scholarly journals Incidence of Missed Diagnosed COVID-19 Pneumonia on Patients Who Admitted Urology Outpatient Clinic

2021 ◽  
Author(s):  
Mehmet Serkan Ozkent ◽  
Burak Yılmaz ◽  
Mustafa Hamarat ◽  
Esma Eroglu
Keyword(s):  
Outpatient Clinic ◽  
Renal Colic ◽  
Demographic Data ◽  
Active Role ◽  
The Novel ◽  
Abdominal Ct ◽  
Asymptomatic Patients ◽  
The World ◽  
Novel Coronavirus ◽  
Lung Base

Purpose: The novel coronavirus disease 2019 (COVID-19) has spread all over the world. The diagnosis of COVID-19 in asymptomatic patients and patients with non-respiratory symptoms remains a big concern. In this study, we aimed to evaluate the incidence of missed diagnosed COVID-19 pneumonia on abdominal computed tomography (CT) performed in patients admitted to our urology outpatient clinic. Methods: We reviewed the files of patients who were admitted to the urology outpatient clinic from 1 April to 1 November retrospectively. We included the patients who performed abdominal CT at the urology outpatient clinic for any reason and recorded demographic data and abdominal CT findings. We excluded patients with pulmonary symptoms and previously diagnosed with COVID-19. Also, patients without abdominal CT were excluded. We evaluated the rates of missed diagnosed COVID-19 pneumonia detection on the lung base images of abdominal CT. Results: 1024 patients were included in this study. We observed that 99 (9.7%) of these patients had findings related to COVID-19 pneumonia on the lung base images of abdominal CT. Although 885 (86.4%) patients had no pathological pulmonary findings, 40 (3.9%) patients had other pathological pulmonary findings. Conclusion: COVID-19 disease has become a pandemic all over the world. All healthcare professionals, including urologists, play an active role in the diagnosis and treatment of this disease. So, it should be kept in mind that COVID-19 pneumonia should be evaluated in patients admitted to the urology outpatient clinic with renal colic or abdominal pain.

scholarly journals Inferring True COVID19 Infection Rates From Deaths

2020 ◽  
Vol 3 ◽  
Author(s):  
Ian McCulloh ◽  
Kevin Kiernan ◽  
Trevor Kent
Keyword(s):  
Monte Carlo ◽  
The Novel ◽  
Infection Rates ◽  
Time To Death ◽  
Global Pandemic ◽  
Asymptomatic Patients ◽  
Co Morbidity ◽  
The World ◽  
Life Threatening ◽  
Novel Coronavirus

The novel coronavirus, SARS-CoV-2, commonly known as COVID19 has become a global pandemic in early 2020. The world has mounted a global social distancing intervention on a scale thought unimaginable prior to this outbreak; however, the economic impact and sustainability limits of this policy create significant challenges for government leaders around the world. Understanding the future spread and growth of COVID19 is further complicated by data quality issues due to high numbers of asymptomatic patients who may transmit the disease yet show no symptoms; lack of testing resources; failure of recovered patients to be counted; delays in reporting hospitalizations and deaths; and the co-morbidity of other life-threatening illnesses. We propose a Monte Carlo method for inferring true case counts from observed deaths using clinical estimates of Infection Fatality Ratios and Time to Death. Findings indicate that current COVID19 confirmed positive counts represent a small fraction of actual cases, and that even relatively effective surveillance regimes fail to identify all infectious individuals. We further demonstrate that the miscount also distorts officials' ability to discern the peak of an epidemic, confounding efforts to assess the efficacy of various interventions.

scholarly journals Characteristics of Confirmed Novel Coronavirus Disease Cases at Shanghai East Hospital: A Retrospective Single-Center Study

2020 ◽  
Author(s):  
Chenghui Fan ◽  
Lihong Qu ◽  
Zhongliang Guo ◽  
Jianhua Zhang ◽  
Jun Wang ◽  
...  
Keyword(s):  
Outpatient Clinic ◽  
Ct Scans ◽  
The Novel ◽  
Single Center Study ◽  
The World ◽  
Laboratory Results ◽  
Local Residents ◽  
Novel Coronavirus ◽  
And Control ◽  
Epidemiological Characteristics

