scholarly journals The Influence of Cigarette Designs and Smoking Regimes on Vapour Phase Yields

Author(s):  
W Purkis ◽  
C Mueller ◽  
M Intorp ◽  
H Seidel

AbstractCigarettes with similar design features but with either cellulose acetate or dual carbon filters were made at 1-mg and 13-mg “tar” levels, as determined under the ISO smoking procedure. Products were smoked under the ISO, Massachusetts and Canadian smoking regimes to provide per-cigarette and per-puff yields of twelve vapour phase (VP) smoke components. The yields generated at the lit end of the cigarette and the significant yield reductions caused by filter ventilation, selective (carbon) adsorption, tobacco rod ventilation and diffusion were estimated in a modelling approach. For a “1-mg tar” carbon-filtered product it was estimated that the VP generated at the lit end was reduced by 99.4% to a machine yield of 17 µg/cig under ISO smoking conditions. Under the Canadian regime with 100% vent blocking, the estimated total VP was lowered 20% by tobacco rod effects and 15% by carbon filter adsorption giving a machine yield of 3487 µg/cig. The carbon filter adsorbed less efficiently partly due to the artificially high smoke temperatures through the filter that would probably not be tolerated by human smokers. Under the Massachusetts regime with 50% vent blocking, conditions better associated with human smoking, the total VP was lowered 51% by filter ventilation, 22% by tobacco rod effects and 17% by carbon filter adsorption giving a machine yield of 659 µg/cig. Ventilation is used to achieve “tar”/nicotine/carbon monoxide yield ceilings at 10/1/10 mg based on the current ISO smoking method. If future regulations were to mandate further reductions in VP then this will only be selectively achieved by increasing filter or tobacco rod ventilation/porosity or by using selective adsorption. It is inevitable that manufacturers will need to add further ventilation into their product to comply with such regulations and this should be reflected in any smoking regime. Furthermore, regimes with 100% vent blocking, that do not produce data reflecting the significant reductions in VP yields, provided to the smoker by ventilation, are misleading and their results will not correlate with relevant biomarker data. When proposing a different smoking regime, it is essential to understand the generation and transfer of smoke within cigarettes and factors involved in the subsequent data interpretation as described in this work. For regulatory evaluation purposes, cigarette characterisation using a regime that removes ventilation, one of the main design tools, is more misleading than the current ISO regime or one with partial vent blocking.

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Sofia Barbieri ◽  
Gabriele Babini ◽  
Jacopo Morini ◽  
Werner Friedland ◽  
Manuela Buonanno ◽  
...  

Abstract The consideration of how a given technique affects results of experimental measurements is a must to achieve correct data interpretation. This might be challenging when it comes to measurements on biological systems, where it is unrealistic to have full control (e.g. through a software replica) of all steps in the measurement chain. In this work we address how the effectiveness of different radiation qualities in inducing biological damage can be assessed measuring DNA damage foci yields, only provided that artefacts related to the scoring technique are adequately considered. To this aim, we developed a unified stochastic modelling approach that, starting from radiation tracks, predicts both the induction, spatial distribution and complexity of DNA damage, and the experimental readout of foci when immunocytochemistry coupled to 2D fluorescence microscopy is used. The approach is used to interpret γ-H2AX data for photon and neutron exposures. When foci are reconstructed in the whole cell nucleus, we obtain information on damage characteristics “behind” experimental observations, as the average damage content of a focus. We reproduce how the detection technique affects experimental findings, e.g. contributing to the saturation of foci yields scored at 30 minutes after exposure with increasing dose and to the lack of dose dependence for yields at 24 hours.


Development ◽  
2015 ◽  
Vol 143 (1) ◽  
pp. 174-179 ◽  
Author(s):  
Joseph D. Barry ◽  
Erika Donà, ◽  
Darren Gilmour ◽  
Wolfgang Huber

2016 ◽  
Vol 254 (2) ◽  
pp. 1600408 ◽  
Author(s):  
Iwan Halim Sahputra ◽  
Aurab Chakrabarty ◽  
Oscar Restrepo ◽  
Othmane Bouhali ◽  
Normand Mousseau ◽  
...  

