scholarly journals Antidiabetic Potential of Alcoholic and Aqueous Extracts of Ficus racemosa Linn. Bark In Normal and Alloxan Induced Diabetic Rats

2009 ◽  
Vol 1 (01) ◽  
Author(s):  
Nikhil K. Sachan ◽  
Yatindra Kumar ◽  
Seema Pushkar ◽  
R. N. Thakur ◽  
Sudhir S. Gangwar ◽  
...  
Keyword(s):  
Blood Glucose ◽  
Blood Glucose Level ◽  
Glucose Level ◽  
Aqueous Extract ◽  
Ethanolic Extract ◽  
Diabetic Rats ◽  
Alcoholic Extract ◽  
Glucose Lowering ◽  
Ficus Racemosa ◽  
Lowering Activity

The present investigation aims to examine the diabetic potential of the plant Ficus racemosa in normal and alloxan induced diabetic rats. The bark extract with water, petroleum ether and with alcohol were screened for blood glucose lowering activity and the alcoholic extract having better therapeutic potential was prepared through Soxhlet extraction for further study. Alcoholic and aqueous extract of bark of Ficus racemosa at a dose of 400 mg/Kg was given to normal and alloxan induced diabetic rats and the blood samples taken from the retero-orbital plexus vein were analyzed for blood glucose level as per standard protocol with available kits through Auto-analyzer. The comparison of blood sugar level as per model schedule showed that in normal group the ethanolic extract, at a dose of 400 mg/Kg intra-peritoneal, the blood glucose lowering 28.66 % while in aqueous extract given group it was 25.90 %. In alloxan induced diabetic rats decrease in blood glucose level in aqueous and ethanolic extract group was found to be 27.01 % and 45.03 % respectively. In conclusion, the ethanolic extract of Ficus racemosa reflected anti-diabetic potential through its glucose lowering activity in experimental animals. It supported the folklore claim of anti-diabetic activity of the plant.

scholarly journals Effects of Fruits Extracts of Three Medicinal Plants on the Blood Glucose Level of Glucose-induced Hyperglycemic and Normal Rabbit Models

2012 ◽  
Vol 3 (1) ◽  
Author(s):  
Ikram Ilahi ◽  
Asghar Khan ◽  
Ubaid Ullah ◽  
Imran Khan ◽  
Jawad Ali ◽  
...  
Keyword(s):  
Body Weight ◽  
Blood Glucose ◽  
Medicinal Plants ◽  
Blood Glucose Level ◽  
Glucose Level ◽  
Methanol Extract ◽  
Second Phase ◽  
Glucose Lowering ◽  
Fruit Extracts ◽  
Lowering Activity

The fruits of Pistacia integerrima (PI), Withania coagulans (WC) and Withania somnifera (WS) have been reported for their medicinal values. The aim of the present study was to compare the glucose lowering activities of the fruit extracts of these three medicinal plants in glucose induced non-diabetic hyperglycemic and normal rabbit models. During the first phase of experiments, the effects of oral administration of 70% methanol extract of each plant fruit (600 mg/kg body weight) and glibenclamide (5 mg/kg body weight) were studied on the glucose level of glucose induced hyperglycemic rabbits, while in the second phase of experiments, the effects of each fruit extract (600 mg/kg body weight) and glibenclamide (5 mg/kg body weight) were assessed on the glucose level of normal rabbits. Among the three fruit extracts, maximum reduction in the blood glucose level was caused by the PI extract (P ˂0.05). The glucose lowering activity of the PI extract was greater than that of the standard, glibenclamide (5mg/kg), during the first phase of experiments. However during the second phase of experiments the hypoglycemic effect of the PI extract was comparable to that of the standard, glibenclamide (5mg/kg). In conclusion the present study reveals that the 70% methanol extract of Pistacia integerrima fruit can decrease glucose level significantly in glucose induced non-diabetic hyperglycemic and normal rabbit models.

