scholarly journals Crocus sativus L. Extract and Its Constituents: Chemistry, Pharmacology and Therapeutic Potential

Molecules ◽  
2021 ◽  
Vol 26 (14) ◽  
pp. 4226
Author(s):  
Nikolaos Pitsikas ◽  
Konstantinos Dimas
Keyword(s):  
Natural Products ◽  
Secondary Metabolites ◽  
Organic Compounds ◽  
Therapeutic Potential ◽  
Crocus Sativus ◽  
Natural Sources ◽  
Crocus Sativus L

Natural products or organic compounds isolated from natural sources as primary or secondary metabolites have inspired numerous drugs [...]

scholarly journals Pharmacological properties and therapeutic potential of saffron ( Crocus sativus L.) in osteosarcoma

2019 ◽  
Vol 72 (1) ◽  
pp. 56-67 ◽  
Author(s):  
Bilal Ege ◽  
Onder Yumrutas ◽  
Miray Ege ◽  
Mustafa Pehlivan ◽  
Ibrahim Bozgeyik
Keyword(s):  
Therapeutic Potential ◽  
Crocus Sativus ◽  
Pharmacological Properties ◽  
Crocus Sativus L

Bioprospecting microbial metagenome for natural products

Biologia ◽  
2013 ◽  
Vol 68 (6) ◽  
Author(s):  
Jana Nováková ◽  
Marián Farkašovský
Keyword(s):  
Natural Products ◽  
Drug Discovery ◽  
Secondary Metabolites ◽  
Functional Diversity ◽  
Genetic Information ◽  
Microbial World ◽  
Future Directions ◽  
Natural Sources ◽  
Bioactive Natural Products ◽  
Uncultured Bacteria

AbstractMining of natural sources for new secondary metabolites has a successful history, which is reflected by the fact that over 50% of all drugs, currently on the market, are derived from natural products. Bacteria are one of the most important sources of bioactive natural products destined for drug discovery. However, less than 1% of the microorganisms observed in different habitats have been cultivated and characterized. To explore the genomic and functional diversity of the vast majority of the microbial world, novel methods were introduced, which are based on analysis of a DNA isolated from environmental communities. Metagenomics represents a strategy offering access to the genetic information present in uncultured bacteria by screening of libraries constructed from DNA isolated from different habitats. Functional- and sequence-driven screens are the major approaches employed to mine metagenomic libraries. This review aims to highlight discoveries in this area and discusses the possible future directions of the field.

scholarly journals Therapeutic Potential of Saffron Crocus (Crocus sativus L.)

2016 ◽  
Vol 4 (12) ◽  
pp. 1240 ◽  
Author(s):  
Zeliha Selamoglu ◽  
Senay Ozgen
Keyword(s):  
Medicinal Plants ◽  
Scarlet Fever ◽  
Therapeutic Potential ◽  
Heart Diseases ◽  
Folk Medicine ◽  
Crocus Sativus ◽  
Folk Remedy ◽  
Herbal Plants ◽  
Crocus Sativus L

Herbal plants are using for folk medicine since immemorial times. Hippocrates who is the father of medicine, refer to 400 medicinal plants and advised ‘‘let food be your medicine and let medicine be your food’’. Most of plants are using today for medicine. It is still acceptable today that prevention is more important than treatment. Saffron was utilized in folk remedy against scarlet fever, smallpox, colds, asthma, eye and heart diseases, tumours, and cancer.

scholarly journals Exploring novel secondary metabolites from natural products using pre-processed mass spectral data

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Hyun Woo Kim ◽  
Seong Yeon Choi ◽  
Hyeon Seok Jang ◽  
Byeol Ryu ◽  
Sang Hyun Sung ◽  
...  
Keyword(s):  
Natural Products ◽  
Secondary Metabolites ◽  
Natural Product ◽  
Spectral Data ◽  
Structural Diversity ◽  
Natural Material ◽  
Natural Sources ◽  
Mass Spectral ◽  
Aerial Parts ◽  
Similar Chemical

