scholarly journals New and bioactive natural products from an endophyte of Panax notoginseng

RSC Advances ◽  
2017 ◽  
Vol 7 (60) ◽  
pp. 38100-38109 ◽  
Author(s):  
Jun Xie ◽  
Ying-Ying Wu ◽  
Tian-Yuan Zhang ◽  
Meng-Yue Zhang ◽  
Wei-Wei Zhu ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Natural Products ◽  
Secondary Metabolites ◽  
Antiviral Activity ◽  
Cytotoxic Activity ◽  
Endophytic Fungi ◽  
Panax Notoginseng ◽  
Bioactive Natural Products

Secondary metabolites with cytotoxic activity, antiviral activity and antimicrobial activity from the endophytic fungi of Panax notoginseng.

scholarly journals Antimicrobial Activity of the Leaf, Flower and Stem Extracts of Sphenoclea zeylanica

2016 ◽  
Vol 4 (3) ◽  
pp. 325-329 ◽  
Author(s):  
J. Gowri ◽  
P.Arockia Sahayaraj ◽  
M Amaladasan
Keyword(s):  
Antimicrobial Activity ◽  
Natural Products ◽  
Secondary Metabolites ◽  
Microbial Activity ◽  
Leaf Extract ◽  
Microbial Growth ◽  
Zone Of Inhibition ◽  
Bioactive Natural Products ◽  
Antibacterial And Antifungal Activities ◽  
Antibacterial And Antifungal

The present study was carried out with an objective to investigate the antimicrobial potentials of leaves, flowers and stem extracts of Sphenoclea zeylanica. The aim of the study was to evaluate the antimicrobial activity and to determine the zone of inhibition of extracts against medically important bacterial and fungal strains. The antimicrobial activity was determined in the extracts using zone of inhibition method. The antibacterial and antifungal activities of extracts (40, 50, 60 and 70) of Sphenoclea zeylanica were tested against B. subtilis, P. vulgaris, S.aureus, E.coli, C. albicans, A. niger, S. typhi and B. cereus. Zone of inhibition of extracts were compared with that of control for antimicrobial activity. The results showed that the leaf extract showed notable inhibition of the microbial growth against the tested organisms. The microbial activity of the Sphenoclea zeylanic a might be due to the presence of various secondary metabolites. Hence, this plant can be used to identify the specific bioactive natural products which may serve as leads in the development of new antimicrobial agents.Int J Appl Sci Biotechnol, Vol 4(3): 325-329

scholarly journals Natural Products from Endophytic Fungi Associated with Rubiaceae Species

2020 ◽  
Vol 6 (3) ◽  
pp. 128
Author(s):  
Jacqueline Santos Cruz ◽  
Carla Amaral da Silva ◽  
Lidilhone Hamerski
Keyword(s):  
Antioxidant Activity ◽  
Natural Products ◽  
Secondary Metabolites ◽  
Neurodegenerative Diseases ◽  
Cytotoxic Activity ◽  
Endophytic Fungi ◽  
Chemical Diversity ◽  
Pharmacological Properties ◽  
Anti Inflammatory

This review presents the chemical diversity and pharmacological properties of secondary metabolites produced by endophytic fungi associated with various genera of Rubiaceae. Several classes of natural products are described for these endophytes, although, this study highlights the importance of some metabolites, which are involved in antifungal, antibacterial, anti-protozoal activities; neurodegenerative diseases; cytotoxic activity; anti-inflammatory and antioxidant activity; and hyperglycemic control.

scholarly journals Isolation of a Novel Polyketide from Neodidymelliopsis sp.

Molecules ◽  
2021 ◽  
Vol 26 (11) ◽  
pp. 3235
Author(s):  
Melissa M. Cadelis ◽  
Hugo Gordon ◽  
Alex Grey ◽  
Soeren Geese ◽  
Daniel R. Mulholland ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Natural Products ◽  
Ambient Temperature ◽  
Crude Extract ◽  
Structure Elucidation ◽  
Fungal Pathogens ◽  
Spectroscopic Techniques ◽  
Bioactive Natural Products

