Bioprospecting microbial metagenome for natural products

Biologia ◽  
2013 ◽  
Vol 68 (6) ◽  
Author(s):  
Jana Nováková ◽  
Marián Farkašovský
Keyword(s):  
Natural Products ◽  
Drug Discovery ◽  
Secondary Metabolites ◽  
Functional Diversity ◽  
Genetic Information ◽  
Microbial World ◽  
Future Directions ◽  
Natural Sources ◽  
Bioactive Natural Products ◽  
Uncultured Bacteria

AbstractMining of natural sources for new secondary metabolites has a successful history, which is reflected by the fact that over 50% of all drugs, currently on the market, are derived from natural products. Bacteria are one of the most important sources of bioactive natural products destined for drug discovery. However, less than 1% of the microorganisms observed in different habitats have been cultivated and characterized. To explore the genomic and functional diversity of the vast majority of the microbial world, novel methods were introduced, which are based on analysis of a DNA isolated from environmental communities. Metagenomics represents a strategy offering access to the genetic information present in uncultured bacteria by screening of libraries constructed from DNA isolated from different habitats. Functional- and sequence-driven screens are the major approaches employed to mine metagenomic libraries. This review aims to highlight discoveries in this area and discusses the possible future directions of the field.

scholarly journals Crocus sativus L. Extract and Its Constituents: Chemistry, Pharmacology and Therapeutic Potential

Molecules ◽  
2021 ◽  
Vol 26 (14) ◽  
pp. 4226
Author(s):  
Nikolaos Pitsikas ◽  
Konstantinos Dimas
Keyword(s):  
Natural Products ◽  
Secondary Metabolites ◽  
Organic Compounds ◽  
Therapeutic Potential ◽  
Crocus Sativus ◽  
Natural Sources ◽  
Crocus Sativus L

Natural products or organic compounds isolated from natural sources as primary or secondary metabolites have inspired numerous drugs [...]

scholarly journals Modern Approaches in the Discovery and Development of Plant-Based Natural Products and Their Analogues as Potential Therapeutic Agents

Molecules ◽  
2022 ◽  
Vol 27 (2) ◽  
pp. 349
Author(s):  
Asim Najmi ◽  
Sadique A. Javed ◽  
Mohammed Al Bratty ◽  
Hassan A. Alhazmi
Keyword(s):  
Natural Products ◽  
Drug Discovery ◽  
Natural Product ◽  
Therapeutic Agents ◽  
Throughput Capacity ◽  
Scientific Interest ◽  
Comprehensive Overview ◽  
Natural Sources ◽  
Discovery Research ◽  
Drug Discovery Research

Natural products represents an important source of new lead compounds in drug discovery research. Several drugs currently used as therapeutic agents have been developed from natural sources; plant sources are specifically important. In the past few decades, pharmaceutical companies demonstrated insignificant attention towards natural product drug discovery, mainly due to its intrinsic complexity. Recently, technological advancements greatly helped to address the challenges and resulted in the revived scientific interest in drug discovery from natural sources. This review provides a comprehensive overview of various approaches used in the selection, authentication, extraction/isolation, biological screening, and analogue development through the application of modern drug-development principles of plant-based natural products. Main focus is given to the bioactivity-guided fractionation approach along with associated challenges and major advancements. A brief outline of historical development in natural product drug discovery and a snapshot of the prominent natural drugs developed in the last few decades are also presented. The researcher’s opinions indicated that an integrated interdisciplinary approach utilizing technological advances is necessary for the successful development of natural products. These involve the application of efficient selection method, well-designed extraction/isolation procedure, advanced structure elucidation techniques, and bioassays with a high-throughput capacity to establish druggability and patentability of phyto-compounds. A number of modern approaches including molecular modeling, virtual screening, natural product library, and database mining are being used for improving natural product drug discovery research. Renewed scientific interest and recent research trends in natural product drug discovery clearly indicated that natural products will play important role in the future development of new therapeutic drugs and it is also anticipated that efficient application of new approaches will further improve the drug discovery campaign.

scholarly journals A Review of Anti-Inflammatory Compounds from Marine Fungi, 2000–2018

Marine Drugs ◽  
2019 ◽  
Vol 17 (11) ◽  
pp. 636 ◽  
Author(s):  
Jianzhou Xu ◽  
Mengqi Yi ◽  
Lijian Ding ◽  
Shan He
Keyword(s):  
Natural Products ◽  
Secondary Metabolites ◽  
Host Response ◽  
Marine Fungi ◽  
Tissue Injury ◽  
Fungal Metabolites ◽  
Bioactive Natural Products ◽  
Anti Inflammatory ◽  
Unique Mechanism ◽  
Inflammatory Action

