scholarly journals Optimization of Prebiotics and Oxygen Scavengers for Bifidobacterium bifidum BB01 Microcapsules by Response Surface Methodology

2018 ◽  
Vol 22 (1) ◽  
pp. 3-12
Author(s):  
Yilin Li ◽  
Guowei Shu ◽  
Yichao Li ◽  
Yu Liu ◽  
Yajuan Song
Keyword(s):  
Ascorbic Acid ◽  
Response Surface Methodology ◽  
Response Surface ◽  
Screening Test ◽  
Xanthan Gum ◽  
Bifidobacterium Bifidum ◽  
Single Factor ◽  
Optimum Conditions ◽  
Oxygen Scavengers ◽  
Single Factor Experiment

Abstract The effects of different prebiotics and oxygen scavengers on making the process of xanthan gum and chitosan (XC) Bifidobacterium bifidum BB01 microcapsules were studied by single factor experiment and Plackett-Burman screening test, ascorbic acid, sodium erythorbate and xylo-oligosaccharide had significant effects. Based on the previous studies, the process XC B. Bifidum BB01 microcapsules were further optimized by Box-Behnken model in this study. Response surface analysis showed that the best additive amoumt of ascorbic acid, sodium erythorbate and xylo-oligosaccharide were 3.0%, 2.36% and 4.99%, respectively. The viable counts of B. Bifidum BB01 microcapsules reached to 1.52×1010CFU/g from 1.25×1010 CFU/g, the encapsulation yield reached to 94.88% from 90% under the optimum conditions. It provided the research foundation for the afterward production and exploration of the process XC B. Bifidum BB01 microcapsules.

scholarly journals Study on optimal adsorption conditions of norfloxacin in water based on response surface methodology

2022 ◽  
Author(s):  
Ming Zhang ◽  
Kuo Zhang ◽  
Jinpeng Wang ◽  
Runjuan Zhou ◽  
Jiyuan Li ◽  
...  
Keyword(s):  
Response Surface Methodology ◽  
Response Surface ◽  
Reaction Temperature ◽  
Polynomial Regression ◽  
Single Factor ◽  
Solution Ph ◽  
Box Behnken Design ◽  
Simulated Wastewater ◽  
Predicted Values ◽  
Single Factor Experiment

Abstract The waste pomelo peel was pyrolyzed at 400 °C to prepare biochar and used as adsorbent to remove norfloxacin (NOR) from simulated wastewater. The adsorption conditions of norfloxacin by biochar were optimized by response surface methodology (RSM). On the basis of single-factor experiment, the adsorption conditions of biochar dosage, solution pH and reaction temperature were optimized by Box-Behnken Design (BBD), and the quadratic polynomial regression model of response value Y1 (NOR removal efficiency) and Y2 (NOR adsorption capacity) were obtained respectively. The results show that the two models are reasonable and reliable. The influence of single factor was as follows: solution pH > biochar dosage > reaction temperature. The interaction between biochar dosage and solution pH was very significant. The optimal adsorption conditions after optimization were as follows: biochar dosage = 0.5 g/L, solution pH = 3, and reaction temperature = 45 °C. The Y1 and Y2 obtained in the verification experiment were 75.68% and 3.0272 mg/g, respectively, which were only 2.38% and 0.0242 mg/g different from the theoretical predicted values of the model. Therefore, the theoretical model constructed by response surface methodology can be used to optimize the adsorption conditions of norfloxacin in water.

scholarly journals Obtaining process of interpolymeric complexes from lactalbumin, xanthan gum and pectin

2014 ◽  
Vol 17 (3) ◽  
pp. 213-220 ◽  
Author(s):  
Virginia Coimbra Zuvanov ◽  
Edwin Elard Garcia-rojas ◽  
Clitor Júnior Fernandes de Souza ◽  
Eliana da Silva Gulão ◽  
Luciano José Barreto Pereira
Keyword(s):  
Experimental Data ◽  
Response Surface Methodology ◽  
Experimental Design ◽  
Response Surface ◽  
Xanthan Gum ◽  
Optimization Process ◽  
Coefficient Of Determination ◽  
Optimum Conditions ◽  
Independent Variables ◽  
Nacl Concentration

In this work, the optimization process of interpolymeric complexes formation between lactalbumin and the polysaccharides xanthan gum and pectin was studied in order to define the optimum conditions for the complexes formation. For the experimental design, response surface methodology (RSM) for three independent variables was used. The optimum conditions for the complexes formation between lactalbumin and xanthan gum were: pH 6.6, NaCl concentration of 0.6 mol/L and xanthan gum concentration 0.083% w/v. And for the complexes formed between pectin and lactalbumin the conditions were: pH 6.6, NaCl concentration of 0.25 mol/L and pectin concentration of 0.113% w/v. The best fitted model for the experimental data was that corresponding to the complex xanthan gum-lactalbumin, whose coefficient of determination (R²) was 0.97.

