Prevalence of naturally occurring antibodies against dog erythrocyte antigen 7 in a population of dog erythrocyte antigen 7–negative dogs from Spain and Italy

2016 ◽  
Vol 77 (8) ◽  
pp. 877-881 ◽  
Author(s):  
Eva Spada ◽  
Daniela Proverbio ◽  
Luis Miguel Viñals Flórez ◽  
Maria del Rosario Perlado Chamizo ◽  
Blanca Serra y Gómez de la Serna ◽  
...  
Keyword(s):  
Naturally Occurring ◽  
Erythrocyte Antigen ◽  
Naturally Occurring Antibodies ◽  
Dog Erythrocyte

scholarly journals Naturally occurring antibodies in cats against dog erythrocyte antigens and vice versa

2017 ◽  
Vol 20 (8) ◽  
pp. 690-695 ◽  
Author(s):  
Vito Priolo ◽  
Marisa Masucci ◽  
Eva Spada ◽  
Daniela Proverbio ◽  
Maria Grazia Pennisi
Keyword(s):  
Room Temperature ◽  
Test Tube ◽  
Blood Type ◽  
Type B ◽  
Routine Procedure ◽  
Naturally Occurring ◽  
High Prevalence ◽  
Naturally Occurring Antibodies ◽  
Cross Match ◽  
Dog Erythrocyte

Objectives The aim of this study was to investigate the presence of naturally occurring antibodies against canine erythrocyte antigens in cats and vice versa. The influence of canine and feline blood type on cross-match results was also studied. Methods Blood samples from 34 cats and 42 dogs were used to perform test tube major and minor cross-match tests and blood typing. Blood from each cat was cross-matched with blood from 2–6 dogs, for a total of 111 cross-match tests. Haemolysis, macro- and microagglutination were considered markers of a positive cross-match. Results Eighty-three overall major cross-match tests were positive at 37°C, 86 at room temperature and 90 at 4°C. The minor cross-match tests were positive in all but two cross-matches performed at 37°C, all tests performed at room temperature and all but one test performed at 4°C. No cats tested totally negative at both major and minor cross-matches performed with samples from any single dog. Prevalence of warm natural antibodies against canine erythrocyte antigens was lower in type B cats than in type A cats, regardless of the blood type of donor dogs. Conclusions and relevance This study reveals a high prevalence of naturally occurring antibodies in cats against dog erythrocyte antigens and vice versa, and suggests that transfusion of cats with canine blood is not recommended as a routine procedure owing to the potential high risk of either acute severe or milder transfusion reactions.

Naturally occurring antibodies reacting with lipoic acid: screening method, characterization and biochemical interest

1994 ◽  
Vol 171 (1) ◽  
pp. 111-119 ◽  
Author(s):  
Stéphane Legastelois ◽  
Vincent Thomas ◽  
Gerard Quash ◽  
Marie-Pierre Métais ◽  
Jacques Tebib ◽  
...  
Keyword(s):  
Lipoic Acid ◽  
Screening Method ◽  
Naturally Occurring ◽  
Naturally Occurring Antibodies

scholarly journals Increased cytotoxicity of normal rabbit serum for lectin-resistant mutants of animal cells.

1984 ◽  
Vol 160 (4) ◽  
pp. 1241-1246
Author(s):  
C Jones
Keyword(s):  
Structural Changes ◽  
Chinese Hamster ◽  
Rabbit Serum ◽  
Cytotoxic Action ◽  
Normal Rabbit Serum ◽  
Animal Cells ◽  
Naturally Occurring ◽  
Alternate Complement Pathway ◽  
Surface Carbohydrates ◽  
Naturally Occurring Antibodies

Plant lectins are cytotoxic and can be used to select for mutants of animal cells that exhibit structural changes in cell surface carbohydrates reflecting glycosylation defects. We isolated eight lectin mutants of Chinese hamster ovary (CHO) cells that appear to represent three different phenotype classes. These lectin mutants were much more sensitive to the cytotoxic action of normal rabbit serum (NRS) than were the parental cells. This increased cytotoxicity was heat sensitive, specifically absorbed, and inhibited by simple and complex carbohydrates. No killing was observed under conditions in which only the alternate complement pathway was active. An NRS-resistant subclone that was isolated from one lectin mutant was shown to have also regained wild type behavior when tested with the lectins. The possibility that naturally occurring antibodies in rabbit serum are reacting with incomplete carbohydrate chains on the surface of the lectin mutants is discussed.