Inflammation is a generalized, nonspecific, and beneficial host response of foreign challenge or tissue injury. However, prolonged inflammation is undesirable. It will cause loss function of involve organs, such as heat, pain redness, and swelling. Marine natural products have gained more and more attention due to their unique mechanism of anti-inflammatory action, and have considered a hotspot for anti-inflammatory drug development. Marine-derived fungi are promising sources of structurally unprecedented bioactive natural products. So far, a plethora of new secondary metabolites with anti-inflammatory activities from marine-derived fungi had been widely reported. This review covers 133 fungal metabolites described in the period of 2000 to 2018, including the structures and origins of these secondary metabolites.

scholarly journals New and bioactive natural products from an endophyte of Panax notoginseng

RSC Advances ◽  
2017 ◽  
Vol 7 (60) ◽  
pp. 38100-38109 ◽  
Author(s):  
Jun Xie ◽  
Ying-Ying Wu ◽  
Tian-Yuan Zhang ◽  
Meng-Yue Zhang ◽  
Wei-Wei Zhu ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Natural Products ◽  
Secondary Metabolites ◽  
Antiviral Activity ◽  
Cytotoxic Activity ◽  
Endophytic Fungi ◽  
Panax Notoginseng ◽  
Bioactive Natural Products

Secondary metabolites with cytotoxic activity, antiviral activity and antimicrobial activity from the endophytic fungi of Panax notoginseng.

Natural Products from Deep-Sea-Derived Fungi ̶ A New Source of Novel Bioactive Compounds?

2018 ◽  
Vol 25 (2) ◽  
pp. 186-207 ◽  
Author(s):  
Georgios Daletos ◽  
Weaam Ebrahim ◽  
Elena Ancheeva ◽  
Mona El-Neketi ◽  
Weiguo Song ◽  
...  
Keyword(s):  
Natural Products ◽  
Drug Discovery ◽  
Secondary Metabolites ◽  
Bioactive Compounds ◽  
Deep Sea ◽  
Underlying Assumption ◽  
Pharmacologically Active ◽  
Promising Source ◽  
New Metabolites

Background: Over the last two decades, deep-sea-derived fungi are considered to be a new source of pharmacologically active secondary metabolites for drug discovery mainly based on the underlying assumption that the uniqueness of the deep sea will give rise to equally unprecedented natural products. Indeed, up to now over 200 new metabolites have been identified from deep-sea fungi, which is in support of the statement made above. Results: This review summarizes the new and/or bioactive compounds reported from deepsea- derived fungi in the last six years (2010 – October 2016) and critically evaluates whether the data published so far really support the notion that these fungi are a promising source of new bioactive chemical entities.

Research progress on secondary metabolites from the ascidians of Aplidium genus

2020 ◽  
Vol 17 ◽  
Author(s):  
Qing-Hua Han ◽  
Xiao-Qing Tian ◽  
Shu-Ming Zhao ◽  
Ya-Nan Lu ◽  
Cheng-Qi Fan
Keyword(s):  
Natural Products ◽  
Secondary Metabolites ◽  
Marine Environment ◽  
Chemical Diversity ◽  
Research Progress ◽  
China Seas ◽  
Bioactive Natural Products ◽  
The Family ◽  
Further Development

Abstract: Ascidians (tunicates) are widely recognized as one of the most prolific producers of bioactive natural products in the marine environment. This present study reviewed the chemical diversity of marine ascidians from the Aplidium genus and their pharmacological applications since Jan 2005. The resources of this genus from China Seas, including the changes of their names in the family Polydinidae were also summarized in this paper. In addition, a concise outlook on their chemi-cal and pharmaceutical investigation is made to support further development

scholarly journals Bioactive Nitrogenous Secondary Metabolites from the Marine Sponge Genus Haliclona

Marine Drugs ◽  
2019 ◽  
Vol 17 (12) ◽  
pp. 682 ◽  
Author(s):  
Jiaying Zhu ◽  
Yang Liu ◽  
Zijun Liu ◽  
Hao Wang ◽  
Huawei Zhang
Keyword(s):  
Natural Products ◽  
Drug Discovery ◽  
Secondary Metabolites ◽  
Marine Sponge ◽  
Literature Search ◽  
Extensive Literature ◽  
Symbiotic Microorganisms ◽  
Bioactive Properties ◽  
Potential Applications ◽  
Extensive Literature Search

Marine sponge genus Haliclona, one of the most prolific sources of natural products, contains over 600 species but only a small part of them had been classified and chemically investigated. On the basis of extensive literature search, this review firstly summarizes 112 nitrogenous secondary metabolites from classified and unclassified Haliclona sponges as well as from their symbiotic microorganisms. Most of these substances have only been found in Haliclona sponges, and display diverse bioactive properties with potential applications in new drug discovery.

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