scholarly journals Formulation and Evaluation of Floating and Mucoadhesive Tablets Containing Rosiglitazone

2019 ◽  
Vol 9 (4-s) ◽  
pp. 145-154
Author(s):  
Jagdish K Arun ◽  
Dharmajit Pattanayak ◽  
Ramesh Adepu ◽  
C.M Hossain ◽  
B. Shrivastava ◽  
...  
Keyword(s):  
Flow Property ◽  
Angle Of Repose ◽  
Compression Properties ◽  
Mucoadhesive Polymers ◽  
Release Studies ◽  
Mucoadhesive Tablets ◽  
Bioadhesive Polymers ◽  
Swelling Studies ◽  
Karaya Gum ◽  
Tapped Density

In this present study, floating mucoadhesive tablets of Rosiglitazone were formulated to improve the gastric retention time and overall bioavailability. Different mucoadhesive polymers like HPMC K200 M, Na CMC, Carbopol 974P, Karaya gum, Chitosan and Xanthan gum were selected to formulate the tablets. Various formulations were prepared by using these polymers in different concentration. The pre-compression blend of Rosiglitazone mucoadhesive tablets were characterized with respect to angle of repose, bulk density, tapped density, carr’s index and hausner’s ratio and all the results indicated that the blend was having good flow property and hence better compression properties. The swelling studies were performed for the formulations and the results depicted that all the formulations have a good swelling index. The drug release studies depicted that the formulations release the drug in first order. So based on the results, formulation RF13 was found to be an optimized formulation. Keywords: Mucoadhesive tablets, Rosiglitazone, Bioadhesive polymers.

Studies on properties of Novel natural disintegrant after processing of Spray dried and Freez dried technique

2021 ◽  
pp. 249-251
Author(s):  
Khairnar Suhas Kishor ◽  
Shadab Husain Ashfaque Husain ◽  
Patil Pooja Ravsaheb ◽  
Gangurde A.B ◽  
Bairagi V.A
Keyword(s):  
Spray Drying ◽  
Freeze Drying ◽  
Low Cost ◽  
Flow Property ◽  
Angle Of Repose ◽  
Porous Powder ◽  
Onset Of Action ◽  
Disintegration Time ◽  
Tapped Density ◽  
Highly Porous

Natural disintegrant are widely used in the development of mouth dissolving tablets and other formulation because of easily available, low cost and rapide onset of action in the mouth dissolving tablet and it enhance the bioavalaibility and disintegration properties as comparaed to synthetic polymer. But aftrer freeze drying and spray drying technique the properties of dsintegrant is increases because its improve the bulkiness and flow property of a powder such as bulk density, tapped density, angle of repose, hausner raio, carrs index etc. by freeze drying the powder are dried and thereby increase the dissolution and disintegration time and highly porous powder is produced by spray drying technique.

FORMULATION AND DEVELOPMENT OF FAST DISSOLVING TABLET OF METOCLOPRAMIDE: AN ANTI-EMETIC DRUG

2019 ◽  
Vol 8 (6) ◽  
Author(s):  
Avilash Carpenter ◽  
M.K. Gupta ◽  
Neetesh Kumar Jain ◽  
Urvashi Sharma ◽  
Rahul Sisodiya
Keyword(s):  
Mechanical Strength ◽  
Standard Procedure ◽  
Flow Property ◽  
Storage Conditions ◽  
Angle Of Repose ◽  
Dissolution Time ◽  
Disintegration Time ◽  
Powder Blend ◽  
Standard Curve ◽  
The Stability

