scholarly journals Effect of hyperbaric oxygen treatment on oxidative stress in patients having diabetes mellitus type 2

2009 ◽  
Vol 62 (5-6) ◽  
pp. 225-230 ◽  
Author(s):  
Sandra Tepic ◽  
Miodrag Zivkovic ◽  
Negra Terzic ◽  
Radmila Krivokuca ◽  
Biljana Ljesevic ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
High Pressure ◽  
Diabetes Mellitus Type 2 ◽  
Vascular Complications ◽  
Vascular Complication ◽  
Diabetes Mellitus Type ◽  
Diabetic Patients ◽  
Peripheral Vascular ◽  
Group I

Introduction The aim of our study was to investigate the influence of breathing oxygen under high pressure on potential prooxidative activity in diabetic patients with serious vascular complications. Material and methods 24 patients with diabetes mellitus type 2, were divided into two groups, 12 patients each, by degree of peripheral vascular complications (by Wagner's scale). The group I was composed of 4 women and 8 men, their average age being 70 years, and average Diabetes duration of 12 years, without clinically manifest peripheral vascular complication (Wagner 0). The group II was composed of 4 women and 8 men, their average age being 74 years, and average illness duration of 17 years, having peripheral vascular complications, classified by Wagner's scale 1-5. Blood samples for biochemical analysis were taken before the therapy, then on the 3rd, 5th, 7th and 10th day of hyperbaric oxygenation treatment. The values of superoxide anion radical (O-), hydrogen peroxide (H2O2) and TBARS as a parameter of lipid peroxidation were measured during the HBOt. All examined patients were treated with the same therapy protocol (10 HBO treatments, under pressure of 1.7-2.2 bar, in duration of 60 minutes). The therapy was provided in monoplace oxygen hyperbaric chamber. Results The obtained results show no statistically significant increase in the values of O2-, H2O2, TBARS during the HBOt compared to the values before the HBOt. However, O2-, H2O2 were significantly reduced after HBOt. Conclusion On the basis of these data, we can conclude that the use of oxygen under high pressure has no influence on the increased prooxidative activities in diabetic patients during and after HBOt, disregarding the degree of the present vascular damages.

scholarly journals Effect of natural polyphenols on diabetes mellitus (type-2) with myocardial infarction: a double-blind placebo controlled trial

2019 ◽  
Vol 6 (2) ◽  
pp. 351
Author(s):  
Rahul Goyal ◽  
S. Nagtilak ◽  
Vijay Thawani ◽  
Shavetika Jindal
Keyword(s):  
Diabetes Mellitus ◽  
Myocardial Infarction ◽  
Diabetes Mellitus Type 2 ◽  
Controlled Trial ◽  
Prognostic Significance ◽  
Vascular Complications ◽  
Diabetes Mellitus Type ◽  
Diabetic Patients ◽  
Double Blind

Background: Diabetes Mellitus Type-2(T2D); is a leading disease in world wide. T2D is a clinical syndrome characterized by hyperglycaemia. Hyperglycemias are caused by an absolute or relative deficiency of insulin and due to insulin resistance. Diabetic patients are highly prone to Reactive Oxygen Species (ROS) and leads to Cardio vascular complications. Several medicines have been recommended to cure T2D; and still discovery of newer drugs are in process. Now a day, the focus of researches in diabetes includes discovery of newer anti-diabetic agents as well as isolating the active compounds from herbal sources. One such herbal source is pomegranate. Pomegranate is polyphenols and antioxidants rich fruit; which has potency to cure T2D and ROS.Methods: A Pomegranate Extract of Whole Fruit (PEWF) was prepared as tablet of 300mg to investigate its effects in patients with T2D. Total 40 participants of either gender with nested cases of T2D with Myocardial Infarction (MI) were included in study. All participants were assigned in two groups (20 each). One group was under “Add On” therapy of PEWF and matching placebos of same colour, shape and size were used as comparator agent for second group (300mg BD for 1 month).Results: Levels of biochemical markers related to T2D were compared to analysed pre and post drug effects by Z test, chi square test and by coefficient of variations. Results highlighted that those participants who were under “add-on” therapy of PEWF showed highly prognostic significance. Thus, PEWF should be consumed in diet as food supplementation.Conclusions: In conclusion, polyphenols and antioxidants rich fruit supplements should be taken in diet for healthy living.

