Linfoma cutâneo em equino Quarto de Milha

Background: Lymphoma, although rare, is the most common hematopoietic neoplasia in horses. The overall incidence of lymphoma is between 1.3-2.8% of all equine neoplasia and it has a prevalence of 0.002-0.5% in the equine population. Lymphoma can be classified as multicentric, alimentary, mediastinal, cutaneous and solitary. The cutaneous is the rarest form and it usually presents with multifocal skin lesions, with no other clinical signs. The diagnoses is accomplished by histopathological examination of a biopsy or cytological examination of a fine needle aspirate. The aim of the current study is to report a case of the rarest form of equine lymphoma, the cutaneous.Case: An 8-year-old equine female, Quarter Mile, was evaluated due to volume’s increase and subcutaneous nodules disseminated along the body. These lesions developed gradually during 2 years. The mare was used for ridding, it was kept in the field with 10 other equines and was the only one affected. The mare was vaccinated for influenza and was negative for glanders and equine infectious anemia. During clinical exam, all vital parameters were within limits and body condition score was classified as 6 (Henneke Chart). It was observed bilateral nasal secretion and depigmentation in ocular and vulvar mucous. It was observed multiple delimited areas with size ranging from few cm up to 7 cm, hard, mobile, painless, located in the subcutaneous and disseminated in the body (including head, neck, thorax, limbs and perineum). Red blood cell, leucocytes, fibrinogen, total plasmatic protein were within normal limits. Due to clinical signs and the potential risk of a zoonosis, the glanders test was repeated (complement fixation test) and the result was negative. Differential diagnoses also included insect hypersensitive, which was discarded since the female did not presented pruritus nor alopecia, lesions gradually increased in size and no seasonality was observed. It was performed excisional biopsy for tissue culture, which revealed no growth of aerobic mesophile bacteria. Histopathological evaluation revealed rounded cell proliferation similar to lymphocytes situated in the deep derma and subcutaneous. After evaluation of history, clinical exam and complementary exams the mare was diagnosed with cutaneous lymphoma. The owner was instructed that there was no available specific treatment with good efficacy and viable for equines at this stage. Besides, it is important to evaluated the mare constantly due the possibility of future lesions in organs or intern lymph nodes.Discussion: Cutaneous lymphoma is an uncommon disease, especially in horses, that can present with variable clinical signs, immunosuppression, rapid systemic disease progression or none at all. In the present case report, during clinical examination lesions were observed in areas of lymphatic drainage. Identification of neoplastic lymphocytes during cytological examination or histopathological evaluation of biopsy tissue can confirm the presence of lymphoma, as performed in the present case. Treatment is palliative and occasionally results in complete cure, mainly in equine with single lesions. The mare had cutaneous lymphoma disseminated all long the body and no clinical signs that could suggest gastrointestinal neoplastic lesions, even though the owner was advised that this animal should be monitored regularly in the future, specially due the possibility of metastatic lesions in any other organ. In equine, lymphoma has low incidence and the cutaneous form is the rarest one. Clinical signs are typically non specific and develop insidiously, so it is important to perform complementary exams for accurate diagnoses and for differential diagnoses of tegumental and infectious diseases.

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Invasive nasal histiocytic sarcoma as a cause of temporal lobe epilepsy in a cat

Journal of Feline Medicine and Surgery Open Reports ◽

10.1177/2055116918811179 ◽

2018 ◽

Vol 4 (2) ◽

pp. 205511691881117 ◽

Cited By ~ 1

Author(s):

Koen M Santifort ◽

Ben Jurgens ◽

Guy CM Grinwis ◽

Ingrid Gielen ◽

Björn P Meij ◽

...

