scholarly journals Correspondence

2012 ◽  
pp. 108-108
Author(s):  
Harry Pachajoa

Recently, Valencia et al., published a very interesting article called «Lipid profile in a group of patients with Turner's syndrome at Clínica Universitaria Bolivariana in the city of Medellín between 2000 and 2009"1. An article which evaluated lipid levels in patients with Turner syndrome in a Colombian clinic, the study associated results of lipid profile with karyotype and other risk factors for coronary heart disease. Because of the importance of the article and the prevalence of Turner syndrome (1 in 2,000 live-born women), it is important to have assessed the relationship with glycaemia and diabetes, when it is clearly recognized that this association exists and may be related to alterations of lipid, body mass index and mortality in these patients2. Although the article mentioned discusses the relationship between Turner syndrome and insulin resistance, it is important to know that a high risk for diabetes type 2 has been demonstrated among women with Turner syndrome, especially those with an isochromosome Xq, and it has been proposed that haploinsufficiency for Xp gene(s) causes the basic deficit in â-cell function seen in 45,X patients and that excess dosage of Xq genes exacerbates the deficit; perhaps by altering other genes involved in â-cell development and function or survival3. Therefore, it is necessary as it was in the article to analyze the laboratory results with those of karyotyping. Additionally, the results of the karyotypes need to be expressed by following the updated nomenclature of the International Standing Committee on Human Cytogenetics (2009)4. Finally, it is important for these patients to receive, as part of their management, genetic screening and genetic counseling where there are protocols defined for monitoring and evaluating other co-morbidities (renal anomalies, cardiac, dental, neurocognitive deficits and behavioral problems, among others) and not only of cardiovascular risk factors.

1984 ◽  
Vol 246 (5) ◽  
pp. E405-E411 ◽  
Author(s):  
W. K. Ward ◽  
J. B. Halter ◽  
J. C. Beard ◽  
D. Porte

States of insulin resistance are characterized by hyperinsulinemia that often appears to be out of proportion to the minimal degree of hyperglycemia. One possible explanation for these findings is that mild hyperglycemia per se can cause an adaptive increase in islet sensitivity to glucose, leading to increased insulin output at a given glucose level. To test this hypothesis, we compared acute insulin responses (AIR) and acute glucagon responses (AGR) to 5-g arginine injections before and after 20-h glucose infusions (200 mg X m-2 X min-1) in 11 healthy men of varying age and degree of adiposity. The 20-h glucose infusion caused an increase in fasting plasma glucose (PG) in all subjects (95 +/- 2 vs. 130 +/- 3 mg/dl). PG was clamped at three levels (approximately 95, 165, and 235 mg/dl) before and after the 20-h glucose infusion. Despite matching of PG levels, consistent increases of AIR were observed after the 20-h glucose infusion: 86 +/- 10 vs. 57 +/- 8 at PG = 95 (P = 0.002); 241 +/- 20 vs. 192 +/- 22 at PG = 165 (P = 0.02); and 508 +/- 59 vs. 380 +/- 50 microU/ml at PG = 235 mg/dl (P = 0.009). In addition, the slope of the relationship between AIR and PG level (potentiation slope), a measure of B cell sensitivity to glucose, increased consistently from 2.28 +/- 0.35 (control) to 3.07 +/- 0.45 (P = 0.004) after the 20-h infusion.(ABSTRACT TRUNCATED AT 250 WORDS)


2015 ◽  
Vol 36 (5) ◽  
pp. 925-929 ◽  
Author(s):  
Nesibe Akyürek ◽  
Mehmet Emre Atabek ◽  
Beray Selver Eklioglu ◽  
Hayrullah Alp

2017 ◽  
Vol 44 (5) ◽  
pp. 580-586 ◽  
Author(s):  
Samina A. Turk ◽  
Sjoerd C. Heslinga ◽  
Jill Dekker ◽  
Linda Britsemmer ◽  
Véronique van der Lugt ◽  
...  

