scholarly journals Initial evaluation of the relationship between CYP2C19 polymorphisms and platelet aggregation in patients with acute myocardial infraction in some hospitals in Hanoi

2017 ◽  
Vol 33 (2) ◽  
Author(s):  
Nguyen Thi Thuy Mau ◽  
Vu Ngoc Trung ◽  
Nguyen Huu Hieu ◽  
Nguyen Thanh Thuy ◽  
Vu Thi Thom ◽  
...  
Keyword(s):  
Platelet Aggregation ◽  
Platelet Aggregation Inhibitors ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Extensive Metabolizer ◽  
Myocardial Infraction ◽  
Aggregation Inhibitors ◽  
The Relationship ◽  
Intermediate Metabolizer ◽  
Cyp2c19 Polymorphisms

CYP2C19 is one of the pricipal enzymes involed in the antiplatelet prodrug in patients with acute myocardial infraction. Different genotypes can cause various responses to platelet aggregation inhibitors. Therefore, we conduct research to evaluate the relationship between CYP2C19 polymorphisms and platelet aggregation in patients with acute myocardial infraction. The study was processed with a cross-sectional study of patients diagnosed acute myocardial infraction had blood samples tested for the gene CYP2C19 and platelet aggregation. The results in 64 consecutive patients, phenotypes based on genotypes: 59,3% poor and intermediate metabolizer, 40,7% extensive metabolizer. The average platelet aggregation of (poor, intermediate) metabolizer and extensive metabolizer were 29,79±13,6 and 23,27±11,6, respectively, there was a high similarity between the groups (p>0,05). The average platelet aggregation of (poor, intermediate) metabolier and extensive metabolizer on the group with Clopidogrel were 26,2±10,5 and 29,9±13,6 (p>0,05), the average with Ticagrelor were 10,8±6,5 and 18,4±8,7 (p>0,05), respectively. The group treated with Ticagrelor had a lower platelet aggregation than the remaining one with Clopidogrel (p<0,01). The study got some initial results that would be important for further studies on the relationship between CYP2C19 polymorphisms and platelet aggregation on Viet Namese patients with acute myocardial infraction.

scholarly journals The Prescription of Vitamin K Antagonists in a Very Old Population: A Cross-Sectional Study of 8696 Ambulatory Subjects Aged Over 85 Years

2020 ◽  
Vol 17 (18) ◽  
pp. 6685
Author(s):  
Patrick Manckoundia ◽  
Clémentine Rosay ◽  
Didier Menu ◽  
Valentine Nuss ◽  
Anca-Maria Mihai ◽  
...  
Keyword(s):  
Vitamin K ◽  
Vitamin K Antagonists ◽  
Oral Anticoagulants ◽  
Direct Oral Anticoagulants ◽  
Platelet Aggregation Inhibitors ◽  
Cross Sectional Study ◽  
Very Elderly ◽  
Cross Sectional ◽  
Aggregation Inhibitors ◽  
Cardiovascular Medications

We compared very elderly people taking vitamin K antagonists (VKA) and those not taking VKA (noVKA). Individuals were included in the noVKA group if there was no VKA on their reimbursed prescriptions during the study period. We also compared three subgroups, constituted by VKA type (fluindione, warfarin, or acenocoumarol). We included individuals aged over 85 years, affiliated to Mutualité Sociale Agricole of Burgundy, who were refunded for prescribed VKA in September 2017. The VKA and noVKA groups were compared in terms of demographic conditions, registered chronic diseases (RCD), number of drugs per prescription and cardiovascular medications. The three VKA subgroups were compared for the same items plus laboratory monitoring, novel and refill VKA prescriptions, and prescriber specialty. Of the 8696 included individuals, 1157 (13.30%) were prescribed VKA. Mean age was 90 years. The noVKA group had fewer women (53.67 vs 66.08%), more RCD (93.43 vs. 71.96%) and more drugs per prescription (6.65 vs. 5.18) than the VKA group (all p < 0.01). Except for direct oral anticoagulants and platelet aggregation inhibitors, the VKA group took significantly more cardiovascular medications. The most commonly prescribed VKA was fluindione (59.46%). Mean age was higher in the warfarin (90.42) than in the acenocoumarol (89.83) or fluindione (89.71) subgroups (p < 0.01). No differences were observed for sex (women were predominant) or RCD. 13% of subjects in this population had a VKA prescription. Fluindione was the most commonly prescribed VKA.

