Microsponges: A Novel Strategy to Control the Delivery Rate of Active Agents with Reduced Skin Irritancy

Microsponges are particulate system which is composed by porous polymeric material. As compare to Conventional topical formulations, microsponge provide controlled release of the drug in the epidermis, it is to ensure that the drug is mainly localized and does not unduly entering the systemic circulation, it is a new area of research. The active ingredient needs to maximize the time to stay on the skin, while reducing transdermal penetration. Apart from this, there is a problem of unethical vehicles that can be viscous sticky deformation and skin irritation. One of the biggest challenges of now a days is to control irritability for a predetermined site of active agents in the human body. Microsponges delivery system is a unique technique for controlled release with low irritant involving many triggers of Mechanism for the release of drugs. The Microsponge Delivery system is a polymeric porous microspheres, which can trap a wide range of effective elements such as anti-fungus, anti-infected, anti- inflammatory agent, fragrance and essential agent. This review includes different techniques used to prepare microsponges, formulation consideration, safety consideration, drug release mechanism, and challenges with microsponge drug delivery system along with their advantages, disadvantages and applications. In the current review, we summarize the updated application and capacity of Microsponge as an effective drug-delivery system to reduce skin irritation. Keywords: Microsponges; quasi-emulsion solvent diffusion; Porous microspheres; Controlled release.

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Microsponges: A Promising Novel Drug Delivery System

Journal of Drug Delivery and Therapeutics ◽

10.22270/jddt.v9i5-s.3649 ◽

2019 ◽

Vol 9 (5-s) ◽

pp. 188-194

Author(s):

K. Naga Jyothi ◽

P. Dinesh Kumar ◽

P. Arshad ◽

M. Karthik ◽

T. Panneerselvam

Keyword(s):

Drug Delivery ◽

Drug Delivery System ◽

Delivery System ◽

Control Release ◽

Release Mechanism ◽

Porous Microspheres ◽

Wide Range ◽

Polymeric Delivery ◽

Novel Drug

Microsponge is recent novel technique for control release and target specific drug delivery system. More and more developments in drug delivery systems are being integrated to optimize the efficacy and cost-effectiveness of the therapy. Microsponges are polymeric delivery system containing porous microspheres having a size range from 5 to 300µm. Microsponge Delivery System (MDS) is a unique technology for controlled drug delivery. This review article mainly deals with Microsponge drug delivery along with its method of preparation, characterization, advantages and release mechanism of MDS. Microsponges are characterized by particle size, entrapment efficacy, true density, % drug content and % yield, dissolution studies, Resiliency, compatibility studies and in-vitro studies. Wide range of applications is also preferred to develop drug with enhanced safety and efficacy. Keywords: Microsponge, Porous microspheres, Control release, Colon.

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Microsponges as Innovative Drug Delivery Systems

International Journal of Pharmaceutical Sciences and Nanotechnology ◽

10.37285/ijpsn.2012.5.1.2 ◽

2012 ◽

Vol 5 (1) ◽

pp. 1597-1606

Author(s):

Dipit Jagannath Ingale ◽

N H Aloorkar ◽

A S KulkarnI ◽

R.A. Patil Patil

Keyword(s):

Drug Delivery ◽

Drug Delivery System ◽

Delivery System ◽

Systemic Circulation ◽

Release Mechanism ◽

Transdermal Drug Delivery System ◽

Innovative Drug ◽

Pharmaceutical Ingredients ◽

Improved Stability ◽

Highly Porous

Transdermal drug delivery system (TDDS) is not practicable for delivery of materials whose final target is skin itself. Controlled release of drugs onto the epidermis with assurance that the drug remains primarily localized and does not enter the systemic circulation in significant amounts is a challenging area of research. Microsponges are highly porous micro-sized particles with a unique ability for entrapping active pharmaceutical ingredients. To control the delivery rate of active agents to a predetermined site in human body has been one of the biggest challenges faced by scientists. Microsponges are safe biologically and offer unique advantage of programmable release. This technology offers entrapment of ingredients and is believed to contribute towards reduced side effects, improved stability, increased elegance and enhanced formulation flexibility. This technology is being used for topical formulations and also for oral administration. The present review describes microsponge technology including its preparation, characterization, programmable parameters and release mechanism of microsponge drug delivery system.

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Halloysite nanotubes as a new drug-delivery system: a review

Clay Minerals ◽

10.1180/claymin.2016.051.3.03 ◽

2016 ◽

Vol 51 (3) ◽

pp. 469-477 ◽

Cited By ~ 29

Author(s):

Muhammad Hanif ◽

Fazila Jabbar ◽

Sana Sharif ◽

Ghulam Abbas ◽

Athar Farooq ◽

...

Keyword(s):

Drug Delivery ◽

Controlled Release ◽

Drug Delivery System ◽

Delivery System ◽

Drug Delivery Systems ◽

Halloysite Nanotubes ◽

Delivery Systems ◽

New Drug ◽

Wide Range ◽

Loading Methods

AbstractNew drug-delivery systems have remained a challenge for pharmaceutical scientists due to the use of expensive polymers and the low loading capacity of prepared nanoparticles. There is pressure to develop formulations that contain not only cheaper materials but also have controlled-release properties. Halloysite nanotubes (HNTs) are a naturally occurring clay mineral similar to kaolin, possessing a special particle shape in the form of an ultramicroscopic multilayered hollow cylinder. Its uses encompass a wide range in anticancer therapy, sustained- and controlled-release drug-delivery systems, cosmetics, delivery of proteins, vaccines and genes. These advantages are due to its biocompatibility, significant mechanical strength and natural availability. The surfaces of the tubules can be modified by coating different polymers for application in the drug-delivery system. This review is focused on the various aspects of HNTs such as structure, properties, loading methods, applications and characterizations.