Aim: The main of the study is to formulate and develop orally disintegrating fast dissolving tablet of Metoclopramide hydrochloride. Material & Methods: Before formulation and development of selected drug, the standard curve in buffer was prepared and absorbance at selected maxima was taken. Then two different disintegrating agents were selected and drug was mixed with disintegrating agents in different ratio. Various Preformulation parameters and evaluation of tablet i.e. disintegration time, dissolution time, friability, hardness, thickness were measured by standard procedure. Result & Discussion: The angle of repose for all the batches prepared. The values were found to be in the range of 30.46 to 36.45, which indicates good flow property for the powder blend according to the USP. The bulk density and tapped density for all the batches varied from 0.49 to 0.54 g/mL and 0.66 to 0.73, respectively. Carr’s index values were found to be in the range of 23.33 to 25.88, which is satisfactory for the powders as well as implies that the blends have good compressibility. Hausner ratio values obtained were in the range of 1.22 to 1.36, which shows a passable flow property for the powder blend based on the USP. The results for tablet thickness and height for all batches was found to range from 4.45 to 4.72 mm and 3.67 to 3.69 mm, respectively. Hardness or breaking force of tablets for all batches was found to range from 32.8 to 36.2 N. Tablet formulations must show good mechanical strength with sufficient hardness in order to handle shipping and transportation. Friability values for all the formulations were found to be in the range of 0.22 % to 0.30 %. Conclusion: Orally disintegrating tablets were compressed in order to have sufficient mechanical strength and integrity to withstand handling, shipping and transportation. The formulation was shown to have a rapid disintegration time that complied with the USP (less than one minute). The data obtained from the stability studies indicated that the orally disintegrating mini-tablets of MTH were stable under different environmental storage conditions. Keywords: Formulation & Development, Fast Dissolving Tablet, Metoclopramide, Anti-Emetic Drug, Oral Disintegrating Tablet

Exploration of Neem Gum, Acrylamide Grafted Neem Gum and Carboxymethylated Neem Gum as Retardant in Tablet Formulation

2020 ◽  
Vol 16 (9) ◽  
pp. 1404-1410
Author(s):  
Rishabha Malviya
Keyword(s):  
Diclofenac Sodium ◽  
Tablet Formulation ◽  
Angle Of Repose ◽  
Wet Granulation ◽  
Binding Agent ◽  
Grafted Polymer ◽  
Model Drug ◽  
Tablet Dosage ◽  
Tapped Density ◽  
Derivatives Of

Background: In the previous study, investigators have synthesized acrylamide grafted and carboxymethylated derivatives of neem gum and evaluated their potential in the formulation of nanoparticles. In continuation of previous work, authors have evaluated neem gum polysaccharide (NGP), acrylamide grafted neem gum polysaccharide (NGP-g-Am) and carboxymethylated neem gum polysaccharide (CMNGP) as binding agent in the tablet dosage form. Methods: Diclofenac sodium was used as a model drug while microcrystalline cellulose and talc were used as excipient in the preparation of granules employing wet granulation technique. NGP, NGP-g-Am and CMNGP were utilized as binding agent in the preparation of granules. Prepared granules were characterized for various pre-compression and post-compression parameters. Results and Discussion: Binding agents were used in the concentration of 4-24%w/w. NGP incorporated granules showed more bulk density and lower values of tapped density, Carr’s index, bulkiness, Hausner’s ratio and angle of repose as compared to NGP-g-Am consisting granules. NGP-g-Am consisting tablets showed more hardness and zero friability as compared to NGP based tablets. Drug content was found lower for the tablets having grafted polymer in place of NGP. CMNGP were also utilized to prepare granules but granules were not be able to compress keeping all the compacting parameters same as used in the case of NGP and NGP-g-Am consisting granules. NGP and NGP-g-Am were able to sustain drug release up to 6 and 8 h, respectively. Conclusion: It can be concluded that NGP-g-Am induces better properties when used as a binder in the tablet formulation than native polymer, while CMNGP cannot be utilized as a binding agent in the preparation of a tablet.

scholarly journals Design and Characterization of Buccoadhesive Liquisolid System of an Antihypertensive Drug

2015 ◽  
Vol 2015 ◽  
pp. 1-9 ◽  
Author(s):  
Nilesh P. Kala ◽  
Divyesh H. Shastri ◽  
Pragna K. Shelat
Keyword(s):  
Ex Vivo ◽  
Flow Parameters ◽  
Mucoadhesive Polymers ◽  
Dissolution Properties ◽  
Powder Characteristics ◽  
Bioadhesive Polymers ◽  
Tablet Formulations ◽  
Permeability Studies ◽  
Aluminium Silicate