Keyword(s):

Soft Tissue ◽

Temporal Lobe Epilepsy ◽

Temporal Lobe ◽

Histopathological Examination ◽

Clinical Signs ◽

Olfactory Neuroblastoma ◽

Histiocytic Sarcoma ◽

Cribriform Plate ◽

Differential Diagnoses ◽

Tissue Mass

Case summary A 10-year-old neutered female domestic shorthair cat was presented with an acute onset of neurological signs suggestive of a right-sided forebrain lesion, temporal lobe epilepsy and generalised seizure activity. MRI of the head revealed an expansile soft tissue mass in the caudal nasal passages (both sides but predominantly right-sided) involving the ethmoid bone and extending through the cribriform plate into the cranial vault affecting predominantly the right frontal lobe and temporal lobe. Histopathological examination of the tumour revealed a histiocytic sarcoma. Relevance and novel information This is the first report of a cat with clinical signs of temporal lobe epilepsy due to an invasive, histiocytic sarcoma. Histiocytic sarcoma, although rare, should be included in the list of differential diagnoses for soft tissue masses extending through the cribriform plate. Other differential diagnoses are primary nasal neoplasia (eg, adenocarcinoma, squamous cell carcinoma, chondrosarcoma and other types of sarcomas), lymphoma and olfactory neuroblastoma. Temporal lobe epilepsy in cats can be the consequence of primary pathology of temporal lobe structures, or it can be a consequence of pathology with an effect on these structures (eg, mass effect or disruption of interconnecting neuronal pathways).

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T-cell Lymphoma in the Nasal Cavity in Goat

Acta Scientiae Veterinariae ◽

10.22456/1679-9216.113702 ◽

2021 ◽

Vol 49 ◽

Author(s):

Millena Oliveira Firmino ◽

Ismael Lira Borges ◽

Gian Libânio Da Silveira ◽

Mikael Leandro Duarte De Lima Tolentino ◽

Erika de Lourdes Gomes Queiroz ◽

...

Keyword(s):

T Cell ◽

Nasal Cavity ◽

Cell Lymphoma ◽

Histopathological Examination ◽

Clinical Signs ◽

T Cell Lymphoma ◽

Differential Diagnoses ◽

Farm Animals ◽

Ocular Involvement ◽

The Right

Background: Lymphomas are considered uncommon in goats, being the multicentric form with the highest number of cases for the species. Primary intranasal lymphomas are often diagnosed in dogs, cats, and humans. In the literature, there is only a description of a multicentric case involving the frontal sinuses and mucosa of the nasal cavity in a goat; therefore, it is important to describe unusual cases of this disease for the inclusion of new clinical and pathological characteristics in the ruminant clinic medicine. The objective of this work is to describe a case of T-cell lymphoma in the nasal cavity of a young goat.Case: The animal had dyspnea and respiratory noise for 15 days. Clinical examination showed nodulation in the right nasal cavity associated with serosanguinous secretion. Tracheostomy was performed; however, after 30 days the animal was euthanized. A sagittal plane of the head showed a pinkish-gray mass in the right and left nasal cavity, with a smooth, multilobulated surface, smooth adhering to the rostral portion of the dorsal concha and occluding the dorsal nasal meatus. Submandibular lymph nodes were slightly enlarged. Histopathological examination of the nasal cavity revealed a non-encapsulated, poorly delimited and ulcerated tumor composed of round cells arranged in a mantle supported by a discrete fibrovascular stroma extending the mucosa and lamina propria. Cells were round with sparse, eosinophilic and poorly delimited cytoplasm. Nuclei varied from round to elongated with condensed chromatin and evident nucleoli. Occasionally, aberrant nuclei, reniform shape and multinucleated cells were seen. Pleomorphism was moderate characterized by anisocytosis and anisocariosis. Typical and atypical mitosis were frequent (0-4 per field of highest magnification [400x]). Amidst the neoplasm, there were multifocal areas of necrosis and hemorrhage associated with a mild lymphocytic inflammatory infiltrate. Immunohistochemistry showed positive immunostaining for Vimentin antibodies and CD3, and negative for pan CK and CD20.Discussion: The lymphomas immunophenotyping is little used when it comes to farm animals, and there are few studies that use this technique for the definitive diagnosis of these neoplasms for small ruminants. The use of this technique must be considered in each case, in order to determine the pathogenesis, the accurate diagnosis and the origin of the neoplastic lymphocytes. In goats, T-cell lymphomas are the most diagnosed, although cases of multicentric B-cell lymphomas with ocular involvement have been diagnosed. In view of the clinical picture of the case described, infectious rhinitis already described in goats, such as aspergillosis and protothecosis, should be included as differential diagnoses. However, the anatomopathological findings facilitate the direction of the diagnosis, since infectious rhinitis presents as nodules / ulcerated masses or focal areas of necrosis associated with purulent secretion and in the histopathological examination it is possible to observe the intralesional etiological agents. In addition, the enzootic ethmoidal tumor must be included, as it has similar clinical signs and affects young animals, but they are adenomas/adenocarcinomas that affect the ethmoidal nasal shells induced by a retrovirus. Lymphomas in the caprine species are rare in the Northeastern semi-arid, but that in the present diagnostic routine occasionally occurs, being important the first description of its nasal shape for its inclusion in the differential diagnoses of diseases that present with clinical obstruction and dyspnea for the species. Keywords: hematopoietic neoplasia, immunophenotyping, lymphocytes, dyspnea.Descritores: neoplasia hematopoietica, imunofenotipagem, linfócitos, dispneia.Título: Linfoma de células T na cavidade nasal de caprino.

