1979-P: Thyroid Hormone Associated with Acanthosis Nigricans and Fat Distribution in Obese Patients Nigricans and Fat Distribution in Obese Patients

Diabetes ◽  
2020 ◽  
Vol 69 (Supplement 1) ◽  
pp. 1979-P
Author(s):  
SHEN QU ◽  
XINGCHUN WANG
Keyword(s):  
Thyroid Hormone ◽  
Acanthosis Nigricans ◽  
Fat Distribution ◽  
Obese Patients

scholarly journals Thyroid hormone associated with Acanthosis Nigricans and fat distribution in obese patients

2020 ◽  
Author(s):  
xingchun wang ◽  
Yao Chen ◽  
Bingwei Ma ◽  
Chunjun Sheng ◽  
Peng Yang ◽  
...  
Keyword(s):  
Thyroid Hormone ◽  
Protective Factor ◽  
Acanthosis Nigricans ◽  
Glycosylated Hemoglobin ◽  
Fat Distribution ◽  
Obese Patients ◽  
Obese Women ◽  
Hormone Levels ◽  
Thyroid Hormone Levels ◽  
Total Fat

Abstract Background: Obesity is more easier exhibiting subclinical hypothyroidism (SH) and acanthosis nigricans (AN). We aimed to elucidate the thyroid hormone levels in obese patients and its association with fat distribution and AN. Methods: In this cross-sectional study, 202 obese men and 239 obese women were enrolled. Anthropometric measurements, glucose-lipid metabolism, thyroid hormone levels and fat distribution were measured. SH were defined by thyroid stimulating hormone (TSH) less than 2.5 mU/L. Results: 1) The prevalence of AN was significantly higher in obese group with SH than without SH (47.3% vs. 36.9%, P=0.035). Number of obese women with SH were larger than men (38.1% vs. 28.2%, P=0.029). Obese women have higher TSH levels, lower free triiodothyronine (FT3) and free thyroxin (FT4) than obese men (all P<0.01). Body mass index (BMI), waist/hip ratio (WHR), glycosylated hemoglobin (HGB), homeostasis model of assessment for insulin resistance index (HOMA-IR) were significantly lower in obese women than men (all P <0.05). 2) In all obesity, FT3 was significantly positively associated with height, weight, NC, WC, WHR, SBP, DBP, FINS, UA and negatively with HDL-C (all P <0.05). FT4 was significantly positively associated with height, weight, BMI, NC, WC, SBP, DBP, UA, HGB and FBG (all P <0.05). TSH was negatively with FBG and HGB (all P <0.05). 3) FT3 was positively with Peripheral fatmass, total leanmass and negatively with Total Fat% and Trunk/peripheral fatmass (P=0.025;P=0.029;P<0.001;P=0.034), FT4 was also positively with total leanmass and negatively with Total Fat%(P=0.008; P=0.017), and TSH was positively with Total Fat%(P=0.032). Conclusion: AN is more likely to happen in the obesity with SH. Obese women have higher probability of SH than men. Relatively slightly insufficient of thyroid function with higher TSH may be protective factor in obese women with better metabolism. Thyroid hormone may beneficial to improving fat distribution and building lean mass in the obesity.

The Clinical Characteristics of Obese Patients with Acanthosis Nigricans and Its Independent Risk Factors

2017 ◽  
Vol 125 (03) ◽  
pp. 191-195 ◽  
Author(s):  
Yueye Huang ◽  
Jiaqi Chen ◽  
Xingchun Wang ◽  
Yan Li ◽  
Shezhen Yang ◽  
...  
Keyword(s):  
Risk Factors ◽  
Clinical Characteristics ◽  
Acanthosis Nigricans ◽  
Obese Patients ◽  
Independent Risk Factors

scholarly journals Cutaneous manifestations in obese patients and non-obese controls in a tertiary care centre: a case-control study

2019 ◽  
Vol 5 (4) ◽  
pp. 695
Author(s):  
Raghuveer Chekuri ◽  
Thameena Mohamed
Keyword(s):  
Acanthosis Nigricans ◽  
Tertiary Care ◽  
Control Group ◽  
Obese Patients ◽  
Striae Distensae ◽  
Tertiary Care Centre ◽  
Cutaneous Manifestations ◽  
High Prevalence ◽  
Skin Conditions ◽  
And Function