Author(s):  
Ta Thi Luong ◽  
Pham Trong Lam ◽  
Dinh Van An

Borophene, a new member of the 2D material family, was proven theoretically and empirically in many recent studies that it has a unique structure and promising properties applied in batteries and electronic devices. In this work, the adsorbability of β12 – borophene towards some main poisonous gases was investigated. Herein, first-principle calculations were employed to obtain the adsorption configurations, adsorption energy of CO, NO, CO2, NH3, and NO2 on b12 – borophene by using three van der Waals correlation functionals: revPBE-vdW, optPBE-vdW, and vdW-DF2. Also, the most stable configurations and diffusion possibilities of the gas molecules on the surface of b12 – borophene were determined visually by using Computational DFT-based Nanoscope. The nature of bonding and interaction between gas molecules and b12 – borophene were disclosed by using the density of states analysis and Bader charge analysis. Remarkably, borophene exhibits as a highly selective adsorbent when having great interactions with NOx gases outweigh the others.


1983 ◽  
Vol 26 ◽  
Author(s):  
F. Lanza ◽  
A. Saltelli

ABSTRACTA simple mathematical model has been set up assuming that the glass leaching is defined by the diffusion and adsorption of the SiO2 in the porous media. It is also assumed that at the contact with the glass, the SiO2 content in the leachant reaches the saturation limit. Experimental weight losses seem to be in good agreement with the calculated values. In order to pass from the leaching rate of the glass to the release of radioactivity, the different radionuclides are subdivided into three different classes following their leaching rate and saturation limit. These three classes are discussed separately. An experiment which allows to measure leaching rate and diffusion of the various elements has been set up. Preliminary results are presented and discussed.


2021 ◽  
Vol 1 ◽  
pp. 171-172
Author(s):  
Jens Eckel ◽  
Martin Navarro ◽  
Stephan Hotzel

Abstract. During the site selection process, regulated by the Site Selection Act (Standortauswahlgesetz – StandAG), the implementer has to identify adequate siting regions and has to perform long-term safety analysis for these regions. The Federal Office for the Safety of Nuclear Waste Management (Bundesamt für die Sicherheit der nuklearen Entsorgung – BASE) as the responsible federal authority has to review the implementer's long-term safety analysis. To perform this duty in the required depth, it will be necessary to recalculate important aspects of the analysis by means of numerical computer programs. In addition, this will allow assessment of the underlying uncertainties of the implementer's long-term safety analysis from a regulatory point of view. Numerical modelling requires a high degree of quality assurance. Therefore, it is of vital importance that the same problem is modelled with different computer programs and – if possible – by different teams of modelers. This strategy is known as the diverse modelling approach. The goal of this approach is to perform a cross-check of the computer programs in use as well as of the correctness of data handling, data interpretation, and model implementation. Comparing outcomes of different modelling teams also integrates complementary views and approaches, which can be beneficial when dealing with complicated problems. The diverse modelling approach forms the basis of regulatory modelling. It can also be implemented within organizations if more than one code is used to tackle the same task. The diverse modelling approach has been carried out at GRS gGmbH over the past two decades by means of the computer programs, TOUGH2-GRS and MARNIE(2). Both (co-)developed programs are thermohydraulic codes that compute transport phenomena in porous media and can be coupled to geochemical codes, see Navarro (2018) and Navarro et al. (2021) for further details. TOUGH2-GRS and MARNIE(2) were applied in various projects, such as preliminary safety analysis Gorleben (VSG, Vorläufige Sicherheitsanalyse Gorleben), ZIESEL and EVEREST. A recent example for the diverse modelling approach was the use of TOUGH2-GRS and MARNIE for the development of indicators for the safe confinement of radionuclides in a deep geological repository (Navarro et al., 2019). A high degree of quality assurance is also achieved by involving computer programs in benchmarks to compare results among different codes for well-defined problems. For the calculation of THM (thermo-hydraulical-mechanical) processes TOUGH2-GRS has been coupled with the geomechanical computer program FLAC3D and this approach has been used in the benchmark BenVaSim (Seher et al., 2019). In this contribution selected works related to TOUGH2-GRS and MARNIE(2) are presented. From this starting-point, ideas and concepts for the continuation of development and quality assurance of the two computer programs at BASE in the near future are outlined. These works will contribute to strengthen the capabilities of BASE in the independent review process of implementer's long-term safety analysis within the site selection process.


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