scholarly journals Anti-diabetic Activity of Ethanolic Extract of Elaeocarpus serratus L. in Streptozotocin-Induced Diabetic Rats

2016 ◽  
Vol 8 (01) ◽  
Author(s):  
DH Geetha ◽  
Indhiramuthu Jayashree ◽  
M. Rajeswari
Keyword(s):  
Body Weight ◽  
Blood Glucose ◽  
Blood Glucose Level ◽  
Glucose Level ◽  
Ethanolic Extract ◽  
Diabetic Rats ◽  
The Body ◽  
Marker Enzymes ◽  
Metabolizing Enzymes ◽  
Liver Marker Enzymes

To investigate the anti-diabetic activity of Elaeocarpus serratus fruit in streptozotocin-induced (STZ) diabetic rats. The dose-dependent effects of 30days oral treatment with ethanol extracts of fruit (200 and 400 mg/kg) of E. serratus on body weight, blood glucose level, total protein, albumin, liver marker enzymes and carbohydrate metabolizing enzymes were evaluated in STZ-induced diabetic rats. Oral administration ethanolic extract of fruit of E. serratus showed significant restoration of the body weight and decrease in the blood glucose level, liver marker enzymes (ALT, AST ALP) and carbohydrate metabolizing enzymes were observed in diabetic rats. These results suggest that fruit extract of E. serratus has valuable anti-diabetic activity in STZ-induced diabetic rats which is comparable to the standard drug glibenclamide and hence might be of use in the management of diabetes.

scholarly journals In vivo Assessment of Antidiabetic Potential and Mapping of Pharmacological Properties of Ethanolic Extract of Leaves of Coccinia grandis on Alloxan-induced Diabetic Rats

2019 ◽  
pp. 1-9
Author(s):  
Zahirul Islam ◽  
Md. Rafat Tahsin ◽  
Ahmad Ullah Faisal ◽  
Tanzia Islam Tithi ◽  
Tasnova Tasnim Nova ◽  
...  
Keyword(s):  
Blood Glucose ◽  
Blood Glucose Level ◽  
Creatinine Level ◽  
Glucose Level ◽  
Safety Profile ◽  
Leaf Extract ◽  
Physiological State ◽  
Ethanolic Extract ◽  
Diabetic Rats ◽  
Coccinia Grandis

Diabetes is a metabolic disease and plant derived products are used to combat this deadly disease. Plant is a diverse source of numerous therapeutic compounds which can be used to ameliorate diabetes. Leaves of Coccinia grandis (L.) (Family: Cucurbitaceae) is one of the leafy vegetable that is used for this purpose traditionally. It has been used against diabetes for a very long time. Our aims were to identify the hypoglycemic effect of extract of leaves of Coccinia grandis as well as to determine its safety profile so that we could use the plant material to improve the diabetic condition. Diabetes was induced in rats by intraperitoneal injection of alloxan at a dose of 150 mg/Kg bodyweight and ethanolic extract of leaves of Coccinia grandis was fed to the rats at a dose of 750 mg/kg. We measured blood glucose level, and safety profile by measuring SGOT, SGPT and creatinine level on diabetic and non-diabetic rats before and after administration of the extract. After measuring blood glucose level, it was found that the hypoglycemic efficacy was comparable to that of metformin (p> 0.05) which was given at a dose of 500 mg/kg. Safety profile were investigated by checking SGOT, SGPT and creatinine level. It was seen that both metformin and leaf extract of Coccinia grandis improved the pathological condition induced by diabetes. Furthermore, in healthy individual rats both metformin and leaf extract of Coccinia grandis did not significantly alter the normal physiological state. It might, therefore, be inferred that the extract of leaves of Coccinia grandis could be used as a good alternative therapy to treat diabetes.

