scholarly journals Tumor Sinus Paranasal Dengan Perluasan Intrakranial dan Metastasis ke Paru

2012 ◽  
Vol 1 (3) ◽  
Author(s):  
Sukri Rahman ◽  
M. Abduh Firdaus
Keyword(s):  
Early Diagnosis ◽  
Physical Examination ◽  
Paranasal Sinuses ◽  
Poor Prognosis ◽  
Pulmonary Metastases ◽  
Distant Metastases ◽  
Surrounding Tissue ◽  
Advanced Stage ◽  
Main Complaint ◽  
Sinonasal Tumor

Abstrak Keganasan hidung dan sinus paranasal (sinonasal) merupakan tumor yang jarang ditemukan, hanya merupakan 1% dari seluruh tumor ganas di tubuh dan 3 % dari keganasan di kepala dan leher. Diagnosis secara dini dan pengobatan sampai saat ini masih merupakan tantangan. Pasien dengan tumor sinonasal biasanya datang pada stadium yang sudah lanjut, dan umumnya sudah meluas ke jaringan sekitarnya. Tidak jarang keluhan utama pasien justru akibat perluasan tumor seperti keluhan mata dan kepala dan bahkan gejala akibat metastsis jauh. Prognosis keganasan ini umumnya buruk. Hal ini karena anatomi sinus yang merupakan rongga yang tersembunyi dalam tulang, yang tidak akan dapat dideteksi dengan pemeriksaan fisik biasa dan sering asimptomatik pada stadium dini serta lokasinya yang berhubungan erat dengan struktur vital. Dilaporkan satu kasus tumor sinus paranasal pada seorang lali-laki berusia 52 tahun yang telah mengalami perluasan ke intrakranial dan metastasis ke paru. Kata kunci: tumor sinonasal, perluasan intrakranial, metastasis paru. Abstract Malignancies of the nasal cavity and paranasal sinuses (sinonasal) are rare, comprising only 1 % of all human malignancies and only 3 % of those arising in the head and neck. Early diagnosis and treatment are still a challenge. A patient with sinonasal tumors usually comes at the advanced stage, and generally has spread to surrounding tissue. Not infrequently the patient's main complaint due to the expansion of the tumors such as eye or head complaints and sometimes even result of distant metastases. It has been associated with a poor prognosis. This is because the anatomy of the sinuses, which is a hidden cavity in the bone, which can not be detected by regular physical examination, tend to be asymptomatic at early stages, and located close anatomic proximity to vital structures. A case of paranasal sinus tumors in a 52-year-old man who has experienced intracranial expansion and pulmonary metastases is reported. Keywords: sinonasal tumor, intracranial expansion, pulmonary metastases.

scholarly journals Sister Mary Joseph’s Nodule: An important Physical Finding.

2021 ◽  
Author(s):  
Elroy Patrick Weledji ◽  
Mbachan Masoeli Takere ◽  
Joviale Christelle Maffo
Keyword(s):  
Poor Prognosis ◽  
African Woman ◽  
Excision Biopsy ◽  
Ovarian Malignancy ◽  
Advanced Stage ◽  
Physical Finding ◽  
Advanced Malignancy ◽  
Main Complaint ◽  
Important Differential Diagnosis ◽  
Sister Mary Joseph’S Nodule

Abstract Background: Sister Mary Joseph’s nodule is a rare but important physical finding as it is a sign of an advanced stage of malignancy.Case presentation: This is a case of an apparently clinically well but immunodeficient 62-year- old African woman whose main complaint was an enlarging violaceous discharging umbilical nodule. A focused history and physical examination complemented by an abdominal computerized tomography (CT) scan was suggestive of an umbilical cutaneous manifestation (Sister Mary Joseph’s nodule) of an underlying disseminated ovarian malignancy. This was confirmed histologically by an excision biopsy of the umbilical nodule.Conclusions: Sister Mary Joseph’s nodule is an important differential diagnosis for an umbilical nodular lesion as it is a sign of advanced malignancy with a generally poor prognosis.