Nifedipine is an antihypertensive BCS class II drug which has poor bioavailability when given orally. The objective of the present study was to increase the bioavailability of nifedipine, by formulation and evaluation of a buccoadhesive liquisolid system using magnesium aluminium silicate (Neusilin) as both carrier and coating material and dissolution media were selected based on the solubility studies. A mixture of carboxymethylcellulose sodium and carbomer was used as mucoadhesive polymers. Buccoadhesive tablets were prepared by direct compression. FTIR studies confirmed no interaction between drug and excipients. XRD studies indicated change/reduction in crystallinity of drug. The powder characteristics were evaluated by different flow parameters to comply with pharmacopoeial specifications. The dissolution studies for liquisolid compacts and tablet formulations were carried out and it was found that nifedipine liquisolid tablets formulated from bioadhesive polymers containing 49% liquisolid system, 17.5% carbomer, and 7.5% carboxymethylcellulose sodium showed the best results in terms of dissolution properties. Prepared formulation batches were evaluated for swelling, bioadhesion strength, ex vivo residence time, and permeability studies. The optimized batch was showing promising features of the system. Formulating nifedipine as a buccoadhesive tablet allows reduction in dose and offers better control over the plasma levels.

Formulation and invitro evaluation of delayed release multiple unit pellets of Lansoprazole in capsules

2021 ◽  
pp. 2625-2630
Author(s):  
Suresh Kolli ◽  
K. Vijayasri ◽  
P.N. Murthy
Keyword(s):  
Acidic Environment ◽  
Drug Content ◽  
Delayed Release ◽  
Accelerated Stability ◽  
Ich Guidelines ◽  
Compressibility Index ◽  
Release Studies ◽  
Enteric Polymer ◽  
Multiple Unit ◽  
Tapped Density

The present research was aimed to formulate and evaluate Lansoprazole delayed release multiple unit pellets in capsules. Lansoprazole degrades in the acidic environment of the stomach. It is also unstable under conditions of high temperature and high humidity which leads to therapeutic inefficiency. Hence it is important to bypass the acidic pH of the stomach. Protection of drug from acidic environment is done by coating the drug with enteric polymer. In the present study, successive layers of drug layer, barrier layer and enteric layer was coated on the inert sugar spheres by using solution/suspension layering technique in Fluidized bed processor (FBP). The prepared drug layered and barrier layered pellets were evaluated for % yield. The prepared lubricated pellets were evaluated for flow properties i.e., bulk density, tapped density, compressibility index and hausner’s ratio. Lubricated pellets filled into size ‘1’ capsules and evaluated for drug content, drug content resisted in acid, invitro drug release studies and compared with the marketed product. The dissimilarity and similarity factors for the optimized and marketed formulations were found to be 84.29. Accelerated Stability Testing (AST) was performed as per the ICH guidelines at 40±5°C/75±5% RH for 6 months and found satisfactory.

scholarly journals FORMULATION AND EVALUATION OF FLURBIPROFEN FAST DISINTEGRATING TABLETS USING NATURAL SUPERDISINTEGRANTS

2016 ◽  
Vol 9 (6) ◽  
pp. 247 ◽  
Author(s):  
Mohammed Sarfaraz ◽  
Surendra Kumar Sharma
Keyword(s):  
Drug Release ◽  
Angle Of Repose ◽  
Lepidium Sativum ◽  
Disintegration Time ◽  
Natural Sources ◽  
Weight Variation ◽  
Wetting Time ◽  
Tapped Density ◽  
Fast Disintegrating Tablets

ABSTRACTObjective: The main objective of this research was to formulate Fast disintegrating tablets of Flurbiprofen incorporating superdisintegrants, isolated from natural sources like Plantago ovata (PO) seeds, Lepidium sativum (LS) seeds and agar-agar.Methods: Superdisintegrants were isolated from their natural sources using reported methods. Swelling index and hydration capacity was determined for the natural superdisintegrants to know their disintegration capacity. The tablet formulations were designed using isolated natural superdisintegrants. The powder blends were evaluated for pre-compressional parameters like angle of repose, bulk density, tapped density, carr’s index, and hausner’s ratio. Fast disintegrating tablets were prepared by direct compression method. The compressed tablets were characterized for post compression parameters.Results: All formulations had hardness, friability, weight variation and drug content within the pharmacopoeial limits. The wetting time was 84 to 254 sec, in vitro disintegration time was between 59.2 to 221 sec, and in-vitro drug release was as low as 11.80% (LS1) to a maximum of 98.99% (PO4) after 4 min of study. Among all, optimized formulation was PO4, as it showed good wetting time (84 sec), fastest disintegration time (59.2 sec), dispersion time (135 sec) and drug release of 98.99.% within 4 min.Conclusion: Flurbiprofen FDT’s were successfully developed using isolated natural disintegrants. The natural disintegrants isolated showed promising results and can prove as effective alternative for synthetic disintegrants.