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INNOVATIVE AND NOVEL STRATEGY: MICROSPONGES FOR TOPICAL DRUG DELIVERY

Journal of Drug Delivery and Therapeutics ◽

10.22270/jddt.v8i5.1885 ◽

2018 ◽

Vol 8 (5) ◽

pp. 28-34 ◽

Cited By ~ 1

Author(s):

Jyoti Jyoti ◽

Sandeep Kumar

Keyword(s):

Drug Delivery ◽

Controlled Release ◽

Drug Delivery System ◽

Patient Compliance ◽

Delivery System ◽

Systemic Exposure ◽

Spherical Particles ◽

Target Drug Delivery ◽

Target Drug ◽

Novel Strategy

Microsponge type of drug delivery is the latest technology which has been introduced in topical skin care, drug products to facilitate the controlled release of the active medicament into the skin in order to reduce systemic exposure and control local cutaneous reactions to active drugs. Microsponge can be loaded into a topical route of drug delivery system for the residue of dosage form of skin and thus controlled release drug delivery system is achieved and in return improving the patient compliance by providing target drug delivery system and prolonging dosage intervals. Microsponge is polymeric delivery systems composed of porous microspheres. They are tiny sponge-like spherical particles and posses large porous surface area. Furthermore, they may enhance stability, reduce side effects, improve patient compliance and modify drug release. Microsponges are the polymer-based microspheres system that has the capacity to entrap a wide variety of substances, and can then be incorporated into a different formulation. Keywords: Microsponge Delivery System, Quasi- emulsion solvent diffusion.

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Versatile Use of Nanosponge in the Pharmaceutical Arena: A Mini-Review

Recent Patents on Nanotechnology ◽

10.2174/1872210514999200901200558 ◽

2020 ◽

Vol 14 (4) ◽

pp. 351-359

Author(s):

Shubham Shrestha ◽

Sankha Bhattacharya

Keyword(s):

Drug Delivery ◽

Controlled Release ◽

Porous Structure ◽

Drug Delivery System ◽

Delivery System ◽

Dosage Form ◽

Carrier System ◽

Current Review ◽

Long Time ◽

Preparation Techniques

Drug delivery for a long time has been a major problem in the pharmaceutical field. The development of a new Nano-carrier system called nanosponge has shown the potential to solve the problem. Nanosponge has a porous structure and can entrap the drug in it. It can carry both hydrophilic and hydrophobic drugs. They also provide controlled release of the drugs and can also protect various substances from degradation. Nanosponge can increase the solubility of drugs and can also be formulated into an oral, topical and parenteral dosage form. The current review explores different preparation techniques, characterization parameters, as well as various applications of nanosponge. Various patents related to nanosponge drug delivery system have been discussed in this study.

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pH and redox dual-sensitive drug delivery system constructed based on fluorescent carbon dots

RSC Advances ◽

10.1039/d0ra09164b ◽

2021 ◽

Vol 11 (5) ◽

pp. 2656-2663

Author(s):

Boye Zhang ◽

Qianqian Duan ◽

Yi Li ◽

Jianming Wang ◽

Wendong Zhang ◽

...

Keyword(s):

Drug Delivery ◽

Controlled Release ◽

Cancer Cells ◽

Fluorescence Imaging ◽

Drug Delivery System ◽

Delivery System ◽

Carbon Dots ◽

Ph Responsive ◽

Charge Reversal ◽

Fluorescent Carbon Dots

The system is pH-responsive and redox-controlled release. And the charge reversal and size transitions of the system can enhance the targeted ability. Moreover, the system can recognize the cancer cells by the fluorescence imaging.

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Marine Polysaccharides as a Versatile Biomass for the Construction of Nano Drug Delivery Systems

Marine Drugs ◽

10.3390/md19060345 ◽

2021 ◽

Vol 19 (6) ◽

pp. 345

Author(s):

Ying Sun ◽

Xiaoli Ma ◽

Hao Hu

Keyword(s):

Drug Delivery ◽

Drug Delivery System ◽

Delivery System ◽

Pharmaceutical Preparations ◽

Utilization Efficiency ◽

Wound Dressings ◽

Marine Biomass ◽

Nano Drug Delivery ◽

Wide Range ◽

Marine Polysaccharide

Marine biomass is a treasure trove of materials. Marine polysaccharides have the characteristics of biocompatibility, biodegradability, non-toxicity, low cost, and abundance. An enormous variety of polysaccharides can be extracted from marine organisms such as algae, crustaceans, and microorganisms. The most studied marine polysaccharides include chitin, chitosan, alginates, hyaluronic acid, fucoidan, carrageenan, agarose, and Ulva. Marine polysaccharides have a wide range of applications in the field of biomedical materials, such as drug delivery, tissue engineering, wound dressings, and sensors. The drug delivery system (DDS) can comprehensively control the distribution of drugs in the organism in space, time, and dosage, thereby increasing the utilization efficiency of drugs, reducing costs, and reducing toxic side effects. The nano-drug delivery system (NDDS), due to its small size, can function at the subcellular level in vivo. The marine polysaccharide-based DDS combines the advantages of polysaccharide materials and nanotechnology, and is suitable as a carrier for different pharmaceutical preparations. This review summarizes the advantages and drawbacks of using marine polysaccharides to construct the NDDS and describes the preparation methods and modification strategies of marine polysaccharide-based nanocarriers.

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