Epidemiological study on the relationship among menopausal condition, bone fragility, and knee osteoarthritis

Abstract Background: Knee osteoarthritis (KOA) occurs more often in middle-aged females. While this age-group experiences comorbid osteoporosis with menopause, its influence on KOA has not been clarified. This epidemiological study aimed to investigate the relationship between menopausal conditions, bone mineral density (BMD), and KOA. Methods: A total of 518 female volunteers who participated in the Iwaki cohort study were enrolled and divided into groups (pre- and post-menopause). Antimullerian hormone (AMH) was measured as a predictive marker for menopause in the pre-menopausal subjects. Weight-bearing anterior-posterior knee radiographs were classified by Kellgren-Lawrence grade, and grade ≥ 2 was defined as definitive KOA (DKOA). Early KOA (EKOA) was defined by Luyten’s criteria, and BMD was measured at a distal radius. The relationship between menopausal condition, BMD, and KOA was analyzed by ROC and regression analysis. Results: Fifty-two participants (10.0%) were diagnosed with EKOA and 204 (39.4%) with DKOA. A total of 393 (75.9%) females began menopause, and the prevalence of DKOA was up to 48.1% and >12.0% in pre-menopause females (p < 0.001, Odds ratio: 6.79). From the ROC analysis in pre-menopausal females, cut-off value of AMH for detecting EKOA was 0.08 ng/ml (AUC: 0.712, p5%CI: 0.527 to 0.897, p-value: 0.025, Odds ratio: 8.28). Regression analysis showed that lower AMH was related to EKOA (p=0.035, Odds ratio: 5.55) and DKOA (p=0.032, Odds 1.59), and lower BMD and high turnover bone metabolism were correlated with DKOA. Conclusions: KOA increased after menopause and was correlated with lower BMD. Furthermore, reduction in AMH was a valuable biomarker for the detection of EKOA.

Download Full-text

Is there a relationship between gestational diabetes and postpartum depression?

Current Women s Health Reviews ◽

10.2174/1573404816999200918115133 ◽

2020 ◽

Vol 16 ◽

Author(s):

Salman Khazaei ◽

Erfan Ayubi ◽

Saeid Bashirian ◽

Ronak Hamzehei ◽

Ensiyeh Jenabi

Keyword(s):

Gestational Diabetes ◽

Postpartum Depression ◽

Odds Ratio ◽

Depression Scale ◽

Binary Logistic Regression ◽

Cross Sectional Study ◽

University Education ◽

P Value ◽

Cross Sectional ◽

The Relationship

Background: The relationship between gestational diabetes and postpartum depression (PPD) is poorly understood and seldom studied. Objective: In an effort to explore this issue, the present study investigated the relationship between gestational diabetes and PPD. Methods: The present cross-sectional study was performed with 342 women who were referred to four urban health centers of Hamadan city, west of Iran. We used convenience sampling as a method to recruit women in each health center. We used a researcher-made checklist for gathering data on socio-demographic characteristics and potential risk factors of PPD. The Persian validated version of the Edinburgh Postnatal Depression Scale (EPDS) was used to assess PPD. Univariate and multivariable binary logistic regression was applied to estimate the odds ratio (OR) (95% confidence interval [CI]). Results: Gestational diabetes was identified as the most important risk factor for PPD with OR (95% CI) of 2.19 (1.11, 4.31); P-value=0.02 after adjusting for other variables. Moreover, the adjusted odds ratio showed that PPD among lesseducated women (primary school) was 3.5 times higher compared to women with a university education (OR=3.54, 95% CI: 1.27, 9.84; P-value=0.01). Conclusion: Our findings suggested that PPD is more likely among women with gestational diabetes and those who were less educated. Interventional and educational activities for reducing the risk of PPD can be targeted for use with this population.

Download Full-text

Hypoxic Status Is Associated With The Intensity Of Hypoxia Inducible Factor (Hif)-1α Expression In A Premature Placenta

Saintika Medika ◽

10.22219/sm.vol17.smumm1.11685 ◽

2021 ◽

Vol 17 (1) ◽

pp. 1-11

Author(s):

Kartini Edwin

Keyword(s):