Optimization of Lactose Content in the Row Milk by Colorimetry via Response Surface Methodology

2014 ◽  
Vol 997 ◽  
pp. 38-42
Author(s):  
Jian Ting Ning ◽  
Jun Rui Wu ◽  
Xi Qing Yue
Keyword(s):  
Mathematical Model ◽  
Response Surface Methodology ◽  
Reaction Time ◽  
Response Surface ◽  
Reaction Temperature ◽  
Raw Milk ◽  
Single Factor ◽  
Optimum Extraction ◽  
Single Factor Experiment

The lactose content in the raw milk by colorimetry was introduced in the paper.On the single-factor experiment basis, it used response surface methodology to establish a quadratic mathematical model of lactose content. After analyzing the significance of the various factors and interactions, the results showed the optimum extraction conditions of detecting lactose content by colorimetry were as follows: reaction temperature 100°C, reaction time 5.2min, amount of precipitation 2.9 mL. In order to verify the method’s accuracy, five kinds of raw milk were chosen to test. The results showed the recoveries were between 97.122%-101.294%, so it is feasible to determine the content of lactose in raw milk.

Extraction of Chondroitin Sulfate from Tilapia Byproducts with Ultrasonic-Microwave Synergistic

2013 ◽  
Vol 726-731 ◽  
pp. 4381-4385 ◽  
Author(s):  
Chang Yu Cheng ◽  
Wei Wen Duan ◽  
Zhen Hua Duan ◽  
Yang Hai ◽  
Xin Gui Lei ◽  
...  
Keyword(s):  
Response Surface Methodology ◽  
Chondroitin Sulfate ◽  
Response Surface ◽  
Microwave Power ◽  
Oreochromis Niloticus ◽  
Optimum Process ◽  
Ultrasonic Power ◽  
Single Factor ◽  
Optimum Conditions ◽  
Extraction And Separation

The optimum conditions for the extraction and separation of chondroitin sulfate from tilapia (Oreochromis niloticus) byproducts were studied in the paper. The chondroitin sulfate was extracted by the combination of ultrasonic and microwave. On the basis of the single factor tests, the response surface methodology was taken to study the optimum process of extraction. Results show that the best conditions for the extraction and separation of chondroitin sulfate from tilapia byproducts are: the ultrasonic power is 50W, the microwave power is 98W, the extraction time is 120s, the ratio of solid to liquid is 1:50 (g/mL), and under these conditions, the extraction rate of chondroitin sulfate is 2.513%.

Optimization of Malachite Green by KOH-Modified Grapefruit Peel Activated Carbon: Application of Response Surface Methodology

2014 ◽  
Vol 529 ◽  
pp. 611-615 ◽  
Author(s):  
Liu Dan Luo ◽  
Hai Yi Huang ◽  
Jian Hong Bi ◽  
Lang Lang Tan ◽  
Hua Zhang ◽  
...  
Keyword(s):  
Mathematical Model ◽  
Response Surface Methodology ◽  
Activated Carbon ◽  
Response Surface ◽  
Malachite Green ◽  
Potassium Hydroxide ◽  
Single Factor ◽  
Grapefruit Peel ◽  
Central Composite ◽  
Single Factor Experiment

Response surface methodology (RSM) was utilized to optimize the best adsorbent conditions on Malachite Green in wastewater by the activated carbon which has been prepared from grapefruit peel with potassium hydroxide activating. Built on single-factor experiment, adsorbent dosage, pH, initial MG concentration and temperature were chosen as influencing factors during adsorption. The experimental mathematical model was arranged according to central composite design (CCD). The results shown that the best conditions were pH 9, initial MG concentration of 2000 mg/L, 1 g/L dosage of KAC and 40°C. Maximum absorption was 1944.35 mg/L.

Optimization of Anthocyanins Extraction from Blueberry Pomace by Spray-Drying Process by Response Surface Methodology

2014 ◽  
Vol 1033-1034 ◽  
pp. 709-712
Author(s):  
Xian Jun Meng ◽  
Jia Chen Zhang ◽  
Bin Li
Keyword(s):  
Response Surface Methodology ◽  
Response Surface ◽  
Spray Drying ◽  
Air Temperature ◽  
Loss Rate ◽  
Single Factor ◽  
Drying Process ◽  
Quadratic Regression ◽  
Drying Technology ◽  
Single Factor Experiment

The effects of maltodextrin concentration,inlet air temperature and outlet air temperature on the anthocyanins extraction from blueberry pomace by spray-drying technology were studied by response surface methodology. Based on single factor experiment, the quadratic regression model of the powder yield and loss rate of anthocyanins were deduced, then variables were analyzed with response surface methodology (RSM) by Box - Benhnken experiment. Results showed that the optimal technological conditions for spray drying the anthocyanins extraction from blueberry pomace were obtained as follows: maltodextrin concentration was 25.15% , inlet air temperature was 183.03°Cand outlet air temperature was 60.00°C.

scholarly journals Homogenate Extraction of Crocins from Saffron Optimized by Response Surface Methodology