EVALUATION OF PHYTOCHEMICAL PROFILE AND ANTIDIABETIC ACTIVITY OF FICUS RACEMOSA (LINN.) STEM BARK IN RATS

INDIAN DRUGS ◽  
2017 ◽  
Vol 54 (01) ◽  
pp. 49-54
Author(s):  
N. D Solanki ◽  
S. K. Bhavsar ◽  
Keyword(s):  
Blood Glucose ◽  
Blood Glucose Level ◽  
Glucose Level ◽  
Diabetic Rats ◽  
Antidiabetic Activity ◽  
Phytochemical Analysis ◽  
Phytochemical Profile ◽  
Ficus Racemosa ◽  
Tlc Analysis ◽  
Mean Blood Glucose

Herbal plants are true bio-resources in traditional systems of medicine. Ficus racemosa (FR) Linn is a herb mentioned in ancient scriptures of Ayurveda having great medicinal importance. The present study aims to investigate phytochemical & antidiabetic activity of FR. Aqueous (AE) and ethanolic (EE) extracts of powdered shade dried bark of FR was used in the study. Phytochemical profile of extracts were evaluated by standard chemical tests & TLC analysis. The antidiabetic activity of AE and EE of FR was evaluated through STZ induced diabetes model by analyzing the blood glucose level before and after the study & mean blood glucose level through an HPLC method in Wistar rats. Prelimianry phytochemical analysis of EE showed presence of major phytoconstituents like alkaloid, glycoside, sterols, flavanoid, phenol, tannins while AE contains carbohydrates, cardiac glycosides, phytosterol, saponin, phenols, and protein. TLC analysis showed higher Rf value in EE in a different set of mobile phase. In acute toxicity study, a single oral dose (2000 mg/kg) did not produce any mortality in rats. 28 days treatment with AE (500 mg/kg) & EE (400 mg/kg) of FR showed a significant reduction (P<0.05) in blood glucose level compared to diabetic control rats (562.4±14.4), while the mean blood glucose level in treated diabetic rats was found significantly 92.69 mg/dl (AE) & 97.6 mg/dl (EE) (P<0.05) low as compared to diabetic rats (171.4 mg/dl). Our study concluded that presence of varieties of phytochemicals in FR provided strong antidiabetes potential.

scholarly journals Effect of administration of Ehretia anacua aqueous extract on blood glucose level in alloxan - induced diabetic rat

2021 ◽  
Vol 11 (2) ◽  
pp. 001-009
Author(s):  
Oyelade Waheed Abimbola ◽  
Oyebode Joseph Ademola ◽  
Fajilade Temilade Olawande
Keyword(s):  
Blood Glucose ◽  
Blood Glucose Level ◽  
Glucose Level ◽  
Aqueous Extract ◽  
Diabetic Rats ◽  
Diabetic Rat ◽  
Control Group ◽  
Albino Rats ◽  
Group I ◽  
Histopathological Studies

The effects of crude aqueous extract of Ehretia anacua on alloxan induced diabetic rats was investigated. Male albino rats of weighing between 120 to 150 were used, divided into 6 groups of five animals per group. Group I received distilled water throughout of the experiment and served as the control. Group II received 110 mg/kg of alloxan interperitoneally. Groups III, IV, V and VI received 110 mg/kg of alloxan and in addition administered with aqueous Ehretia anacua extract daily for 14 days. Blood glucose level was monitored at five days interval for fourteen days. Target organs (pancrease) was taken from each rat. The histopathological studies of the pancrease were examined. In alloxan - induced diabetic rats, blood glucose level was significantly increased compared with the control rats. Treating diabetic rats with 50, 100 and 200 mg/kg bw Ehretia anacua caused a significant decrease in the blood glucose level. The Photomicrograph of the histopathology examination of the pancrease (× 100) of the groups treated with alloxan showed poor architecture was destroyed whereas those treated with Ehretia nancua showed normal architecture. This illustrates the amelliorative effects of the extract on the alloxan-induced tocicity. It could be concluded from these results that, Ehretia nancua extract should be used in manufacture processes of the natural products as functional foods or as a dietary supplement with anti-diabecretic activity as hypoglycemic effect.

