scholarly journals Synthesis, Spectral Characterization, Thermal and In vitro Antimicrobial Studies for Novel Co(II) and Ni(II) Complexes of (N,N'-(1,2-Phenylene)Bis(2-Aminobenzamide)

2019 ◽  
Vol 16 ◽  
pp. 5360-5374 ◽  
Author(s):  
Hanaa A. El-Boraey ◽  
Azza A. Serag El-Din ◽  
Ahmed A. Sakr
Keyword(s):  
Metal Complexes ◽  
Free Ligand ◽  
Molar Conductance ◽  
Diffusion Method ◽  
Disc Diffusion ◽  
Disc Diffusion Method ◽  
Antimicrobial Studies ◽  
Positive Strain ◽  
Positive Controls

Novel metal complexes of Co(II) and Ni(II) have been  prepared from reaction of their different salts with previously prepared ligand (L) namely (N,N'-(1,2-phenylene)bis(2-aminobenzamide). Synthesis ligand and its metal (II) complexes (1-5) were reported and characterized with the help of analytical and physiochemical analysis as elemental, IR spectra, thermal (TG/DTG), UV-Vis, magnetic susceptibility and molar conductance in DMF, On the view of the previous data and measurements, the structure and composition species behave as mononuclear and octahedral geometry has been proposed for all the complexes except for complex (1) adopted tetrahedral structure. Furthermore, the in vitro antibacterial Staphylococcus aureus (ATCC 25923) as Gram-positive strain, Escherichia coli (ATCC 25922) as Gram-negative strain and antifungal Candida albicans (ATCC 10231) have been studied for all samples using disc diffusion method against Ampicillin and Fluconazole as positive controls, respectively. The results show that complexation facilitates the activity of most studied metal complexes than the free ligand.

scholarly journals Synthesis, Spectroscopic, and Antimicrobial Studies on Bivalent Nickel and Copper Complexes of Bis(thiosemicrbazone)

2007 ◽  
Vol 2007 ◽  
pp. 1-7 ◽  
Author(s):  
Sulekh Chandra ◽  
Smriti Raizada ◽  
Monika Tyagi ◽  
Archana Gautam
Keyword(s):  
Metal Complexes ◽  
Metal Ion ◽  
Copper Complexes ◽  
Free Ligand ◽  
Antimicrobial Properties ◽  
Molar Conductance ◽  
Spectral Studies ◽  
Central Metal ◽  
Antimicrobial Studies

A series of metal complexes of Cu(II) and Ni(II) having the general composition[M(L)X2]with benzil bis(thiosemicarbazone) has been prepared and characterized by element chemical analysis, molar conductance, magnetic susceptibility measurements, and spectral (electronic, IR, EPR, mass) studies. The IR spectral data suggest the involvement of sulphur and azomethane nitrogen in coordination to the central metal ion. On the basis of spectral studies, an octahedral geometry has been assigned for Ni(II) complexes but a tetragonal geometry for Cu(II) complexes. The free ligand and its metal complexes have been tested in vitro against a number of microorganisms in order to assess their antimicrobial properties.

scholarly journals Synthesis, Spectroscopic Characterization And Antimicrobial Evaluation of Novel Nitrogen Containing Metal Complexes

2019 ◽  
Vol 16 ◽  
pp. 6313-6324
Author(s):  
Hanaa A. El-Boraey ◽  
Aballah El-domiaty
Keyword(s):  
Metal Complexes ◽  
Spectroscopic Characterization ◽  
Molar Conductance ◽  
Diffusion Method ◽  
Disc Diffusion ◽  
Disc Diffusion Method ◽  
Magnetic Studies ◽  
Antibacterial And Antifungal Activities ◽  
Antimicrobial Evaluation ◽  
Antibacterial And Antifungal