Objective.To investigate the prevalence of conduction disorders in patients with early arthritis and the relationship with inflammation and traditional cardiovascular (CV) risk factors.Methods.Patients with rheumatoid arthritis (RA) have a 2-fold higher risk of sudden cardiac death, possibly owing to conduction disorders. This increased risk might already be present at the clinical onset of arthritis. Therefore, we assessed electrocardiography, blood pressure, 28-joint Disease Activity Score (DAS28), lipid profile, erythrocyte sedimentation rate (ESR), and C-reactive protein (CRP) level in 480 patients with early arthritis at baseline and after 1 year.Results.The prevalence of conduction disorders was 12.5%. Conduction times at baseline were not associated with DAS28, ESR, or CRP levels and did not change during antirheumatic treatment. Baseline and the improvement in DAS28 (European League Against Rheumatism response), ESR, and CRP were significantly associated with heart rate, lipid profile, and blood pressure. Elevated total cholesterol and blood pressure were associated with an increased QRS time. The change in heart rate differed 7.3 bpm between patients with the least versus largest DAS improvement.Conclusion.The prevalence of conduction disorders in patients with early arthritis was 12.5%, which is similar to the general population and was not associated with changes in inflammation markers. However, a high cholesterol was associated with a prolonged QRS time. Therefore, the emphasis of CV risk management in arthritis should not be only on treatment of disease activity but also on traditional CV risk factors. The relationship between the improvement in disease activity and heart rate is remarkable because this could imply a 10-year CV mortality risk difference of 24%.


2011 ◽  
pp. 54-60
Author(s):  
Eduar Valencia ◽  
Lina María Serna ◽  
Carlos Mauricio Medina ◽  
Álvaro Arango

Introduction: Turner syndrome patients can present lipid profile alterations, which associated with obesity, frequent in these patients, causes increased cardiovascular risk, lowering their life expectancy. This research evaluates lipid profiles of patients with Turner syndrome between 2000 and 2009 and these are associated to the karyotype and other risk factors for coronary disease. Objective: To describe the lipid profile and other cardiovascular risk factors in a group of girls with Turner syndrome. Methods: This is a descriptive and retrospective study, which evaluated the clinical records of 21 girls with Turner syndrome. We sought metabolic risk factors for coronary disease such as lipid profile, weight, body mass index, and blood pressure. Results: Age at time of diagnostics ranged between 8 months to 17 years, four patients were below 10 years of age and 17 patients were over 11 years of age. The karyotype revealed: 57.3% with 45x monosomy, 33% with 46xx-45x mosaicism, and 9.5% with 46x-qx mosaicism. None of the patients was obese; the total cholesterol levels ranged from 116 mg/dl to 225 mg/dl with a mean of 168.7. When these patients were grouped by age, we found that 25% of those younger than 10 years of age had high levels of cholesterol vs. 58.8% for those over 10 years of age. Regarding the karyotype of the six patients with 46xx-45x karyotype, five (71.4%) presented hypercholesterolemia; 95.2% of the patients were normotensive. Discussion: This research revealed Turner syndrome patients present lipid profile alterations at early ages. Conclusion: It is important to include in the follow up protocol in these patients the lipid profile control and, thus, be able to conduct early interventions to improve their quality of life.


