scholarly journals Xerostomia appearance in type 1 diabetes mellitus children in RSUPN dr. Cipto Mangunkusumo Jakarta

2011 ◽  
Vol 23 (1) ◽  
Author(s):  
Adis Tyaning Puspitasari ◽  
Rosiliwati Wihardja ◽  
Jakobus Runkat
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Flow Rate ◽  
Salivary Flow ◽  
Diabetes Mellitus Type 1 ◽  
Salivary Flow Rate ◽  
Metabolic Disturbances ◽  
Oral Dryness

Diabetes mellitus is a chronic metabolic disease characterized by hyperglycemia due to insulin deficiency. As a result, there will be metabolic disturbances on carbohydrate, fat, and protein. Diabetes mellitus type 1 may occur because of pancreatic B cells damage resulting in decreased secretion of insulin in absolute terms. Xerostomia is the medical term for the subjective complaint of dry mouth due to the lack of saliva and can occur in patients with type 1 diabetes mellitus. The purpose of this study was to obtain data on the salivary flow rate and oral dryness complaints in children with type 1 diabetes mellitus The method of this study was descriptive by survey technique. The sample was obtained by purposive sampling and consisted of 30 children with type 1 diabetes mellitus in RSUPN Dr. Cipto Mangunkusumo Jakarta in April to May 2010. The study was conducted with an objective examination by measuring the salivary flow rate and subjective examination using a questionnaire. The results showed that the salivary flow rate from an average of 30 respondents was below normal values. The most common complaints about the dryness of the mouth cavity were thirst, 24 patients (80.00%), and oral dryness 19 patients (63.33%). The conclusion from this study showed that children with type 1 diabetes mellitus were having oral dryness complaints and the decrease of salivary flow rate.

Salivary flow rate, buffer capacity, and urea concentration in adolescents with type 1 diabetes mellitus

2016 ◽  
Vol 29 (12) ◽  
Author(s):  
Ivana Maria Saes Busato ◽  
Carlos Cesar De Antoni ◽  
Thiago Calcagnotto ◽  
Sérgio Aparecido Ignácio ◽  
Luciana Reis Azevedo-Alanis
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Flow Rate ◽  
Buffer Capacity ◽  
Salivary Flow ◽  
Urea Concentration ◽  
Type 1 Dm ◽  
Salivary Concentration

Abstract Background: The objective of the study was to analyze salivary flow rate, urea concentration, and buffer capacity in adolescents with type 1 diabetes mellitus (type 1 DM) in two different stages. Methods: This study was performed on adolescents (14–19 years), allocated between two groups: type 1 DM group comprised 32 adolescents with type 1 DM, and non-type 1 DM group comprised 32 nondiabetics. The adolescents in type 1 DM group were evaluated at a baseline (T0) and after 15 months (T1), and those in non-type 1 DM group were only evaluated at T0. Diabetic status was determined by glycosylated hemoglobin (GHb) and capillary glucose tests. Measurement of salivary flow was performed by means of stimulated saliva (SSFR) collection. The buffer capacity (BC) was determined, and analysis of urea salivary concentration was performed using the colorimetric method. Results: At T0, there were significant differences between diabetics and nondiabetics for SSFR and BC (p<0.05). In diabetics, SSFR was 0.790 mL/min in T0 and 0.881 mL/min in T1 (p>0.05). BC at T0 was 4.8, and at T1, it was 3.9 (p=0.000). Urea concentration mean value had a significant decrease at T1 (28.13) compared with T0 (34.88) (p=0.013). There was a negative correlation between SSFR and urea salivary concentration at both T0 (r=−0.426, p≤0.05) and T1 (r=−0.601, p≤0.01). Conclusions: In adolescents with type 1 DM, hyposalivation at T0 was associated with an increase in urea salivary concentration. At T1, hyposalivation was associated with a reduction in BC, and an increase in salivary urea.

scholarly journals The Influence of Type 1 Diabetes Mellitus on Dental Caries and Salivary Composition

