A common promoter variant of the leptin gene is associated with changes in the relationship between serum leptin and fat mass in obese girls

OBJECTIVES/SPECIFIC AIMS: The main aim of this study was to investigate the relationship between measures of adiposity and FGF-23 in a sample of patients with CKD stages 3-4. METHODS/STUDY POPULATION: This study was a clinic-based cross-sectional investigation of 71 CKD patients who underwent body composition and anthropometric assessments as part of the relationship of insulin sensitivity in kidney disease and vascular health (RISKD) study. Dual energy x-ray absorptiometry (DEXA) scans were used to measure total fat mass and body mass index (BMI) was computed using baseline weight and height measurements. Biomarkers included serum FGF-23 (C-terminal), serum leptin, high sensitivity C-reactive protein (hsCRP), serum triglycerides, high density lipoprotein (HDL) cholesterol and total cholesterol. Creatinine-based estimated glomerular filtration rate (eGFR) was computed using the CKD-EPI equation. Multiple linear regression with robust standard errors was used to investigate the relationship between FGF2-3 and measures of adiposity (BMI, total fat mass and serum leptin). Log-transformation was performed for variables (FGF-23, hsCRP and serum lipids) with considerable skewness. RESULTS/ANTICIPATED RESULTS: The median age of the study participants was 68 (IQR: 60, 73) years; 26% were female and 23% were African-American. Median eGFR was 46.9 ml/min/1.73m2 (IQR: 41.9, 52.8), median BMI was 31 kg/m2 (IQR: 27, 35). Log FGF-23 had a significant positive correlation with BMI (r = 0.27, p = 0.02), total fat mass (r = 0.30, p = 0.01) and serum leptin (r = 0.43, p < 0.0001). After full adjustment for age, sex, race, eGFR, log hsCRP, log HDL and log triglycerides, a 50% increase in FGF-23 was associated with a 1 kg/m2 [95% CI: 0.1, 1.9; p = 0.03] increase in BMI, a 2.5 kg [95% CI: 0.2, 4.8; p = 0.03] increase in total fat mass and a 6.7 ng/mL [95% CI: 1.0, 12.4; p = 0.02] increase in serum leptin. DISCUSSION/SIGNIFICANCE OF IMPACT: In this sample of patients with moderate-to-severe CKD, we found a significant independent association between higher FGF-23 levels and higher adiposity (BMI, total fat mass and the pro-atherogenic adipocytokine, leptin). The underlying causes and the implications of these associations − particularly in bone and vascular health − need to be further investigated.

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The Relationship of Abdominal Fat Mass Assessed by Helical or Conventional Computed Tomography to Serum Leptin Concentration

Journal of Atherosclerosis and Thrombosis ◽

10.5551/jat.11.173 ◽

2004 ◽

Vol 11 (3) ◽

pp. 173-179 ◽

Cited By ~ 6

Author(s):

Junji Kobayashi ◽

Takeyoshi Sasaki ◽

Mitsuyo Watanabe

Keyword(s):

Computed Tomography ◽

Fat Mass ◽

Abdominal Fat ◽

Serum Leptin ◽

Relationship Of ◽

The Relationship

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The relationship between the serum leptin concentrations of thyrotoxic patients during treatment and their total fat mass is different from that of normal subjects

Clinical Endocrinology ◽

10.1046/j.1365-2265.1998.00627.x ◽

1998 ◽

Vol 49 (5) ◽

pp. 589-595 ◽

Cited By ~ 27

Author(s):

Tina Zimmermann-Belsing ◽

Marianne Dreyer ◽

Jens Juul Holst ◽

Ulla Feldt-Rasmussen

Keyword(s):

Fat Mass ◽

Normal Subjects ◽

Serum Leptin ◽

Total Fat ◽

The Relationship

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Relationship between Leptin Concentration in Cord Blood and Foetal Growth and Maternal Anthropometry of GDM Mothers at Delivery

Journal of Bangladesh College of Physicians and Surgeons ◽

10.3329/jbcps.v25i1.166 ◽

1970 ◽

Vol 25 (1) ◽

pp. 9-13

Author(s):