Confidence Interval ◽

Premature Birth ◽

Odds Ratio ◽

Critical Role ◽

Hypoxia Inducible Factor ◽

Biological Materials ◽

P Value ◽

Live Births ◽

Infant Morbidity ◽

The Relationship

Prematurity refers to live births before 37 weeks of gestation and associated with infant morbidity/mortality. Activation of HIF during the final pregnancy phase is believed to play a critical role in the pathogenesis of premature birth and other pregnancy disorders. This study aimed to analyze the relationship between hypoxicstatus and the intensity of HIF-1α expression in a premature placenta.Stored biological materials premature placenta (paraffin blocks) was used in this study. Thirtyone samples of placental hypoxia (H) and 28 samples of premature placental non-hypoxia (N) as controls, were selected non-random consecutively. Subsequently, immunohistochemistry was performed to analyze HIF-1α expression. TheChi-square testwas used to analyze the data and a p-value <0.05 was considered statistically significant.Moderate to strong intensity of HIF-1α expressionwas observed in 58% of hypoxic placenta samples, whereas most of non-hypoxic placental samples(86%) did not expressed or expressed weaklyHIF-1α.There was a significant correlation between the intensity of HIF-1α expression and placental hypoxia (p <0.05) and Odds Ratio (OR) value was 8.31 with a 95% confidence interval (2.32-29.77). The conclusion shows that hypoxic status is associated with intensity of hypoxia inducible factor (HIF)-1α expression in a premature placenta.

Download Full-text

The relationship between craniomandibular disorders and occlusal disharmonies in the adolescent population of the Republic of Serbia

Stomatoloski glasnik Srbije ◽

10.2298/sgs0402083d ◽

2004 ◽

Vol 51 (2) ◽

pp. 83-88 ◽

Cited By ~ 1

Author(s):

Slobodan Dodic ◽

Vladimir Sinobad ◽

Igor Djordjevic

Keyword(s):

Regression Analysis ◽

Multiple Regression Analysis ◽

Multiple Regression ◽

Odds Ratio ◽

Signs And Symptoms ◽

Craniomandibular Disorders ◽

Computer Evaluation ◽

Adolescent Population ◽

The Republic ◽

The Relationship

Using a special questionnaire adapted for computer evaluation, the prevalence of signs and symptoms of craniomandibular disorders (CMD) and occlusal disharmonies was investigated in a group of 500 adolescents of the Republic of Serbia ranging between 18 and 25 years of age. The presence of signs (symptoms) of CMD and occlusal discrepancies was established using clinical exsamination and evaluated according to the clinical disfunction index (D i) and index of the occlusal state (Oi) proposed by Helkimo et al. 1974. The results of this study revealed that 327 (65.4%) adolescents in the examined group had at least one sign (symptom) of CMD, (Di > 1), and that 271 (54.2%) adolescent had also mild, or severe occlusal discrepancies (Oi > 1). The percentage of persons with signs(symptoms) of CMD was significantly greater in the group having occlusal discrepancies (X = 7.76, P<0.01). The multiple regression analysis of the obtained data and the ODDS ratio confirmed the risk of CMD in the group with occlusal discrepancies to be 2.5 times greater than in the group of adolescents without occlusal discrepancies.

Download Full-text

Relationship Between Unbound Bilirubin Levels and Acute Bilirubin Encephalopathy in Exchange Transfusion Neonates

10.21203/rs.3.rs-154330/v1 ◽

2021 ◽

Author(s):

Yiyi Ding ◽

Shuo Wang ◽

Rui Guo ◽

Aizhen Zhang ◽

Yufang Zhu

Keyword(s):

Logistic Regression ◽

Blood Glucose ◽

Odds Ratio ◽

Exchange Transfusion ◽

Binary Logistic Regression ◽

P Value ◽

Bilirubin Encephalopathy ◽

Unbound Bilirubin ◽

Independent Variable ◽

The Relationship

Abstract BACKGROUND: Evidence regarding the relationship between unbound bilirubin levels and acute bilirubin encephalopathy was limited. Therefore, this study set out to investigate whether the unbound bilirubin level was independently related to acute bilirubin encephalopathy in children who underwent exchange transfusion after adjusting for other covariates. METHODS: A total of 46 neonates who underwent exchange transfusion were involved in The First People's Hospital Of Changde City in China from 2016-1-1 to 2018-12-31. The target independent variable and the dependent variable were unbound bilirubin levels measured at baseline and acute bilirubin encephalopathy respectively. Covariates involved in this study included sex, age, birth weight, blood glucose, red blood cell, hemolysis, receive phototherapy before exchange transfusion. RESULTS: The average gestational age of 46 selected participants was 38.6 ± 1.3 weeks old, the average age was 146.5 ± 86.9 hours old, 52.17% of them were male. Result of fully-adjusted binary logistic regression showed unbound bilirubin levels were positively associated with risk of acute bilirubin encephalopathy after adjusting confounders (Odds ratio = 1.41, 95% confidence intervals 1.05-1.91, P value <0.05). CONCLUSION: Unbound bilirubin levels are associated with neonatal acute bilirubin encephalopathy. The mechanism of unbound bilirubin levels leading to neonatal acute bilirubin encephalopathy needs to be further explored.

