<p>Korelasi usia kronologis dengan densitas tulang mandibula pada radiograf panoramik pada pasien perempuan usia 5-35 tahun</p><p>Corellation between chronological age with mandibular bone density on panoramic radiographs of female patients aged 5-35 years</p>

Pendahuluan: Tingkat perkembangan dan maturasi seorang pasien tidak dapat diketahui secara pasti dari usia kronologis, dikarenakan adanya variasi waktu percepatan pertumbuhan pubertas pada setiap individu, maka perlu ditentukan usia biologisnya. Usia biologis ini dapat ditentukan dari usia tulang berupa kualitas tulang yang dapat dilihat dari ukuran densitas tulang. Radiograf panoramik dapat menilai kualitas kepadatan (densitas) tulang secara makrostruktur dan mikrostruktur. Penelitian ini menggunakan sampel perempuan karena perempuan cenderung kehilangan densitas mineral tulang lebih cepat daripada laki-laki. Tujuan penelitian ini yaitu menganalisis korelasi usia kronologis dengan densitas tulang pada radiograf panoramik pada pasien perempuan. Metode: Jenis penelitian ini adalah cross-sectional, dengan menggunakan analisis korelasi. Populasi penelitian menggunakan data primer dari seluruh radiograf panoramik pasien perempuan usia 5-35 tahun pada bulan Desember 2016-Januari 2017 di Rumah Sakit Gigi dan Mulut (RSGM) Universitas Padjadjaran dengan jumlah sampel 64 orang. Analisis densitas tulang trabekula mandibula dilakukan dengan menggunakan software ImageJ dengan Region of Interest (ROI) 4x4mm pada tepi distal foramen mentale mandibula. Hasil: Rerata ukuran densitas tulang trabekula pada kelompok usia 5-11 tahun 17,54%, kelompok usia 12-16 tahun 21,06%, kelompok usia 18-25 tahun 24,01%, dan kelompok usia 26-35 tahun 25,96% dengan hasil korelasi Pearson r = 0,827, dan nilai p=0,0001. Simpulan: Terdapat korelasi antara usia kronologis dengan nilai densitas tulang trabekula pada radiograf panoramik pasien perempuan, yaitu semakin bertambahnya usia kronologis maka nilai densitas tulang juga akan semakin meningkat sesuai dengan rentang usia penelitian 5-35 tahun.Kata kunci: Usia kronologis, densitas tulang, radiograf panoramik, software imageJ. ABSTRACTIntroduction: The level of development and maturation of a patient can not be known with certainty from chronological age, due to variations in the time of pubertal growth spurt in each individual, it is necessary to determine the biological age. This biological age can be determined from bone age in bone quality, which can be seen from the bone density measurement. Panoramic radiographs can assess the quality of bone density macrostructure and microstructure. This study used a female sample because female tend to lose bone mineral density faster than male. This study was aimed to analyse the correlation between chronological age and bone density on female patients’ panoramic radiographs. Methods: This research was cross-sectional with correlation analysis. The study population used was the primary data from all panoramic radiographs of female patients aged 5-35 years in December 2016-January 2017 at Universitas Padjadjaran Dental Hospital (RSGM Unpad) with a total sample of 64 people. Mandibular trabecular bone density analysis was performed using ImageJ software with a 4x4mm Region of Interest (ROI) on the mandibular mental foramen’s distal edge. Results: The mean size of trabecular bone density in the 5-11 years age group was 17.54%, the 12-16 years age group was 21.06%, the 18-25 year age group was 24.01%, and the 26-35 years age group was 25.96%; with the results of Pearson correlation r=0.827, and the p-value = 0.0001. Conclusion: There is a correlation between chronological age and the value of trabecular bone density on the panoramic radiograph of female patients, that is, the increasing of chronological age will also increase the value of bone density, according to the age range of the study (5-35 years).Keywords: Chronological age, bone density, panoramic radiographs, image-J software.