scholarly journals Primary Small Cell Neuroendocrine Carcinoma of Paranasal Sinuses

2014 ◽  
Vol 2014 ◽  
pp. 1-4 ◽  
Author(s):  
Maliha Khan ◽  
Sobia Nizami ◽  
Aibek E. Mirrakhimov ◽  
Benjamin Maughan ◽  
Justin A. Bishop ◽  
...  
Keyword(s):  
Neuroendocrine Carcinoma ◽  
Paranasal Sinuses ◽  
Poor Prognosis ◽  
Cell Cancer ◽  
Distant Metastases ◽  
Management Plan ◽  
Small Cell ◽  
Small Cell Neuroendocrine Carcinoma ◽  
Cervical Lymph Nodes ◽  
Platinum Based Chemotherapy

Small cell neuroendocrine carcinoma of the paranasal sinuses is an extremely rare and aggressive neoplasm. Despite aggressive management, the tumor carries a poor prognosis, with a high risk of local recurrence or distant metastases. The management strategy is based on that for pulmonary small cell cancer and includes platinum-based chemotherapy combined with radiotherapy. We are reporting a case of an 89-year-old female patient diagnosed with small cell carcinoma of right-sided ethmoid and sphenoid sinuses. The tumor was found to have invaded the right orbit and anterior cranial fossa. Metastases to cervical lymph nodes and bone were also found. Due to the extended stage and poor prognosis of the patient, the management plan is palliative chemoradiotherapy.

Metastatic follicular thyroid carcinoma to the paranasal sinuses: a case report and review

1997 ◽  
Vol 111 (7) ◽  
pp. 647-651 ◽  
Author(s):  
Ken W. Altman ◽  
Natasha Mirza ◽  
Lucien Philippe
Keyword(s):  
Thyroid Carcinoma ◽  
Paranasal Sinuses ◽  
Poor Prognosis ◽  
Follicular Thyroid Carcinoma ◽  
Treatment Options ◽  
Distant Metastases ◽  
Differentiated Thyroid Carcinoma ◽  
Endoscopic Biopsy ◽  
Primary Lesion ◽  
Ethmoid Sinuses

AbstractThyroid carcinoma metastatic to the paranasal sinuses is extremely rare, with only 11 cases reported in the English and European literature. We report a case of metastatic follicular thyroid carcinoma to the clivus with extension into the sphenoid and posterior ethmoid sinuses. Pathological diagnosis was obtained using an intranasal endoscopic biopsy. As with our patient, metastatic thyroid carcinoma may present with symptoms related to distant metastases rather than the primary lesion. Distant metastases in differentiated thyroid carcinoma portends a poor prognosis. Our case of metastatic thyroid carcinoma to the paranasal sinuses is summarized in the context of the 11 additional cases, and treatment options are discussed.

Folate receptor: a potential target in ovarian cancer

Pteridines ◽  
2015 ◽  
Vol 26 (1) ◽  
pp. 1-12 ◽  
Author(s):  
Marie Bartouskova ◽  
Bohuslav Melichar ◽  
Beatrice Mohelnikova-Duchonova
Keyword(s):  
Ovarian Cancer ◽  
Anticancer Agents ◽  
Poor Prognosis ◽  
Current Knowledge ◽  
Folate Receptor ◽  
Gynecological Cancer ◽  
Predictive Biomarkers ◽  
Receptor Expression ◽  
Advanced Stage ◽  
Potential Therapeutic Target