S Jahan ◽

TR Das ◽

KB Biswas

Keyword(s):

Body Mass Index ◽

Birth Weight ◽

Cord Blood ◽

Body Mass ◽

Anthropometric Measurements ◽

Anthropometric Parameters ◽

Serum Leptin ◽

C Peptide ◽

Cord Serum ◽

The Relationship

Background and Aims: Cord blood leptin may reflect the leptinemic status of a newborn at birth more accurately than the leptin values of blood collected from other sites. The present study was undertaken to determine the relationship of cord serum leptin concentration at birth with neonatal and maternal anthropometric parameters. Materials and Methods: Blood was taken from the umbilical cord of the babies at delivery. Maternal anthropometric measurements were recorded at admission for delivery. Neonatal anthropometric measurements were recorded within 48 hours after delivery. Linear regression analysis was used to explore the relationship between cord serum leptin concentration and anthropometric parameters of the baby and the mother. Both Serum leptin and serum C-peptide levels were measured by chemiluminescence-based ELISA method. Results: The leptin concentration (ng/ml, mean±SD) in cord blood was 39.13±14.44. Cord leptin levels correlated with birth weight (r=0.673, p<0.0001), ponderal index (r=0.732, p<0.0001) but it did not correlate with maternal body mass index, gestational age (r=0.135, p=0.349) at delivery or cord serum C-peptide concentration (r=-0.049, p=0.735) or placental weight (r=0.203, p=0.157). Conclusion: There are associations between cord leptin concentration at delivery and birth weight, ponderal index (PI) of the babies but not body mass index (BMI) of the mothers. High leptin levels of the baby could represent an important feedback modulator of substrate supply and subsequently for adipose tissue status during late gestation. (J Bangladesh Coll Phys Surg 2007; 25 : 9-13)

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Glucocorticoid-induced lipolysis across human ageing and the relationship to fat mass and androgens

Endocrine Abstracts ◽

10.1530/endoabs.38.p399 ◽

2015 ◽

Author(s):

Zaki Hassan-Smith ◽

Angela Taylor ◽

Beverly Hughes ◽

Theresa Brady ◽

Pamela Jones ◽

...

Keyword(s):

Fat Mass ◽

Human Ageing ◽

The Relationship

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Insulin-resistant patients with type 2 diabetes mellitus have higher serum leptin levels independently of body fat mass

Acta Diabetologica ◽

10.1007/s005920200027 ◽

2002 ◽

Vol 39 (3) ◽

pp. 105-110 ◽

Cited By ~ 93

Author(s):

S. Fischer ◽

M. Hanefeld ◽

S. M. Haffner ◽

C. Fusch ◽

U. Schwanebeck ◽

...

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Type 2 Diabetes Mellitus ◽

Body Fat ◽

Fat Mass ◽

Body Fat Mass ◽

Serum Leptin ◽

Insulin Resistant

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Testosterone substitution of hypogonadal men prevents the age-dependent increases in body mass index, body fat and leptin seen in healthy ageing men: results of a cross-sectional study

Acta Endocrinologica ◽

10.1530/eje.0.1460505 ◽

2002 ◽

pp. 505-511 ◽

Cited By ~ 34

Author(s):

C Rolf ◽

S von Eckardstein ◽

U Koken ◽

E Nieschlag

Keyword(s):

