scholarly journals A pilot study on the use of 3D printers in veterinary medicine

2021 ◽  
Vol 14 (3) ◽  
pp. 159-164
Author(s):  
Leonardo Leonardi ◽  
◽  
Roberto Marsili ◽  
Enrico Bellezza ◽  
Giovanni Angeli ◽  
...  
Keyword(s):  
Additive Manufacturing ◽  
3D Printing ◽  
Bone Tissue ◽  
Three Dimensional ◽  
The Body ◽  
Porous Scaffolds ◽  
Layer By Layer ◽  
Three Dimensional Objects ◽  
Cellular Attachment

Additive manufacturing (AM) is the process of joining materials to create layer-by-layer three-dimensional objects using a 3D printer from a digital model. The great advantage of Additive Manufacturing is to allow a freer design than traditional processes. The development of additive manufacturing processes has permitted to optimize the production of the customized product through the modeling of the geometry and the knowledge of the morphometric parameters of the body structures. 3D printing has revolutionized the field of Regenerative Medicine because, starting from computerized tomography (CT) images and using traditional materials such as plastic and metals, it can provide customized prostheses for each patient, which adapt perfectly to the needs of the subject and act as structures support. 3D printing allows you to print three-dimensional porous scaffolds with a precise shape and chemical composition suitable for medical and veterinary use. Some of these scaffolds are biodegradable and appear to be ideal for bone tissue engineering. In fact, they are able to simulate extracellular matrix properties that allow mechanical support, favoring mechanical interactions and providing a model for cellular attachment and in vivo stimulation of bone tissue formation.

scholarly journals Three-dimensionally printed polycaprolactone/multicomponent bioactive glass scaffolds for potential application in bone tissue engineering

2020 ◽  
Vol 6 (1) ◽  
pp. 57-69
Author(s):  
Amirhosein Fathi ◽  
Farzad Kermani ◽  
Aliasghar Behnamghader ◽  
Sara Banijamali ◽  
Masoud Mozafari ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
3D Printing ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Three Dimensional ◽  
Layer By Layer ◽  
Composite Scaffolds ◽  
3D Printed ◽  
Co Doped

AbstractOver the last years, three-dimensional (3D) printing has been successfully applied to produce suitable substitutes for treating bone defects. In this work, 3D printed composite scaffolds of polycaprolactone (PCL) and strontium (Sr)- and cobalt (Co)-doped multi-component melt-derived bioactive glasses (BGs) were prepared for bone tissue engineering strategies. For this purpose, 30% of as-prepared BG particles (size <38 μm) were incorporated into PCL, and then the obtained composite mix was introduced into a 3D printing machine to fabricate layer-by-layer porous structures with the size of 12 × 12 × 2 mm3.The scaffolds were fully characterized through a series of physico-chemical and biological assays. Adding the BGs to PCL led to an improvement in the compressive strength of the fabricated scaffolds and increased their hydrophilicity. Furthermore, the PCL/BG scaffolds showed apatite-forming ability (i.e., bioactivity behavior) after being immersed in simulated body fluid (SBF). The in vitro cellular examinations revealed the cytocompatibility of the scaffolds and confirmed them as suitable substrates for the adhesion and proliferation of MG-63 osteosarcoma cells. In conclusion, 3D printed composite scaffolds made of PCL and Sr- and Co-doped BGs might be potentially-beneficial bone replacements, and the achieved results motivate further research on these materials.

scholarly journals Additive Manufacturing of Biopolymers for Tissue Engineering and Regenerative Medicine: An Overview, Potential Applications, Advancements, and Trends

2021 ◽  
Vol 2021 ◽  
pp. 1-20 ◽  
Author(s):  
Dhinakaran Veeman ◽  
M. Swapna Sai ◽  
P. Sureshkumar ◽  
T. Jagadeesha ◽  
L. Natrayan ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Additive Manufacturing ◽  
3D Printing ◽  
Regenerative Medicine ◽  
Tissue Regeneration ◽  
Three Dimensional ◽  
Porous Scaffolds ◽  
Wide Range ◽  
Potential Applications ◽  
Pharmaceutical Industries