Four novel Mn(II), Co(II), Cu(II) complexes with nitrogen containing ligand (L) i.e. N,N-((Z)-ethane-1,2-diylidine)bis(2-amino benzo hydrazide) have been synthesized and structurally characterized by elemental analysis, spectral, thermal (TG/DTG), molar conductance and magnetic susceptibility measurements. From the spectroscopic and magnetic studies it has been concluded that all complexes have a six coordinated octahedral geometry. The Schiff base and their metal complexes have also been screened for their antibacterial and antifungal activities by using a modified Kirby-Bauer disc diffusion method.

scholarly journals Synthesis, Spectroscopic, and Antimicrobial Studies on Bivalent Zinc and Mercury Complexes of 2-Formylpyridine Thiosemicarbazone

2009 ◽  
Vol 2009 ◽  
pp. 1-6 ◽  
Author(s):  
Sulekh Chandra ◽  
Shikha Parmar ◽  
Yatendra Kumar
Keyword(s):  
Metal Complexes ◽  
Metal Ion ◽  
Free Ligand ◽  
Antimicrobial Properties ◽  
Molar Conductance ◽  
Spectral Studies ◽  
Central Metal ◽  
Tetrahedral Geometry ◽  
Antimicrobial Studies

A series of metal complexes of Zn(II) and Hg(II) having the general composition [where L = 2-formylpyridine thiosemicarbazone; M = Zn(II) and Hg(II); X = , and ] have been prepared and characterized by elemental chemical analysis, molar conductance, and spectral (IR and mass) studies. The IR spectral data suggests the involvement of sulphur and azomethane nitrogen in coordination to the central metal ion. On the basis of spectral studies, a tetrahedral geometry has been assigned for Zn(II) and Hg(II) complexes. The free ligand and its metal complexes have been tested in vitro against a number of microorganisms in order to assess their antimicrobial properties.

scholarly journals Essential Oil from Leaves of Lantana canescens and L. lopez-palacii Grown in Colombia

2011 ◽  
Vol 6 (2) ◽  
pp. 1934578X1100600
Author(s):  
Andrés F. Peralta-Bohórquez ◽  
Clara Quijano-Célis ◽  
Mauricio Gaviria ◽  
Consuelo Vanegas-López ◽  
Jorge A. Pino
Keyword(s):  
Essential Oil ◽  
Volatile Compounds ◽  
Diffusion Method ◽  
Disc Diffusion ◽  
Enterobacter Sakazakii ◽  
Bacterial Strains ◽  
Disc Diffusion Method ◽  
Germacrene D ◽  
In Vitro Antibacterial Activity

The chemical composition of the volatile compounds from the leaves of Lantana canescens Kunth (Verbenaceae) and L. lopez-palacii Moldenke grown in Colombia were analyzed by GC and GC/MS. One hundred and thirty-nine volatile compounds were identified in L. canescens, of which the major ones were β-caryophyllene (13.5%), germacrene D (10.3%) and 1-octen-3-ol (8.4%). In the oil obtained from L. lopez-palacii, eighty-three compounds were identified, of which the most prominent were 1-octen-3-ol (24.4%) and β-caryophyllene (15.2%). The in vitro antibacterial activity of the L. lopez-palacii essential oil was studied against three bacterial strains using the disc diffusion method. No antimicrobial activity was found against Escherichia coli, Enterobacter sakazakii and Listeria monocytogenes.

scholarly journals THE METAL COMPLEXES OF NOVEL SCHIFF BASE CONTAINING ISATIN: CHARACTERIZATION, ANTIMICROBIAL, ANTIOXIDANT AND CATALYTIC ACTIVITY STUDY

2019 ◽  
pp. 206-210
Author(s):  
VAIRALAKSHMI M ◽  
PRINCESS R ◽  
JOHNSON RAJA S
Keyword(s):  
Catalytic Activity ◽  
Metal Complexes ◽  
1H Nmr ◽  
Metal Ion ◽  
Analytical Data ◽  
Free Ligand ◽  
Molar Conductance ◽  
Diffusion Method ◽  
Spectral Studies ◽  
Standard Drug