Fat Mass ◽

Serum Testosterone ◽

Cross Sectional Study ◽

Fat Content ◽

Sectional Study ◽

Cross Sectional ◽

Serum Leptin ◽

Testosterone Substitution ◽

Age Dependent ◽

Total Fat

INTRODUCTION: In healthy men, body weight and total fat content increase with advancing age, while serum testosterone levels decrease. In order to elucidate whether a causal relationship between these phenomena exists, we investigated the influence of testosterone or human chorionic gonadotrophin substitution on body mass index (BMI), total fat mass and serum leptin in testosterone-treated and untreated hypogonadal patients in comparison with ageing eugonadal men. METHODS: In a cross-sectional study, the inter-relationships of body weight, total fat mass, serum sex hormones and leptin were analysed in untreated hypogonadal men (n=24; age 19-65 years), treated hypogonadal men (n=61; age 20-67 years) and healthy eugonadal men (n=60; age 24-78 years). Total fat mass was assessed by bioimpedance measurement. Univariate and multiple linear regression analysis was used to detect possible differences. RESULTS: In eugonadal men, serum testosterone levels decreased with advancing age (correlation coefficients: r=-0.71; P<0.0001), while BMI (r=0.39; P=0.002), total fat content (r=0.51; P<0.0001) and leptin (r=0.48; P<0.0001) increased significantly. In untreated hypogonadal patients, an increase in BMI (r=0.50; P=0.013) and total fat mass (r=0.41; P=0.044) was also observed with advancing age. However, in substituted hypogonadal patients, no age-dependent change in BMI (r=0.067; P=0.606), body fat content (r=-0.083; P=0.522), serum testosterone (r=-0,071; P=0.59) or serum leptin (r=-0.23; P=0.176) was found. CONCLUSION: Since testosterone-substituted older hypogonadal men show BMI and fat mass similar to those of younger eugonadal men and since non-treated hypogonadal men are similar to normal ageing men, testosterone appears to be an important factor contributing to these changes. Thus ageing men should benefit from testosterone substitution as far as body composition is concerned.

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Composición corporal y rendimiento físico de jugadores de fútbol soccer universitario por posición de juego (Body composition and physical performance of college soccer by player´s position)

Retos ◽

10.47197/retos.v0i39.75075 ◽

2020 ◽

pp. 52-57

Author(s):

Oswaldo Ceballos-Gurrola ◽

Fernando Bernal-Reyes ◽

Marquelia Jardón-Rosas ◽

María Cristina Enríquez-Reyna ◽

Jesús Durazo- Quiroz ◽

...

Keyword(s):

Body Composition ◽

Physical Performance ◽

Body Mass ◽

Fat Mass ◽

Physical Characteristics ◽

Soccer Players ◽

Hip Circumference ◽

Soccer Teams ◽

Physical Abilities ◽

The Relationship

Se propuso determinar la relación que existe entre la composición corporal y el rendimiento físico de jugadores de fútbol soccer universitario. Participaron 26 jugadores de sexo masculino con edad promedio de 20.7 años (DT = 1.7), pertenecientes a los equipos representativos de fútbol soccer de dos universidades mexicanas. Se midieron características morfológicas, de composición corporal y físicas para las posiciones de defensa, mediocampo y delantero. Se determinó el nivel de asociación entre las variables. Los resultados muestran que los defensas presentan mayor masa corporal, diámetro de húmero y circunferencia de cadera que los delanteros (p < .05), no así respecto a los jugadores de mediocampo. No se presenta diferencia en la expresión de las capacidades físicas y del porcentaje de masa grasa de los jugadores por posición de juego (p > .05). La masa grasa se asoció de manera directa con la velocidad (.427*, p < .05). Se encontraron diferencias en la masa ósea y corporal por posición de juego entre defensas, mediocampistas y delanteros. Los hallazgos sugieren la influencia de la composición corporal en el rendimiento físico de los participantes. Abstract. The aim of the study was to determine the relationship between body composition and physical performance in college soccer players. Twenty-six male players with an average age of 20.7 years (SD = 1.7), belonging to the representative soccer teams of two Mexican universities participated in the research. Morphological, body composition, and physical characteristics were measured for the defense, midfield, and forward positions. The level of association between variables was determined. The results show that defenders have greater body mass, humerus diameter, and hip circumference than forwards (p <. 05), whereas no differences were found in comparison to midfielders. There is no difference in players’ expression of physical abilities and percentage of fat mass by playing position (p > .05). Fat mass was directly associated with speed (.427 *, p < .05). Differences were found in bone and body mass by playing position between defenders, midfielders, and forwards. The findings hint at an influence of body composition on participants’ physical performance.

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