Fungi have become an invaluable source of bioactive natural products, with more than 5 million species of fungi spanning the globe. Fractionation of crude extract of Neodidymelliopsis sp., led to the isolation of a novel polyketide, (2Z)-cillifuranone (1) and five previously reported natural products, (2E)-cillifuranone (2), taiwapyrone (3), xylariolide D (4), pachybasin (5), and N-(5-hydroxypentyl)acetamide (6). It was discovered that (2Z)-cillifuranone (1) was particularly sensitive to ambient temperature and light resulting in isomerisation to (2E)-cillifuranone (2). Structure elucidation of all the natural products were conducted by NMR spectroscopic techniques. The antimicrobial activity of 2, 3, and 5 were evaluated against a variety of bacterial and fungal pathogens. A sodium [1-13C] acetate labelling study was conducted on Neodidymelliopsis sp. and confirmed that pachybasin is biosynthesised through the acetate polyketide pathway.

scholarly journals Cytotoxic activity of marine sponge extracts from the sub-Antarctic Islands and the Southern Ocean

2016 ◽  
Vol Volume 112 (Number 11/12) ◽  
Author(s):  
Elisabeth K. Olsen ◽  
Christopher K. de Cerf ◽  
Godwin A. Dziwornu ◽  
Eleonora Puccinelli ◽  
Isabelle J. Ansorge ◽  
...  
Keyword(s):  
Natural Products ◽  
Southern Ocean ◽  
Cytotoxic Activity ◽  
Marine Invertebrates ◽  
Cold Water ◽  
Research Effort ◽  
Benthic Invertebrate ◽  
Marine Sponges ◽  
Bioactive Natural Products ◽  
Prince Edward Islands

Abstract Over the past 50 years, marine invertebrates, especially sponges, have proven to be a valuable source of new and/or bioactive natural products that have the potential to be further developed as lead compounds for pharmaceutical applications. Although marine benthic invertebrate communities occurring off the coast of South Africa have been explored for their biomedicinal potential, the natural product investigation of marine sponges from the sub-Antarctic Islands in the Southern Ocean for the presence of bioactive secondary metabolites has been relatively unexplored thus far. We report here the results for the biological screening of both aqueous and organic extracts prepared from nine specimens of eight species of marine sponges, collected from around Marion Island and the Prince Edward Islands in the Southern Ocean, for their cytotoxic activity against three cancer cell lines. The results obtained through this multidisciplinary collaborative research effort by exclusively South African institutions has provided an exciting opportunity to discover cytotoxic compounds from sub-Antarctic sponges, whilst contributing to our understanding of the biodiversity and geographic distributions of these cold-water invertebrates. Therefore, we acknowledge here the various contributions of the diverse scientific disciplines that played a pivotal role in providing the necessary platform for the future natural products chemistry investigation of these marine sponges from the sub- Antarctic Islands and the Southern Ocean.

Bioactive Natural Products of Endophytic Fungi from Marine Algae

Marine OMICS ◽  
2016 ◽  
pp. 383-405
Author(s):  
Vasuki Subramanian ◽  
P. Anantharaman ◽  
K. Kathiresan
Keyword(s):  
Natural Products ◽  
Endophytic Fungi ◽  
Marine Algae ◽  
Bioactive Natural Products

scholarly journals Evaluation of antimicrobial, antioxidant and cytotoxic properties of bioactive compounds produced from endophytic fungi of Himalayan yew (Taxus wallichiana) in Nepal

F1000Research ◽  
2020 ◽  
Vol 9 ◽  
pp. 379 ◽  
Author(s):  
Dhurva Prasad Gauchan ◽  
Pratistha Kandel ◽  
Astha Tuladhar ◽  
Ashesh Acharya ◽  
Upendra Kadel ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Secondary Metabolites ◽  
Ethyl Acetate ◽  
Bioactive Compounds ◽  
Endophytic Fungi ◽  
Diffusion Method ◽  
Dry Extract ◽  
Brine Shrimp Lethality Assay ◽  
Fungal Extracts ◽  
Taxus Wallichiana