Objectives: The aim of our work was to synthesize novel mixed ligand-metal complexes and evaluation of antimicrobial, antioxidant assay, and analysis of catalytic oxidation of cyclohexane. Methods: The complexes were characterized by means of various physicochemical techniques such as elemental analysis, molar conductance, magnetic susceptibility, infrared (IR), electronic absorption, 1H NMR (proton magnetic resonance), and mass spectral studies. The antimicrobial screening study was done by disc diffusion method. The catalytic activity of the complexes was observed in the oxidation of cyclohexane using eco-friendly hydrogen peroxide as oxidant. Results: On comparing the 1H NMR and IR spectral data of free ligand and its complexes, it was found to be azomethine (CH=N) proton which is formed in the free ligand. During complexation, the azomethine proton is coordinated to the metal ion and the phenolic oxygen is coordinated to the metal ion by deprotonation. The analytical data and mass spectra of the ligand and the complexes confirm the stoichiometry of metal complexes as being of the (MLY)Cl type and the metal to ligand ratio is 1:1. The antimicrobial, antioxidant, and catalytic potential were evaluated and the result shows the better activity of the complexes than the ligand. Conclusion: It was found to be copper(II) and zinc(II) complexes which are effective against all the bacteria when compared to standard drug streptomycin. Copper(II) complex was found to be effective antibacterial agent against Aspergillus niger and Aspergillus flavus in comparison to the standard drug Nystatin. The zinc complex exhibited good catalytic activity.

In vitro sensitivity of Hungarian Actinobaculum suis strains to selected antimicrobials

2003 ◽  
Vol 51 (1) ◽  
pp. 53-59 ◽  
Author(s):  
I. Biksi ◽  
Andrea Major ◽  
L. Fodor ◽  
Keyword(s):  
Type Strain ◽  
Diffusion Method ◽  
Resistance Pattern ◽  
Disc Diffusion ◽  
Disc Diffusion Method ◽  
Antimicrobial Sensitivity ◽  
Variable Sensitivity ◽  
Agar Dilution ◽  
Almost All

In vitro antimicrobial sensitivity of 12 Hungarian isolates and the type strain ATCC 33144 of Actinobaculum suis to different antimicrobial compounds was determined both by the agar dilution and by the disc diffusion method. By agar dilution, MIC50 values in the range of 0.05-3.125µg/ml were determined for penicillin, ampicillin, ceftiofur, doxycycline, tylosin, pleuromutilins, chloramphenicol, florfenicol, enrofloxacin and lincomycin. The MIC50 value of oxytetracycline and spectinomycin was 6.25 and 12.5µg/ml, respectively. For ofloxacin, flumequine, neomycin, streptomycin, gentamicin, nalidixic acid, nitrofurantoin and sulphamethoxazole + trimethoprim MIC50 values were in the range of 25-100µg/ml. With the disc diffusion method, all strains were sensitive to penicillin, cephalosporins examined, chloramphenicol and florfenicol, tetracyclines examined, pleuromutilins, lincomycin and tylosin. Variable sensitivity was observed for fluoroquinolones (flumequine, enrofloxacin, ofloxacin), most of the strains were susceptible to marbofloxacin. Almost all strains were resistant to aminoglycosides but most of them were sensitive to spectinomycin. A strong correlation was determined for disc diffusion and MIC results (Spearman's rho 0.789, p<0001). MIC values of the type strain and MIC50 values of other tested strains did not differ significantly. Few strains showed a partially distinct resistance pattern for erythromycin, lincomycin and ampicillin in both methods.

scholarly journals Synthesis, Characterization and Biological Evaluation of Fe(III) and Cu(II) Complexes with 2,4-Dinitrophenyl hydrazine and Thiocyanate Ions

2019 ◽  
Vol 31 (4) ◽  
pp. 780-784
Author(s):  
P. Manimaran ◽  
S. Balasubramaniyan
Keyword(s):  
Antioxidant Activity ◽  
Metal Complexes ◽  
Radical Scavenging Activity ◽  
Radical Scavenging ◽  
Free Ligand ◽  
Antimicrobial Activities ◽  
Biological Evaluation ◽  
Diffusion Method ◽  
Spectral Studies