scholarly journals Association of naturally occurring antibodies to β-amyloid with cognitive decline and cerebral amyloidosis in Alzheimer’s disease

2021 ◽  
Vol 7 (1) ◽  
pp. eabb0457
Author(s):  
Yu-Hui Liu ◽  
Jun Wang ◽  
Qiao-Xin Li ◽  
Christopher J. Fowler ◽  
Fan Zeng ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Decline ◽  
Plasma Levels ◽  
Imaging Biomarkers ◽  
Amino Terminus ◽  
Cross Sectional ◽  
Naturally Occurring ◽  
Β Amyloid ◽  
Naturally Occurring Antibodies

The pathological relevance of naturally occurring antibodies to β-amyloid (NAbs-Aβ) in Alzheimer’s disease (AD) remains unclear. We aimed to investigate their levels and associations with Aβ burden and cognitive decline in AD in a cross-sectional cohort from China and a longitudinal cohort from the Australian Imaging, Biomarkers and Lifestyle (AIBL) study. NAbs-Aβ levels in plasma and cerebrospinal fluid (CSF) were tested according to their epitopes. Levels of NAbs targeting the amino terminus of Aβ increased, and those targeting the mid-domain of Aβ decreased in both CSF and plasma in AD patients. Higher plasma levels of NAbs targeting the amino terminus of Aβ and lower plasma levels of NAbs targeting the mid-domain of Aβ were associated with higher brain amyloidosis at baseline and faster cognitive decline during follow-up. Our findings suggest a dynamic response of the adaptive immune system in the progression of AD and are relevant to current passive immunotherapeutic strategies.

scholarly journals The Lutheran Blood Groups: A Second Example of Anti-Lub and Three Further Examples of Anti-Lua

Blood ◽  
1957 ◽  
Vol 12 (11) ◽  
pp. 998-1003 ◽  
Author(s):  
TIBOR J. GREENWALT ◽  
THOMAS SASAKI
Keyword(s):  
Single Dose ◽  
Blood Group ◽  
Blood Donors ◽  
Double Dose ◽  
Transfusion Reaction ◽  
Her Family ◽  
Naturally Occurring ◽  
Hemolytic Transfusion Reaction ◽  
Naturally Occurring Antibodies ◽  
Immune Antibody

Abstract 1. An example of the blood group antibody, anti-Lub, was found in a patient who had a mild hemolytic transfusion reaction. It was shown to possess the characteristics of an immune antibody and to be able to distinguish between a single dose and a double dose of the Lub gene. 2. Three new examples of the antibody, anti-Lua, are presented. All of them were found in normal blood donors and have properties which indicate that they are naturally occurring antibodies. Dr. R. R. Race and Dr. R. Sanger confirmed the presence of anti-Lub in Mrs. S.’s serum, and studied other members of her family and the three anti-Lua sera. We are grateful to them for many favors and their kind encouragement. We are obligated to Miss Marie Cutbush for making available the LuaLua cells from Mrs. R. and her sister, and for a supply of anti-Lub serum. Thanks are due to Dr. A. E. Mourant who furnished our original supply of anti-Lua serum and to Dr. Philip Levine for the anti-Tja and anti-Vel sera. We are indebted to Dr. J. M. Fine of Milwaukee for permission to study Mrs. S. and to the patient and her family for their cooperation. The sera from 18,613 blood donors were studied by Betty McCarthy, Rosemary Polka, Pearl Lemke, Agnes Molnar, Jeannette Flagstadt and Betty Hutter.

Naturally occurring antibodies to bovine serum albumin in the parotid saliva of rats

1975 ◽  
Vol 20 (7) ◽  
pp. 415-418 ◽  
Author(s):  
T. Dishon ◽  
J. Sela ◽  
M. Ulmansky ◽  
E. Rosenmann ◽  
J.H. Boss
Keyword(s):  
Bovine Serum Albumin ◽  
Serum Albumin ◽  
Bovine Serum ◽  
Parotid Saliva ◽  
Naturally Occurring ◽  
Naturally Occurring Antibodies
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