scholarly journals Decline in blood hemoglobin concentrations is associated with familial longevity

2016 ◽  
Vol 68 (3) ◽  
pp. 533-540
Author(s):  
Yong-Han He ◽  
Shao-Yan Pu ◽  
Wen Li ◽  
Xiao-Qiong Chen ◽  
Fu-Hui Xiao ◽  
...  
Keyword(s):  
Energy Metabolism ◽  
Inverse Relationship ◽  
First Generation ◽  
Methylenetetrahydrofolate Reductase ◽  
Age Groups ◽  
Human Longevity ◽  
Heritable Phenotype ◽  
Nuclear Receptor Subfamily ◽  
Familial Longevity ◽  
Generation Offspring

Hemoglobin(HGB)in the blood carries oxygen from the lungs to other organs to produce energy. Calorie restriction has been shown to slow aging and extend lifespan. Thus, we hypothesized that HGB maybe associated with human longevity as a link to energy metabolism. To test this hypothesis, HGB levels in the blood of 60 centenarian(CEN) families were measured and its association with age(20-80 and 20-100 years)was studied, as well as the associations of CEN HGB with levels in first generation offspring (F1) and their spouses (F1SP). The results showed no association of HGB with age between 20 and 80 years (r=-0.097, p=0.160); however a strikingly inverse relationship with age between 20 and 100 years (r=-0.526, p<0.001)was revealed. After dividing the samples into four age groups (20-39, 40-59, 60-80 and ?100 years), the HGB in CEN were significantly lower than that of F1SP(p<0.001). Interestingly, the HGB levels of CEN were significantly associated with that of F1(r=0.379, p=0.015)but not with F1SP(r=0.022, p=0.451), suggesting that HGB could be a heritable phenotype. Furthermore, the genes methylenetetrahydrofolate reductase(MTHFR), nuclear receptor subfamily 2, group C, member 1(NR2C1)and NR2C2were differentially expressed in CEN when compared to F1SP, which may likely be responsible for the changes in HGB levels. In conclusion, our results suggest that HGB is a heritable phenotype which associates with familial longevity.

Association between Social Media Use for Health Purpose and Depressive Symptoms: A Cross-Sectional Survey (Preprint)

2020 ◽  
Author(s):  
Hee Yun Lee ◽  
Yan Luo ◽  
Cho Rong Won ◽  
Jiyoung Lee ◽  
Jeongwon Baik
Keyword(s):  
Social Media ◽  
Depressive Symptoms ◽  
Social Networking Sites ◽  
Inverse Relationship ◽  
Age Groups ◽  
Cross Sectional Survey ◽  
Cross Sectional ◽  
Use Of Social Media ◽  
The Relationship ◽  
Health Purpose

BACKGROUND The use of social media or social networking sites (SNS) is increasing across all age groups, and one of the primary motives of using SNS is to seek health-related information. Although previous research examining the effect of SNS use on depression exist, studies regarding the effect of SNS use for health purpose on depression is limited. OBJECTIVE Our study aims to explore the relationship between SNS use for health purpose and depression across the four age groups (18-34 years old, 35-49 years old, 50-64 years old, and above 65 years old). METHODS A sample of 6,789 adults aged 18 and older was extracted from a 2017 and 2018 Health Information National Trends Survey (HINTS). Univariate and bivariate analyses to examine the association between each variable and four age groups were conducted. Multiple linear regression analyses to predict depression level among participants with use of SNS for health purpose were conducted. RESULTS SNS use for health purpose and depression were positively associated for three age groups but not for those 65 years or older (=0.13, P<0.05; =0.08, P<0.05; =0.09, P<0.05). Income and self-reported health status indicated an inverse relationship for all age groups. The relationship with marital status differed based on age group with 18 and 34 years old showing an inverse relationship (=-0.13, P<0.01) while 65 years or older showing a positive relationship (=0.06, P<0.05). Gender was positively associated among those in the 35-49 years old (=0.09, P<0.05) and 65 years or older (=0.07, P<0.05). Being Non-Hispanic White was positively associated with depression among 50-64 years old (=0.07, P<0.001) and 65 years or older (=0.08, P<0.05). CONCLUSIONS Age-tailored education on determining accurate and reliable information shared via SNS is needed to reduce depressive symptoms.