As a technique of producing fabric engineering scaffolds, three-dimensional (3D) printing has tremendous possibilities. 3D printing applications are restricted to a wide range of biomaterials in the field of regenerative medicine and tissue engineering. Due to their biocompatibility, bioactiveness, and biodegradability, biopolymers such as collagen, alginate, silk fibroin, chitosan, alginate, cellulose, and starch are used in a variety of fields, including the food, biomedical, regeneration, agriculture, packaging, and pharmaceutical industries. The benefits of producing 3D-printed scaffolds are many, including the capacity to produce complicated geometries, porosity, and multicell coculture and to take growth factors into account. In particular, the additional production of biopolymers offers new options to produce 3D structures and materials with specialised patterns and properties. In the realm of tissue engineering and regenerative medicine (TERM), important progress has been accomplished; now, several state-of-the-art techniques are used to produce porous scaffolds for organ or tissue regeneration to be suited for tissue technology. Natural biopolymeric materials are often better suited for designing and manufacturing healing equipment than temporary implants and tissue regeneration materials owing to its appropriate properties and biocompatibility. The review focuses on the additive manufacturing of biopolymers with significant changes, advancements, trends, and developments in regenerative medicine and tissue engineering with potential applications.

scholarly journals Layered 3D Printing by Tethered Pyro-Electrospinning

2020 ◽  
Vol 2020 ◽  
pp. 1-9 ◽  
Author(s):  
Sara Coppola ◽  
Giuseppe Nasti ◽  
Veronica Vespini ◽  
Pietro Ferraro
Keyword(s):  
3D Printing ◽  
Three Dimensional ◽  
Multiwall Carbon Nanotubes ◽  
Processing Parameters ◽  
Layer By Layer ◽  
Biocompatible Polymer ◽  
Intrinsic Factors ◽  
Electric Effect ◽  
Mild Temperature

Nowadays it is easy to imagine that the exploitation of different additive manufacturing approaches could find use in regenerative medicine and frontiers nanotechnology with a strong interest in the development of in vivo bio-incubators that better replicate the tissue environment. Various electrospinning technologies have been exploited for the fabrication of composite polymeric architectures, where fibers have been used for the construction layer by layer of micro-architectures. Unfortunately, in case of processing biomaterials, the intrinsic factors of the materials could become obstacles when considering such advanced engineering methods. Here, for the first time, we use the pyro-EHD process for the fabrication of layered three-dimensional architectures made using a biodegradable and biocompatible polymer. The proposed approach for layered 3D printing works at mild temperature allowing deposition at high resolution and great flexibility in manufacturing, avoiding high voltage generators, and nozzles. The layered 3D printing, activated by the pyro-electric effect, is discussed and characterized in terms of geometrical features and processing parameters. Different geometries and micro-architecture (wall, square, triangle, and hybrid structures) have been demonstrated and over printing of composite polymer, obtained by mixing multiwall carbon nanotubes and fluorochrome, has been discussed, focusing on the use of a biodegradable and biocompatible polymer.

Importance of 3D Printing Technology in Medical Fields

2019 ◽  
pp. 21-40
Author(s):  
Ranjit Barua ◽  
Sudipto Datta ◽  
Amit Roychowdhury ◽  
Pallab Datta
Keyword(s):  
Tissue Engineering ◽  
Additive Manufacturing ◽  
3D Printing ◽  
New Technology ◽  
Three Dimensional ◽  
Layer By Layer ◽  
Medical Field ◽  
Printing Technology ◽  
3D Printing Technology ◽  
Proper Material

Three-dimensional or 3D printing technology is a growing interest in medical fields like tissue engineering, dental, drug delivery, prosthetics, and implants. It is also known as the additive manufacturing (AM) process because the objects are done by extruding or depositing the material layer by layer, and the material may be like biomaterials, plastics, living cells, or powder ceramics. Specially in the medical field, this new technology has importance rewards in contrast with conventional technologies, such as the capability to fabricate patient-explicit difficult components, desire scaffolds for tissue engineering, and proper material consumption. In this chapter, different types of additive manufacturing (AM) techniques are described that are applied in the medical field, especially in community health and precision medicine.