scholarly journals FABRICATION OF NANO CLAY INTERCALATED POLYMERIC MICROBEADS FOR CONTROLLED RELEASE OF CURCUMIN

2021 ◽  
pp. 206-215
Author(s):  
DHARMENDER PALLERLA ◽  
SUMAN BANOTH ◽  
SUNKARI JYOTHI
Keyword(s):  
Drug Release ◽  
In Vitro Release ◽  
Controlled Drug Release ◽  
Fickian Diffusion ◽  
Simulated Gastric Fluid ◽  
Release Mechanism ◽  
Release Studies ◽  
Swelling Studies ◽  
Vitro Release

Objective: The objective of this study was to formulate and evaluate the Curcumin (CUR) encapsulated sodium alginate (SA)/badam gum (BG)/kaolin (KA) microbeads for controlled drug release studies. Methods: The fabricated microbeads were characterized by fourier transform infrared spectroscopy (FTIR), differential scanning calorimetry (DSC), thermogravimetric analysis (TGA), X-ray diffraction (X-RD), and scanning electron microscopy (SEM). Dynamic swelling studies and in vitro release kinetics were performed in simulated intestinal fluid (pH 7.4) and simulated gastric fluid (pH 1.2) at 37 °C. Results: FTIR confirms the formation of microbeads. DSC studies confirm the polymorphism of CUR in drug loaded microbeads which indicate the molecular level dispersion of the drug in the microbeads. SEM studies confirmed the microbeads are spherical in shape with wrinkled and rough surfaces. XRD studies reveal the molecular dispersion of CUR and the presence of KA in the developed microbeads. In vitro release studies and swelling studies depend on the pH of test media, which might be suitable for intestinal drug delivery. The % of drug release values fit into the Korsmeyer-Peppas equation and n values are obtained in the range of 0.577-0.664, which indicates that the developed microbeads follow the non-Fickian diffusion drug release mechanism. Conclusion: The results concluded that the CUR encapsulated microbeads are potentially good carriers for controlled drug release studies.

scholarly journals Isolation and preliminary evaluation of Mulva Neglecta mucilage: a novel tablet binder

2016 ◽  
Vol 52 (1) ◽  
pp. 201-210 ◽  
Author(s):  
Haroon Rahim ◽  
Abdul Sadiq ◽  
Shahzeb Khan ◽  
Kamran Ahmad Chishti ◽  
Fazli Amin ◽  
...  
Keyword(s):  
Binding Capacity ◽  
Diclofenac Sodium ◽  
Angle Of Repose ◽  
Binding Potential ◽  
Wet Granulation ◽  
Preliminary Evaluation ◽  
Disintegration Time ◽  
Tablet Dosage ◽  
Tapped Density ◽  
Pvp K30

ABSTRACT The aim of this study was to evaluate binding potential of Mulva neglecta mucilage (MNM) with subsequent comparison to PVP K30. Eight batches of Diclofenac sodium tablets were prepared by wet granulation technique keeping different concentrations (4, 6, 8 & 10% w/w) of Mulva neglecta mucilage (extracted from leaves of Mulva neglecta) and PVP K30 as standard binder. The granules of formulated batches showed bulk density (g/mL) 0.49 ± 0.00 to 0.57 ± 0.00, tapped density (g/mL) 0.59 ± 0.01 to 0.70 ± 0.01, Carr's index 09.27 ± 0.95 to 19.65 ± 0.59, Hausner's ratio 1.12 ± 0.00 to 1.24 ± 0.01 and angle of repose 30.37 ± 2.90 °C to 36.86 ± 0.94 °C. Tablets were compressed to hardness 7.50 to 7.95 kg/cm2. The tablets showed 0.39 ± 0.02 to 0.39 ± 0.01% friability and 7:20 to 14:00 min disintegration time. Granules and post-compression evaluation revealed that parameters assessed were all found to be within the pharmacopoeial limits. The results (hardness, disintegration and dissolution) proved that Mulva neglecta mucilage has better binding capacity for preparation of uncoated tablet dosage form as compared to PVP K30. Among all the formulations, MN-1 to MN-4 showed slow release as compared to PV-1 to PV-4 and thereby Mulva neglecta mucilage exhibited satisfactory drug release phenomenon tablets of diclofenac sodium.

