transfusion Neonates

2021 ◽  
Author(s):  
Yiyi Ding ◽  
Shuo Wang ◽  
Rui Guo ◽  
Aizhen Zhang ◽  
Yufang Zhu
Keyword(s):  
Logistic Regression ◽  
Blood Glucose ◽  
Odds Ratio ◽  
Exchange Transfusion ◽  
Binary Logistic Regression ◽  
P Value ◽  
Bilirubin Encephalopathy ◽  
Unbound Bilirubin ◽  
Independent Variable ◽  
The Relationship

Abstract BACKGROUND: Evidence regarding the relationship between unbound bilirubin levels and acute bilirubin encephalopathy was limited. Therefore, this study set out to investigate whether the unbound bilirubin level was independently related to acute bilirubin encephalopathy in children who underwent exchange transfusion after adjusting for other covariates. METHODS: A total of 46 neonates who underwent exchange transfusion were involved in The First People's Hospital Of Changde City in China from 2016-1-1 to 2018-12-31. The target independent variable and the dependent variable were unbound bilirubin levels measured at baseline and acute bilirubin encephalopathy respectively. Covariates involved in this study included sex, age, birth weight, blood glucose, red blood cell, hemolysis, receive phototherapy before exchange transfusion. RESULTS: The average gestational age of 46 selected participants was 38.6 ± 1.3 weeks old, the average age was 146.5 ± 86.9 hours old, 52.17% of them were male. Result of fully-adjusted binary logistic regression showed unbound bilirubin levels were positively associated with risk of acute bilirubin encephalopathy after adjusting confounders (Odds ratio = 1.41, 95% confidence intervals 1.05-1.91, P value <0.05). CONCLUSION: Unbound bilirubin levels are associated with neonatal acute bilirubin encephalopathy. The mechanism of unbound bilirubin levels leading to neonatal acute bilirubin encephalopathy needs to be further explored.

scholarly journals Relationship Between Foot Length and Gestational Age in Pakistan

2020 ◽  
Vol 7 ◽  
pp. 2333794X2097420
Author(s):  
Shiyam Sunder Tikmani ◽  
Sana Roujani ◽  
Syed Iqbal Azam ◽  
Haleema Yasmin ◽  
Khadija Bano ◽  
...  
Keyword(s):  
Gestational Age ◽  
Preterm Births ◽  
P Value ◽  
Live Births ◽  
Foot Length ◽  
Risk Of Mortality ◽  
Measuring Tape ◽  
A Prospective Study ◽  
Stratified Analysis ◽  
The Relationship

Preterm births have a high risk of mortality. Therefore, knowledge of the gestational age (GA) at birth is crucial to guide the appropriate management of a newborn. Common methods for estimating GA such as the last menstrual period, ultrasonography, and post-natal Ballard scoring have some limitations. This study aimed to determine the relationship between foot length and GA to develop and validate an equation for predicting GA of Pakistani newborns. We conducted a prospective study in a large obstetric hospital in Pakistan. Data for this analysis were extracted from the hospital files of eligible women by trained study midwives. Midwives were also trained in performing the Ballard examination and taking foot length using a disposable measuring tape within an hour of the birth. The GA was calculated using an android-based GA calculator. Simple and multiple linear regression were used to construct predicting equations for GA. Both the foot length and GA were available for 1542 cases. The median GA was 34.5 (IQR 4.7) weeks and the median foot length was 7 cm (IQR 1.4). There was a positive linear relationship between foot length and GA ( r2 81.7%, P-value < .001). Stratified analysis showed an r2 of 81.7% for males and 81.6% for females. The r2 for stillbirths was 84.1% and, 82.3% for live births. The r2 for macerated stillbirths was 88.6% and 90.6% for fresh stillbirths. In resource poor settings, the use of foot length can estimate GA in both live births and stillbirths and can easily identify preterm infants.

scholarly journals The moderating effect of psychedelics on the prospective relationship between prescription opioid use and suicide risk among marginalized women

2018 ◽  
Vol 32 (12) ◽  
pp. 1385-1391 ◽  
Author(s):  
Elena Argento ◽  
Melissa Braschel ◽  
Zach Walsh ◽  
M Eugenia Socias ◽  
Kate Shannon
Keyword(s):  
Suicidal Ideation ◽  
Confidence Interval ◽  
Suicide Risk ◽  
Moderating Effect ◽  
Prescription Opioid ◽  
P Value ◽  
Opioid Use ◽  
Marginalized Women ◽  
Prescription Opioid Use ◽  
The Relationship

