scholarly journals Low moisture starch for improved viability and stability of new Probiotic L. plantarum 299v preparation

2018 ◽  
Vol 72 (2) ◽  
pp. 107-113
Author(s):  
Davor Korcok ◽  
Olivera Colic ◽  
Nada Trsic-Milanovic ◽  
Bogdan Mitic
Keyword(s):  
Vitamin C ◽  
Beneficial Effect ◽  
Human Health ◽  
Process Parameters ◽  
Active Ingredient ◽  
Pharmaceutical Preparations ◽  
Pharmaceutical Manufacturing ◽  
Therapeutic Action ◽  
Active Ingredients ◽  
Level Of Evidence

Probiotic pharmaceutical preparations are more and more popular because of the increasing level of evidence of their beneficial effect on human health. The goal of this study was to determine and develop the encapsulated probiotic formulation with the optimal filling amount of active ingredient - Lactobacillus plantarum that would, in combination with other active ingredients: iron, vitamin C and excipient starch, fulfil requirements for therapeutic action while maintaining process parameters? requirements of manufacturing as well. The optimal formulation of a multicomponent probiotic-based formulation that fulfils requirements for sustaining all active ingredients while respecting technological process requirements, will enable a routine pharmaceutical manufacturing that could yield both efficient and safe dietary products.

scholarly journals Analysis of the consumption of sports supplements in elite fencers according to sex and competitive level

2021 ◽  
Vol 13 (1) ◽  
Author(s):  
Fernando Mata ◽  
Raúl Domínguez ◽  
Álvaro López-Samanes ◽  
Ángela Sánchez-Gómez ◽  
Pablo Jodra ◽  
...  
Keyword(s):  
Vitamin C ◽  
Whey Protein ◽  
Performance Improvement ◽  
Medical Doctors ◽  
Sports Performance ◽  
Level Of Evidence ◽  
Total Consumption ◽  
Main Motivation ◽  
Sports Supplements ◽  
Australian Institute

Abstract Background The aim of this study was to analyze the consumption of sports supplements (SS) in competitive level fencers and compare differences based on sex and competitive level (international and national). Methods A total of 49 fencers (18 men and 31 women) of national (n = 16) and international (n = 33) level completed a questionnaire with questions about SS consumption and the possible repercussions on health and / or sports performance. The results were analyzed based on the different categorizations established by the Australian Institute of Sport (AIS), as well as by sex and level of competence to which the participants belonged to. Results 46.9% of fencers have consumed SS with the main motivation being performance improvement (34.2%). Medical doctors were the individuals who were more likely to advise men to consume SS (50.0% vs 5.6%; OR = 3.29 [1.50–7.20]). Friends were most likely to advise women (38.9% vs 8.3%; OR = 1.75 [1.05–2.93]). The most consumed SS were sport drinks (44.9%), vitamin C (43.4%), sport bars (38.8%), and caffeine (28.6%). In regards to the SS categories, it was observed differences in the interaction level·sex in medical supplements (p = 0.017). In addition, there was a higher prevalence of whey protein consumption in women (25.8% vs 0%; p = 0.020) and iron consumption in men (33% vs 6.5%; p = 0.039). Conclusions The prevalence of SS use in fencers is within the values previously reported in athletes of the same competitive level. There were no differences by sex and competitive level in the total consumption of SS, nor in each of the groups of level of evidence, being sport drinks, bars and caffeine the most consumed SS.

scholarly journals Vitamin C in Human Health and Disease

Nutrients ◽  
2021 ◽  
Vol 13 (5) ◽  
pp. 1595
Author(s):  
Dariusz Nowak
Keyword(s):  
Eighteenth Century ◽  
Vitamin C ◽  
Human Health ◽  
Citrus Fruit ◽  
Ancient Egypt ◽  
Vitamin Supplement ◽  
Vitamin C Deficiency ◽  
Health And Disease

Although the symptoms related to vitamin C deficiency were known in ancient Egypt and eighteenth century Scottish surgeon James Lind found that scurvy (a disease resulting from insufficient dietary ingestion of vitamin C) could be effectively treated with citrus fruit, this vitamin was discovered only in the year 1912 and then after 21 years it was chemically synthetized and introduced to the market as the first vitamin supplement [...]