2018 ◽  
Vol 2018 ◽  
pp. 1-7 ◽  
Author(s):  
Lulëjeta Ferizi ◽  
Fatmir Dragidella ◽  
Lidvana Spahiu ◽  
Agim Begzati ◽  
Vjosa Kotori
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Oral Health ◽  
Dental Caries ◽  
Type 1 Diabetes Mellitus ◽  
Flow Rate ◽  
Buffer Capacity ◽  
Salivary Flow ◽  
Control Group

Diabetes mellitus is the most common chronic disease that affects the oral health. The aim of the study is to evaluate the dental caries, salivary flow rate, buffer capacity, and Lactobacilli in saliva in children with type 1 diabetes mellitus compared to the control group.Methods.The sample consisted of 160 children of 10 to 15 years divided into two groups: 80 children with type 1 diabetes mellitus and 80 children as a control group. Dental caries was assessed using the DMFT index for permanent dentition. Stimulated saliva was collected among all children. Salivary flow rate and buffer capacity were measured, and the colonies ofLactobacillusin saliva were determined. The observed children have answered a number of questions related to their dental visits and parents’ education. The data obtained from each group were compared statistically using the chi-square test and Mann–WhitneyU-test. The significant level was set atp<0.05.Results. DMFT in children with type 1 diabetes was significantly higher than that in the control group (p<0.001). Diabetic children have a low level of stimulated salivary flow rate compared to control children (0.86 ± 0.16 and 1.10 ± 0.14). The buffer capacity showed statistically significant differences between children with type 1 diabetes and control group (p<0.001). Also, children with type 1 diabetes had a higher count and a higher risk ofLactobacilluscompared to the control group (p<0.05andp<0.001).Conclusion. The findings we obtained showed that type 1 diabetes mellitus has an important part in children’s oral health. It appears that children with type 1 diabetes are exposed to a higher risk for caries and oral health than nondiabetic children.

Metabolomic profiling of acute diabetes complications in children with type 1 diabetes mellitus

2020 ◽  
Vol 7 ◽  
pp. 1-9
Author(s):  
Beata Małachowska ◽  
Wojciech Fendler
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Statistical Analysis ◽  
Decision Tree ◽  
Type 1 Diabetes Mellitus ◽  
Acute Type ◽  
Metabolic Disturbances ◽  
Negative Ionization ◽  
Group Comparisons

Acute type 1 diabetes mellitus (T1DM) complications – diabetes ketoacidosis (DKA) and hypoglycemia (HG) – are dangerous not only as a threat to patients’ life but also because of their long-term sequelae. Aim: Evaluation of serum metabolic changes caused by episode of DKA and HG, that can be detected despite restoring parameters typically changed during the episodes. Selection of putative long-standing biomarkers of past episodes of DKA and HG. Materials and methods: Four groups of children with T1DM were recruited: patients after episode of DKA and HG, children with established T1DM (EDM) and patients with newly diagnosed diabetes without diabetes ketoacidosis (NDM). Serum samples were collected in three group-specific time points (since the hospital admission): 0h – 24h – 72h for DKA and NDM group and 0h – 12h – 48h for HG group. From EDM patients only one sample was collected during running routine laboratory tests. Patients were assigned to two batches: DKA-NDM-EDM (N = 20x3, N = 10x3, N = 10) and HG-EDM- -NDM (N = 10x3, N = 25, N = 15x3). All patients within the batches were matched based on age and sex. Metabolic fingerprinting was performed with LC- -QTOF-MS (Agilent 6550 iFunnel). Results: In DKA batch after technical filtering 248 metabolomic features out of 712 (in positive ionization) and 295 out of 652 (in negative ionization) were suitable for between-group comparisons. Statistical analysis selected 22 metabolic features as putative biomarkers of episodes of DKA occurrence in nearest 72h. Decision tree to diagnose past DKA episode, based on two best metabolites, achieved sensitivity of 95% (CI (confidence interval): 81.79–99.13%) and specificity of 80% (CI: 67.30–88.81%). In HG batch after technical filtering 359 metabolomic features out of 1006 (in positive ionization) and 374 out of 763 (in negative ionization) were suitable for between-group comparisons. Statistical analysis selected 9 metabolic features as putative biomarkers of episodes of DKA occurrence in nearest 48h. Decision tree to diagnose past HG episode, based on two best metabolites, achieved sensitivity of 90% (CI: 72.32–97.38%) and specificity 80% (CI: 68.39–88.26%). Conclusions: Metabolic disturbances caused by DKA may be traced in serum up to 72h after the episode and for hypoglycemia up to 48h.