Download Full-text

Association Between Bone Mineral Density And Serum Creatinine In People < 46 Years Old

10.21203/rs.3.rs-634897/v1 ◽

2021 ◽

Author(s):

Yanru Guo ◽

Xianyang Zhu

Keyword(s):

Bone Mineral Density ◽

Regression Analysis ◽

Linear Regression ◽

Serum Creatinine ◽

Bone Mineral ◽

Linear Regression Analysis ◽

Lumbar Bone Mineral Density ◽

Multivariate Linear Regression Analysis ◽

Mineral Density ◽

The Relationship

Abstract Purpose: To research the relationship between serum creatinine and lumbar bone mineral density in people aged <46 years. Methods: A total of 10,968 subjects from the American Nhanes database were included in this cross-sectional study, including 5,744 males (mean age 26.2 years) and 5224 females (mean age 26.7 years). The exposure factor is the serum creatinine value, and the outcome indicator is the lumbar bone mineral density. This study mainly used multivariate linear regression analysis to test the relationship between lumbar bone mineral density and serum creatinine. Results: In the multivariate linear regression analysis, serum creatinine was positively correlated with lumbar bone mineral density (β = 0.122, 95%CI: 0.047-0.198), but in the subgroup analysis stratified by sex, this positive correlation only exists in the female population (Β = 0.186, 95%CI: 0.070-0.301).Conclusions: Our study found that in women aged <46 years with normal renal function, there is a positive correlation between serum creatinine and lumbar BMD. And in those people, the determination of serum creatinine can provide a sensitive biomarker for the early identification and treatment of Osteopenia or osteoporosis.

Download Full-text

Association between changes in hip-knee-ankle angle and hindfoot alignment after total knee arthroplasty for varus knee osteoarthritis

BMC Musculoskeletal Disorders ◽

10.1186/s12891-021-04488-y ◽

2021 ◽

Vol 22 (1) ◽

Author(s):

Naicheng Diao ◽

Fei Yu ◽

Bo Yang ◽

Lifeng Ma ◽

Heyong Yin ◽

...

Keyword(s):

Total Knee Arthroplasty ◽

Knee Osteoarthritis ◽

Knee Arthroplasty ◽

Weight Bearing ◽

Linear Regression Analysis ◽

Varus Knee ◽

Hindfoot Alignment ◽

Total Knee ◽

American Orthopaedic ◽

The Relationship

Abstract Background The change in hip-knee-ankle (HKA) angle after total knee arthroplasty (TKA) may cause an adjustment in hindfoot alignment (HFA). However, the relationship between the changes in HKA angle and HFA is still not well studied. This study aimed to investigate the association between HKA angle and hindfoot alignment changes after TKA for varus knee osteoarthritis. Methods A prospective study was carried out in which 108 patients with varus knee deformities were radiographically and clinically evaluated before and 3 months after TKA. The relationship of change in HFA with correction in HKA angle was investigated. Results The results showed that the HFA was adjusted significantly by 3 months after TKA (p < 0.001), along with improved American Orthopaedic Foot and Ankle Society (AOFAS) ankle hindfoot score (p < 0.001). Next, a univariate correlation and linear regression analysis showed that the change in HFA was weakly correlated with the change in HKA angle (r=-0.262, β=-0.14, 95 % CI: -0.23 to -0.04, P = 0.006). Further stratified analysis and interaction tests revealed that age has a distinct effect on the correlation between the changes in HFA and HKA angle. The correlation was dramatically greater in the group under 65 years (r=-0.474, β=-0.26, 95 % CI: -0.41 to -0.12, P = 0.001), whilst, no correlation was observed in those above 65 years old (r=-0.036, β=-0.02, 95 % CI: -0.14 to 0.11, P = 0.779). Conclusions Our findings indicated that correction of HKA after TKA tend to promote adjustment in the hindfoot alignment toward re-balance of the whole lower limb weight-bearing axis. However, this mechanism obviously weakens in elderly patients. Therefore, if apparent hindfoot deformity exists in these patients before TKA, more perioperative intervention is required for hindfoot adjustment, and even HKA undercorrection may be considered.

