scholarly journals Hydroxyapatite and porphyrin-fullerene nanoparticles for diagnostic and therapeutic delivery of paramagnetic ions and radionuclides

2018 ◽  
pp. 86-93 ◽  
Author(s):  
M.A. Orlova ◽  
A.L. Nikolaev ◽  
T.P. Trofimova ◽  
A.P. Orlov ◽  
A.V. Severin ◽  
...  
Keyword(s):  
Enzymatic Synthesis ◽  
Therapeutic Potential ◽  
Leukemia Cells ◽  
Therapeutic Delivery ◽  
Fullerene Nanoparticles ◽  
Actual Use ◽  
The Subject ◽  
Paramagnetic Ions ◽  
Radiopharmaceutical Agents ◽  
Over Time

Nanoparticles for drug delivery are the subject of extensive research. Importantly, they can transform in size during synthesis or actual use, thereby changing their cytotoxic properties. The aim of the present work was to study the tendency of [67Zn] porphyrin-fullerene nanoparticles (BFNP) to aggregate over time and to compare the properties of hydroxyapatite (HAP) nanoparticles obtained through 3 different techniques. We found that aggregation of BFNP nanoparticles does not affect their function but attenuates their cytotoxicity against leukemia cells. We were also able to obtain HAP nanoparticles with programmable properties (such as size, shape or the capacity to adsorb metal ions, ligands and chemical complexes) through enzymatic synthesis by varying its conditions. The synthesized HAP nanoparticles contain short-lived isotopes of zinc and copper (in the form of ions and complexes with pyrimidine or thiazine derivatives). These tumoricidal components (a radionuclide and a ligand or a complex) determine the diagnostic and therapeutic potential of the obtained radiopharmaceutical agents.

Without the Power to Drink or Contract

2020 ◽  
Vol 24 (1) ◽  
pp. 26-48
Author(s):  
Warren Swain
Keyword(s):  
Alcohol Consumption ◽  
Social Activity ◽  
Individual Responsibility ◽  
Roman Law ◽  
Current Position ◽  
Modern Times ◽  
The Will ◽  
The Subject ◽  
The Law ◽  
Over Time

Intoxication as a ground to set aside a contract is not something that has proved to be easy for the law to regulate. This is perhaps not very surprising. Intoxication is a temporary condition of varying degrees of magnitude. Its presence does however raise questions of contractual autonomy and individual responsibility. Alcohol consumption is a common social activity and perceptions of intoxication and especially alcoholism have changed over time. Roman law is surprisingly quiet on the subject. In modern times the rules about intoxicated contracting in Scottish and English law is very similar. Rather more interestingly the law in these two jurisdictions has reached the current position in slightly different ways. This history can be traced through English Equity, the works of the Scottish Institutional writers, the rise of the Will Theory, and all leavened with a dose of judicial pragmatism.

STORYTELLING AND MEANING RECONSTRUCTION: A METAPHORICAL PERSPECTIVE

2016 ◽  
Vol 24 (2) ◽  
pp. 159-169
Author(s):  
M L Mojapelo
Keyword(s):  
Personal Development ◽  
Real Life ◽  
Human Existence ◽  
Meaning Reconstruction ◽  
Changing Patterns ◽  
The Subject ◽  
Changes Over Time ◽  
Over Time

Storytelling consists of an interaction between a narrator and a listener, both of whom assign meaning to the story as a whole and its component parts. The meaning assigned to the narrative changes over time under the influence of the recipient‟s changing precepts and perceptions which seem to be simplistic in infancy and more nuanced with age. It becomes more philosophical in that themes touching on the more profound questions of human existence tend to become more prominently discernible as the subject moves into the more reflective or summative phases of his or her existence. The aim of this article is to demonstrate the metaphorical character of a story, as reflected in changing patterns of meaning assigned to the narrative in the course of the subjective receiver‟s passage through the various stages of life. This was done by analysing meaning, from a particular storytelling session, at different stages of a listener‟s personal development. Meaning starts as literal and evolves through re-interpretation to abstract and deeper levels towards application in real life.