scholarly journals Evaluation of Vascular Endothelial Function in Children with Type 1 Diabetes Mellitus

2021 ◽  
Vol 10 (21) ◽  
pp. 5065
Author(s):  
Karolina Nocuń-Wasilewska ◽  
Danuta Zwolińska ◽  
Agnieszka Zubkiewicz-Kucharska ◽  
Dorota Polak-Jonkisz
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Endothelial Dysfunction ◽  
Type 1 Diabetes Mellitus ◽  
Diabetes Mellitus Type 1 ◽  
Vascular Endothelial ◽  
Healthy Controls ◽  
Linear Correlations ◽  
Pai 1

Diabetic kidney disease belongs to the major complications of diabetes mellitus. Here, hyperglycaemia is a key metabolic factor that causes endothelial dysfunction and vascular changes within the renal glomerulus. The aim of the present study was to assess the function of the vascular endothelium in children with type 1 diabetes mellitus (type 1 diabetes) by measuring selected endothelial lesion markers in blood serum. The selected markers of endothelial lesions (sVCAM-1, sICAM-1, sE-SELECTIN, PAI-1, ADMA and RAGE) were assayed by the immunoenzymatic ELISA method. The study involved 66 patients (age: 5–18 years) with type 1 diabetes and 21 healthy controls (age: 5–16 years). In the type 1 diabetes patients, significantly higher concentrations of all of the assayed markers were observed compared to the healthy controls (p < 0.001). All of the evaluated markers positively correlated with the disease duration, the age, and BMI of the patients, while only PAI-1 and sE-SELECTIN were characteristic of linear correlations with the estimated glomerular filtration rate (eGFR). It can be concluded that endothelial inflammatory disease occurs in the early stages of type 1 diabetes mellitus in children. The correlations between PAI-1, sE-SELECTIN, and eGFR suggest an advantage of these markers over other markers of endothelial dysfunction as prognostic factors for kidney dysfunction in children with type 1 diabetes.

scholarly journals Variability of glycemia and cognitive impairment in patients with diabetes mellitus type 1.

2018 ◽  
Vol 96 (8) ◽  
pp. 741-745
Author(s):  
Yu. G. Samoylova ◽  
M. V. Matveeva ◽  
N. G. Zhukova ◽  
M. A. Rokank
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Cognitive Impairment ◽  
Type 1 Diabetes Mellitus ◽  
Cognitive Functions ◽  
Risk Index ◽  
Diabetes Mellitus Type 1 ◽  
Diabetes Mellitus Type ◽  
The Relationship

Diabetes mellitus type 1 is associated with impaired cognitive function. Based on the results of systematic reviews and meta-analyzes, the most likely modifiable risk factor is the degree of metabolic control, in particular the variability of glycemia. Aims: to determine the influence of the variability of glycemia on cognitive functions in patients with type 1 diabetes mellitus. Material and methods. Design-observational, one-stage, cross-sectional research. We examined 30 patients with type 1 diabetes mellitus who were divided into 2 groups: 1 group (main) with cognitive impairment, and 2 (control) with normal cognitive functions. All patients were screened for cognitive functions using the Montreal scale (MoCa test). For the diagnosis of fluctuations in glucose level, continuous monitoring of glycemia was carried out using the iPro-2 device (Medtronic, USA): mean glycemic mean (MEAN), standard deviation (SD), mean amplitude of glycemic fluctuation (MAGE), long-term glycemic index (CONGA) Glycemia lability index (LI), hypoglycemia risk index (LBGI), hyperglycemia risk index (HBGI), mean hourly rate of glycemic change (MAG). Results. The study revealed that in patients with type 1 diabetes mellitus, cognitive impairment was dominated by a violation of constructive praxis, memory and attention. Recorded a significant difference in MEAN, SD, CONGA, Gindex, LBGI, HBGI, MAGE, Mvalue and MAG. Correlation analysis revealed the relationship of cognitive impairments with the level of HbA1c, as well as the variability parameters MEAN, SD, CONGA, Gindex, LBGI, HBGI, MAGE, Mvalue, MAG. Conclusions. The relationship between the variability of glycemia and cognitive impairment was registered in patients with type 1 diabetes mellitus

scholarly journals Diabetes Mellitus Type-1 and Psychosocial Intervention to Improve Quality of Life