Download Full-text

Hubungan Pengetahuan dan Sikap dengan Perilaku Pencegahan Covid-19 pada Siswa di SMPN 13 Pesawaran

Malahayati Nursing Journal ◽

10.33024/mnj.v3i4.4744 ◽

2021 ◽

Vol 3 (4) ◽

pp. 529-537

Author(s):

Achmad Farich ◽

Wahid Tri Wahyudi ◽

Chelda Ernita

Keyword(s):

Junior High School ◽

Odds Ratio ◽

Quantitative Research ◽

P Value ◽

Chi Square ◽

Cross Sectional ◽

Optimal Behavior ◽

Knowledge And Attitudes ◽

Prevention Behavior ◽

The Relationship

ABSTRACT : RELATIONSHIP OF KNOWLEDGE AND ATTITUDE WITH COVID-19 PREVENTION BEHAVIOR IN STUDENTS AT SMPN 13 PESAWARANIntroduction: Based on observations made on offline students (outside the network) it was found that there were students who did not understand, obey and apply health protocols at school. It was found (39.7%) of students did not comply with the health protocol outside the supervision of the teacher, such as not bringing a mask to school, not keeping the distance between friends, and still having students touching the face area.Objective: It is known how the relationship between knowledge and attitudes with Covid-19 prevention behavior in students at SMPN 13 Pesawaran.Methods: This research uses quantitative research with observational analytic methods, namely research that tries to understand the relationship between variables by analyzing the data that has been obtained. The research design used is a cross-sectional design to determine the relationship between knowledge and attitudes with COVID-19 prevention behavior in offline students at State Junior High School (SMP N) 13 Pesawaran.Results: Statistical test of knowledge using chi-square, obtained P-Value 0.000 so that P-Value (0.0<0.5) then there is a relationship with the value of Odds Ratio 9.8 attitude statistic test using chi-square, obtained P-Value 0.01 so P-Value (0.1<0.5) then there is a relationship with the value of Odds Ratio 8.Conclusions and suggestions: Students of SMPN 13 Pesawaran have less than optimal knowledge and attitudes accompanied by less than optimal behavior in preventing Covid-19. To further improve supervision of school residents so that they always comply with health protocols to break the transmission line of Covid-19. Keywords: Knowledge, Attitude, Covid-19 Prevention Behavior INTISARI : HUBUNGAN PENGETAHUAN DAN SIKAP DENGAN PERILAKU PENCEGAHAN COVID-19 PADA SISWA DI SMPN 13 PESAWARANPendahuluan : Berdasarkan pengamatan yang dilakukan pada siswa luring (luar jaringan)ditemukan adanya siswa yang belum memahami, mematuhi dan menerapkan protokol kesehatan disekolah. Ditemukan (39,7%) siswa yang tidak mematuhi protokol kesehatan diluar pengawasan guru seperti tidak membawa masker saat kesekolah, tidak menjaga jarak antar teman dan masih adanya siswa yang menyentuh area wajah. Tujuan : Diketahui bagaimana hubungan pengetahuan dan sikap dengan perilaku pencegahan Covid-19 Pada Siswa Di SMPN 13 Pesawaran.Metode : Penelitian menggunakan jenis penelitian kuantitaif dengan metode analitik observasional, yaitu penelitian yang mencoba memahami hubungan antar variable dengan menganalisis data yang telah diperoleh. Desain penelitian yang digunakan yaitu desain cross-sectional untuk mengetahui hubungan antara pengetahuan dan sikap dengan perilaku pencegahan COVID-19 pada siswa yang luring di Sekolah Menengah Pertama Negeri (SMP N) 13 Pesawaran.Hasil : Uji statistik pengetahuan menggunakan chi-square, didapat P-Value 0.000 sehingga P-Value ɑ (0.0<0.5) maka terdapat hubungan dengan nilai Oods Ratio 9.8 uji statistik sikap menggunakan chi-square, didapat P-Value 0.01 sehingga P-Value ɑ (0.1<0.5) maka terdapat hubungan dengan nilai Oods Ratio 8.Kesimpulan dan saran : Siswa SMPN 13 Pesawaran memiliki pengetahuan dan sikap yang kurang optimal diiringi dengan perilaku yang kurang optimal dalam pencegahan Covid-19. Agar bisa lebih meningkatkan pengawasan pada warga sekolah agar selalu mematuhi protokol kesehatan agar dapat memutus tali penularan Covid-19. Kata Kunci: Pengetahuan, Sikap, Perilaku Pencegahan Covid-19