Coping Style as a Mediator of the Relationship Between Depressive Symptoms and Deliberate Self-Harm

Crisis ◽  
2011 ◽  
Vol 32 (5) ◽  
pp. 272-279 ◽  
Author(s):  
Allison S. Christian ◽  
Kristen M. McCabe
Keyword(s):  
Depressive Symptoms ◽  
Undergraduate Students ◽  
Cross Sectional Study ◽  
Self Report ◽  
Hierarchical Regression ◽  
Cross Sectional ◽  
Deliberate Self Harm ◽  
Self Blame ◽  
Self Harm ◽  
The Relationship

Background: Deliberate self-harm (DSH) occurs with high frequency among clinical and nonclinical youth populations. Although depression has been consistently linked with the behavior, not all depressed individuals engage in DSH. Aims: The current study examined maladaptive coping strategies (i.e., self-blame, distancing, and self-isolation) as mediators between depression and DSH among undergraduate students. Methods: 202 students from undergraduate psychology courses at a private university in Southern California (77.7% women) completed anonymous self-report measures. Results: A hierarchical regression model found no differences in DSH history across demographic variables. Among coping variables, self-isolation alone was significantly related to DSH. A full meditational model was supported: Depressive symptoms were significantly related to DSH, but adding self-isolation to the model rendered the relationship nonsignificant. Limitations: The cross-sectional study design prevents determination of whether a casual relation exists between self-isolation and DSH, and obscures the direction of that relationship. Conclusions: Results suggest targeting self-isolation as a means of DSH prevention and intervention among nonclinical, youth populations.

New Platelet Aggregation Inhibitors

1997 ◽  
Vol 17 (01) ◽  
pp. 43-48 ◽  
Author(s):  
R. Verhaeghe ◽  
J. Vermylen
Keyword(s):  
Platelet Aggregation ◽  
Platelet Aggregation Inhibitors ◽  
Aggregation Inhibitors

IDENTIFIKASI SERTA HUBUNGAN KONSTRUKSI SUMUR GALI TERHADAP KANDUNGAN COLIFORM PADA AIR SUMUR GALI DI DUSUN JIKEN KABUPATEN LOMBOK TIMUR

2019 ◽  
Vol 7 (2) ◽  
pp. 115
Author(s):  
Dini Yuliansari
Keyword(s):  
Cross Sectional Study ◽  
Coliform Bacteria ◽  
Well Water ◽  
Chi Square ◽  
Cross Sectional ◽  
Content Variable ◽  
Chi Square Test ◽  
Dug Wells ◽  
Dug Well ◽  
The Relationship

The well is one of the source water used for bathing, washing, and drinking by the citizens in Jiken Hamlet, Rarang Village, Terara Sub-District. Poor dug well construction conditions can affect the amount of coliform bacteria contained in the dug well water. The purpose of this study is to identify the construction of dug wells and the content of coliform bacteria in dug well water and determine the relationship between dug well construction and the content of coliform bacteria. This research is analytic with a cross sectional study design. The results were obtained from 11 samples of dug wells which were observed in construction and the coliform content was known that all samples did not requirements as good dug well construction. Coliform content test results showed that as many as 5 dug well water samples did not pass the clean water quality standards. The results of data analysis with the chi-square test variable construction of dug wells with coliform content variable  showed 0,172 > 0,05, then the concluded is the dug well not suitable to use by people in that area as a source of water for daily needs.