Antioxidative Role of Synthetic and Natural Ascorbic Acid (Vitamin C) in Metabolic Pathways of A Biological System

2021 ◽  
Vol 15 (12) ◽  
pp. 3143-3143
Author(s):  
Naveed Shuja
Keyword(s):  
Ascorbic Acid ◽  
Vitamin C ◽  
Silica Gel ◽  
Biological System ◽  
Metabolic Pathways ◽  
Citrus Fruit ◽  
Pharmaceutical Preparations ◽  
Metabolic Reaction ◽  
Fresh Vegetables

The properties of a substance are determined by the structure of its component molecules. Ascorbic acid occurs abundantly in fresh fruit, especially blackcurrants, citrus fruit and strawberries, and in most fresh vegetables; good sources are broccoli and peppers. It is destroyed by heat and is not well stored in the body3. Ascorbic acid is a good reducing agent and facilitates many metabolic reaction and repair processes. In pharmaceutical preparations and fruit juices, ascorbic acid is readily separated from other compounds by TLC on silica gel and quantitated directly by absorption at 254nm. Serum and plasma may be deproteinized with twice the volume of methanol or ethanol.

scholarly journals Effect of three composts with active ingredients of Pseudomonas fluorescens on the development of white root disease and production of rubber plants

2021 ◽  
Vol 22 (8) ◽  
Author(s):  
NURHAYATI DAMIRI ◽  
RIZAL ROFIQI ◽  
MULAWARMAN MULAWARMAN ◽  
SUPLI E. RAHIM ◽  
TRI RAPANI FEBYANTI
Keyword(s):  
Pseudomonas Fluorescens ◽  
Active Ingredient ◽  
Root Disease ◽  
Biological Agent ◽  
The Other ◽  
Active Ingredients ◽  
Severe Infections ◽  
Rigidoporus Lignosus ◽  
The Impact ◽  
Latex Production

Abstract. Damiri N, Rofiqi R, Mulawarnam, Rahim SE, Febyanti TP. 2021. Effect of three composts with active ingredients of Pseudomonas fluorescens on the development of white root disease and production of rubber plants. Biodiversitas 22: 3237-3242. White root disease (WRD) caused by Rigidoporus lignosus is a very dangerous disease and a scourge for rubber farmers because it can result in decreased production and kill rubber plants. This research was conducted to observe the impact of compost enriched with the biological agent Pseudomonas fluorescens on the development of white root disease and production in rubber plants. The results showed that the application of compost with active ingredient of P. fluorescens isolates A and B reduced the severity of white root disease in plants with mild, moderate and severe infections, 34.12%, 29.31% and 57.21% respectively. Application of compost with P. fluorescens isolates A and B, either singly or in combination, can increase latex production. The treatment of giving compost enriched with P. fluorescens isolates AR and ABR on rubber plants infected with mild WRD resulted in the highest latex production of 406 gm and 402.74 gm per plant, respectively. These two treatments did not differ from each other but were significantly different from the other treatments and controls.

BIOMECHANICAL ENERGY METABOLISM MODEL OF SPORTS MEDICINE

2021 ◽  
Vol 27 (7) ◽  
pp. 674-677
Author(s):  
Lu Jin
Keyword(s):  
Energy Metabolism ◽  
Knee Joint ◽  
Human Health ◽  
Contact Surface ◽  
Sports Medicine ◽  
Level Of Evidence ◽  
Joint Stress ◽  
Tibiofemoral Joint ◽  
Whole Process ◽  
Peak Value

ABSTRACT Introduction: This is a study on the reasonable organization and collocation of sports health elements in different sports forms, and how this is reflected through scientific exercise instructors. Objective: To improve the effect of sports medicine on the biomechanical energy metabolism of human health. Methods: The biomechanical model of knee joint stress was used to analyze the mechanical behavior of knee joint flexion, such as movement and contact; the variation law and peak value of stress on the contact surface of the tibiofemoral joint were obtained. Results: Based on the changes of stress on tibiofemoral joint contact surface and the peak value of the data obtained in this paper, the model and data basis were provided for guiding scientific sports training and sports medicine treatment, preventing knee joint sports injury, knee joint inflammation, and reasonably improving sports performance. Conclusions: Sports medicine is effective in improving human health. The objects of clinical exercise guidance include all people, from infancy to the old age. The function of exercise is recognized in the effect of the whole process of prevention, treatment and rehabilitation of a variety of clinical diseases. The effectiveness of exercise in the whole process of disease is also recognized. Level of evidence II; Therapeutic studies - investigation of treatment results.