Evaluation of the alterations in the serum blood sugar level, the activity of AST and ALT enzymes of diabetes mellitus type 2 in Iraqi women patients

2021 ◽  
Vol 16 (8) ◽  
pp. 98-102
Author(s):  
Hashim Abdul Razzaq Iman ◽  
Hussein Murtadha Jinan
Keyword(s):  
Diabetes Mellitus ◽  
Blood Sugar ◽  
Diabetes Mellitus Type 2 ◽  
Correlation Factor ◽  
Diabetes Mellitus Type ◽  
Fasting Blood Sugar ◽  
Diabetic Patients ◽  
Cell Dysfunction ◽  
Iraqi Women

Diabetes mellitus type 2 (T2DM) results from beta cell dysfunction or reduced action of insulin responsive. The objective of this study was to examine the relevance between blood sugar, the activity of aspartate aminotransferase (AST) and alanine aminotransferase (ALT) in fasting women diabetic patients in different durations. A total of sixty-eight women were divided into three groups: first a healthy group – non-diabetic (twenty-six women), second and third groups (twenty-one) were diabetic patients of age 35 – 50 and 51 – 69 years respectively. Serum fasting blood sugar was significantly (P < 0.05) elevated to 181.60 mg/dl in female patients with 35 – 50 years. The same effect happened in activity of AST to 32.91 u/L in 51 – 69 years and ALT was 28.43 u/L in 35 – 50 years. No significant differences were found between the aged and fasting blood sugar, AST and ALT in diabetic patients. The correlation factor (r) between fasting blood sugar and the activity of ALT was highly significant.

ARTIFICIAL NEURAL NETWORKS FOR ESTIMATING GLOMERULAR FILTRATION RATE BY URINARY DIPSTICK FOR TYPE 2 DIABETIC PATIENTS

2016 ◽  
Vol 28 (03) ◽  
pp. 1650016
Author(s):  
Yu Chu-Su ◽  
Chien-Sheng Liu ◽  
Ruey-Shin Chen ◽  
Chii-Wann Lin
Keyword(s):  
Diabetes Mellitus ◽  
Glomerular Filtration Rate ◽  
Glomerular Filtration ◽  
Diabetes Mellitus Type 2 ◽  
Filtration Rate ◽  
Optimal Combination ◽  
Diabetes Mellitus Type ◽  
Diabetic Patients ◽  
Test Items

Background: The result of a standard urinary dipstick from a patient with diabetes mellitus type 2 can be used to predict the estimated glomerular filtration rate (eGFR). We designed a multilayer perceptron (MLP) to investigate the possibility and optimal number of variables for the prediction. Methods: A total of 299 volunteers with diabetes mellitus type 2 were included. The blood and urine samples from volunteers were analyzed for blood sugar, glycated hemoglobin, serum creatinine, and urine chemistry. The urine chemistry was examined by a standard urinary dipstick. Volunteer age and gender and six test items of the dipstick were set as eight variables for this study. The eight variables were grouped and examined for the optimal combination. The eight variables from 232 of 299 volunteers were used to train an MLP for the optimal variables. The performance of trained MLP was validated by the data from 69 of 232 volunteers. Results: The optimal combination for variables was the six test items of the dipstick and volunteer age. The area under the curve (0.928), accuracy (0.879), sensitivity (0.83), and specificity (0.88) of the trained MLP were examined. Conclusions: The results demonstrate the eGFR prediction potential of the results of a urinary dipstick using this method.

An Evaluation of Hemoglobin Concentration in Patients with Diabetes Mellitus Type 2

2019 ◽  
Vol 9 (02) ◽  
Author(s):  
Karem Kdaer Karem ◽  
Saba Ibrahim Salih ◽  
Wafaa Kadhim Jassim
Keyword(s):  
Diabetes Mellitus ◽  
Diabetes Mellitus Type 2 ◽  
Hemoglobin Concentration ◽  
The Body ◽  
Diabetes Mellitus Type ◽  
Diabetic Patients ◽  
Other Information ◽  
Patients With Diabetes ◽  
Age Range