Candidate Age as a Factor in Promotability Ratings

1992 ◽  
Vol 21 (2) ◽  
pp. 197-210 ◽  
Author(s):  
Taylor Cox ◽  
Stella M. Nkomo
Keyword(s):  
Job Performance ◽  
Field Study ◽  
Inverse Relationship ◽  
Age Groups ◽  
Performance Ratings ◽  
Job Tenure ◽  
Moderator Variable

This paper presents research addressed to understanding how candidate age affects promotability. A field study of 125 lower-level managers indicated that age had an inverse relationship with promotability for both young and older managers and also appeared to serve as a moderator variable for the job tenure and education factors. Job tenure and education were relevant criteria only for the younger managers. By contrast, job performance ratings were significant for both age groups. Alternative explanations for the results and the implications of the findings are discussed.

scholarly journals Reproductive performance of the Antarctic tardigrades, Acutuncus antarcticus (Eutardigrada: Hypsibiidae), revived after being frozen for over 30 years and of their offspring

2019 ◽  
Vol 188 (3) ◽  
pp. 839-847
Author(s):  
Megumu Tsujimoto ◽  
Hiroshi Kagoshima ◽  
Hiroshi Kanda ◽  
Kenichi Watanabe ◽  
Satoshi Imura
Keyword(s):  
Reproductive Performance ◽  
First Generation ◽  
Dna Analysis ◽  
Term Survival ◽  
Long Term Survival ◽  
Genetic Types ◽  
Genetic Sequences ◽  
The Antarctic ◽  
Generation Offspring

Abstract Studies on the long-term survival of animals often focus on the specific instance of survival of animals only, and descriptions of subsequent reproduction are generally not reported. In this study, we recorded the reproductive performance of the first-generation offspring of the resuscitated individual (SB-1) and the hatchling of the resuscitated egg (SB-3) of the Antarctic tardigrade, Acutuncus antarcticus, after being frozen for 30.5 years. By providing further detailed description of the reproduction of SB-1 and SB-3 after revival, and then comparing the reproductive performance with that of their first-generation offspring, the possible indications of the damage accrued during the long-term preservation in SB-1 and SB-3 were more specifically detected. Additionally, the DNA analysis revealed two distinctively different mitochondrial genetic sequences of A. antarcticus between the SB strains and the LSW strain. The observed differences in some of the reproductive parameters between the two genetic types suggested a possible relationship between the life-history traits and genetic type in the species A. antarcticus. Further experiments using the SB-1 and SB-3 strains reared for a long period to exclude the instant effect of preservation are expected to improve our understanding of the mechanisms underlying the long-term survival of animals.

scholarly journals Oxidative Stress and Longevity in Okinawa: An Investigation of Blood Lipid Peroxidation and Tocopherol in Okinawan Centenarians

2010 ◽  
Vol 2010 ◽  
pp. 1-10 ◽  
Author(s):  
Makoto Suzuki ◽  
D. Craig Willcox ◽  
Matthew W. Rosenbaum ◽  
Bradley J. Willcox
Keyword(s):  
Oxidative Stress ◽  
Free Radical ◽  
Vitamin E ◽  
Age Groups ◽  
Plasma Lipid ◽  
Lipid Peroxide ◽  
Human Longevity ◽  
Free Radical Theory ◽  
Radical Theory ◽  
Theory Of Aging