2021 ◽  
Vol 1 (4) ◽  
pp. 80-85
Author(s):  
Sarah Amalia
Keyword(s):  
Quality Of Life ◽  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Diabetes Mellitus Type 1 ◽  
Diabetes Mellitus Type ◽  
Self Control ◽  
Comprehensive Treatment

Type 1 diabetes mellitus is the most common chronic endocrine pathology among children. Data from the Indonesian Pediatric Association (IDAI) states that the incidence of DM in children aged 0-18 years has increased by 700% over a period of 10 years. Treatment includes diet, physical activity, insulin medication, and proper self-control. The necessary changes in habits and lifestyles can lead to psychosocial problems, including anxiety, depression and eating disorders. Subsequently, the child or adolescent and his or her family group may move into new balance characterized by good self-control and adherence to treatment, or deepen individual and group disorders which may reappear, especially in adolescence. The comprehensive treatment of type 1 diabetes mellitus requires addressing these aspects through multidisciplinary teams which include medical and psychosocial professionals. This review analyses the main aspects related to the psychosocial impact of diabetes mellitus type 1 among children, adolescents and their families mental. A substantial amount of behavioral science research has demonstrated that psychosocial factors play an integral role in the management of diabetes in both children and adults. Research has also shown how psychosocial therapies that can improve regimen adherence, glycemic control, psychosocial functioning, and quality of life.

scholarly journals Impact of Hyperglycemia on Xerostomia and Salivary Composition and Flow Rate of Adolescents with Type 1 Diabetes Mellitus

10.5772/22321 ◽  
2011 ◽  
Author(s):  
Ivana Maria Saes Busato ◽  
Maria Angela Naval Machado ◽  
Joao Armando ◽  
Antonio Adilson Soares de Lima ◽  
Carlos Cesar ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Flow Rate

scholarly journals Characteristics of cognitive function in patients with diabetes mellitus type 1 younger depending transferred hypoglycemic conditions

2017 ◽  
pp. 17-21
Author(s):  
N. Zherdоva ◽  
B. Mankovsky
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Cognitive Impairment ◽  
Cognitive Function ◽  
Type 1 Diabetes Mellitus ◽  
Depression Scale ◽  
Diabetes Mellitus Type 1 ◽  
Diabetes Mellitus Type ◽  
Patients With Diabetes

Many studies focus on the effect of compensation of diabetes, glucose-lowering therapy of choice, the influence of cardio - vascular diseases in the state of cognition. At the same time, not enough attention is paid to cognitive impairment in patients with type 1 diabetes mellitus, especially young people. The aim of our study was to investigate the prognostic factors of dementia in patients with type 1 diabetes mellitus are younger. 33 patients were examined with type 1 diabetes and 10 people in the control group. Of the 33 patients with diabetes, 21 people had hypoglycemia in the last 3 months and 12 without hypoglycemic states. To identify depression used two questionnaires: Centre for Epidemiologic Studies Depression Scale (CES-D) and the Hospital Anxiety and Depression Scale (HAD). Evaluation of cognitive impairment was conducted using the following methods: The test "5 words", sample Schulte, the scale of assessment of mental status ( MMSE), test battery on the frontal dysfunction (BLD), evaluation of test o’clock. To reveal the 10-year risk of dementia patients used the scale which was developed by a team of researchers at Utrecht University Medical Rudolf Magnus. In patients with type 1 diabetes with hypoglycemia marked deterioration in cognitive function, according to the neuropsychological tests, namely the BLD and MMSE compared with  patient without hypoglycemia. The risk of developing dementia over 10 years in patients with diabetes mellitus type 1 young up 2.2 times compared with patients without hypoglycemia. Hypoglycemic state is the main risk factor that leads to the development of cognitive impairment, and this is a factor which can be influenced by insulin properly selected.

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