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Histopathological Evaluation of Lymph Node Biopsies: A Hospital Based Study

Journal of Enam Medical College ◽

10.3329/jemc.v2i1.11915 ◽

2012 ◽

Vol 2 (1) ◽

pp. 8-14

Author(s):

Md Atiqur Rahman ◽

Md Mamun Ali Biswas ◽

Syeda Tasfia Siddika ◽

Abdul Mannan Sikder

Keyword(s):

Lymph Node ◽

Lymph Nodes ◽

Hodgkin Lymphoma ◽

Histopathological Examination ◽

Age Groups ◽

The Body ◽

Cross Sectional ◽

Cervical Lymph Nodes ◽

Female Ratio ◽

Histopathological Evaluation

Background: Lymphadenopathy is a common manifestation of a large variety of disorders,both benign and malignant. It is essential to define the pattern of disorders presenting primarily as lymph node enlargement in a particular environment. Histopathological examination of the lymph node biopsies is a gold standard test in the distinction between reactive and malignant lymphoid proliferations as well as for detailed subtyping oflymphomas. We designed this study in our population for histopathological evaluation of lymph nodes that might be helpful for clinical management of these lesions. Objective: Histopathological evaluation of lymphadenopathy from excised specimen, in relation to ageand sex of the patients, and distribution of the lymph nodes. Materials and Methods: It was a retrospective cross sectional study conducted in the department of Pathology, Enam MedicalCollege & Hospital, Savar, Dhaka during the period from January 2006 to December 2010. Lymph node biopsies of all patients of both sexes and all age groups were included.Metastatic lymph nodes associated with evidence of primaries elsewhere in the body were excluded from the study. Total 191 lymph node biopsies were selected for histopathological evaluation. Among these 90 (47.12%) were from males and 101 (52.88%) were from females with male to female ratio being 1:2.1. The age of the patients ranged from 2 to 85 years with a mean age of 35.73 ± 18 years. Results: Cervical lymph nodes were the most common (56%) biopsied group. Of the 191 cases 59 cases (30.89%) were reactive lymphadenitis, 64 cases (33.5%) were tuberculosis, 2 cases (1.05%) were non-caseous granuloma, 11 cases (5.76%) were Hodgkin lymphoma, 22 cases (11.52%) were non-Hodgkin lymphoma, 24 cases (12.57%) were metastatic neoplasm and 9 cases (4.7%) were other lesions.Conclusion: Tuberculosis was the most common cause of lymphadenopathy, followed by reactive lymphadenitis and the cervical group of lymph nodes was most frequently affected. DOI: http://dx.doi.org/10.3329/jemc.v2i1.11915 J Enam Med Col 2012; 2(1):8 -14