PHYSICAL DISORDERS AFTER HYSTERECTOMY DEPEND ON MRS AND SERUM ESTRADIOL LEVELS

2016 ◽  
pp. 41-45
Author(s):  
Lam Huong Le
Keyword(s):  
Key Words ◽  
Cross Sectional Study ◽  
Sexual Disorders ◽  
Serum Estradiol ◽  
Sectional Study ◽  
Cross Sectional ◽  
Total Hysterectomy ◽  
Physical Disorders ◽  
The Relationship ◽  
Estradiol Levels

Objectives: To study the relationship between serum estradiol and physical disorders after hysterectomy. Methods: A descriptive cross sectional study on 151 women after total hysterectomy from 12/2008 to 11/2010 at Hue Cental Hospial. Results: Serious disorders in total hysterectomy group include: physical disorders (34.78%), maternal disorders (71.74%), sexual disorders (58.70%). There were significant differences these disorders between total hysterectomy group and hysterectomy with/without accessiory remove group, as well as menopause group. Conclusion: Serum estradiol levels was inversely correlated with physical disorders, martenal disorders, sexual disorders and other disorders. Key words: hysterectomy, serum estradiol

POLA ASUH ORANGTUA TERHADAP TINGKAT KEMANDIRIAN PERSONAL HYGIENE CUCI TANGAN DAN GOSOK GIGI PADA ANAK PRASEKOLAH

2020 ◽  
Vol 15 (2) ◽  
pp. 200-205
Author(s):  
Dina Dewi Anggraini
Keyword(s):  
Survey Research ◽  
Quantitative Study ◽  
Parenting Style ◽  
Cross Sectional Study ◽  
Personal Hygiene ◽  
P Value ◽  
Sectional Study ◽  
Cross Sectional ◽  
Test Analysis ◽  
The Relationship

ABSTRACT   The study aims todetermine the relationship between parenting style and the level of independence of Personal Hygiene Hand Wasting and Tooth Brush in Preschoolers in Kindergarten Negeri Pembina Blora in 2019. The study is a quantitative study, based on the research location including the type of field reseaerch, based on the ansence of the treatment of subjects including survey research, based on time is a cross sectional study, and based on objectives includin correlation analytics. The population in this study were all parents in Kindergarten Negeri Pembina Blora as many as 85 respondents. Based on the sample calculation, the sample obtained in this study that most parent in Kindergarten Negeri Pembina Blora amounted to 70 respondents. Srearmen’s rho test analysis results parenting parents with the level of independence of personal hygiene hand wasting result obtained p value = 0,000 < α (0,05), and parenting patters with the independence of personal hygiene tooth brush obtained results p value = 0,000 < α (0,05). So it can be concluded that were is a significant relationship between parenting parents with the level of independence of personal hygiene washing hands and brushing their tooth at preschoolers in Kindergarten Negeri Pembina Blora in 2019. Keywords: parenting; personal hygiene, preschool ABSTRAK   Penelitian ini bertujuan untuk mengetahui Hubungan Pola Asuh Orangtua Terhadap Tingkat Kemandirian Personal Hygiene Cuci Tangan dan Gogok Gigi pada Anak Prasekolah di TK Negeri Pembina Blora Tahun 2019. Penelitian ini adalah penelitian kuantitatif, berdasarkan tempat penelitian termasuk jenis penelitian lapangan, berdasarkan tidak adanya perlakuan terhadap subjek termasuk penelitian survey, berdasarkan waktu merupakan penelitian cross sectional, dan berdasarkan tujuan termasuk analitik korelasi. Populasi dalam penelitian ini adalah seluruh orangtua di TK Negeri Pembina Blora sebanyak 85 responden. Berdasarkan perhitungan sampel  maka diperoleh sampel pada penelitian ini adalah sebagian orangtua di TK Negeri Pembina Blora sebanyak 70 responden. Hasil analisis uji spearmen’s rho pola asuh orangtua dengan tingkat kemandirian personal hygiene cuci tangan didapatkan hasil p value = 0,000 < α (0,05), dan pola asuh orangtua dengan kemandirian personal hygiene gosok gigi didapatkan hasil p value = 0,000 < α (0,05). Sehingga dapat disimpulkan bahwa ada hubungan yang signifikan antara pola asuh orang tua dengan tingkat kemandirian personal hygiene cuci tangan dan gosok gigi pada anak prasekolah di TK Negeri Pembina Blora Tahun 2019. Kata kunci: pola asuh; personal hygiene; prasekolah