Imagining Sonic Stories

2019 ◽  
pp. 441-457
Author(s):  
Vincent Meelberg
Keyword(s):  
Temporal Development ◽  
Sound Collage ◽  
The Subject ◽  
Over Time

Sonic narratives are the subject of Vincent Meelberg’s chapter, in which he discusses the capacity of sound not only to trigger narratives but also to tell stories that unfold over time. Meelberg uses his own sound collage work as an example of how narratives can be created through a sequence of sounds. He argues that sonic narratives emerge when the sequence of sounds represents a temporal development. Examples are provided that show how this temporal development emerges from either the referential qualities (hearing a succession of concrete events) or the acoustic qualities (e.g., the succession of tension and release) of the sound.

scholarly journals Using Cartographies to Map Time and Space in Teacher Learning in and Outside School

2021 ◽  
Vol 20 ◽  
pp. 160940692199290
Author(s):  
Paulo Padilla-Petry ◽  
Fernando Hernández-Hernández ◽  
Joan-Anton Sánchez-Valero
Keyword(s):  
Secondary School ◽  
Teacher Learning ◽  
Secondary School Teachers ◽  
Leisure Activities ◽  
Visual Methods ◽  
School Teachers ◽  
Video Recordings ◽  
The Subject ◽  
Pedagogical Relations ◽  
Over Time

This article explores the relations between teachers’ visual cartographies and oral narratives to better understand the spatial and temporal relations on teacher learning. It builds on a research project whose main questions were: 1) How and where do secondary school teachers learn to teach? 2) What are the consequences of this learning in their pedagogical relations and their students’ learning processes and results? Since narrative research has been a common way of approaching the subject and have led to an emphasis on learning as a journey across contexts and over time, some of its contributions to explore teachers’ learning paths are theoretically discussed, and visual methods, particularly cartographies, are also examined. Furthermore, the article presents the analysis of cartographies and video recordings of 29 secondary school teachers focusing on the interactions in different spaces and moments in time described by them. Findings suggest that learning to be a teacher may happen in interactions with objects, people and spaces beyond the boundaries of school, university and formal places of training and learning. They also show that the rhizomatic character of the cartographies may not prevent teleological thinking or the idea that any kind of learning is purposeful. Finally, this paper concludes that teachers’ learning does not fit the representational frame that distinguishes between formal contents and leisure activities, classrooms and private spaces, lessons and bodies, emotions and knowledge.

scholarly journals Influence of Hydrogeochemistry on Tunnel Drainage in Evaporitic Formations: El Regajal Tunnel Case Study (Aranjuez, Spain)

2021 ◽  
Vol 13 (3) ◽  
pp. 1505
Author(s):  
Ignacio Menéndez Pidal ◽  
Jose Antonio Mancebo Piqueras ◽  
Eugenio Sanz Pérez ◽  
Clemente Sáenz Sanz
Keyword(s):  
High Speed ◽  
Civil Engineering ◽  
Saturation Index ◽  
The Subject ◽  
Under Construction ◽  
Underground Flow ◽  
Very High ◽  
Over Time

Many of the large number of underground works constructed or under construction in recent years are in unfavorable terrains facing unusual situations and construction conditions. This is the case of the subject under study in this paper: a tunnel excavated in evaporitic rocks that experienced significant karstification problems very quickly over time. As a result of this situation, the causes that may underlie this rapid karstification are investigated and a novel methodology is presented in civil engineering where the use of saturation indices for the different mineral specimens present has been crucial. The drainage of the rock massif of El Regajal (Madrid-Toledo, Spain, in the Madrid-Valencia high-speed train line) was studied and permitted the in-situ study of the hydrogeochemical evolution of water flow in the Miocene evaporitic materials of the Tajo Basin as a full-scale testing laboratory, that are conforms as a whole, a single aquifer. The work provides a novel methodology based on the calculation of activities through the hydrogeochemical study of water samples in different piezometers, estimating the saturation index of different saline materials and the dissolution capacity of the brine, which is surprisingly very high despite the high electrical conductivity. The circulating brine appears unsaturated with respect to thenardite, mirabilite, epsomite, glauberite, and halite. The alteration of the underground flow and the consequent renewal of the water of the aquifer by the infiltration water of rain and irrigation is the cause of the hydrogeochemical imbalance and the modification of the characteristics of the massif. These modifications include very important loss of material by dissolution, altering the resistance of the terrain and the increase of the porosity. Simultaneously, different expansive and recrystallization processes that decrease the porosity of the massif were identified in the present work. The hydrogeochemical study allows the evolution of these phenomena to be followed over time, and this, in turn, may facilitate the implementation of preventive works in civil engineering.