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THE DIFFERENCES OF CHRONOLOGICAL AGE WITH DENTAL AGE BASED ON THE ALQAHTANI METHODE AGED 6-12 YEARS

10.54052/jhds.v1n1.p60-70 ◽

2021 ◽

Vol 1 (Volume 1 No 1) ◽

pp. 60-70

Author(s):

Mutiara Sukma Suntana ◽

Ira Artilia ◽

Lucy Pertiwi

Keyword(s):

Wilcoxon Test ◽

Chronological Age ◽

Sufficient Information ◽

Dental Age ◽

Research Subjects ◽

Cross Sectional ◽

Panoramic Radiographs ◽

Female Patients ◽

Significant Difference ◽

Male Patients

The chronological age of a person can not provide sufficient information. We can use the dental age in panoramic radiographs to know the growth process appropriately compared to The London Atlas of the Alqahtani method. Children aged 6-12 years have various factors that can affect the velocity in tooth growth and development, such as male and female. This study aims to determine the chronological patient's age differences with dental age based on the Alqahtani method on a panoramic radiograph at Unjani Dental and Oral Education Hospital. This type of research is Analytical Observational with the Cross-Sectional Study method. Research subjects were obtained from all medical records panoramic radiographs with 72 panoramic radiographs aged 6-12 years, divided into 36 male patients and 36 female patients. Differences in chronological age with dental age were analyzed statistically using the Mann-Whitney test and Wilcoxon test, previously tested for the normality using Kolmogorov- Smirnov. The results showed a significant difference between chronological age and dental age by gender and in all patients at the Unjani Dental and Oral Education Hospital (p<0,05). Based on the analysis of the data obtained, all patients in RSGMP Unjani aged 6-12 years have different dental developmental growth processes, and the dental development growth of female patients was faster than male patients. It can be concluded that the dental age is not always comparable with chronological age because of various factors such as gender, genetics and environment, which can affect the dental age.

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Genetic analysis of vertebral trabecular bone density and cross-sectional area in older men

Osteoporosis International ◽

10.1007/s00198-010-1296-0 ◽

2010 ◽

Vol 22 (4) ◽

pp. 1079-1090 ◽

Cited By ~ 19

Author(s):

J. M. Zmuda ◽

◽

L. M. Yerges-Armstrong ◽

S. P. Moffett ◽

L. Klei ◽

...

Keyword(s):

Bone Density ◽

Genetic Analysis ◽

Trabecular Bone ◽

Older Men ◽

Cross Sectional Area ◽

Sectional Area ◽

Trabecular Bone Density ◽

Cross Sectional ◽

Vertebral Trabecular Bone

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COMPARISION OF DENTAL SCORING SYSTEM WITH RADIOGRAPHIC SKELETAL SYSTEM IN AGE ESTIMATION

JKCD ◽

10.33279/2307-3934.2019.9103 ◽

2019 ◽

Vol 9 (1) ◽

pp. 9-11

Author(s):

Sadaf Ambreen

Keyword(s):

Age Estimation ◽

Scoring System ◽

Skeletal Age ◽

Chronological Age ◽

Age Group ◽

Dental Age ◽

Scoring Method ◽

Cross Sectional ◽

Study Results ◽

Male Subjects

Objectives: To compare Demirjian Dental scoring method with Greulich-Pyle (GP) Skeletal method of age estimation in pubertal children. Materials and Methods: Sample of the study included 267 male healthy subjects of 11-16 years of age group.. Demirjian Scoring system was utilized to evaluate the orthopantomograms to assess their Dental age and the Hand-Wrist radiographs were analyzed to calculate the skeletal age by utilizing GP atlas. Chronological age was obtained from the date of birth of the subject .Both methods were compared with one another and with the chronological age. It was a cross-sectional study and only healthy male subjects without any clinical abnormalities were included in the study. Results: A total of 267 male subjects of 11-16 years of age group were assessed by Demirjian and Greulich Pyle Methods. Both were compared with Chronological Age. Data obtained was statistically analyzed and the Student “t” test was applied in the study population. The mean difference between Chronolgical age and dental age was 0.69years and that of chronological age and skeletal age was 0.87 years. It was observed from dental age assessment that it does not differ much from the skeletal age. Conclusion: It was concluded that Demirjian method of Age Estimation is more precise than Greulich Pyle method of Age Estimation. Furthermore both methods can be used selectively in Medicolegal cases to access bone age which can be easily correlated to chronological age.

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Cessation of ambulation results in a dramatic loss of trabecular bone density in boys with Duchenne muscular dystrophy

Bone Abstracts ◽

10.1530/boneabs.2.p134 ◽

2013 ◽

Author(s):

Crabtree Nicola ◽

Bebbington Natalie ◽

Roper Helen ◽

McMurchie Heather ◽

Shaw Nicholas

Keyword(s):

Duchenne Muscular Dystrophy ◽

Muscular Dystrophy ◽

Bone Density ◽

Trabecular Bone ◽

Trabecular Bone Density

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OSTEOPOROSIS AND RISK FACTORS IN THE PATIENTS ON CHRONIC HEMODIALYSIS

Journal of Medicine and Pharmacy ◽

10.34071/jmp.2014.6.7 ◽

2015 ◽

pp. 50-58

Author(s):