3D Printing: Basic Concepts Mathematics and Technologies

2013 ◽  
Vol 2 (2) ◽  
pp. 58-71
Author(s):  
Alexander Rompas ◽  
Charalampos Tsirmpas ◽  
Ianos Papatheodorou ◽  
Georgia Koutsouri ◽  
Dimitris Koutsouris
Keyword(s):  
3D Printing ◽  
Three Dimensional ◽  
Real Life ◽  
Fused Deposition Modelling ◽  
Layer By Layer ◽  
Three Dimensional Objects ◽  
Stl File ◽  
Fused Deposition ◽  
3D Printers ◽  
Object Layer

3D printing is about being able to print any object layer by layer. But if one questions this proposition, can one find any three-dimensional objects that can't be printed layer by layer? To banish any disbeliefs the authors walked together through the mathematics that prove 3d printing is feasible for any real life object. 3d printers create three-dimensional objects by building them up layer by layer. The current generation of 3d printers typically requires input from a CAD program in the form of an STL file, which defines a shape by a list of triangle vertices. The vast majority of 3d printers use two techniques, FDM (Fused Deposition Modelling) and PBP (Powder Binder Printing). One advanced form of 3d printing that has been an area of increasing scientific interest the recent years is bioprinting. Cell printers utilizing techniques similar to FDM were developed for bioprinting. These printers give us the ability to place cells in positions that mimic their respective positions in organs. Finally, through a series of case studies the authors show that 3d printers have made a massive breakthrough in medicine lately.

scholarly journals Graphene Coated Scaffold for Bone Tissue Engineering: Physicochemical and Osteogenic Characterizations

2021 ◽  
Author(s):  
Sajad Bahrami ◽  
Nafiseh Baheiraei ◽  
Mostafa Shahrezaee
Keyword(s):  
Tissue Engineering ◽  
Bone Tissue ◽  
Three Dimensional ◽  
Chemical Properties ◽  
Cranial Bone ◽  
Drying Methods ◽  
Porous Scaffolds ◽  
Alizarin Red

Abstract Variety of bone-related diseases and injures and limitations of traditional regeneration methods need to introduce new tissue substitutes. Tissue engineering and regeneration combined with nanomedicine can provide different natural or synthetic and combined scaffolds with bone mimicking properties for implant in the injured area. In this study, we synthesized collagen (Col) and reduced graphene oxide coated collagen (Col-rGO) scaffolds and evaluated their in vitro and in vivo effects on bone tissue repair. Col and Col-rGO scaffolds were synthesized by chemical crosslinking and freeze-drying methods. The surface topography, mechanical and chemical properties of scaffolds were characterized and showed three-dimensional (3D) porous scaffolds and successful coating of rGO on Col. rGO coating enhanced mechanical strength of Col-rGO scaffolds compared with Col scaffolds by 2.8 folds. Furthermore, Col-rGO scaffolds confirmed that graphene addition not only did not any cytotoxic effects but also enhanced human bone marrow-derived mesenchymal stem cells (hBMSCs) viability and proliferation with 3D adherence and expansion. Finally, scaffolds implantation into rabbit cranial bone defect for 12 weeks showed increased bone formation, confirmed by Hematoxylin-Eosin (H&E) and alizarin red staining. Altogether, the study showed that rGO coating improves Col scaffold properties and could be a promising implant for bone injuries.

Importance of 3D Printing Technology in Medical Fields

2021 ◽  
pp. 704-717
Author(s):  
Ranjit Barua ◽  
Sudipto Datta ◽  
Amit Roychowdhury ◽  
Pallab Datta
Keyword(s):  
Tissue Engineering ◽  
Additive Manufacturing ◽  
3D Printing ◽  
New Technology ◽  
Three Dimensional ◽  
Layer By Layer ◽  
Medical Field ◽  
Printing Technology ◽  
3D Printing Technology ◽  
Proper Material

Three-dimensional or 3D printing technology is a growing interest in medical fields like tissue engineering, dental, drug delivery, prosthetics, and implants. It is also known as the additive manufacturing (AM) process because the objects are done by extruding or depositing the material layer by layer, and the material may be like biomaterials, plastics, living cells, or powder ceramics. Specially in the medical field, this new technology has importance rewards in contrast with conventional technologies, such as the capability to fabricate patient-explicit difficult components, desire scaffolds for tissue engineering, and proper material consumption. In this chapter, different types of additive manufacturing (AM) techniques are described that are applied in the medical field, especially in community health and precision medicine.

Where Is the Missing Matter?