Background. The Free Radical Theory of Aging mechanistically links oxidative stress to aging. Okinawa has among the world's longest-lived populations but oxidative stress in this population has not been well characterized.Methods. We compared plasma lipid peroxide (LPO) and vitamin E—plasma and intracellular tocopherol levels (total α, β, and γ), in centenarians with younger controls.Results. Both LPO and vitamin E tocopherols were lower in centenarians, with the exception of intracellular β-tocopherol, which was significantly higher in centenarians versus younger controls. There were no significant differences between age groups for tocopherol: cholesterol and tocopherol: LPO ratios. Correlations were found between α-Tocopherol and LPO in septuagenarians but not in centenarians.Conclusions. The low plasma level of LPO in Okinawan centenarians, compared to younger controls, argues for protection against oxidative stress in the centenarian population and is consistent with the predictions of the Free Radical Theory of Aging. However, the present work does not strongly support a role for vitamin E in this phenomenon. The role of intracellular β-tocopherol deserves additional study. More research is needed on the contribution of oxidative stress and antioxidants to human longevity.

The use of English among Italo-Australians in Sydney

1991 ◽  
Vol 14 (1) ◽  
pp. 59-89 ◽  
Author(s):  
Antonia Rubino ◽  
Camilla Bettoni
Keyword(s):  
First Generation ◽  
Language Use ◽  
Second Generation ◽  
Age Groups ◽  
Personal Characteristics ◽  
Research Project ◽  
Italian Regions ◽  
First Results ◽  
Australian Community ◽  
Main Factors

Abstract This article presents the first results of a research project which investigates patterns of language use in the Italo-Australian community in Sydney. All three languages spoken by the majority of Italo-Australians are taken into account: Italian, dialect and English. This article focusses on English. Use of English by 202 subjects (of different generations, Italian regions, age groups and socioeconomic backgrounds) is explored in 46 situations in four domains (family, friendship, work/school and transactions), taking into account congruent and incongruent situations with regard to three main factors: interlocutor, topic of conversation and place where it takes place. The data show a widespread shift to English which starts among younger subjects of the first generation and increases dramatically among the second generation. Furthermore, use of English by Italo-Australians depends more on personal characteristics of speakers and addressees (such as age and generation) than on topic or place of conversation.

Relationship of Body Weight and Physical Activity with Aging Inbred Mice and First Generation Offspring

2008 ◽  
Vol 40 (Supplement) ◽  
pp. S326
Author(s):  
Michael J. Turner ◽  
Elizabeth Grindstaff ◽  
Sean M. Courtney ◽  
Ala'a El Masri ◽  
Steven R. Kleeberger ◽  
...  
Keyword(s):  
Physical Activity ◽  
Body Weight ◽  
First Generation ◽  
Inbred Mice ◽  
Relationship Of ◽  
Generation Offspring

scholarly journals Minireview: Transgenerational Inheritance of the Stress Response: A New Frontier in Stress Research

Endocrinology ◽  
2010 ◽  
Vol 151 (1) ◽  
pp. 7-13 ◽  
Author(s):  
Stephen G. Matthews ◽  
David I. W. Phillips
Keyword(s):  
Stress Response ◽  
First Generation ◽  
Intervention Strategies ◽  
Stress Axis ◽  
Biological Processes ◽  
Transgenerational Inheritance ◽  
Transgenerational Transmission ◽  
New Frontier ◽  
Stress Responsiveness ◽  
Generation Offspring

Abstract It is well established in animal models that the prenatal environment can have a major impact on stress axis function throughout life. These changes can predispose to various metabolic, cardiovascular, and neurobiological pathophysiologies. Emerging evidence indicates that the same programming effects occur in humans. It is now becoming clear that the pathophysiological effects are not confined to the first-generation offspring and that there is transgenerational memory of fetal experience that can extend across multiple generations. The complex mechanisms by which transgenerational transmission of stress responsiveness occur are rapidly becoming a focus of investigation. Understanding these fundamental biological processes will allow for development of intervention strategies that prevent or reverse adverse programming of the stress response.

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