Detection of Microaneurysms Using Grey Wolf Optimization for Early Diagnosis of Diabetic Retinopathy
The diabetic retinopathy is the leading cause of blindness worldwide, so early detection of diabetic retinopathy is necessary to reduce eye-related diseases. The accurate identification of microaneurysms is crucial for the detection of diabetic retinopathy, because it appears as the first sign of the disease. In this study, a new model is proposed to detect microaneurysms from the retinal images for early diagnosis of diabetic retinopathy. At first, the fundus images are collected from e-ophtha microaneurysms and DiaretDB1 datasets. Next, image pre-processing is accomplished using image normalization, low light image enhancement, gradient weighting and shade correction. The pre-processing methods significantly brighten the contrast of the fundus images for better visual quality and extract the hidden details of the dark conditions. In addition, Hessian based filter and Otsu threshold are used to extract the foreground objects like microaneurysms from the enhanced fundus images. At last, Grey Wolf Optimization (GWO) is used to predict the correctness of segmented microaneurysms candidates. The experimental results have revealed that the proposed model enhanced the microaneurysms detection up to 0.06-0.30 f-score value compared to the other existing models local convergence index features and local features with k-nearest neighbor. In addition, the proposed model has achieved 85.72% and 86.16% of accuracy respectively on e-ophtha microaneurysms and DiaretDB1 datasets.