The metal complexes of Fe(III) and Cu(II) were prepared by using 2,4-dinitrophenyl hydrazine (DNPH) and thiocyanate (SCN) with stirrer refluxed for about 6 h. The prepared Fe(III) and Cu(II) complexes were characterized by elemental analysis, molar conductance, magnetic susceptibility and electronic spectrum, FT-IR spectral studies. The result suggested the octahedral geometry for Fe(III) and Cu(II) complexes. Powder X-ray diffraction indicate the crystalline nature of the metal complexes. The antimicrobial activities of the Fe(III) and Cu(II) complexes were tested with various micro organisms by disc diffusion method. The antimicrobial results indicate that the metal complexes are highly active with compared to the free ligand. The in vitro antioxidant activity of the free ligand and its metal complexes was assayed by radical scavenging activity (DPPH). The result proposed that Fe (III) and Cu(II) complexes exhibited strong antioxidant activity than that of the ligand.

scholarly journals Synthesis and in vitro antibacterial activity of Cephradine Benzoate

1970 ◽  
Vol 10 (3) ◽  
pp. 148-151
Author(s):  
M Ahmad ◽  
M Rahman ◽  
P Kumar Paul
Keyword(s):  
Antibacterial Activity ◽  
Salmonella Typhi ◽  
Shigella Dysenteriae ◽  
Diffusion Method ◽  
Disc Diffusion ◽  
Disc Diffusion Method ◽  
Nmr Studies ◽  
Shigella Boydii ◽  
Group B

Aims & Methods: The present study was undertaken to compare the antibacterial activity of a cephradine derivative with that of the parent antibiotic cephradine. Cephradine was converted to its benzoyl derivative by Schotten-Baumann method for the first time. Disc diffusion method was employed to find out the antibacterial activity against EPEC, ETEC, E. Agg, Salmonella typhi, Salmonella group B, Shigella boydii, Shigella dysenteriae 1, Shigella dysenteriae 2, Shigella flexinariae and Shigella sonnei. Melting point, TLC, HPLC, UV, FTIR and <sup>1</sup>H NMR studies were carried out to check the purity and confirm that the derivative was cephradine benzoate. Results: The benzoyl derivative showed promising activity against tested bacteria. The results obtained from the study demonstrate that the benzoyl derivative could be a potential antibacterial agent. Key words: Cephradine benzoate, antibacterial activity, disc diffusion method.   DOI: http://dx.doi.org/ 10.3329/bjms.v10i3.8356 BJMS 2011; 10(3): 148-151

scholarly journals Studies of Antimicrobial Activity of 2',4',5'- and 2',3',4'-Trimethoxy Flavanones

2016 ◽  
Vol 8 (2) ◽  
pp. 209-216
Author(s):  
A. Rahim ◽  
R. Ali ◽  
A. Islam
Keyword(s):  
Pathogenic Bacteria ◽  
Sclerotium Rolfsii ◽  
Antibacterial Activities ◽  
Diffusion Method ◽  
Disc Diffusion ◽  
Disc Diffusion Method ◽  
Filter Paper Disc ◽  
Antibacterial And Antifungal ◽  
Paper Disc

 2',4',5'- and 2',3',4'-trimethoxy flavanones have been synthesized starting with 2-hydroxyacetophone and substituted aldehyde. Antibacterial activities of the flavanones have been tested along with their corresponding chalcones against two human pathogenic bacteria (Streptococcus-b-haemolyticus and  Klebsiella sp. (G-)). Antifungal activities of the flavanones have also been investigated against  two plants pathogenic mold fungi (Rhizactonia solani Sclerotium rolfsii). The structures of the synthesized compounds have been characterized with the help of  UV, IR and 1H NMR and 13C-NMR spectra. The antibacterial and antifungal screening were performed in vitro by the filter paper disc diffusion method and poisoned food technique. The flavanones showed antibacterial activity while no activity was observed to their corresponding chalcones against the tested bacteria. On the other hand, chalcones and their corresponding flavanones both showed fungicidal activities.