On the Demonstration of Formulæ connected with Interest and Annuities

1854 ◽  
Vol 4 (4) ◽  
pp. 277-282
Author(s):  
De Morgan
Keyword(s):  
Actual Use ◽  
The Subject ◽  
Life Annuities

In most branches of mathematics, the actual use of fundamental processes in the form which the first definitions suggest, is often supplanted, either by processes of greater skill, or by the use of pure reasoning. In the subject of which this paper treats, there has not been much attempt to connect formulæ by reasoning. The actual exhibition of successive annual results has been the only method extensively employed; and it throws the required total result into a series of terms: this series is either algebraically summed, or calculated term by term for insertion in a table.The present paper is intended to show that this summation of algebraical series may be dispensed with, at least in questions of annuities certain : and also that common points of principle, which the ordinary methods leave altogether out of sight, will reduce many questions of life annuities to an absolute coincidence of form with the corresponding questions of ordinary annuities.

The Genesis and Development of the Maqāṣid al-Qur’ān

2013 ◽  
Vol 30 (3) ◽  
pp. 39-58
Author(s):  
Tazu Islam
Keyword(s):  
Compact Form ◽  
Television Programs ◽  
The Public ◽  
The Status ◽  
The Subject ◽  
Scholarly Discussion ◽  
Over Time ◽  
Academic Debate

Maqāṣid al-Qur’ān is an emerging science that promotes an understanding of the Qur’anic discourse’s purposive (maqasidic) angle. Beginning with preliminary ideas in the fifth Islamic century, it has now achieved the status, in the eyes of many prominent contemporary Muslims, of being a specific science. Having been the subject of scholarly discussion in articles, books, television programs, seminars and conferences, this subject has created a new academic debate in the very contemporary field of Qur’anic studies. This study explores its genesis and conceptual developments over time by analyzing the root of this science as well as how it has fared at the hands of early and modern scholarship of the Qur’an. Its findings are expected to contribute to presenting this field to the public in a compact form.

The Fall of Balmaceda and Public Finance in Chile: New Data for an Old Debate

1982 ◽  
Vol 24 (4) ◽  
pp. 421-460 ◽  
Author(s):  
John R. Bowman ◽  
Michael Wallerstein
Keyword(s):  
Public Finance ◽  
Economic Development ◽  
Latin America ◽  
Discrete Event ◽  
Political Stability ◽  
Parliamentary System ◽  
Presidential System ◽  
The Subject ◽  
New Generation ◽  
Over Time

The 1891 civil war that led to the downfall of President José Manuel Balmaceda is without doubt one of the most visible episodes of Chilean history. Already the subject of a voluminous bibliography by 1894 (Echeverría y Reyes, 1894), the “revolution's” importance to historians of Chile actually increased over time as a new generation of scholars came to view it not merely as a discrete event of limited intrinsic interest but as an important key to understanding Chile's subsequent political and economic development. In retrospect, the conflict came to be seen as a “crucial watershed” in Chilean history (Blakemore, 1974: 243), marking the replacement of a presidential system—1833-1891—notable in nineteenth-century Latin America for political stability, by a parliamentary system—1891-1924—notorious for political and monetary disorder.

scholarly journals Application of transparent microperforated panel to acrylic partitions for desktop use: A case study by prototyping

2021 ◽  
Author(s):  
Kimihiro Sakagami ◽  
Midori Kusaka ◽  
Takeshi Okuzono ◽  
Shigeyuki Kido ◽  
Daichi Yamaguchi
Keyword(s):  
Adverse Effect ◽  
Sound Absorption ◽  
Acoustic Environment ◽  
Actual Use ◽  
Acrylic Sheet ◽  
Absorption Performance ◽  
The Subject ◽  
Droplet Penetration ◽  
Absorption Characteristics

There are various measures currently in place to prevent the spread of COVID-19; however, in some cases, these can have an adverse effect on the acoustic environment in buildings. For example, transparent acrylic partitions are often used in eating establishments, meeting rooms, offices, etc., to prevent droplet infection. However, acrylic partitions are acoustically reflective; therefore, reflected sounds may cause acoustic problems such as difficulties in conversation or the leakage of conversation. In this study, we performed a prototyping of transparent acrylic partitions to which a microperforated panel (MPP) was applied for sound absorption while maintaining transparency. The proposed partition is a triple-leaf acrylic partition with a single acrylic sheet without holes between two MPP sheets, as including a hole-free panel is important to a possible droplet penetration. The sound absorption characteristics were investigated by measuring the sound absorption in a reverberation room. As the original prototype showed sound absorption characteristics with a gentle peak and low values due to the openings on the periphery, it was modified by closing the openings of the top and sides. The sound absorption performance was improved to some extent when the top and sides were closed, although there remains the possibility of further improvement. This time, only the sound absorption characteristics were examined in the prototype experiments. The effects during actual use will be the subject of future study.

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