scholarly journals Improving Micromeritic Properties of Ibuprofen: An Agglomeration Approach

2017 ◽  
Vol 20 (1) ◽  
pp. 90-98
Author(s):  
Md Sazzadul Islam ◽  
Md Saiful Islam Pathan
Keyword(s):  
Water Solubility ◽  
Tween 80 ◽  
Pharmaceutical Journal ◽  
Angle Of Repose ◽  
Release Behavior ◽  
Flow Properties ◽  
Physical Form ◽  
Reduced Compressibility ◽  
The Common ◽  
Tapped Density

Ibuprofen is one of the common NSAIDs having poor water solubility, low dissolution, weak flow properties and reduced compressibility. These downsides of ibuprofen crystal upraise crucial challenges during development of a dosage form. The aim of this present work was to modify the physical form of ibuprofen by changing micromeritic properties. Seven different formulations of ibuprofen agglomerates such as F-1, F-2, F-3, F-4, F-5, F-6 and F-7 were prepared to convert the needle shaped ibuprofen crystals into agglomerates so that the desired micromeritic properties can be achieved. In this study, agglomerates of ibuprofen were prepared by Quasi emulsion solvent diffusion (QESD) method in association with two surfactants (sodium lauryl sulphateand Tween 80) at three different concentrations for each. The micromeritic properties of the prepared agglomerates were evaluated for bulk density, tapped density, Carr’s index, Hausner’s ratio, angle of repose along with the release behavior of agglomerates. From dissolution study, it was observed that the release of drug was directly proportional to the surfactant concentration. Here, it was also revealed that there was no interaction among ibuprofen and other excipients as evident from DSC and FTIR studies.Bangladesh Pharmaceutical Journal 20(1): 90-98, 2017

scholarly journals The Effects of Calcination on Mineral Composition and Physical Properties of Limestones and Oyster Shells Derived from Different Sources

2021 ◽  
Vol 11 (4) ◽  
pp. 578-586
Author(s):  
Khalil . ◽  
Ridho Kurniawan Rusli ◽  
Andri .
Keyword(s):  
Physical Properties ◽  
Mineral Composition ◽  
Fine Particles ◽  
Oyster Shell ◽  
Angle Of Repose ◽  
Chemical Compositions ◽  
Mineral Concentration ◽  
Tapped Density ◽  
Different Sources ◽  
Decomposition Properties

Limestones and oyster shells are normally used in raw or roasted meal form in the livestock diet. Calcination is intended to improve the mineral concentration and physical characteristics of limestones and oyster shells which vary based on different chemical compositions, textures, and impurities of their types and habitats. The present research aimed to study the effects of calcination on mineral composition and the physical properties of limestones and oyster derived from various sources. Limestone samples from three local limestone mining and oyster shell samples from three shellfish species were calcined by burning at a temperature of 800-1000°C. The calcined products were analyzed for mineral content (Ca, P, Mg, Cu, Zn, and Mn), physical properties (bulk density, tapped density, specific density, and angle of repose), and particle size. Results indicated that calcination had no significant effect on Ca and P concentrations but reduced micro mineral concentration. Limestones had a higher Mg concentration than that of oyster shells, and calcination increased Mg concentration. Calcined oyster shells had higher densities, percentages of fine particles, and lower angles of response. The results suggested that the type of limestones and oyster shells could determine their thermal decomposition properties.

Sign in / Sign up

Export Citation Format

Share Document