scholarly journals Effect of Afghan Talkhak (Acroptilon Repens) Aqueous Extract on Blood Glucose Level in Diabetic Rats

2021 ◽  
Vol 12 (2) ◽  
pp. 275-279
Author(s):  
Banafsha Zainal Bayat ◽  
Kawsar Alami ◽  
Sayed Yousof Mousavi
Keyword(s):  
Blood Glucose ◽  
Glucose Tolerance ◽  
Blood Glucose Level ◽  
Glucose Level ◽  
Aqueous Extract ◽  
Glucose Tolerance Test ◽  
Tolerance Test ◽  
Diabetic Rats ◽  
Diabetic Group ◽  
Acroptilon Repens

The aim of this study is the evaluation of the effect of Afghan talkhak (Acroptilon Repens) root aqueous extract on blood glucose level of diabetic rats. Rats were randomly divided into 5 groups (1 Normal, 1 Diabetic and 3 extract groups). Experimental diabetes was induced by single-dose intraperitoneal (i.p.) injection of streptozotocin (55 mg/kg) in diabetic and extracts groups. 72 hour later, the induction of diabetes was approved and extract groups were received Acroptilon Repens aqueous extract (200, 300, 400 mg/kg) by i.p. administration for 15 days. The blood glucose level and body weight of all groups were measured on baseline, 0, 5, 10 and 15th days. The glucose tolerance test had performed on days 0 and 15. The results showed that aqueous extract of Afghan Acroptilon Repens in extract groups (200 and 300 mg/kg) could significantly decrease the blood glucose level, and improve the glucose tolerance, as compared with the diabetic group (P<0.0001). However, there was not a significant difference in the blood glucose level and glucose tolerance test among the group which received 400 mg/kg dose of Acroptilon Repens and the diabetic group (P>0.05). In conclusion, Acroptilon Repens root aqueous extract possessed antihyperglycemic activity. 

PENGENDALIAN KADAR GLUKOSA DARAH OLEH TEH HIJAU DAN ATAU TEH DAUN MURBEI PADA TIKUS DIABETES

2010 ◽  
Vol 5 (2) ◽  
pp. 87
Author(s):  
Rusman Efendi ◽  
Evy Damayanthi ◽  
Lilik Kustiyah ◽  
Nastiti Kusumorini
Keyword(s):  
Blood Glucose ◽  
Blood Glucose Level ◽  
Green Tea ◽  
Glucose Level ◽  
Diabetic Rats ◽  
Feed Consumption ◽  
Font Size ◽  
High Prevalence ◽  
The Difference ◽  
Control Diabetes

<p class="MsoNormal" style="margin: 0cm 7.1pt 6pt 14.2pt; text-align: justify; text-indent: 1cm;"><span style="font-size: 10pt;">Diabetes mellitus is degeneratif disease with high prevalence that happens in many countries. Several studies had been done to control diabetes by using green tea, mullberry leaf  tea, and their mixture. The aim of this research was to analyze the influence of the administration green tea, mullbery leaf tea, and their mixtures to blood glucose level of diabetic rats both during 120 minutes after administration. This research had four phases, first to determine the best mullberry leaf tea, second to fourth phases respectively, determine turnover of blood glucose level on normal rats; attempt during 120 minutes on diabetic rats.  The result of research during 120 minutes have showed that blood glucose level on diabetic rats which were administered by green tea, mullberry leaf tea and their mixture is significantly difference with diabetic rats which were administered by water. Blood glucose level at baseline increased at 30<sup>th </sup>minutes and showed the difference significantly and then until 60<sup>th</sup> and 120<sup>th</sup> minutes and relatively stable. During 120 minutes after feed consumption, inhibition of blood glucose level occured increasingly on diabetic rats which were administered by green tea, mullberry leaf tea, and their mixture compared to diabetic rats which were administered by water.</span></p>

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