Background: Endophytic fungi are largely underexplored in the discovery of natural bioactive products though being rich sources of novel compounds with promising pharmaceutical potential. In this study, Taxus wallichiana, which has huge medicinal value, was investigated for its endophytic diversity and capability to produce bioactive secondary metabolites by analyzing antioxidant, antimicrobial and cytotoxic properties. Methods: The endophytes were identified by ITS-PCR using genomic DNA samples. The secondary metabolites were extracted by solvent extraction method using ethyl acetate. The antioxidant activity was analyzed by Thin Layer Chromatography, Total Phenol Content (TPC), Total Flavonoid Content (TFC) and DPPH assay, and the antimicrobial activity was analyzed by agar-well diffusion method. Brine shrimp lethality assay was used to analyze the cytotoxicity of the fungal extracts. Results: Out of 16 different Taxus trees sampled from different locations of Dhorpatan, 13 distinctive endophytic fungi were isolated and grouped into 9 different genera: Bjerkandera, Trichoderma, Preussia, Botrytis, Arthrinium, Alternaria, Cladosporium, Sporormiella and Daldinia. The ethyl acetate extracts isolated from three endophytic fungi: Alternaria alternata, Cladosporium cladosporioides and Alternaria brassicae showed significant TPC values of 204±6.144, 312.3±2.147 and 152.7±4.958µg GAE/mg of dry extract, respectively, and TFC values of 177.9±2.911, 644.1±4.202 and 96.38±3.851µg RE/mg of dry extract, respectively. Furthermore, these three extracts showed a dose dependent radical scavenging activity with IC50 concentration of 22.85, 22.15 and 23.001 µg/ml, respectively. The extracts of C. cladosporioides and A. brassicae also showed promising antimicrobial activity against Escherichia coli, Staphylococcus aureus and Bacillus subtilis with a minimum inhibitory concentration of 250μg/ml for all bacteria. Both the samples showed cytotoxic property against shrimp nauplii with LC50 of 104.2 and 125.9µg/ml, respectively. Conclusions: The crude fungal extracts obtained from endophytes: A. alternata, C. cladosporioides and A. brassicae upon purification and further identification of the bioactive compounds can be a fascinating source for novel pharmaceutical agents.

scholarly journals A Review of Anti-Inflammatory Compounds from Marine Fungi, 2000–2018

Marine Drugs ◽  
2019 ◽  
Vol 17 (11) ◽  
pp. 636 ◽  
Author(s):  
Jianzhou Xu ◽  
Mengqi Yi ◽  
Lijian Ding ◽  
Shan He
Keyword(s):  
Natural Products ◽  
Secondary Metabolites ◽  
Host Response ◽  
Marine Fungi ◽  
Tissue Injury ◽  
Fungal Metabolites ◽  
Bioactive Natural Products ◽  
Anti Inflammatory ◽  
Unique Mechanism ◽  
Inflammatory Action

Inflammation is a generalized, nonspecific, and beneficial host response of foreign challenge or tissue injury. However, prolonged inflammation is undesirable. It will cause loss function of involve organs, such as heat, pain redness, and swelling. Marine natural products have gained more and more attention due to their unique mechanism of anti-inflammatory action, and have considered a hotspot for anti-inflammatory drug development. Marine-derived fungi are promising sources of structurally unprecedented bioactive natural products. So far, a plethora of new secondary metabolites with anti-inflammatory activities from marine-derived fungi had been widely reported. This review covers 133 fungal metabolites described in the period of 2000 to 2018, including the structures and origins of these secondary metabolites.

scholarly journals Antimicrobial Potential of Endophytes from Datura metel Linn.

2018 ◽  
Vol 8 (4) ◽  
pp. 27
Author(s):  
Madhu Priya M. ◽  
P. Agastian Simiyon Theoder
Keyword(s):  
Antimicrobial Activity ◽  
Disease Resistance ◽  
Secondary Metabolites ◽  
Endophytic Fungi ◽  
Higher Plants ◽  
Antimicrobial Potential ◽  
Therapeutic Drugs ◽  
Datura Metel ◽  
Novel Products ◽  
Ethyl Acetate Extracts

Endophytes are a suite of microorganisms that grow in the tissues of higher plants. Endophytes constitute a valuable source of secondary metabolites for the discovery of new potential therapeutic drugs.  Endophytes can have many effects on their host such as enhancement of stress, insect and disease resistance, and herbicide activities when in association with their host plant. The present study was to examine the antimicrobial activity of ethyl acetate extracts of endophytic fungi (both extra and intracellular) and actinomycete from the stem and root of Datura metel L. The crude extract of these endophytic isolates were screened for their antimicrobial potential. Among the endophytes, the extracellular fungal extract showed the highest antimicrobial activity when compared to intracellular fungi and actinomycetes. The studies and isolation of these compounds can be used as a good approach to search of novel products.

Endophytic fungi found in association with Smallanthus sonchifolius (Asteraceae) as resourceful producers of cytotoxic bioactive natural products

2008 ◽  
Vol 49 (2) ◽  
pp. 142-151 ◽  
Author(s):  
Margareth B. C. Gallo ◽  
Fernanda O. Chagas ◽  
Marília O. Almeida ◽  
Cláudia C. Macedo ◽  
Bruno C. Cavalcanti ◽  
...  
Keyword(s):  
Natural Products ◽  
Endophytic Fungi ◽  
Bioactive Natural Products ◽  
Smallanthus Sonchifolius
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