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Infectious colitis treatment

Kazan medical journal ◽

10.17816/kazmj79883 ◽

1929 ◽

Vol 25 (4) ◽

pp. 391-395

Author(s):

I. V. Murashov

Keyword(s):

Intestinal Flora ◽

Clinical Signs ◽

Specific Treatment ◽

The Body ◽

Great Success ◽

Waste Products ◽

Infectious Colitis ◽

Current State ◽

Infectious Origin ◽

Colon And Rectum

The enormous interest currently given to colitis in general and their treatment in particular prompts me to share the methods that I have been using for many years and with great success in the treatment of colitis of infectious origin, which include colitis caused by an infection of a very diverse nature: or entering the intestine from the outside , such as amoeba dysenteriae Councilman et Lafleur s. entamoeba hystolytica Schaudinn, bac. dysenteriae Schiga-Kruse s. bacterium dysenteriae Migula, bac. Flexner'a, bac. His-Roussel'a, bac. Strong'a, pseudo-dysentery bacilli, or developing due to increased virulence of the regulars of the intestine, for example, b. coli, b. proteus, streptococci, etc., or, finally, colitis, as a complication in other infectious diseases, for example, with typhoid fever, measles, flu, etc., and all these forms of colitis are so similar to each other that it is impossible to distinguish them from each other neither by clinical signs, nor by the course: there may be mild and severe cases, acute and chronic, regardless of their origin; one and the same symptomatology is reduced to local and general phenomena; in the latter case, as a result of the general intoxication of the body with the waste products of the intestinal flora absorbed from the intestine (feverish state, coated tongue, headaches, general fatigue, darkening of consciousness, convulsions, decline in heart activity, etc.); as for the symptoms of local origin, they boil down to colicky abdominal pain, increased urge to lower, tenesmus, secretion of blood and mucus, as an expression of intoxication of the mucous membrane of the colon and rectum, caused by the same intestinal flora. All these symptoms in their entirety and essence form the basis of the course and direction of the doctor's thought at the patient's bedside. We have to think, as G.I.Ivashentsev quite reasonably states1), about the destruction and elimination of the infectious principle, the neutralization and elimination of toxins, the prevention and treatment of severe lesions of the colon mucosa. All these conditions are met in the best way by our method of treatment. In the current state of our knowledge, the specific treatment of colitis recedes into the background.

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Isolated epiglottic tuberculosis: presented as severe respiratory distress

International Journal of Otorhinolaryngology and Head and Neck Surgery ◽

10.18203/issn.2454-5929.ijohns20202795 ◽

2020 ◽

Vol 6 (7) ◽

pp. 1364

Author(s):

Saurabh Gupta ◽

Ashok Kumar Singh ◽

Anjali Tiwari

Keyword(s):

Pulmonary Tuberculosis ◽

Respiratory Distress ◽

Histopathological Examination ◽

Systemic Disease ◽

Correct Diagnosis ◽

Posterior Part ◽

The Body ◽

Inspiratory Stridor ◽

Severe Respiratory Distress ◽

Laryngeal Tuberculosis

<p class="abstract">Tuberculosis is a systemic disease and it can involve any organ of the body. Laryngeal tuberculosis, caused by mycobacterium tuberculosis is quite common in our ENT practice but it is usually a complication of pulmonary tuberculosis, and most patients with laryngeal tuberculosis have coexisting active pulmonary tuberculosis. Most of the times the area of involvement in this secondary laryngeal tuberculosis is posterior part of the larynx. We are reporting a case of isolated primary epiglottic tuberculosis, which is a rare entity, who presented with severe respiratory distress and inspiratory stridor. It was initially suspected and misdiagnosed as a case of laryngeal carcinoma because of common laryngoscopic findings of diffuse edema, deformed laryngeal cartilages and ulcerations in both of these conditions but on further evaluation it was diagnosed as primary epiglottic tuberculosis with no pulmonary involvement. After making the correct diagnosis from histopathological examination, the patient was managed successfully by anti tubercular treatment.</p>

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Feline cutaneous lymphoma: an evaluation of disease presentation and factors affecting response to treatment

Journal of Feline Medicine and Surgery ◽

10.1177/1098612x211028837 ◽

2021 ◽

pp. 1098612X2110288

Author(s):

Jacob Siewert ◽

MacKenzie A Pellin ◽

Brian D Husbands ◽

Kaitlin M Curran ◽

Diane Scavelli ◽

...