Abstract Background: Since the outbreak of the novel coronavirus disease (COVID-19), the fever outpatient clinic has been open in Shanghai East Hospital (SEH). We analyzed the data for all 4,699 patients from SEH and the 27 confirmed COVID-19 cases among them to determine the clinical and epidemiological characteristics of confirmed COVID-19 cases identified in the SEH. Methods: Data were collected for patients who visited the fever outpatient clinic in the SEH between January 23 and April 30, 2020. We compared the characteristics of confirmed cases, including age, occupation, area, symptoms, laboratory results, and computed tomography (CT) scans, by month.Results: By April 30, 4,699 patients had visited the fever outpatient clinic of the SEH; of those, 27 (0.57%) were confirmed COVID-19 cases. Among the confirmed domestic cases identified between January and February, four of five were from Wuhan, Hubei. Following the spread of the epidemic to other parts of the world, all confirmed cases identified in March–April were cases of individuals who were returning from abroad, mainly Chinese students living abroad. Further, all cases were from outside Shanghai, and no local residents were diagnosed in the clinic. Symptoms, laboratory tests, and CT scans were consistent with previous literature reports of positive COVID-19 cases. Conclusions: Given the necessity to control the spread of this epidemic domestically and abroad, the focus of COVID-19 prevention and control has shifted. In Shanghai, measures taken to prevent COVID-19 spread were very successful. Early isolation and quarantine are necessary and effective measures.

Comparative docking of SARS-CoV-2 receptors antagonists from repurposing drugs

2020 ◽  
Author(s):  
Micael Davi Lima de Oliveira ◽  
Kelson Mota Teixeira de Oliveira
Keyword(s):  
World Health Organisation ◽  
World Health ◽  
Lung Cells ◽  
The Novel ◽  
High Modulation ◽  
Main Protease ◽  
The World ◽  
Novel Coronavirus ◽  
Viral Receptors ◽  
Theoretical Results

According to the World Health Organisation, until 16 June, 2020, the number of confirmed and notified cases of COVID-19 has already exceeded 7.9 million with approximately 434 thousand deaths worldwide. This research aimed to find repurposing antagonists, that may inhibit the activity of the main protease (Mpro) of the SARS-CoV-2 virus, as well as partially modulate the ACE2 receptors largely found in lung cells, and reduce viral replication by inhibiting Nsp12 RNA polymerase. Docking molecular simulations were performed among a total of 60 structures, most of all, published in the literature against the novel coronavirus. The theoretical results indicated that, in comparative terms, paritaprevir, ivermectin, ledipasvir, and simeprevir, are among the most theoretical promising drugs in remission of symptoms from the disease. Furthermore, also corroborate indinavir to the high modulation in viral receptors. The second group of promising drugs includes remdesivir and azithromycin. The repurposing drugs HCQ and chloroquine were not effective in comparative terms to other drugs, as monotherapies, against SARS-CoV-2 infection.

Association and treatment of diabetes in patients affected by Covid-19

2020 ◽  
Vol 11 (SPL1) ◽  
pp. 1198-1201
Author(s):  
Syed Yasir Afaque
Keyword(s):  
Diabetes Mellitus ◽  
Prognostic Value ◽  
Heart Diseases ◽  
The Novel ◽  
The World ◽  
Treatment Of Diabetes ◽  
Coronavirus Infection ◽  
Composite Outcomes ◽  
Novel Coronavirus ◽  
The Impact

In December 2019, a unique coronavirus infection, SARS-CoV-2, was first identified in the province of Wuhan in China. Since then, it spread rapidly all over the world and has been responsible for a large number of morbidity and mortality among humans. According to a latest study, Diabetes mellitus, heart diseases, Hypertension etc. are being considered important risk factors for the development of this infection and is also associated with unfavorable outcomes in these patients. There is little evidence concerning the trail back of these patients possibly because of a small number of participants and people who experienced primary composite outcomes (such as admission in the ICU, usage of machine-driven ventilation or even fatality of these patients). Until now, there are no academic findings that have proven independent prognostic value of diabetes on death in the novel Coronavirus patients. However, there are several conjectures linking Diabetes with the impact as well as progression of COVID-19 in these patients. The aim of this review is to acknowledge about the association amongst Diabetes and the novel Coronavirus and the result of the infection in such patients.