<p class="abstract"><strong>Background:</strong> Obesity has emerged as one of the most serious public health concerns in the 21<sup>st</sup> century. It is responsible for varied changes in structure and function of different components of skin. Skin care of obese patients deserves particular attention, not only because of high prevalence of cutaneous alteration but mainly because many of these disorders are preventable and could be treated, improving patient’s quality of life.</p><p class="abstract"><strong>Methods:</strong> Two hundred patients with BMI ≥30 kg/m<sup>2</sup> and two hundred age and sex matched controls (BMI: 18.5-24.9 kg/m<sup>2</sup>) were included in this study.<strong></strong></p><p class="abstract"><strong>Results:</strong> Compared to the control group, obese patients were having higher prevalence of various skin conditions of which most common were acanthosis nigricans, acrochordons, striae distensae, frictional hyperpigmentation and infections.</p><p class="abstract"><strong>Conclusions:</strong> There is increased incidence and severity of cutaneous manifestations like acanthosis nigricans, acrochordons, striae distensae, frictional hyperpigmentation and infections in obese patients than control subjects. These can be used as markers for the early detection of various components of metabolic syndrome.</p>

scholarly journals Melatonin Treatment Improves Insulin Resistance and Pigmentation in Obese Patients with Acanthosis Nigricans

2018 ◽  
Vol 2018 ◽  
pp. 1-7 ◽  
Author(s):  
Hang Sun ◽  
Xingchun Wang ◽  
Jiaqi Chen ◽  
Aaron M. Gusdon ◽  
Kexiu Song ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Insulin Sensitivity ◽  
Acanthosis Nigricans ◽  
Resistance Index ◽  
Inflammatory Factors ◽  
Model Assessment ◽  
Obese Patients ◽  
Inflammatory Status ◽  
Before And After ◽  
Matsuda Index

Objective. This study aimed to determine the effects of melatonin on insulin resistance in obese patients with acanthosis nigricans (AN). Methods. A total of 17 obese patients with acanthosis nigricans were recruited in a 12-week pilot open trial. Insulin sensitivity, glucose metabolism, inflammatory factors, and other biochemical parameters before and after the administration of melatonin were measured. Results. After 12 weeks of treatment with melatonin (3 mg/day), homeostasis model assessment insulin resistance index (HOMA-IR) (8.99 ± 5.10 versus 7.77 ± 5.21, p<0.05) and fasting insulin (37.09 5 ± 20.26 μU/ml versus 32.10 ± 20.29 μU/ml, p<0.05) were significantly decreased. Matsuda index (2.82 ± 1.54 versus 3.74 ± 2.02, p<0.05) was significantly increased. There were also statistically significant declines in the AN scores of the neck and axilla, body weight, body mass index, body fat, visceral index, neck circumference, waist circumference, and inflammatory markers. Conclusions. It was concluded that melatonin could improve cutaneous symptoms in obese patients with acanthosis nigricans by improving insulin sensitivity and inflammatory status. This trial is registered with ClinicalTrials.gov NCT02604095.

scholarly journals A cross-sectional descriptive clinical study of dermatological manifestations in obesity

2017 ◽  
Vol 3 (3) ◽  
pp. 337 ◽  
Author(s):  
Sivakumar S. ◽  
Banupriya K.
Keyword(s):  
Metabolic Syndrome ◽  
Acanthosis Nigricans ◽  
Varicose Veins ◽  
Western World ◽  
Obese Patients ◽  
Cross Sectional ◽  
Insulin Levels ◽  
Skin Tags ◽  
Skin Conditions ◽  
Morbid Conditions

<p class="abstract"><strong>Background:</strong> <span lang="EN-IN">Obesity is major health hazard in the western world, however studies on skin manifestations in obese patients are limited. Most common co-morbid conditions associated with obesity are hypertension, Type 2 Diabetes Mellitus, dyslipidaemia, degenerative joint diseases etc. Skin conditions such as acrochordons, acanthosis Nigricans can be easily made out on inspection and seen most commonly with obesity. It is important for the clinicians to routinely screen patients for obesity and co-morbid conditions.</span>The aims were t<span lang="EN-IN">o study the prevalence of various skin disorders in obese patients and the frequency of skin changes in various obesity classes and to study the presence of metabolic syndrome and its association with leptin and insulin levels in those patients with acanthosis Nigricans and skin tags.</span></p><p class="abstract"><strong>Methods:</strong> <span lang="EN-IN">Cross-sectional descriptive study done on 100 patients with a BMI &gt;30 and waist circumference &gt;90 cm (in males) and &gt;80 cm (in females).</span><strong></strong></p><p class="abstract"><strong>Results:</strong> <span lang="EN-IN">Acanthosis Nigricans was the most prevalent skin condition (65%) and the association statistically was significant (p=0.012). Association of Skin tags (second commonest, in 42%) with p=0.012. Acanthosis Nigricans and skin tags among the various skin conditions studied like psoriasis, striae-distensae, fissure-feet, pyoderma, intertrigo, varicose veins, seborrheic dermatitis, Hand-feet eczema, osteoarthritis, candiasis was significantly associated with obesity. </span></p><p class="abstract"><strong>Conclusions:</strong> <span lang="EN-IN">Acanthosis Nigricans and skin tags among the various skin conditions studied had a strong correlation with obesity and metabolic syndrome which may be a marker for atherosclerosis and cardiovascular risk. It was also noted that in patients with Acanthosis Nigricans and skin tags, who had metabolic syndrome, there was an elevation of the plasma leptin levels and fasting plasma insulin levels but not significant with a p=0.25.</span></p>