Author(s):  
Meilani Kumala ◽  
Susy Olivia Lontoh ◽  
Novendy Novendy

Background: The prevalence of hypertension in the world today increases year by year. Monitoring data of non communicable diseases (NCD), 2017 shows that the number and risk of death for Indonesian people in productive age is quite high. Research on the relationship between risk factors and hypertension in low-income productive age communities in Indonesia has not been widely studied. Objective: This study aims to determine the relationship between nutritional status, waist circumference (WC) and lipid profile with hypertension in people of low income productive age. Methods: The design of this study was cross sectional. Identity data were collected through interview, blood pressure, anthropometry, waist circumference data were obtained by measuring and blood lipid profile, fasting blood sugar data were carried out by laboratory test. The data that had been obtained were tested using Fisher’s exact test. Results: As many as 50% of 62 subjects had hypetension, 38.7% of subjects had overweight, 33,87% of subjects had obesity and 61.9% of subjects had WC above normal or including central obesity. As many as 37.1% of subjects had hypercholesterolemia, 90.3% had low density lipoproteinemia (LDL) above normal, 16.1% of subjects had high density lipoproteinemia (HDL) below normal and 22.6% of subjects had hypertriglyceridemia. The results of Fisher's exact test showed that there was no relationship between nutritional status, WC and lipid profiles with hypertension. The prevalence odds ratio (POR) showed that subjects with over nutrition and obesity have a 1.63 times risk of developing hypertension; subjects with central obesity had a 1.73 times risk of developing hypertension; subjects with hypercholesterolemia had a 2.7-fold risk of developing hypertension and subjects with high LDL had 2.15 times the risk of developing hypertension, while POR of HDL and triglycerides showed a neutral value or not a risk factor for hypertension. Conclusion: Nutritional status, WC, lipid profile have no relationship with hypertension in low-income productive age people in Indonesia. Based on the POR, it was found that obesity, WC, cholesterol and LDL were risk factors for hypertension, whereas triglycerides and HDL did not affect the incidence of hypertension Keywords: nutritional status; waist circumferences; lipid profile; productive age; low income AbstrakLatar Belakang: Pevalensi hipertensi di dunia dewasa ini meningkat dari tahun ke tahun. Data monitor kemajuan penyakit tidak menular (PTM), 2017 menunjukkan bahwa angka dan risiko kematian masyarakat dengan usia produktif di Indonesia cukup tinggi.Penelitian hubungan faktor risiko terhadap hipertensi pada masyarakat usia produktif berpenghasilan rendah di Indonesia belum banyak dikaji lebih dalam. Tujuan: Penelitian yang dilakukan untuk mengetahui hubungan status gizi, lingkar pinggang (Lpi) dan profil lipid dengan hipertensi pada masyarakat usia produktif berpenghasilan rendah. Metode: Desain penelitian ini adalah potong lintang. Data identitas dikumpulkan melalui wawancara, data tekanan darah, antropometri, lingkar pinggang diperoleh dengan melakukan pengukuran dan data profil lipid darah, gula darah puasa dilakukan dengan pemeriksaan laboratorium. Data yang telah diperoleh, diuji menggunakan uji Fisher’s exact. Hasil: Sebanyak 50% dari 62 subjek mengalami hipertensi, 38,7% subjek mempunyai status gizi berlebih, 33,9% subjek termasuk obesitas dan 61,9% subjek mempunyai Lpi di atas normal atau obesitas sentral. Sebanyak 37,1% subjek mengalami hiperkolesterolemia, 90,3% mempunyai low density lipoproteinemia (LDL) di atas normal, 16,1% subjek mempunyai high density lipoproteinemia (HDL) dibawah normal dan 22,6% subjek mengalami hipertrigliseridemia. Hasil uji Fisher’s exact menunjukkan tidak terdapat hubungan antara status gizi, Lpi dan profil lipid dengan hipertensi. Prevalence odds ratio menunjukkan subjek dengan status gizi berlebih dan obesitas mempunyai risiko 1,63 kali mengalami hipertensi; subjek dengan obesitas sentral mempunyai risiko 1,73 kali mengalami hipertensi; subjek dengan hiperkolesterolemia mempunyai risiko 2,7 kali mengalami hipertensi dan subjek dengan LDL yang tinggi mempunyai risiko 2,15 kali mengalami hipertensi, sedangkan POR HDL dan trigliserida memperlihatkan tidak merupakan faktor risiko hipertensi. Kesimpulan: Status gizi, Lpi, profil lemak darah tidak mempunyai hubungan dengan kejadian hipertensi pada masyarakat usia produktif berpenghasilan rendah. Gizi lebih dan obesitas, Lpi, kolesterol dan LDL merupakan faktor risiko kejadian hipertensi sedangkan, triglieserida dan HDL tidak memengaruhi kejadian hipertensi.


2009 ◽  
Author(s):  
W. Douglas Tynan ◽  
Meredith Dreyer ◽  
Meredith Lutz Stehl

2012 ◽  
Vol 32 (S 01) ◽  
pp. S39-S42 ◽  
Author(s):  
S. Kocher ◽  
G. Asmelash ◽  
V. Makki ◽  
S. Müller ◽  
S. Krekeler ◽  
...  

SummaryThe retrospective observational study surveys the relationship between development of inhibitors in the treatment of haemophilia patients and risk factors such as changing FVIII products. A total of 119 patients were included in this study, 198 changes of FVIII products were evaluated. Results: During the observation period of 12 months none of the patients developed an inhibitor, which was temporally associated with a change of FVIII products. A frequent change of FVIII products didn’t lead to an increase in inhibitor risk. The change between plasmatic and recombinant preparations could not be confirmed as a risk factor. Furthermore, no correlation between treatment regimens, severity, patient age and comorbidities of the patients could be found.


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