3D Printing ◽  
2017 ◽  
pp. 145-152
Author(s):  
Tihomir Mitev
Keyword(s):  
Additive Manufacturing ◽  
3D Printing ◽  
Industrial Revolution ◽  
Raw Materials ◽  
New Technology ◽  
Three Dimensional ◽  
Material Object ◽  
Layer By Layer ◽  
Solid Objects ◽  
Thing In Itself

The additive manufacturing (or the popular 3D printing) is relatively new technology which opens new spaces for entrepreneurial imagination and promises next stage of the industrial revolution. It is creating three dimensional solid objects from a digital file. The printer transforms the file into a material object layer by layer, using different raw materials. Today, the additive manufacturing is successfully used in architecture, medicine and healthcare, light and heavy industries, education, etc. The paper analyses the roles of actors in manufacturing the objects. It starts with the Heideggerian questioning of technology (), searching for the causes of bringing into appearance of the 3D model. According to Heideggerian analysis the technology is represented as an ‘unveiling of the truth'. The paper suggests that the old understanding of matter as a thing-in-itself should be replaced by a new, flexible, fluid, concept of matter, which is more or less manipulable. The matter is no more an occasion for object's taking place. On the other hand, it seems 3D printing technology is reduced to mere means; a simple intermediary, a copier of ideas. From that perspective the paper questioning the problem of action in ANT and search how action and interaction is distributed and how actors constitutes themselves as well as their actor-world.

Where is the Missing Matter?

2015 ◽  
Vol 7 (1) ◽  
pp. 10-17 ◽  
Author(s):  
Tihomir Mitev
Keyword(s):  
Additive Manufacturing ◽  
3D Printing ◽  
Industrial Revolution ◽  
Raw Materials ◽  
New Technology ◽  
Three Dimensional ◽  
Material Object ◽  
Layer By Layer ◽  
Solid Objects ◽  
Thing In Itself

The additive manufacturing (or the popular 3D printing) is relatively new technology which opens new spaces for entrepreneurial imagination and promises next stage of the industrial revolution. It is creating three dimensional solid objects from a digital file. The printer transforms the file into a material object layer by layer, using different raw materials. Today, the additive manufacturing is successfully used in architecture, medicine and healthcare, light and heavy industries, education, etc. The paper analyses the roles of actors in manufacturing the objects. It starts with the Heideggerian questioning of technology (), searching for the causes of bringing into appearance of the 3D model. According to Heideggerian analysis the technology is represented as an ‘unveiling of the truth'. The paper suggests that the old understanding of matter as a thing-in-itself should be replaced by a new, flexible, fluid, concept of matter, which is more or less manipulable. The matter is no more an occasion for object's taking place. On the other hand, it seems 3D printing technology is reduced to mere means; a simple intermediary, a copier of ideas. From that perspective the paper questioning the problem of action in ANT and search how action and interaction is distributed and how actors constitutes themselves as well as their actor-world.

scholarly journals APPLICATIONS OF 3D PRINTING TECHNOLOGIES IN THE GARMENT INDUSTRY

2018 ◽  
Vol 16 (2) ◽  
pp. 104-107
Author(s):  
Veronica Verlan ◽  
Marcela Irovan
Keyword(s):  
Additive Manufacturing ◽  
3D Printing ◽  
Manufacturing Process ◽  
New Technology ◽  
Three Dimensional ◽  
Advanced Technology ◽  
Innovative Technologies ◽  
Three Dimensional Objects ◽  
Aesthetic Appearance ◽  
3D Printed

The usage of innovative technologies has become one of the most widespread ways of diversifying the current supply of clothing and footwear products. Therefore, using the 3D printing technologies in the garment production is a remarkable example of the symbiosis of creativity and technology, which creates unusual and fashionable clothing pieces. Although the 3D printing technology is a relatively new technology and allows creating unique garments it must not neglect important features of clothing products such as cost-accessibility, comfort and aesthetic appearance. The research on these aspects is prior to implement this technology in the manufacturing process. The study includes the analysis of the current 3D printing technologies which are used for obtaining three-dimensional objects, the current directions of implementing this technology in the industry, as well as the opportunities of applying this technology in the process of clothing’s creation. Therefore, this paper concludes the study with the creation of a clothing product – a blouse for women, which is including a 3D printed part confirming this way the possibility of creation of clothing products, which would integrate innovative elements which were obtained by implementing the advanced technology of additive manufacturing.

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