Evaluation of Thyroid Hormone Replacement Dosing in Overweight and Obese Patients After a Thyroidectomy

Thyroid ◽  
2019 ◽  
Vol 29 (11) ◽  
pp. 1558-1562 ◽  
Author(s):  
Vardan Papoian ◽  
Dorina Ylli ◽  
Erin A. Felger ◽  
Leonard Wartofsky ◽  
Jennifer E. Rosen
Keyword(s):  
Thyroid Hormone ◽  
Hormone Replacement ◽  
Obese Patients ◽  
Thyroid Hormone Replacement

Significant Bone Loss in Obese Patients with Acanthosis Nigricans after LSG—One-Year Follow-Up Study

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 2062-P
Author(s):  
YOUYANG ZHANG ◽  
ZHIYIN ZHANG ◽  
CUILING ZHU ◽  
SIQI SUN ◽  
YING YIN ◽  
...  
Keyword(s):  
Bone Loss ◽  
Acanthosis Nigricans ◽  
Obese Patients ◽  
Follow Up Study ◽  
One Year

scholarly journals Lean Patients with Non-Alcoholic Fatty Liver Disease Have a Severe Histological Phenotype Similar to Obese Patients

2018 ◽  
Vol 7 (12) ◽  
pp. 562 ◽  
Author(s):  
Lukas Denkmayr ◽  
Alexandra Feldman ◽  
Lars Stechemesser ◽  
Sebastian Eder ◽  
Stephan Zandanell ◽  
...  
Keyword(s):  
Liver Disease ◽  
Thyroid Hormone ◽  
Fatty Liver Disease ◽  
Fasting Glucose ◽  
Hormone Replacement ◽  
Obese Patients ◽  
Alcoholic Fatty Liver ◽  
Thyroid Hormone Replacement ◽  
Lean Nafld ◽  
Alcoholic Fatty Liver Disease

A small proportion of lean patients develop non-alcoholic fatty liver disease (NAFLD). We aimed to report the histological picture of lean NAFLD in comparison to overweight and obese NAFLD patients. Biopsy and clinical data from 466 patients diagnosed with NAFLD were stratified to groups according to body mass index (BMI): lean (BMI ≤ 25.0 kg/m², n confirmed to be appropriate = 74), overweight (BMI > 25.0 ≤ 30.0 kg/m², n = 242) and obese (BMI > 30.0 kg/m², n = 150). Lean NAFLD patients had a higher rate of lobular inflammation compared to overweight patients (12/74; 16.2% vs. 19/242; 7.9%; p = 0.011) but were similar to obese patients (25/150; 16.7%). Ballooning was observed in fewer overweight patients (38/242; 15.7%) compared to lean (19/74; 25.7%; p = 0.014) and obese patients (38/150; 25.3%; p = 0.006). Overweight patients had a lower rate of portal and periportal fibrosis (32/242; 13.2%) than lean (19/74; 25.7%; p = 0.019) and obese patients (37/150; 24.7%; p = 0.016). The rate of cirrhosis was higher in lean patients (6/74; 8.1%) compared to overweight (4/242; 1.7%; p = 0.010) and obese patients (3/150; 2.0% p = 0.027). In total, 60/466; 12.9% patients were diagnosed with non-alcoholic steatohepatitis (NASH). The rate of NASH was higher in lean (14/74; 18.9% p = 0.01) and obese (26/150; 17.3%; p = 0.007) compared to overweight patients (20/242; 8.3%)). Among lean patients, fasting glucose, INR and use of thyroid hormone replacement therapy were independent predictors of NASH in a multivariate model. Lean NAFLD patients were characterized by a severe histological picture similar to obese patients but are more progressed compared to overweight patients. Fasting glucose, international normalized ratio (INR) and the use of thyroid hormone replacement may serve as indicators for NASH in lean patients.

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