AbstractOvarian cancer is the most frequent cause of gynecological cancer-related death. Unfortunately, many patients are diagnosed at an advanced stage and have a poor prognosis. The standard treatment for advanced disease involves maximal cytoreductive surgery and chemotherapy based on platinum compounds and taxanes. Patients presenting at an advanced stage have a higher risk of recurrence. The development of drug resistance currently represents a major obstacle in the systematic treatment and, therefore, the discovery of new anticancer agents and approaches should improve the poor prognosis of these patients. Folate receptor α is overexpressed in epithelial ovarian cancer (EOC), but has limited expression in nonmalignant human tissues. The degree of folate receptor expression corresponds with the stage and grade of the disease. Because of this, folate receptor α seems to be a potential therapeutic target for the treatment of ovarian cancer. Currently, several approaches have been studied to target this protein in ovarian cancer treatment. This review summarizes current knowledge about the potential usage of folate receptors as prognostic and predictive biomarkers as well as their role in the management and targeted therapy of ovarian cancer.

MRI features in a malignant glomus jugulare tumour

1993 ◽  
Vol 107 (11) ◽  
pp. 1066-1069 ◽  
Author(s):  
Alexandra C. Athanassopoulou ◽  
Labros L. Vlahos ◽  
Athanassios D. Gouliamos ◽  
Eliana D. Kailidou ◽  
John G. Papailiou ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Pulmonary Metastases ◽  
Distant Metastases ◽  
Resonance Imaging ◽  
Malignant Tumours ◽  
Regional Lymph Nodes ◽  
Glomus Jugulare ◽  
Mri Features ◽  
Magnetic Resonance Imaging Mri ◽  
Glomus Jugulare Tumour

AbstractMagnetic resonance imaging (MRI) features in a case of malignant glomus jugulare tumour are reported. Chemodectomas are benign in 95 per cent of cases and malignant in five per cent. Only one case report of CT findings in this unusual CP angle tumour with pulmonary metastases has been cited in the literature.It is concluded that MRI can provide useful information about the nature of chemodectomas although it cannot dislinguish between benign and malignant tumours, except when regional lymph nodes are involved or when distant metastases exist.

scholarly journals Scalp Metastasis of Mesothelioma

2021 ◽  
Author(s):  
İlkin Yetişkin ◽  
Berna Eren Kömürcüoğlu ◽  
Eylem Yıldırım
Keyword(s):  
Adrenal Gland ◽  
Malignant Mesothelioma ◽  
Malignant Tumor ◽  
Late Stage ◽  
Poor Prognosis ◽  
Early Stage ◽  
Asbestos Exposure ◽  
Distant Metastases ◽  
Rare Neoplasm ◽  
Scalp Metastasis

Mesothelioma is a primary malignant tumor of the mesothelial cells lining the pleura, pericardium and peritoneum, which is frequently seen between the ages of 40-60. Malignant mesothelioma (MM) is a rare neoplasm with a poor prognosis, usually associated with asbestos exposure. It is characterized by aggressive local invasion and metastatic spread. Extrathoracic lymphogenous-hematogenous metastases are rare at the time of diagnosis and in the early stage. However, metastases develop in at least half of the cases in the late stage of the disease. After the spread of serous membranes, distant metastases to the bone, adrenal gland, and liver are frequently observed. Skin and scalp metastases are rarely observed. Our case MPM is presented because it is a rare scalp metastasis.

scholarly journals TESTICULAR TORSION OF UNDESCENDED TESTIS IN A CHILD

2011 ◽  
Vol 18 (03) ◽  
pp. 535-537
Author(s):  
MAQSOOD AHMAD ◽  
MUMTAZ AHMAD ◽  
MUHAMMAD SAQIB
Keyword(s):  
Differential Diagnosis ◽  
Early Diagnosis ◽  
Physical Examination ◽  
Blood Supply ◽  
Spermatic Cord ◽  
Testicular Torsion ◽  
Undescended Testis ◽  
Accurate Diagnosis ◽  
Acute Scrotum ◽  
Prompt Treatment