scholarly journals Efek Antimikroba Ekstrak Air Daun Mengkudu (Morinda citrifolia L.) terhadap Bakteri Shigella dysenteriae Secara In Vitro

2021 ◽  
Vol 3 (1) ◽  
pp. 14-18
Author(s):  
Qyana Al Farisi ◽  
Yuke Andriane ◽  
Miranti Kania Dewi
Keyword(s):  
Water Extract ◽  
Antimicrobial Effect ◽  
Negative Control ◽  
Shigella Dysenteriae ◽  
Morinda Citrifolia ◽  
High Price ◽  
Diffusion Method ◽  
Disc Diffusion ◽  
Disc Diffusion Method

Kematian akibat infeksi Shigella, terutama Shigella dysenteriae dapat mencapai lebih dari 10% terutama pada anak dan lanjut usia pada kondisi tanpa pemberian terapi yang efektif. Siprofloksasin merupakan lini pertama untuk pengobatan infeksi Shigella, akan tetapi obat ini memiliki beberapa kekurangan di antaranya harga yang mahal dan resistensi. Daun mengkudu merupakan tanaman tradisional yang diduga memiliki efek antimikro dan diharapkan dapat menjadi alternatif terapi antibiotik bagi Shigella dysenteriae yang saat ini sudah banyak mengalami resistensi. Tujuan penelitian ini adalah mengetahui efek antimikro ekstrak air daun mengkudu (Morinda citrifolia L.) terhadap bakteri Shigella dysenteriae. Penelitian ini bersifat eksperimental laboratorium murni. Zona hambat ditentukan melalui metode difusi cakram. Objek penelitian yang digunakan adalah Shigella dysenteriae ATCC nomor 13313. Sampel uji berupa ekstrak air daun mengkudu konsentrasi 100%, kontrol positif (siprofloksasin) dan kontrol negatif (aquadest) dengan 9 kali pengulangan. Hasil uji antimikro dengan metode difusi cakram menunjukkan tidak terbentuk zona hambat pada ekstrak air daun mengkudu konsentrasi 100%. Hal tersebut menunjukkan ekstrak air daun mengkudu konsentrasi 100% tidak memiliki efek antimikro terhadap bakteri Shigella dysenteriae. Kadar flavonoid, tanin, dan alkaloid yang terdapat dalam ekstrak air daun mengkudu konsentrasi 100% pada penelitian ini kemungkinan belum cukup untuk menghasilkan efek yang diharapkan. Antimicrobial Effect of Water Extract of Noni (Morinda citrifolia L.) Leaves against Shigella dysenteriae In VitroDeath due to infection with Shigella, especially Shigella dysenteriae, can reach more than 10%, especially in children and the elderly in conditions without effective therapy. Ciprofloxacin is the first line for the treatment of Shigella infection, however this drug has several disadvantages including high price and resistance. Noni leaf is a traditional plant that is thought to have antimicrobial effects and is expected to be an alternative antibiotic therapy for Shigella dysenteriae which is currently experiencing a lot of resistance. The purpose of this study was to determine the antimicrobial effect of the water extract of noni leaves (Morinda citrifolia L.) on Shigella dysenteriae bacteria. This research is a pure laboratory experimental study. The zone of inhibition is determined by the disc diffusion method. The research object used was Shigella dysenteriae ATCC number 13313. The test sample was a water extract of noni leaves with a concentration of 100%, positive control (ciprofloxacin) and negative control (aquadest) with 9 repetitions. The results of the antimicrobial test using the disc diffusion method showed no inhibition zone was formed in the water extract of noni leaves with a concentration of 100%. This shows that a water extract of noni leaves with a concentration of 100% did not have an antimicrobial effect against the Shigella dysenteriae bacteria. The levels of flavonoids, tannins, and alkaloids contained in the water extract of noni leaves with a concentration of 100%  in this study may not be sufficient to produce the expected effect.

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