Keyword(s):

Physical Examination ◽

Cell Size ◽

Single Agent ◽

Clinical Signs ◽

Specific Treatment ◽

Response To Therapy ◽

Cutaneous Lymphoma ◽

Response To Treatment ◽

Treatment Modalities ◽

Teaching Hospitals

Objectives The primary goal of this study was to characterize the clinical presentation of feline cutaneous lymphoma. The secondary aims included determining if treatment or initial response to treatment affected the overall survival of patients, and understanding if disease characteristics such as immunophenotype, cell size or the presence of epitheliotropism influenced response to treatment. Methods Veterinary medical oncologists at four academic veterinary teaching hospitals submitted cases of feline patients with cutaneous lymphoma diagnosed by histopathology or cytology. Signalment, feline leukemia virus (FeLV)/feline immunodeficiency virus (FIV) status, physical examination findings, clinical signs, diagnostic tests, therapy, response and outcome, and necropsy findings, when available, were recorded. Results Forty-one patients were identified and described. The majority of patients were domestic shorthair cats (n = 29). The median age at diagnosis was 12.3 years. Males were over-represented in the population (n = 30). In the majority of patients (n = 33), the FIV/FeLV status was unknown. Twenty patients were fully staged. Thirty-four patients were treated with a variety of modalities, including surgery, radiation, single-agent or combination chemotherapy, or prednisolone only. In multiple patients, surgery or radiation was combined with a systemic therapy. Of 34 patients treated with some form of therapy, 20 responded (achieving either a partial response or complete remission). Conclusions and relevance Clinical signs and physical examination findings varied among patients. Response to therapy appeared to be associated with survival (P = 0.0025); however, this population was highly censored. Immunophenotype, cell size and the presence of epitheliotropism did not influence treatment response. Results were limited by small numbers of patients, heterogeneous disease manifestations and treatment protocols. Further studies are necessary to evaluate the effect of specific treatment modalities and disease subtype on prognosis.

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Enzootic nasal adenocarcinoma in small ruminants in Jordan

Veterinarska stanica ◽

10.46419/vs.51.2.12 ◽

2020 ◽

Vol 51 (2) ◽

pp. 219-223

Author(s):

Wael Hananeh ◽

Myassar El-Ekish ◽

Rami Mukbel ◽

Zuhair Bani Ismail ◽

Mousa Daradka

Keyword(s):

Histopathological Examination ◽

Clinical Signs ◽

Small Ruminants ◽

Radiographic Examination ◽

Low Grade ◽

Cytological Examination ◽

Awassi Sheep ◽

Nasal Adenocarcinoma ◽

Nasal Passages ◽

First Time

Enzootic nasal adenocarcinoma (ENA) is a viral-associated tumor of the secretory epithelium of the nasal passages of small ruminants. The tumor is locally invasive but not metastatic. Although disease prevalence (up to 15%) and geographic distribution have been reported in the literature throughout most of the world (except Australia and New Zealand), the disease has until now remained unreported in Jordan. In this report, we describe the occurrence, clinical signs, radiographic signs and pathological features of the disease in a series of cases in Awassi sheep (3 cases) and Damascus breed goats (2 cases) for the first time in Jordan. Overall, the affected animals were adults (3-5 years of age), all females, with variable degrees of facial and nasal deformities resulting in difficulty in respiration. Radiographic examination of the skull revealed soft tissue density mass originating in the nasal turbinate and invading the surrounding nasal structures. Cytological examination of fine needle aspirate indicated low-grade carcinoma. All animals were humanely euthanized and the nasal passages were explored. Variable size masses were removed and histopathological examination confirmed the diagnosis of enzootic nasal adenocarcinoma.