Synthetic and semi-synthetic drugs as promising therapeutic option for the treatment of COVID-19

2020 ◽  
Vol 20 ◽  
Author(s):  
Ekta Shirbhate ◽  
Preeti Patel ◽  
Vijay K Patel ◽  
Ravichandran Veerasamy ◽  
Prabodh C Sharma ◽  
...  
Keyword(s):  
Therapeutic Option ◽  
Antiviral Treatment ◽  
The Novel ◽  
Clinical Experiences ◽  
Synthetic Compounds ◽  
Synthetic Drugs ◽  
Global Pandemic ◽  
The World ◽  
Novel Coronavirus

: The novel coronavirus disease-19 (COVID-19), a global pandemic that emerged from Wuhan, China has today travelled all around the world, so far 216 countries or territories with 21,732,472 people infected and 770,866 deaths globally (as per WHO COVID-19 update dated August 18, 2020). Continuous efforts are being made to repurpose the existing drugs and develop vaccines for combating this infection. Despite, to date, no certified antiviral treatment or vaccine prevails. Although, few candidates have displayed their efficacy in in vitro studies and are being repurposed for COVID-19 treatment. This article summarizes synthetic and semi-synthetic compounds displaying potent activity in their clinical experiences or studies against COVID-19 and also focuses on mode of action of drugs being repositioned against COVID-19.

scholarly journals An outline of SARS-CoV-2 pathogenesis and the complement cascade of immune system

2021 ◽  
Vol 45 (1) ◽  
Author(s):  
Padmalochan Hembram
Keyword(s):  
Immune System ◽  
Dark Side ◽  
Main Body ◽  
The Novel ◽  
Transmission Chain ◽  
The World ◽  
Therapeutic Molecules ◽  
Rapid Transmission ◽  
Novel Coronavirus ◽  
Near Future

Abstract Background Coronavirus disease 19 is a viral infection caused by a novel coronavirus, SARS-CoV-2. It was first notified in Wuhan, China, is now spread into numerous part of the world. Thus, the world needs urgent support and encouragement to develop a vaccine or antiviral treatments to combat the atrocious outbreak. Main body of the abstract The origin of this virus is yet unknown; however, rapid transmission from human-to-human “Anthroponosis” has widely confirmed. The world is witnessing a continuous hike in SARS-CoV-2 infection. In light of the outbreak of coronavirus disease 19, we have aimed to highlight the basic and vital information about the novel coronavirus. We provide an overview of SARS-CoV-2 transmission, timeline and its pathophysiological properties which would be an aid for the development of therapeutic molecules and antiviral drugs. Immune system plays a crucial role in virus infection in order to control but may have dark side when becomes uncontrollable. The host and SARS-CoV-2 interaction describe how the virus exploits host machinery and how overactive host immune response can cause disease severity also addressed in this review. Short conclusion Safe and effective vaccines may be the game-changing tools, but in the near future wearing mask, washing hands at regular intervals, avoiding crowed, maintaining physical distancing and hygienic surrounding, must be good practices to reduce and break the transmission chain. Still, research is ongoing not only on how vaccines protect against disease, but also against infection and transmission.

scholarly journals 458. Molecular SARS-CoV-2 Testing During the COVID-19 Outbreak: Experiences of a Hospital in Southeast Michigan, USA

2020 ◽  
Vol 7 (Supplement_1) ◽  
pp. S296-S297
Author(s):  
Trini A Mathew ◽  
Jonathan Hopkins ◽  
Diane Kamerer ◽  
Shagufta N Ali ◽  
Daniel Ortiz ◽  
...  
Keyword(s):  
Clinical Features ◽  
Diagnostic Testing ◽  
Beaumont Hospital ◽  
High Capacity ◽  
Turnaround Time ◽  
Molecular Diagnostic ◽  
The Novel ◽  
Repeat Testing ◽  
Asymptomatic Patients ◽  
Novel Coronavirus

Abstract Background The novel Coronavirus SARS CoV-2 (COVID-19) outbreak was complicated by the lack of diagnostic testing kits. In early March 2020, leadership at Beaumont Hospital, Royal Oak Michigan (Beaumont) identified the need to develop high capacity testing modalities with appropriate sensitivity and specificity and rapid turnaround time. We describe the molecular diagnostic testing experience since initial rollout on March 16, 2020 at Beaumont, and results of repeat testing during the peak of the COVID-19 pandemic in MI. Methods Beaumont is an 1100 bed hospital in Southeast MI. In March, testing was initially performed with the EUA Luminex NxTAG CoV Extended Panel until March 28, 2020 when testing was converted to the EUA Cepheid Xpert Xpress SARS-CoV-2 for quicker turnaround times. Each assay was validated with a combination of patient samples and contrived specimens. Results During the initial week of testing there was > 20 % specimen positivity. As the prevalence grew the positivity rate reached 68% by the end of March (Figure 1). Many state and hospital initiatives were implemented during the outbreak, including social distancing and screening of asymptomatic patients to increase case-finding and prevent transmission. We also adopted a process for clinical review of symptomatic patients who initially tested negative for SARS-CoV-2 by a group of infectious disease physicians (Figure 2). This process was expanded to include other trained clinicians who were redeployed from other departments in the hospital. Repeat testing was performed to allow consideration of discontinuation of isolation precautions. During the surge of community cases from March 16 to April 30, 2020, we identified patients with negative PCR tests who subsequently had repeat testing based on clinical evaluation, with 7.1% (39/551) returning positive for SARS- CoV2. Of the patients who expired due to COVID-19 during this period, 4.3% (9/206) initially tested negative before ultimately testing positive. Figure 1 BH RO testing Epicurve Figure 2: Screening tool for repeat COVID19 testing and precautions Conclusion Many state and hospital initiatives helped us flatten the curve for COVID-19. Our hospital testing experience indicate that repeat testing may be warranted for those patients with clinical features suggestive of COVID-19. We will further analyze these cases and clinical features that prompted repeat testing. Disclosures All Authors: No reported disclosures