Thi Dung Nguyen ◽

Tam Vo

Keyword(s):

Quality Of Life ◽

Risk Factors ◽

Bone Density ◽

Region Of Interest ◽

Cross Sectional Study ◽

Chronic Hemodialysis ◽

Cross Sectional ◽

X Ray ◽

Density Reduction

Background: The patients on hemodialysis have a significantly decreased quality of life. One of many problems which reduce the quality of life and increase the mortality in these patients is osteoporosis and osteoporosis associated fractures. Objectives: To assess the bone density of those on hemodialysis by dual energy X ray absorptiometry and to examine the risk factors of bone density reduction in these patients. Patients and Method: This is a cross-sectional study, including 93 patients on chronic hemodialysis at the department of Hemodialysis at Cho Ray Hospital. Results: Mean bone densities at the region of interest (ROI) neck, trochanter, Ward triangle, intertrochanter and total neck are 0.603 ± 0.105; 0.583 ± 0.121; 0.811 ± 0.166; 0.489 ± 0.146; 0.723 ± 0.138 g/cm2 respectively. The prevalences of osteoporosis at those ROI are 39.8%, 15.1%; 28%; 38.7%; and 26.9% respectively. The prevalences of osteopenia at those ROI are 54.8%; 46.3%; 60.2%; 45.2% and 62.7% respectively. The prevalence of osteopososis in at least one ROI is 52.7% and the prevalence of osteopenia in at least one ROI is 47.3%. There are relations between the bone density at the neck and the gender of the patient and the albuminemia. Bone density at the trochanter is influenced by gender, albuminemia, calcemia and phosphoremia. Bone density at the intertrochanter is affected by the gender. Bone density at the Ward triangle is influenced by age and albuminemia. Total neck bone density is influenced by gender, albuminemia and phosphoremia. Conclusion: Osteoporosis in patients on chronic hemodialysis is an issue that requires our attention. There are many interventionable risk factors of bone density decrease in these patients. Key words: Osteoporosis, DEXA, chronic renal failure, chronic hemodialysis

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Faculty Opinions recommendation of Whole-exome sequencing reveals a heterozygous LRP5 mutation in a 6-year-old boy with vertebral compression fractures and low trabecular bone density.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.718048076.793481338 ◽

2013 ◽

Author(s):

Wim van Hul

Keyword(s):

Bone Density ◽

Trabecular Bone ◽

Exome Sequencing ◽

Whole Exome Sequencing ◽

Vertebral Compression Fractures ◽

Trabecular Bone Density ◽

Compression Fractures ◽

Whole Exome

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The effect of deer antler from East Kalimantan to increase trabecular bone density and calcium levels in serum on osteoporotic mice

Journal of Basic and Clinical Physiology and Pharmacology ◽

10.1515/jbcpp-2020-0140 ◽

2021 ◽

Vol 0 (0) ◽

Author(s):

Retno Widyowati ◽

Suciati Suciati ◽

Dewi Melani Haryadi ◽

Hsin-I Chang ◽

IPG Ngurah Suryawan ◽

...

Keyword(s):

Bone Density ◽

Trabecular Bone ◽

Aqueous Extract ◽

Dependent Manner ◽

Aqueous Extracts ◽

Trabecular Bone Density ◽

Male Mice ◽

Deer Antler ◽

East Kalimantan ◽

Dose Dependent

Abstract Objectives Glucocorticoid-induced osteoporosis (dexamethasone) is a primary cause of secondary osteoporosis by the decreasing formation and increasing resorption activities. Previously, the in vitro study showed that 70% ethanol and aqueous extract of deer antler have increased alkaline phosphatase in osteoblast cell that known as marker of bone formation. The mind of this study is to analyze the effect of deer antlers in increasing the bone trabecular density of osteoporosis-induced male mice. Methods This study used a post-test control group design. A total of 54 healthy male mice were randomly divided to nine groups, i.e., healthy control, osteoporotic, positive control, 70% ethanol (4, 8, and 12 mg/kg BW), and aqueous extracts (4, 8, and 12 mg/kg BW) of deer antler groups. All of the interventions were given 1 mL of test sample for 4 weeks orally. The bone densities were determined using histomorphometry by Image J and Adobe Photoshop. The statistical data were performed using SPSS 23 and statistical significance was set at p<0.05. Results The results showed that alendronate group, 70% ethanol, and aqueous extract groups increased bone density and calcium levels in serum (p<0.05) compared to osteoporotic group in dose dependent manner. It indicated that 70% ethanol and aqueous extract of deer antler stimulating bone turnover and aqueous extract showed the highest. Conclusions Dexamethasone induction for 4 weeks caused osteoporotic mice and the administration of 70% ethanol and aqueous extracts of deer antler from East Kalimantan increased trabecular bone density and calcium levels in dose dependent manner.