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Infantile cranial fasciitis

Pediatric Hematology/Oncology and Immunopathology ◽

10.24287/1726-1708-2019-18-4-66-78 ◽

2019 ◽

Vol 18 (4) ◽

pp. 66-78

Author(s):

A. Yu. Kugushev ◽

A. V. Lopatin ◽

S. A. Yasonov ◽

D. V. Rogozhin

Keyword(s):

Histopathological Examination ◽

Benign Lesion ◽

Clinical Signs ◽

Specific Treatment ◽

Signs And Symptoms ◽

Malignant Neoplasms ◽

Surgical Removal ◽

True Incidence ◽

Cranial Fasciitis ◽

Clinical Signs And Symptoms

Cranial fasciitis (CF) is a rare benign lesion of the skull. Due to the rarity of this disease, prospective studies of it have not been conducted. The first description dedicated of the case of CF was in 1980. Later were descriptions of only clinical cases of observation and treatment of children with this pathology. For these reasons, questions regarding true incidence, genetic risk factors, prognosis and long-term still unanswered. Clinically, CF is represented by a dense, painless, growing mass on the scalp. Given the rarity of the occurrence of CF in differential diagnosis, it is usually not considered. In addition, there are no pathognomonic clinical signs and symptoms, and changes on MRI are often non-specific. Treatment involves removal of the tumor mass, after which a histopathological examination confirms the diagnosis of CF. As a rule, a good result is observed with complete resection, however, in this case it has to necessary to perform auto-bone grafting of the skull bone defect. CF is a rare and underexplored fibroproliferative disease. Because of its locally invasive nature and nonspecific manifestations of CF, it is often difficult to distinguish from malignant neoplasms and infections. Complete surgical removal is the best choice to make diagnosis and successful treatment. Parents gave their consent to use information about the child in the article.

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Idiopathic Diﬀuse Lipomatosis in Dogs

Acta Scientiae Veterinariae ◽

10.22456/1679-9216.84750 ◽

2016 ◽

Vol 44 (1) ◽

pp. 5

Author(s):

Gisele Vieira Sechi ◽

Carolina Zaghi Cavalcante ◽

Marconi Rodrigues De Farias ◽

...

Keyword(s):