The second type of diabetes Mellitus is the most common type of diabetes, its represent about 90-95% of diabetes cases. In this disease, the response of the body to insulin does not occur properly in a condition known as insulin resistance. The diabetes may accompany with anemia because the hormone erythropoietin (EPO) which is produced by the kidneys is regulates red blood cell production and the Kidney has been damaged at several levels as a complication of diabetes, the complication range from diabetic nephropathy to chronic kidney disease. This study was conducted at the AL-Kafeel Hospital, Kerbala from October 2016 to December2016. The study included 60 adult patients with age range from 43-67 years and having diabetes mellitus type 2. Fasting blood sugar and Hb tests were made and accompanied with other information like age and duration of diabetes mellitus. The results show that 43% of diabetic patients had anemia and there is a strong negative connection between Hb levels and the duration of getting diabetes (p0.01). We conclude from this study that anemia is may developed in Type 2DM patients and the diabetic patients should be taken care of toprevent the development of diseases and other complications.

scholarly journals Therapeutic Effect of Folate and Cobalamin in Diabetics

2021 ◽  
Author(s):  
Farah Qudsia ◽  
Samreen Riaz
Keyword(s):  
Diabetes Mellitus ◽  
Diabetes Mellitus Type 2 ◽  
Microvascular Complications ◽  
Well Being ◽  
Diabetes Mellitus Type ◽  
Diabetic Patients ◽  
Cardiovascular Comorbidities ◽  
Enhance Insulin Sensitivity ◽  
High Chance

Diabetes Mellitus type 2 is a metabolic ailment. It is a condition when insulin is produced by our body but, it is not used properly by us. The number of diabetic patients is increasing in the whole world. The problem of obesity is also very closely related to it, which itself is expanding. The individuals diagnosed with type 2 Diabetes Mellitus have high chance of microvascular problems (like nephropathy, retinopathy and neuropathy). They are also at the verge of facing macrovascular ailments (like cardiovascular comorbidities). This indicates that many antidiabetic agents should be administered in combination, to maintain normal sugar level in blood. The management for the patients suffering from diabetes should be effective and harmless for them. It should also improve the general well-being of the patients. So many remedies have been developed for the management of diabetes. Several of them are being developed. We should enhance insulin sensitivity to let our body use insulin effectively. We also must stop the increasing pancreatic β-cell failure which is a specific characteristic of Diabetes Mellitus type 2. The microvascular complications must also be avoided or revoked. Our direst need is to develop agents which may help us in achieving goals mentioned earlier. Many micronutrients are involved in combating the Diabetes Mellitus and complication associated to the malady. These micronutrients are vitamins. Our main focus in this chapter are Vitamins B9 (Folate) and B12 (Cobalamin). Many researches have shown that the said parameters were decreased in patients suffering from Diabetes Mellitus. The level of these two vitamins should be maintained to the normal level and not toward the border line. The maintained level of these vitamins will help in controlling the main problems in patients suffering from Diabetes Mellitus like neuropathy, anemia and many others. By taking these vitamins along with other preventive measures, Diabetes Mellitus can be controlled and can be less dangerous.

scholarly journals The Effects of DPP4 Inhibitors on Lipid Status and Blood Pressure in Rats with Diabetes Mellitus Type 2

2019 ◽  
Vol 20 (4) ◽  
pp. 301-307 ◽  
Author(s):  
Stefani Bolevich ◽  
Nevena Draginic ◽  
Marijana Andjic ◽  
Nevena Jeremic ◽  
Sergey Bolevich ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Blood Pressure ◽  
Diabetes Mellitus Type 2 ◽  
Density Lipoprotein ◽  
Diabetes Mellitus Type ◽  
Albino Rats ◽  
Dpp4 Inhibitors ◽  
Lipid Status ◽  
Group I

Abstract The aim of the present study was to examine, evaluate and compare the effects of administered dipeptidyl peptidase-4 (DPP4) inhibitors saxagliptin and sitagliptin on lipid status parameters and blood pressure in rats with streptozotocine induced diabetes mellitus type 2. Forty-eight Wistar albino rats were divided randomly into 4 groups: 1. group I: control healthy group; 2. group II: rats with diabetes mellitus type 2; 3. group III: rats with diabetes mellitus type 2+ treated with 0.6 mg/kg of sitagliptin; 4. group IV: rats with diabetes mellitus type 2 treated with 0.45 mg/kg of saxagliptin. The rats from experimental groups were fed with a high-fat diet for 4 weeks and after 6–8 h of starvation received one dose of streptozotocin (STZ) intraperitoneally (25 mg/kg body weight) to induce type 2 diabetes mellitus (T2DM). Animals with fasting glucose above 7 mmol/L and insulin over 6 mmol/L were included in the study as rats with T2DM. Upon completion of the experiments, the blood was collected from the anesthetized animals and serum triglyceride (TG), total cholesterol (TCH), high density lipoprotein (HDL), and low density lipoprotein (LDL) were measured using spectrophotometry and commercial kits. At the beginning of the study and the day before sacrificing animals, the blood pressure and heart rate were measured by a tail-cuff noninvasive method. DPP4 inhibitors, as glucagon-like peptide-1 (GLP-1) agonists, were associated with modest reductions in DBP, LDL-C, TCH, and TGL and significant improvement in HDL, SBP and HR.

scholarly journals Frequency and pattern of dyslipidemia in diabetes mellitus type 2.

