Target drug delivery system as a new scarring modulation after glaucoma filtration surgery

In this study, a transferrin/folic acid double-targeting graphene oxide drug delivery system loaded with doxorubicin was designed. Graphene oxide was prepared by ultrasound improved Hummers method and was modified with Pluronic F68, folic acid, and transferrin to decrease its toxicity and to allow dual-targeting. The results show that the double target drug delivery system (TFGP*DOX) has good and controllable drug delivery performance with no toxicity. Moreover, TFGP*DOX has a better inhibitory effect on SMMC-7721 cells than does a single target drug delivery system (FGP*DOX). The results of drug release analysis and cell inhibition studies showed that TFGP*DOX has a good sustained release function that can reduce the drug release rate in blood circulation over time and improve the local drug concentration in or near a targeted tumor. Therefore, the drug loading system (TFGP*DOX) has potential application value in the treatment of hepatocellular carcinoma.

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Mesoporous silica nanoparticles in target drug delivery system: A review

International Journal of Pharmaceutical Investigation ◽

10.4103/2230-973x.160844 ◽

2015 ◽

Vol 5 (3) ◽

pp. 124 ◽

Cited By ~ 259

Author(s):

Charu Bharti ◽

Neha Gulati ◽

Upendra Nagaich ◽

AshokKumar Pal

Keyword(s):

Drug Delivery ◽

Mesoporous Silica ◽

Silica Nanoparticles ◽

Drug Delivery System ◽

Delivery System ◽

Mesoporous Silica Nanoparticles ◽

Target Drug Delivery ◽

Target Drug ◽

System A ◽

Target Drug Delivery System

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TAT-modified serum albumin nanoparticles for sustained-release of tetramethylpyrazine and improved targeting to spinal cord injury

Journal of Nanobiotechnology ◽

10.1186/s12951-020-00766-4 ◽

2021 ◽

Vol 19 (1) ◽

Author(s):

Yan Lin ◽

Yujie Wan ◽

Xingjie Du ◽

Jian Li ◽

Jun Wei ◽

...

Keyword(s):

Drug Delivery ◽

Spinal Cord ◽

Drug Delivery System ◽

Delivery System ◽

Target Drug Delivery ◽

Target Drug ◽

Cord Injury ◽

Target Drug Delivery System ◽

Targeting Ability

Abstract Background Spinal Cord injury (SCI) is a kind of severe traumatic disease. The inflammatory response is a significant feature after SCI. Tetramethylpyrazine (TMP), a perennial herb of umbelliferae, is an alkaloid extracted from ligustici. TMP can inhibit the production of nitric oxide and reduce the inflammatory response in peripheral tissues. It can be seen that the therapeutic effect of TMP on SCI is worthy of affirmation. TMP has defects such as short half-life and poor water-solubility. In addition, the commonly used dosage forms of TMP include tablets, dropping pills, injections, etc., and its tissue and organ targeting is still a difficult problem to solve. To improve the solubility and targeting of TMP, here, we developed a nanotechnology-based drug delivery system, TMP-loaded nanoparticles modified with HIV trans-activator of transcription (TAT-TMP-NPs). Results The nanoparticles prepared in this study has integrated structure. The hemolysis rate of each group is less than 5%, indicating that the target drug delivery system has good safety. The results of in vivo pharmacokinetic studies show that TAT-TMP-NPs improves the bioavailability of TMP. The quantitative results of drug distribution in vivo show that TAT-TMP-NPs is more distributed in spinal cord tissue and had higher tissue targeting ability compared with other treatment groups. Conclusions The target drug delivery system can overcome the defect of low solubility of TMP, achieve the targeting ability, and show the further clinical application prospect.

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Synthesis, Characterization, and Evaluation of a Novel Amphiphilic Polymer RGD-PEG-Chol for Target Drug Delivery System

The Scientific World JOURNAL ◽

10.1155/2014/546176 ◽

2014 ◽

Vol 2014 ◽

pp. 1-10 ◽

Cited By ~ 6

Author(s):

Shi Zeng ◽

Fengbo Wu ◽

Bo Li ◽

Xiangrong Song ◽

Yu Zheng ◽

...

Keyword(s):

Drug Delivery ◽

Drug Delivery System ◽

Delivery System ◽

Large Scale ◽

Film Formation ◽

Low Cost ◽

Amphiphilic Polymer ◽

Target Drug Delivery ◽

H Nmr ◽

Target Drug

An amphiphilic polymer RGD-PEG-Chol which can be produced in large scale at a very low cost has been synthesized successfully. The synthesized intermediates and final products were characterized and confirmed by1H nuclear magnetic resonance spectrum (1H NMR) and Fourier transform infrared spectrum (FT-IR). The paclitaxel- (PTX-) loaded liposomes based on RGD-PEG-Chol were then prepared by film formation method. The liposomes had a size within 100 nm and significantly enhanced the cytotoxicity of paclitaxel to B16F10 cell as demonstrated by MTT test (IC50= 0.079 μg/mL of RGD-modified PTX-loaded liposomes compared to 9.57 μg/mL of free PTX). Flow cytometry analysis revealed that the cellular uptake of coumarin encapsulated in the RGD-PEG-Chol modified liposome was increased for HUVEC cells. This work provides a reasonable, facile, and economic approach to prepare peptide-modified liposome materials with controllable performances and the obtained linear RGD-modified PTX-loaded liposomes might be attractive as a drug delivery system.

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Effects of rosiglitazone/PHBV drug delivery system on postoperative fibrosis in rabbit glaucoma filtration surgery model

Drug Delivery ◽

10.1080/10717544.2019.1648590 ◽

2019 ◽

Vol 26 (1) ◽

pp. 812-819 ◽

Cited By ~ 2

Author(s):

Feng Zhang ◽

Ke Liu ◽

Zheng Pan ◽

Mengdan Cao ◽

Dengming Zhou ◽

...

Keyword(s):

Drug Delivery ◽

Drug Delivery System ◽

Delivery System ◽

Filtration Surgery ◽

Glaucoma Filtration Surgery ◽

Postoperative Fibrosis

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INNOVATIVE AND NOVEL STRATEGY: MICROSPONGES FOR TOPICAL DRUG DELIVERY

Journal of Drug Delivery and Therapeutics ◽

10.22270/jddt.v8i5.1885 ◽

2018 ◽

Vol 8 (5) ◽

pp. 28-34 ◽

Cited By ~ 1

Author(s):

Jyoti Jyoti ◽

Sandeep Kumar

Keyword(s):

Drug Delivery ◽

Controlled Release ◽

Drug Delivery System ◽

Patient Compliance ◽

Delivery System ◽

Systemic Exposure ◽

Spherical Particles ◽

Target Drug Delivery ◽

Target Drug ◽

Novel Strategy

Microsponge type of drug delivery is the latest technology which has been introduced in topical skin care, drug products to facilitate the controlled release of the active medicament into the skin in order to reduce systemic exposure and control local cutaneous reactions to active drugs. Microsponge can be loaded into a topical route of drug delivery system for the residue of dosage form of skin and thus controlled release drug delivery system is achieved and in return improving the patient compliance by providing target drug delivery system and prolonging dosage intervals. Microsponge is polymeric delivery systems composed of porous microspheres. They are tiny sponge-like spherical particles and posses large porous surface area. Furthermore, they may enhance stability, reduce side effects, improve patient compliance and modify drug release. Microsponges are the polymer-based microspheres system that has the capacity to entrap a wide variety of substances, and can then be incorporated into a different formulation. Keywords: Microsponge Delivery System, Quasi- emulsion solvent diffusion.

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