Quality Of Life ◽

Veterinary Medicine ◽

Rare Disease ◽

Lipolytic Activity ◽

Tumour Size ◽

Systemic Disease ◽

Clinical Signs ◽

The Body ◽

Type I

Background: Idiopathic diffuse lipomatosis is a rare disease in veterinary medicine. It is characterized by excessive proliferation of adipocytes, which results in the formation of fatty tumours throughout the body. In humans, this disease is also known as Madelung’s disease or multiple symmetric lipomatosis and is classifed as type I and II. The aim of this study was to investigate two cases of dogs diagnosed with idiopathic diffuse lipomatosis and compare their characteristics with those found in humans.Cases: Case 1 - A 3-year-old standard poodle female was taken for veterinary evaluation for a slow-growing tumoural lesion over the neck and trunk. The tumours measured >30 cm in diameter that caused irregular and protruding folds resulting in a signifcant loss of body architecture. No clinical signs of adjacent systemic disease were observed. Elliptical excisions of the skin revealed diffuse mature adipocytes and hyperplastic and dysplastic lipoblast hypertrophy of the panniculus, which was associated with epidermodermal hypotrophy and skin appendages. The combination of these fndings supported a diagnosis of idiopathic diffuse lipomatosis. The animal underwent surgical therapy. However, the clinical symptoms recurred within two months. Owing to the continuous recurrence of tumours and history of three other surgeries, it was decided to euthanize the animal. Case 2 - An 11-year-old female cocker spaniel preenting tumoural lesions of insidious evolution and widespread distribution. Clinical examination revealed the presence of multiple subcutaneous tumours in the lateral, lumbosacral, and abdominal regions of the pelvic limb. No clinical signs of adjacent systemic disease were observed. Biopsies of tumoural lesions also supported the diagnosis of idiopathic diffuse lipomatosis. The animal was fed a low-calorie diet, after which its body weight decreased without inducing any changes in tumour size. In addition, the animal underwent surgical treatment for removal of the largest tumours. After surgery, the animal was monitored for 1year and showed no tumour recurrence.Discussion: In veterinary medicine, lipomatosis is an extremely rare disease. Therefore, before diagnosing a case, it is necessary to exclude other proliferative disorders of the adipose tissue, among which, the most common are lipomas and liposarcomas. There are no genetic studies related to lipolytic activity or adipocyte proliferation in animals. However, it is believed that the aetiology of idiopathic diffuse lipomatosis is similar to the pathophysiology of the human form of multiple symmetrical lipomatosis, and could be associated with a primary lipid metabolism disorder. In this study, the two cases described showed a distinct distribution in the type of tumours. In case 1, the tumours were well defned and focused in the cervical and thoracic region, a pattern similar to human type I lipomatosis. However, in case 2, the fat accumulationswere diffuse and mainly located in the posterior region of the animal’s body similar to type II lipomatosis. No animals presented intra-abdominal or intrathoracic fat infltration, diagnosed by ultrasound or radiography. There is no description of any treatment capable of being effective. However, surgical procedures are recommended to minimize the occurrence of tumours and improve the quality of life of the affected animals. In the two cases described in this study, it was diffcult to completely resect the tumours. In the frst case, the recurrence of fatty deposits and performance of multiple interventions resulted in a poor quality of life of the animal, which was fnally euthanized to avoid further suffering. Therefore, frequentrecurrences might correlate with a poor prognosis in dogs.Keywords: fat, subcutaneous, tumour, skin.

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Fournier’s gangrene due to Salmonella Typhimurium in a healthy male: a rare aberrant infection

Infectious Disorders - Drug Targets ◽

10.2174/1871526520666201117143421 ◽

2020 ◽

Vol 20 ◽

Author(s):

Varsha Gupta ◽

Lipika Singhal ◽

Kritika Pal ◽

Mani Bhushan ◽

Rajeev Sharma ◽

...

Keyword(s):

Salmonella Typhimurium ◽

Systemic Disease ◽

External Genitalia ◽

Fournier’S Gangrene ◽

The Body ◽

Healthy Male ◽

Fournier's Gangrene ◽

Salmonella Infections ◽

Chief Complaints ◽

Human Infections

Introduction: Human Salmonella infections have been classically distinguised into diseases caused by typhoidal and non-typhoidal salmonella (NTS). Typhiodal salmonella includes S. enterica serovars Typhi and Paratyphi that cause the systemic disease but are restricted to human infections, while NTS consists mainly of other serovars that predominantly cause self-limiting gastroenteritis in humans. Localisation of foci with persisting infection occurs due to dissemination of the bacteria throughout the body and can cause a variety of rare clinical syndromes at aberrant sites. Fournier’s gangrene, a rapidly progressive, often fatal, necrotizing fasciitis of the external genitalia and perineum due to Salmonella Typhimurium, is a rare manifestation and has never been reported. Case: A 22-year-old male, apparently healthy patient with no relevant past medical history presented to surgical emergency with chief complaints of swelling of bilateral scrotal area. Infective etiology was considered and a diagnosis of fournier’s gangrene was made. Pure growth of Salmonella Typhimurium was obtained after repeated subculture and was identified biochemically and on serotyping, as Salmonella enterica serotype Typhimurium using specific antisera. Conclusion: In our case report, we describe a case of fournier’s gangrene due to Salmonella Typhimurium in an otherwise healthy male to highlight the unusual presentation of Non typhoidal salmonellae at an aberrant site. We also emphasize the importance of using selective media like Selenite F broth for isolation of Salmonella Typhimurium from a pus sample.

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