The effect of Wogonoside on the expression of pulmonary fibrosis factor in Mycoplasma pneumoniae pneumonia

2020 ◽  
Author(s):  
Huihui Wang ◽  
Xiaoxi Wang ◽  
Zhimin Yang ◽  
Huixing Xu ◽  
Xin Wang ◽  
...  
Keyword(s):  
Mycoplasma Pneumoniae ◽  
Active Ingredient ◽  
A549 Cells ◽  
Scutellaria Baicalensis ◽  
Chinese Herbs ◽  
Affinity Constant ◽  
Active Ingredients ◽  
Pulmonary Interstitial Fibrosis ◽  
Mycoplasma Pneumoniae Pneumonia ◽  
Tof Ms

Abstract BACKGROUND Mycoplasma pneumoniae pneumonia (MPP) is an acute respiratory infectious pneumonia with pulmonary interstitial fibrosis. TGF-β1 is well accepted as the central mediator for fibrosis which promotes the formation of tissue fibrosis factor. Qinbaiqingfei pellet (Qinbai) has already been approved as the first effective new traditional Chinese medicine which can delay activities of Mycoplasma pneumoniae (M.pneumoniae) and protect lung epithelial cells in clinical trials. However, the mechanism of Qinbai inhibiting the expression of TGF-β1 is still unclear. METHODS The Chinese herbs in Qinbai were screened by surface plasmon resonance (SPR) and it was deteimined that Scutellaria baicalensis extracts in Qinbai showed the best binding with TGF-β1. Then the active ingredient whicn can be bound with TGF-β1 protein in the solution of Qinbai and Scutellaria baicalensis was isolated and analyzed by UPLC-Q-TOF-MS, which proved the active ingredient was Wogonoside. The affinity constant of Wogonoside and TGF-β1 protein was measured by SPR affinity analysis. A549 cells infected with M.pneumoniae were intervened by Wogonoside, and then the expression of TGF-β1 and Smad3 in A549 cells were analyzed by PCR and western blotting. RESULTS The results showed the bound effect of Scutellaria baicalensis and TGF-β1 was effective. The active ingredients which can be bound with TGF-β1 in the solution of Scutellaria baicalensis and Qinbai were obtained and analyzed to investigate the mechanism of Qinbai inhibiting the expression of TGF-β1. UPLC-Q-TOF-MS results showed that the active ingredients was Wogonoside. SPR affinity analysis showed that the affinity constant was 21.71 µM. Pharmacological experiments revealed that Wogonoside strongly inhibited the expression of TGF-β1 and Smad3 in A549 cells infected by M.pneumoniae. CONCLUSION Wogonoside in Qinbai can be bound with TGF-β1 and down-regulate the expression of lung fibrosis factors TGF-β1 and Smad3. The finding may improve our understanding the molecular mechanism of Qinbai mediating MPP and provide new sights into the future pharmacological investigation of Qinbai.

Biological Significance of Ascorbic Acid (Vitamin C) in Human Health - A Review

2003 ◽  
Vol 3 (1) ◽  
pp. 5-13 ◽  
Author(s):  
Khalid Iqbal . ◽  
Alam Khan . ◽  
M. Muzaffar Ali Khan .
Keyword(s):  
Ascorbic Acid ◽  
Vitamin C ◽  
Human Health ◽  
Biological Significance

scholarly journals Low Vitamin C Status in Patients with Cancer Is Associated with Patient and Tumor Characteristics

Nutrients ◽  
2020 ◽  
Vol 12 (8) ◽  
pp. 2338 ◽  
Author(s):  
Rebecca White ◽  
Maria Nonis ◽  
John F. Pearson ◽  
Eleanor Burgess ◽  
Helen R. Morrin ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Vitamin C ◽  
Human Health ◽  
Cancer Patients ◽  
Vital Role ◽  
Tumor Characteristics ◽  
Patients With Cancer ◽  
Plasma Ascorbate ◽  
Number Of Patients ◽  
Low Levels

Vitamin C (ascorbate) acts as an antioxidant and enzyme cofactor, and plays a vital role in human health. Vitamin C status can be affected by illness, with low levels being associated with disease due to accelerated turnover. However, robust data on the ascorbate status of patients with cancer are sparse. This study aimed to accurately measure ascorbate concentrations in plasma from patients with cancer, and determine associations with patient or tumor characteristics. We recruited 150 fasting patients with cancer (of 199 total recruited) from two cohorts, either prior to cancer surgery or during cancer chemo- or immunotherapy. A significant number of patients with cancer had inadequate plasma ascorbate concentrations. Low plasma status was more prevalent in patients undergoing cancer therapy. Ascorbate status was higher in women than in men, and exercising patients had higher levels than sedentary patients. Our study may prompt increased vigilance of ascorbate status in cancer patients.

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