AbstractMany natural product chemists are working to identify a wide variety of novel secondary metabolites from natural materials and are eager to avoid repeatedly discovering known compounds. Here, we developed liquid chromatography/mass spectrometry (LC/MS) data-processing protocols for assessing high-throughput spectral data from natural sources and scoring the novelty of unknown metabolites from natural products. This approach automatically produces representative MS spectra (RMSs) corresponding to single secondary metabolites in natural sources. In this study, we used the RMSs of Agrimonia pilosa roots and aerial parts as models to reveal the structural similarities of their secondary metabolites and identify novel compounds, as well as isolation of three types of nine new compounds including three pilosanidin- and four pilosanol-type molecules and two 3-hydroxy-3-methylglutaryl (HMG)-conjugated chromones. Furthermore, we devised a new scoring system, the Fresh Compound Index (FCI), which grades the novelty of single secondary metabolites from a natural material using an in-house database constructed from 466 representative medicinal plants from East Asian countries. We expect that the FCIs of RMSs in a sample will help natural product chemists to discover other compounds of interest with similar chemical scaffolds or novel compounds and will provide insights relevant to the structural diversity and novelty of secondary metabolites in natural products.

Effect of natural products on diabetes associated neurological disorders

2017 ◽  
Vol 28 (3) ◽  
pp. 271-293 ◽  
Author(s):  
Sita Sharan Patel ◽  
Malairaman Udayabanu
Keyword(s):  
Natural Products ◽  
Secondary Metabolites ◽  
Neurological Disorders ◽  
Therapeutic Potential ◽  
Neurological Complications ◽  
Brain Regions ◽  
Special Focus ◽  
Traditional System ◽  
Efficient Management ◽  
Current Review

AbstractDiabetes mellitus, a metabolic disorder, is associated with neurological complications such as depression, anxiety, hypolocomotion, cognitive dysfunction, phobias, anorexia, stroke, pain, etc. Traditional system of medicine is long known for its efficient management of diabetes. The current review discusses the scope of some common medicinal herbs as well as secondary metabolites with a special focus on diabetes-mediated central nervous system complications. Literatures suggest that natural products reduce diabetes-mediated neurological complications partly by reducing oxidative stress and/or inflammation or apoptosis in certain brain regions. Natural products are known to modulate diabetes-mediated alterations in the level of acetylcholinesterase, choline acetyltransferase, monoamine oxidase, serotonin receptors, muscarinic receptors, insulin receptor, nerve growth factor, brain-derived neurotrophic factor, and neuropeptide in brain. Further, there are several natural products reported to manage diabetic complications with unknown mechanism. In conclusion, medicinal plants or their secondary metabolites have a wide scope and possess therapeutic potential to effectively manage neurological complications associated with chronic diabetes.

scholarly journals Therapeutic Potential of Saffron (Crocus sativus L.) in Ischemia Stroke

2021 ◽  
Vol 2021 ◽  
pp. 1-8
Author(s):  
Shakiba Azami ◽  
Zahra Shahriari ◽  
Samira Asgharzade ◽  
Tahereh Farkhondeh ◽  
Mahmood Sadeghi ◽  
...  
Keyword(s):  
Therapeutic Potential ◽  
Crocus Sativus ◽  
Pharmacological Effects ◽  
Oxidative Stress Markers ◽  
Neuroprotective Effects ◽  
Beneficial Effects ◽  
Stress Markers ◽  
Ancient Times ◽  
And Oxidative Stress ◽  
Crocus Sativus L

Stroke is the second leading cause of death and a main cause of disability worldwide. The majority (approximately 80%) of strokes are ischemic. Saffron (Crocus sativus L.) has been considered for medicinal purposes since ancient times. Pharmacological effects of saffron are attributed to the presence of crocin, crocetin, picrocrocin, and safranal. In the present review, we summarized the reported neuroprotective effects of saffron and its active constituents against cerebral ischemia stroke. Saffron and its components exert its beneficial effects as an antioxidant, anti-inflammatory, and antiapoptotic agent though inhibition of biochemical, inflammatory, and oxidative stress markers. Taken together, this review indicates that saffron and its ingredients could be a potent candidate in the process of new drug production for the treatment of ischemia stroke.

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