Background/aims: Given high rates of depression and suicide among marginalized women, and increasing calls to integrate trauma-informed biomedical and community-led structural interventions, this study longitudinally examines the potential moderating effect of psychedelic use on the relationship between other illicit drug use and suicide risk. Methods: Data (2010–2017) were drawn from a community-based, prospective open cohort of marginalized women in Vancouver, Canada. Extended Cox regression analyses examined the moderating effect of psychedelic use on the association between other illicit drug use and incidence of suicidal ideation or attempt over follow-up. Results: Of 340 women without suicidal ideation or attempt at baseline, 16% ( n=53) reported a first suicidal episode during follow-up, with an incidence density of 4.63 per 100 person-years (95% confidence interval 3.53–6.07). In unadjusted analysis, psychedelic use moderated the relationship between prescription opioid use and suicide risk: among women who did not use psychedelics, prescription opioid use increased the hazard of suicide (hazard ratio 2.91; 95% confidence interval 1.40–6.03) whereas prescription opioid use was not associated with increased suicidal ideation or attempt among those who used psychedelics (hazard ratio 0.69; 95% confidence interval 0.27–1.73) (interaction term p-value: 0.016). The moderating effect of psychedelics remained significant when adjusted for confounders (interaction term p-value: 0.036). Conclusions: Psychedelic use had a protective moderating effect on the relationship between prescription opioid use and suicide risk. In the context of a severe public health crisis around prescription opioids and lack of addiction services tailored to marginalized women, this study supports calls for innovative, evidence-based and trauma-informed interventions, including further research on the potential benefits of psychedelics.

scholarly journals Tobacco Use Is Associated With Increased 90-Day Readmission Among Patients Undergoing Surgery for Degenerative Spine Disease

2020 ◽  
pp. 219256822096403
Author(s):  
Michelle Connor ◽  
Robert G. Briggs ◽  
Phillip A. Bonney ◽  
Krista Lamorie-Foote ◽  
Kristina Shkirkova ◽  
...  
Keyword(s):  
Confidence Interval ◽  
Median Time ◽  
Tobacco Use ◽  
Spine Surgery ◽  
Odds Ratio ◽  
Postoperative Infection ◽  
Thoracolumbar Spine ◽  
P Value ◽  
Degenerative Spine ◽  
Spine Disorders

Study Design: Retrospective database study. Objective: Tobacco use is associated with complications after surgical procedures, including poor wound healing, surgical site infections, and cardiovascular events. We used the Nationwide Readmissions Database (NRD) to determine if tobacco use is associated with increased 30- and 90-day readmission among patients undergoing surgery for degenerative spine disorders. Methods: Patients who underwent elective spine surgery were identified in the NRD from 2010 to 2014. The study population included patients with degenerative spine disorders treated with discectomy, fusion, or decompression. Descriptive and multivariate logistic regression analyses were performed to identify patient and hospital factors associated with 30- and 90-day readmission, with significance set at P value <.001. Results: Within 30 days, 4.8% of patients were readmitted at a median time of 9 days. The most common reasons for 30-day readmission were postoperative infection (12.5%), septicemia (3.5%), and postoperative pain (3.0%). Within 90 days, 7.3% were readmitted at a median time of 18 days. The most common reasons for 90-day readmission were postoperative infection (9.6%), septicemia (3.5%), and pneumonia (2.3%). After adjustment for patient and hospital characteristics, tobacco use was independently associated with readmission at 90 days (odds ratio 1.05, 95% confidence interval 1.03-1.07, P < .0001) but not 30 days (odds ratio 1.02, 95% confidence interval 1.00-1.05, P = .045). Conclusions: Tobacco use is associated with readmission within 90 days after cervical and thoracolumbar spine surgery for degenerative disease. Tobacco use is a known risk factor for adverse health events and therefore should be considered when selecting patients for spine surgery.

scholarly journals Hubungan Pengetahuan dan Sikap dengan Perilaku Pencegahan Covid-19 pada Siswa di SMPN 13 Pesawaran