The effect of type of water supply on water quality in a developing community in South Africa

1997 ◽  
Vol 35 (11-12) ◽  
pp. 35-40 ◽  
Author(s):  
B. Genthe ◽  
N. Strauss ◽  
J. Seager ◽  
C. Vundule ◽  
F. Maforah ◽  
...  
Keyword(s):  
Water Quality ◽  
Water Supply ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
E Coli ◽  
Guideline Values ◽  
Developing Communities ◽  
Quality Guideline ◽  
And Control ◽  
The Relationship

Efforts to provide water to developing communities in South Africa have resulted in various types of water supplies being used. This study examined the relationship between the type of water supply and the quality of water used. Source (communal taps, private outdoor and indoor taps) and point-of-use water samples were examined for heterotrophic plate counts (HPC), total and faecal coliforms, E. coli, and coliphages. Ten percent of samples were also analysed for enteric viruses, Giardia and Cryptosporidium. Approximately 320 households were included in a case-control study. In addition, a cross-sectional study was conducted. Both studies examined the relationship between different types of water facilities and diarrhoea among pre-school children. The source water was of good microbial quality, but water quality was found to have deteriorated significantly after handling and storage in both case and control households, exceeding drinking water quality guideline values by 1-6 orders of magnitude. Coliphage counts were low for all water samples tested. Enteric viruses and Cryptosporidium oocysts were not detected. Giardia cysts were detected on one occasion in case and control in-house samples. Comparisons of whether in-house water, after handling and storage, complied with water quality guideline values demonstrated households using communal taps to have significantly poorer quality than households using private outdoor or indoor taps for HPC and E. coli (χ2 = 14.9, P = 0.001; χ2 = 6.6, P = 0.04 respectively). A similar trend (although not statistically significant) was observed for the other microbial indicators. The cross-sectional study demonstrated an apparent decrease in health risk associated with private outdoor taps in comparison to communal taps. This study suggests that a private outdoor tap is the minimum level of water supply in order to ensure the supply of safe water to developing communities.

Is there a relationship between gestational diabetes and postpartum depression?

2020 ◽  
Vol 16 ◽  
Author(s):  
Salman Khazaei ◽  
Erfan Ayubi ◽  
Saeid Bashirian ◽  
Ronak Hamzehei ◽  
Ensiyeh Jenabi
Keyword(s):  
Gestational Diabetes ◽  
Postpartum Depression ◽  
Odds Ratio ◽  
Depression Scale ◽  
Binary Logistic Regression ◽  
Cross Sectional Study ◽  
University Education ◽  
P Value ◽  
Cross Sectional ◽  
The Relationship

Background: The relationship between gestational diabetes and postpartum depression (PPD) is poorly understood and seldom studied. Objective: In an effort to explore this issue, the present study investigated the relationship between gestational diabetes and PPD. Methods: The present cross-sectional study was performed with 342 women who were referred to four urban health centers of Hamadan city, west of Iran. We used convenience sampling as a method to recruit women in each health center. We used a researcher-made checklist for gathering data on socio-demographic characteristics and potential risk factors of PPD. The Persian validated version of the Edinburgh Postnatal Depression Scale (EPDS) was used to assess PPD. Univariate and multivariable binary logistic regression was applied to estimate the odds ratio (OR) (95% confidence interval [CI]). Results: Gestational diabetes was identified as the most important risk factor for PPD with OR (95% CI) of 2.19 (1.11, 4.31); P-value=0.02 after adjusting for other variables. Moreover, the adjusted odds ratio showed that PPD among lesseducated women (primary school) was 3.5 times higher compared to women with a university education (OR=3.54, 95% CI: 1.27, 9.84; P-value=0.01). Conclusion: Our findings suggested that PPD is more likely among women with gestational diabetes and those who were less educated. Interventional and educational activities for reducing the risk of PPD can be targeted for use with this population.

Sign in / Sign up

Export Citation Format

Share Document