scholarly journals COVID-19 Vaccination: From Interesting Agent to the Patient

Vaccines ◽  
2021 ◽  
Vol 9 (2) ◽  
pp. 120
Author(s):  
Anis Daou
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Gastrointestinal Tract ◽  
Circulatory System ◽  
The Novel ◽  
Lead Compound ◽  
Fda Approval ◽  
The World ◽  
The Central Nervous System ◽  
Novel Coronavirus

The vaccination for the novel Coronavirus (COVID-19) is undergoing its final stages of analysis and testing. It is an impressive feat under the circumstances that we are on the verge of a potential breakthrough vaccination. This will help reduce the stress for millions of people around the globe, helping to restore worldwide normalcy. In this review, the analysis looks into how the new branch of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) came into the forefront of the world like a pandemic. This review will break down the details of what COVID-19 is, the viral family it belongs to and its background of how this family of viruses alters bodily functions by attacking vital human respiratory organs, the circulatory system, the central nervous system and the gastrointestinal tract. This review also looks at the process a new drug analogue undergoes, from (i) being a promising lead compound to (ii) being released into the market, from the drug development and discovery stage right through to FDA approval and aftermarket research. This review also addresses viable reasoning as to why the SARS-CoV-2 vaccine may have taken much less time than normal in order for it to be released for use.

scholarly journals Defending against the Novel Coronavirus (COVID-19) outbreak: How can the Internet of Things (IoT) help to save the world?

2020 ◽  
Vol 9 (2) ◽  
pp. 136-138 ◽  
Author(s):  
Md. Siddikur Rahman ◽  
Noah C. Peeri ◽  
Nistha Shrestha ◽  
Rafdzah Zaki ◽  
Ubydul Haque ◽  
...  
Keyword(s):  
Internet Of Things ◽  
The Internet ◽  
The Novel ◽  
The World ◽  
Novel Coronavirus ◽  
The Internet Of Things

NEW INSPIRATION FROM CHINA'S PHILOSOPHY OF "UNITY OF MAN AND HEAVEN": CONTEMPORARY INTERNATIONAL RELATIONS UNDER THE COVID-19 PANDEMIC

2021 ◽  
pp. 21-34
Author(s):  
PU JINGXIN
Keyword(s):  
International Relations ◽  
Human Society ◽  
The Novel ◽  
The World ◽  
The Face ◽  
New Type ◽  
Novel Coronavirus ◽  
The Ancient Chinese ◽  
Self Protection ◽  
Harmonious Community

Abstract: The danger of the novel coronavirus has not yet come to an end, and new variants have begun to attack the world. What philosophy should humankind’s strategy be based on when human society as a group is fighting against Covid-19, as the pandemic ravages the world? Unfortunately, political leaders of various countries have failed to achieve the overall awareness of attacking the pandemic for a shared future for mankind so far. In the face of the pandemic, mankind as a whole urgently needs to break through the narrow nation-oriented ideology of seeking only self-protection. The International Community should establish a new type of international cooperation featuring the concept of harmony of "all things under heaven as a unity". The international relations system dominated by the power ofwestern discourse is now in a bottleneck. The main aim of this article is to study the ancient Chinese wisdom of "the Unity of Man and Heaven" philosophy and build a global harmonious community. The author argues that the “export” of the aforementioned wisdom must be a priority for Chinese scholars. Keywords: Tao; Unity of Man and Heaven; Novel Coronavirus; Anthropocentrism; Harmony.

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