2021 ◽  
Vol 3 (4) ◽  
pp. 529-537
Author(s):  
Achmad Farich ◽  
Wahid Tri Wahyudi ◽  
Chelda Ernita
Keyword(s):  
Junior High School ◽  
Odds Ratio ◽  
Quantitative Research ◽  
P Value ◽  
Chi Square ◽  
Cross Sectional ◽  
Optimal Behavior ◽  
Knowledge And Attitudes ◽  
Prevention Behavior ◽  
The Relationship

ABSTRACT : RELATIONSHIP OF KNOWLEDGE AND ATTITUDE WITH COVID-19 PREVENTION BEHAVIOR IN STUDENTS AT SMPN 13 PESAWARANIntroduction: Based on observations made on offline students (outside the network) it was found that there were students who did not understand, obey and apply health protocols at school. It was found (39.7%) of students did not comply with the health protocol outside the supervision of the teacher, such as not bringing a mask to school, not keeping the distance between friends, and still having students touching the face area.Objective: It is known how the relationship between knowledge and attitudes with Covid-19 prevention behavior in students at SMPN 13 Pesawaran.Methods: This research uses quantitative research with observational analytic methods, namely research that tries to understand the relationship between variables by analyzing the data that has been obtained. The research design used is a cross-sectional design to determine the relationship between knowledge and attitudes with COVID-19 prevention behavior in offline students at State Junior High School (SMP N) 13 Pesawaran.Results: Statistical test of knowledge using chi-square, obtained P-Value 0.000 so that P-Value (0.0<0.5) then there is a relationship with the value of Odds Ratio 9.8 attitude statistic test using chi-square, obtained P-Value 0.01 so P-Value (0.1<0.5) then there is a relationship with the value of Odds Ratio 8.Conclusions and suggestions: Students of SMPN 13 Pesawaran have less than optimal knowledge and attitudes accompanied by less than optimal behavior in preventing Covid-19. To further improve supervision of school residents so that they always comply with health protocols to break the transmission line of Covid-19. Keywords: Knowledge, Attitude, Covid-19 Prevention Behavior     INTISARI : HUBUNGAN PENGETAHUAN DAN SIKAP DENGAN PERILAKU PENCEGAHAN COVID-19 PADA SISWA DI SMPN 13 PESAWARANPendahuluan : Berdasarkan pengamatan yang dilakukan pada siswa luring (luar jaringan)ditemukan adanya siswa yang belum memahami, mematuhi dan menerapkan protokol kesehatan disekolah. Ditemukan (39,7%) siswa yang tidak mematuhi protokol kesehatan diluar pengawasan guru seperti tidak membawa masker saat kesekolah, tidak menjaga jarak antar teman dan masih adanya siswa yang menyentuh area wajah. Tujuan : Diketahui bagaimana hubungan pengetahuan dan sikap dengan perilaku pencegahan Covid-19 Pada Siswa Di SMPN 13 Pesawaran.Metode : Penelitian menggunakan jenis penelitian kuantitaif dengan metode analitik observasional, yaitu penelitian yang mencoba memahami hubungan antar variable dengan menganalisis data yang telah diperoleh. Desain penelitian yang digunakan yaitu desain cross-sectional untuk mengetahui hubungan antara pengetahuan dan sikap dengan perilaku pencegahan COVID-19 pada siswa yang luring di Sekolah Menengah Pertama Negeri (SMP N) 13 Pesawaran.Hasil : Uji statistik pengetahuan menggunakan chi-square, didapat P-Value 0.000 sehingga P-Value ɑ (0.0<0.5) maka terdapat hubungan dengan nilai Oods Ratio 9.8 uji statistik sikap menggunakan chi-square, didapat P-Value 0.01 sehingga P-Value ɑ (0.1<0.5) maka terdapat hubungan dengan nilai Oods Ratio 8.Kesimpulan dan saran : Siswa SMPN 13 Pesawaran memiliki pengetahuan dan sikap yang kurang optimal diiringi dengan perilaku yang kurang optimal dalam pencegahan Covid-19. Agar bisa lebih meningkatkan pengawasan pada warga sekolah agar selalu mematuhi protokol kesehatan agar dapat memutus tali penularan Covid-19. Kata Kunci: Pengetahuan, Sikap, Perilaku Pencegahan Covid-19

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