2018 ◽  
Vol 2018 ◽  
pp. 1-6 ◽  
Author(s):  
Yingpeng Tong ◽  
Yu Jiang ◽  
Dan Guo ◽  
Yongqiu Yan ◽  
Shiping Jiang ◽  
...  
Keyword(s):  
Response Surface Methodology ◽  
Response Surface ◽  
Ethanol Concentration ◽  
Extraction Yield ◽  
Extraction Time ◽  
Process Conditions ◽  
Extraction Temperature ◽  
Single Factor ◽  
Extraction Voltage ◽  
Homogenate Extraction

Saffron, which has many kinds of biological activities, has been widely used in medicine, cosmetics, food, and other fields of health promotion industries. Crocins are the main component of saffron (Crocus sativus L.). At present, most of the extraction methods for crocins require long time or special instruments to complete the process and some of them are not suitable for industrial production at present. In this article, homogenate extraction technology which is a convenient and efficient method was developed for crocins extraction from saffron. Firstly, the influences of extraction voltage, extraction time, ethanol concentration, and temperature on crocins yield were studied by single factor experiments; and then response surface methodology (RSM) was used to optimize levels of four variables based on the result of single factor experiments. Results showed that the optimum extraction process conditions for crocins were as follows: extraction voltage, 110 V; ethanol concentration, 70%; extraction temperature, 57°C; and extraction time, 40 s. Based on these conditions, the extraction yield of crocins can reach 22.76% which is higher than ultrasonic extraction method. Therefore, homogenate extraction is an effective way to extract crocins from saffron with higher extraction yield and shorter extraction time.

scholarly journals Enzyme optimization to reduce the viscosity of pitanga (Eugenia uniflora L.) juice

2016 ◽  
Vol 19 (0) ◽  
Author(s):  
Ricardo Schmitz Ongaratto ◽  
Luiz Antonio Viotto
Keyword(s):  
Response Surface Methodology ◽  
Response Surface ◽  
Incubation Time ◽  
Regression Models ◽  
Incubation Temperature ◽  
Correlation Coefficients ◽  
Enzyme Concentration ◽  
Optimum Conditions ◽  
Activity Time ◽  
Independent Variables

Summary The aim of this work was to separately evaluate the effects of pectinase and cellulase on the viscosity of pitanga juice, and determine the optimum conditions for their use employing response surface methodology. The independent variables were pectinase concentration (0-2.0 mg.g–1) and cellulase concentration (0-1.0 mg.g–1), activity time (10-110 min) and incubation temperature (23.2-56.8 °C). The use of pectinase and cellulase reduced the viscosity by about 15% and 25%, respectively. The results showed that enzyme concentration was the most important factor followed by activity time, and for the application of cellulase the incubation temperature had a significant effect too. The regression models showed correlation coefficients (R2) near to 0.90. The pectinase application conditions that led to the lowest viscosity were: concentration of 1.7 mg.g–1, incubation temperature of 37.6 °C and incubation time of 80 minutes, while for cellulase the values were: concentration of 1.0 mg.g-1, temperature range of 25 °C to 35 °C and incubation time of 110 minutes.

scholarly journals OPTIMIZATION OF REFLUX EXTRACTION FOR CAESALPINIA SAPPAN LINN. WOOD BY USING RESPONSE SURFACE METHODOLOGY

2020 ◽  
Vol 83 (1) ◽  
pp. 85-92
Author(s):  
Mohd Azahar Mohd Ariff ◽  
Muhammad Syafiq Abd Jalil ◽  
Noor ‘Aina Abdul Razak ◽  
Jefri Jaapar
Keyword(s):  
Particle Size ◽  
Response Surface Methodology ◽  
Drinking Water ◽  
Response Surface ◽  
Extraction Time ◽  
Percentage Error ◽  
Optimum Conditions ◽  
Caesalpinia Sappan ◽  
The Mean ◽  
Repeated Runs

Caesalpinia sappan linn. (CSL) is a plant which is also known as Sepang tree contains various medicinal values such as to treat diarrhea, skin rashes, syphilis, jaundice, drinking water for blood purifying, diabetes, and to improve skin complexion. The aim of this study is to obtain the most optimum condition in terms of the ratio of sample to solvent, particle size, and extraction time to get the highest amount of concentration of the CSL extract. In this study, the ranges of each parameters used were: ratio sample to solvent: 1.0:20, 1.5:20, 2.0:20, 2.5:20, 3.0:20, particle size: 1 mm, 500 um, 250 um, 125 um, 63 um, and extraction time: 1 hr, 2 hr, 3 hr, 4 hr, 5 hr. The concentration was analyzed using a UV-vis spectrophotometer. The optimum conditions were obtained by response surface methodology. From the design, 20 samples were run throughout this experiment. The optimized value from the RSM were 2.0:20 for ratio sample to solvent, 125 µm of particle size and 2.48 hours with the concentration of 37.1184 ppm. The accuracy of the predictive model was validated with 2 repeated runs and the mean percentage error was less than 3%. This confirmed the model’s capability for optimizing the conditions for the reflux extraction of CSL’s wood.

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