The children presenting with acute scrotum have many diseases in differential diagnosis and testicular torsion in undescended testis and normal testis is an important consideration. Torsion of the testis, or more correctly, torsion of the spermatic cord, is a surgical emergency because it causes strangulation of gonadal blood supply with subsequent testicular necrosis and atrophy. In most of cases history and physical examination are sufficient to make an accurate diagnosis. While other causes may require simple treatment but torsion require immediate exploration to save the testis. Early diagnosis and prompt treatment is essential to help such children.

scholarly journals CHARACTERISTICS OF RECURRENCE NASOPHARYNGEAL CARCINOMA IN HASAN SADIKIN HOSPITAL PERIOD 2017-2019

2020 ◽  
Vol 2 (02) ◽  
pp. 62-63
Author(s):  
Mohammad Adithya Prawiranata ◽  
Yussy Afriani Dewi
Keyword(s):  
Nasopharyngeal Carcinoma ◽  
Distant Metastases ◽  
Neck Surgery ◽  
Initial Therapy ◽  
Stage Iii ◽  
Surrounding Tissue ◽  
Recurrent Nasopharyngeal Carcinoma ◽  
Over 40 Years ◽  
Head Neck Surgery ◽  
Head Neck

Abstract Introduction: Nasopharyngeal carcinoma is a malignancy that occurs in the squamous epithelium in the nasopharynx region. Recurrent Nasopharyngeal carcinoma is defined as tumor recurrence after the complete remission. Patients with recurrent NPC always experience local, regional, or both failure, with or without distant metastases and can damage surrounding tissue.. Methods: This research method was a retrospective descriptive based on medical record data in patients with recurrent nasopharyngeal carcinoma at ORL-HNS outpatient ward subdivision of Head Neck Surgery, RSHS, Bandung from 2017 to 2019. Result: In RSHS Bandung, there was 1727 patient NPC period 2017-2019. There was 135 recurrent nasopharyngeal carcinoma patients (7,8 %) consist of 96 male and 39 female, aged over 40 years as many as 107 patients. More patients were found in T3-T4 (56%), N2-N3(56%), M0 (91%), stage III-IV (75%). The duration of the patient experienced a relapse after initial therapy for more than 24 months (52%).  Conclusion: Characteristics of recurrent nasopharyngeal carcinoma most of them come with stage III-IV, T3-T4 without distant metastases, with a recurrence within less than 24 months. There was 7,8% recurrent nasopharyngeal carcinoma patients Keywords: Charactherisic, Nasopharyngeal Carcinoma, Recurrence

scholarly journals Novel Indications of Epigenetic Therapy in Ovarian Cancer

2021 ◽  
Author(s):  
Courtney Griffiths ◽  
Michelle Bilbao ◽  
Lauren Krill ◽  
Olga Ostrovsky
Keyword(s):  
Gene Expression ◽  
Ovarian Cancer ◽  
Early Diagnosis ◽  
Gynecologic Cancer ◽  
Epigenetic Modifications ◽  
Epigenetic Therapy ◽  
Intratumor Heterogeneity ◽  
Survival Outcomes ◽  
Advanced Stage ◽  
Stage Disease

Early diagnosis and intervention are some of the longstanding challenges associated with ovarian cancer, which is the leading cause of gynecologic cancer mortality. While the majority of patients who present with advanced stage disease at time of diagnosis will initially respond to traditional combination platinum and taxane-based chemotherapy in conjunction with cytoreductive surgery, approximately 70% will ultimately recur due to chemoresistance within the first two years. Intratumor heterogeneity is proposed to be a leading factor in the development of chemoresistance and resultant poorer outcomes for those with recurrent or advanced stage disease. Both inherent and acquired mechanisms of chemoresistance are postulated to be a result of alterations in gene expression, also known as epigenetic modifications. Therefore, epigenetic therapy is a pivotal avenue which allows for reversal of chemoresistance in cancer through the targeting of aberrant mutations. In this chapter, we discuss how these epigenetic modifications prove to be promising targets in cancer therapy leading to heightened drug sensitivity and improved patient survival outcomes.

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