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POS1092 SUBCHONDRAL BONE NORMALIZATION AFTER KNEE JOINT DISTRACTION TREATMENT AS MEASURED WITH CT

Annals of the Rheumatic Diseases ◽

10.1136/annrheumdis-2021-eular.1329 ◽

2021 ◽

Vol 80 (Suppl 1) ◽

pp. 825.2-826

Author(s):

M. Jansen ◽

A. Ooms ◽

T. D. Turmezei ◽

J. W. Mackay ◽

S. Mastbergen ◽

...

Keyword(s):

Bone Density ◽

Trabecular Bone ◽

Cortical Bone ◽

Subchondral Bone ◽

Trabecular Bone Density ◽

Bone Thickness ◽

Cortical Bone Thickness ◽

Bone Changes ◽

One Year ◽

Shape Changes

Background:In addition to cartilage degeneration, knee osteoarthritis (OA) causes bone changes, including cortical bone thickening, subchondral bone density decrease, and bone shape changes as a result of widening and flattening condyles and osteophyte formation. Knee joint distraction (KJD) is a joint-preserving treatment for younger (<65 years) knee OA patients that has been shown to reverse OA cartilage degradation. On radiographs, KJD showed a decrease in subchondral bone density and an increase in osteophyte formation. However, these bone changes have never been evaluated with a 3D imaging technique.Objectives:To evaluate cortical bone thickness, subchondral trabecular bone density, and bone shape on CT scans before and one year after KJD treatment.Methods:19 KJD patients were included in an extended imaging protocol, undergoing a CT scan before and one year after treatment. Stradview v6.0 was used for semi-automatic tibia and femur segmentation from axial thin-slice (0.45mm) CT scans. Cortical bone thickness (mm) and trabecular bone density (Hounsfield units, HU) were measured with an automated algorithm. Osteophytes were excluded. Afterwards, wxRegSurf v18 was used for surface registration. Registration data was used for bone shape measurements. MATLAB R2020a and the SurfStat MATLAB package were used for data analysis and visualization. Two-tailed F-tests were used to calculate changes over time. Two separate linear regression models were used to show the influence of baseline Kellgren-Lawrence grade and sex on the changes over time. Statistical significance was calculated with statistical parametric mapping; a p-value <0.05 was considered statistically significant. Bone shape changes were explored visually using vertex by vertex displacements between baseline and follow-up. Patients were separated into two groups based on whether their most affected compartment (MAC) was medial or lateral. Only patients with axial CT scans at both time points available for analysis were included for evaluation.Results:3 Patients did not have complete CTs and in 1 patient the imaged femur was too short, leaving 16 patients for tibial analyses and 15 patients for femoral analyses. The MAC was predominantly the medial side (medial MAC n=14; lateral n=2). Before treatment, the MAC cortical bone was compared to the rest of the joint (Figure 1). One year after treatment, MAC cortical thickness decreased, although this decrease of up to approximately 0.25 mm was not statistically significant. The trabecular bone density was also higher before treatment in the MAC, and a decrease was seen throughout the entire joint, although statistically significant only for small areas on mostly the MAC where this decrease was up to approximately 80 HU (Figure 1). Female patients and patients with a higher Kellgren-Lawrence grade showed a somewhat larger decrease in cortical bone thickness. Trabecular density decreased less for patients with a higher Kellgren-Lawrence grade, and female patients showed a higher density decrease interiorly while male patients showed a higher decrease exteriorly. None of this was statistically significant. The central areas of both compartments showed an outward shape change, while the outer ring showed inward changes.Conclusion:MAC cortical bone thickness shows a partial decrease after KJD. Trabecular bone density decreased on both sides of the joint, likely as a direct result of the bicompartmental unloading. For both subchondral bone parameters, MAC values became more similar to the LAC, indicating (partial) subchondral bone normalization in the most affected parts of the joint. The bone shape changes may indicate a reversal of typical OA changes, although the inward difference that was seen on the outer edges may be a result of osteophyte-related changes that might have affected the bone segmentation. In conclusion, KJD treatment shows subchondral bone normalization in the first year after treatment, and longer follow-up might show whether these changes are a temporary result of joint unloading or indicate more prolonged bone changes.Disclosure of Interests:None declared.

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