2021 ◽  
Vol 28 (06) ◽  
pp. 828-832
Author(s):  
Akhtar Ali ◽  
Rabeel Nawaz ◽  
Faiza Dildar Ghuman ◽  
Syed Muhammad Hasan ◽  
Sadia Iqbal ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Diabetes Mellitus Type 2 ◽  
Elevated Serum ◽  
Diabetes Mellitus Type ◽  
University Hospital ◽  
Diabetic Patients ◽  
Serum Triglycerides ◽  
Cross Sectional ◽  
Detailed Medical History

Objective: This study was designed to evaluate the frequency and pattern of dyslipidemia in patients of diabetes mellitus type 2. Study Design: Cross Sectional Observational study. Setting: Medicine Department and National Institute of Diabetes and Endocrinology OPD of Dow University Hospital OJHA Campus Karachi Sindh. Period: March 2018 to September 2018. Material & Methods: 142 diabetes mellitus type 2 patients aged between 35-60 years, selected by non-probability consecutive sampling method. Detailed medical history and blood sample for fasting lipid profile was obtained from each diabetic patient. Result: Out of 142 diabetic patients investigated for dyslipidemia, 72 (50.7%) were male and 70 (49.3%) were female with a mean age of 47.49±6.40 (35-60) years. Dyslipidemia was detected in 114 (80.3%) patients; with most common abnormality was elevated serum triglycerides (54.9%), followed by decreased serum HDL cholesterol (50.7%), elevated serum VLDL cholesterol (50.0%), elevated serum cholesterol (38.7%) and elevated serum LDL cholesterol (16.9%). Conclusion: It was concluded that diabetes mellitus type 2 is directly correlated with higher incidence of dyslipidemia.

The association of the metabolic profile in diabetes mellitus type 2 patients with obsessive compulsive disorder and depression: New insights

2011 ◽  
Vol 26 (S2) ◽  
pp. 873-873
Author(s):  
K. Kontoangelos ◽  
A. Raptis ◽  
C.C. Papageorgiou ◽  
G.N. Papadimitriou ◽  
A.D. Rabavilas ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Obsessive Compulsive Disorder ◽  
Diabetes Mellitus Type 2 ◽  
Metabolic Profile ◽  
Rating Scale ◽  
Diabetes Mellitus Type ◽  
Diabetic Patients ◽  
Obsessive Compulsive ◽  
Compulsive Disorder

IntroductionThe high comorbidity of depression in patients with diabetes mellitus type 2 has been established.ObjectivesThe association between Obsessive Compulsive Disorder (OCD) and diabetes mellitus type 2 is poorly understood.AimsThe aim of the present study was to assess the degree in which diabetes mellitus type 2 is accompanied by OCD.Method131 diabetic patients, 55 female and 76 male were randomly enrolled and during the first assessment was administered in all participants the Zung Self Rating Scale (ZUNG) and the Maudsley O-C Inventory Questionnaire (MOCI). After one year, while an intensive effort to improve the patients’ metabolic profile was performed, the diabetic patients that were initially uncontrolled (n = 31) were re-evaluated by the same psychometric tools. From those 31 patients 10 had managed to control their metabolic profile.ResultsMOCI and the sub-scale of slowness are statistically related with the diabetic profile (controlled-uncontrolled), with uncontrolled patients scoring significantly higher on the overall MOCI score and the factor of slowness of MOCI scale (p = 0.028). Regarding the association between the values of Glycosylated Haemoglobin (HbA1c) and the scores of MOCI it was found that they were significantly positively correlated in overall scores (p = 0,028) and in the subscale of slowness (p = 0,028). The analysis revealed a positive association between depression (p = 0.004) and obsessive compulsive disorder symptomatology (p < 0.001) and thepatient’s metabolic profile.ConclusionsDiabetes mellitus type 2 is associated with obsessive compulsive disorder symptomatology and depression. Improvements in glycaemic control were found to decrease the severity of the symptoms.

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