Download Full-text

Associations of Serum MicroRNA with Bone Mineral Density in Community-Dwelling Subjects: The Yakumo Study

BioMed Research International ◽

10.1155/2020/5047243 ◽

2020 ◽

Vol 2020 ◽

pp. 1-7 ◽

Cited By ~ 1

Author(s):

Hiroaki Nakashima ◽

Kei Ando ◽

Kazuyoshi Kobayashi ◽

Taisuke Seki ◽

Shinya Ishizuka ◽

...

Keyword(s):

Risk Factors ◽

Bone Mineral Density ◽

Logistic Regression ◽

Regression Analysis ◽

Bone Mineral ◽

Logistic Regression Analysis ◽

Odds Ratio ◽

Significant Risk ◽

Mineral Density ◽

Confidential Interval

Osteoporosis is a disease characterized by deterioration of bone tissue and mass, with an increasing global prevalence. Therefore, the discovery of biomarkers for osteoporosis would help to guide appropriate treatment. Circulating microRNAs (miRNAs) have become increasingly recognized as biomarkers for detecting diseases. However, few studies have investigated the association of circulating miRNA with osteoporosis in the general population. The aim of this study was to identify miRNA associated with osteoporosis in a general resident health check-up for potential use as an osteoporosis biomarker. We conducted a cross-sectional study as part of a health check-up program and recruited 352 volunteers (139 men, 213 women, mean age 64.1±9.6 years). Osteoporosis was diagnosed according to the WHO classification. Twenty-two candidate microRNAs were screened through real-time quantitative PCR, and miRNAs associated with osteoporosis were analyzed using logistic regression analysis including other risk factors. In total, 95 females and 30 males were diagnosed with osteoporosis with bone mineral density tests (BMD: T‐score<−2.5). We found that miR195 was significantly lower in females, while miR150 and miR222 were significantly higher in males. The results of the logistic regression analysis indicated that in females, higher age and lower miR195 (odds ratio: 0.45, 95% confidential interval: 0.03–0.98) were significant risk factors for lower BMD, while the presence of a smoking habit and lower miR150 (odds ratio: 1.35, 95% confidential interval: 1.02–1.79) were significant risk factors for osteoporosis. Serum levels of miR195 and miR150 are independently associated with low bone mineral density in females and males, respectively.

Download Full-text

Evaluation of Relationship between Mesiodistal Width of Permanent Canines and Premolars with Permanent Lower First Molars and Incisors for Space Analysis

Journal of Isfahan Dental School ◽

10.18502/ijds.v17i2.6878 ◽

2021 ◽

Author(s):

Shabnam Yazdani ◽

Nasim Esnaashari ◽

Mehdi Rafie ◽

Negah Bazghaleh

Keyword(s):

Regression Analysis ◽

Cross Sectional Study ◽

P Value ◽

Sectional Study ◽

Prediction Formula ◽

Cross Sectional ◽

Present Cross Sectional Study ◽

The Relationship ◽

Dental Cast ◽

Digital Caliper

Introduction: One of the simplest methods to predict mesiodistal width of permanent canines and premolars is using Tanaka and Johnston’s prediction formula; however, dental size varies according to race. The study aimed to examine the relationship between incisors mesiodistal width and mandibular first molar’s with mesiodistal width of maxillary and mandibular canines and premolars and to determine the reliability of Tanaka and Johnston prediction formula. Materials & Methods: In the present cross-sectional study, 200 pairs of a dental cast of 12-25 years old were selected and the greatest mesiodistal width of canines and premolars crown in each jaw and incisors and mandibular first molars were measured with a digital caliper with 0.01 resolution. Data were analyzed using regression analysis, t-test (p value < 0.05). Results: There was a significant statistical difference between actual width and Tanaka and Johnston prediction formula in the group under study (p value < 0.001). Moreover, a new linear equation for the prediction of mesiodistal width of maxillary and mandibular canines and premolars based on mesiodistal width of lower incisors and mandibular first molars was developed using regression analysis. Conclusion: In statistical terms, Tanaka and Johnston’s prediction formula is not applicable for the population under study because maxillary estimated measures were a little high and mandibular estimated measures were a little low.

Download Full-text