scholarly journals FEATURES OF THE IMMUNE STATUS OF WOMEN OF REPRODUCTIVE AGE SUFFERING FROM GENITAL INFECTIOUS-INFLAMMATORY PROCESSES

Author(s):  
N. V. KOLESNIKOVA ◽  
G. A. CHUDILOVA ◽  
L. V. LOMTATIDZE ◽  
E. F. FILIPPOV ◽  
S. V. KOVALEVA ◽  
...  
2017 ◽  
Vol 23 (2) ◽  
Author(s):  
Natalya Drohomyretska

Hemomicrocirculatory system – is a complex structure that reacts in every pathological process even before the clinical period and takes the first blow. The study of microhemocirculation will provide an opportunity to solve the important for practical medicine questions of pathogenesis of many diseases, as for the prevention and treatment of regional disorders of blood circulation.The objective of the research is to study the state of the hemomicrocirculatory bed (HMCB) of adventitia of varicose veins of the small pelvis (VVSP) in women with chronic inflammatory processes of the organs of the small pelvis (CIPOSP).Materials and methods of research. To evaluate the restructuring of the HMCB of adventitia of VVSP, the operating material of 12 women of reproductive age was used. Mainly, there were pieces of the ovarian vein. The study of the HMCB in the vein wall was performed by the non-injecting method of silver impregnation according to V.V. Kupriyanov. To standardize the results, the condition of the HMCB of adventitia of the venous wall in norm was studied in 5 women of reproductive age, who died as a result of various traumas.Results of the research. After the performed studies, the structural-morphological changes of the HMCB of the adventitia of the small pelvis veins were revealed. The dilation of capillaries, postcapillaries, postcapillary venules was observed. The diameter of the vessels of the HMCB of the ovarian vein adventitia was: venule – 94.21 ± 1.38 μM in comparison with the norm – 48.78 ± 1.60 μM (p<0.001); post-capillary venules – 46.76 ± 1.04 μM in comparison with the norm – 28.29 ± 1.1.01 μM (p<0.001); the capillaries were 11.22 ± 0.14 μM in comparison with the norm – 8.24 ± 0.16 μM (p<0.05), arterioles – 29.02 ± 0.76 μM in comparison with the norm – 25.19 ± 1.15 μM (p<0.01). The architectonics of the arterioles is almost unchanged. Lumen of venules is filled with formed elements. The structure of capillaries is polymorphic. The capillary net was localized and concentrated or was formed as a thick planar net, the capillaries were expanded. There were arterio-venulous anastomoses. Endothelial nuclei are shortened. In some preparations, the diameter of the arterioles corresponded to the diameter of the collection venules.  Conclusions:1. The first discovered by us changes in HMCB of adventitia of varicose veins of the small pelvis in women with CIPOSP can be one of the pathogenetic links of the development and progression of the varicose vein itself, which in turn aggravates the course of chronic inflammation.      2. The timely appointment of drugs that improve microcirculation will enable to prevent the development of dystrophic changes in the vein wall, improve the course of chronic inflammatory processes and reduce or completely eliminate the syndrome of “chronic pelvic pain”.


Nutrients ◽  
2016 ◽  
Vol 8 (2) ◽  
pp. 74 ◽  
Author(s):  
Fabian Rohner ◽  
James Wirth ◽  
Bradley Woodruff ◽  
Faraja Chiwile ◽  
Hannah Yankson ◽  
...  

2012 ◽  
Vol 2012 ◽  
pp. 1-17 ◽  
Author(s):  
Carolyn Tam ◽  
Deborah O'Connor ◽  
Gideon Koren

There are increasing concerns that exposure to unmetabolized folic acid, which results from folic acid intakes that overwhelm the liver's metabolic capacity, may be associated with adverse effects. In this paper, we examined the folic acid status of women of reproductive age in relation to dietary intake and the effect of folic acid supplementation (1.1 mg or 5 mg). Plasma unmetabolized folic acid was not significantly correlated with folate intake estimated by food frequency questionnaire or biomarkers. The proportion of women with detectable levels of unmetabolized folic acid increased from 65% to 100% after twelve weeks of supplementation (P<0.05); however, the increase in concentrations did not reach statistical significance and the effect was not sustained. Moreover, there were no significant differences between the two doses. This suggests that there are mechanisms by which the body adapts to high folic acid intakes to limit exposure to unmetabolized folic acid.


2018 ◽  
Vol 27 (1) ◽  
pp. 36-40
Author(s):  
Razia Sultana ◽  
Syeda Rumana Hoque ◽  
Umme Jamila Akter Manni ◽  
Md Motlabur Rahman ◽  
Pankaj Kanti Datta ◽  
...  

Background/context: Dietary diversity (DD) is universally recognized as a key component of healthy diets. Healthy diet is one of the most important determinants that can influence nutritional status of women of reproductive age. Materials and Methods: This cross sectional study was conducted in Shitpara village of Sreepur Upazila under Gazipur district during February to June 2013 to assess the dietary diversity and nutritional status of women of reproductive age. Convenient sampling technique was adopted to select 181 women. Interview schedule & checklist used as research instrument. Results: The mean(+/-s.d.)age of the respondents was 27.45+/-9.38 years, 133(80%) of them were married and 176(97.2%) are literate. Mean family size was 5.34+/- 2.386 persons and mean family income was 9611.05 Taka per month. Among 133 married women, 68(51%) have 2 or less than two children. Their mean(+/-s.d.) dietary diversity score was 5.13+/- 1.19 and majority 149(82%) of them having medium dietary diversity tercile (4-6). All of them ate carbohydrate types of food, 174(96.1%) protein rich foods & 83(45.9%) vit.A rich vegetables & fruits. Their mean BMI was 22.35 +/- 3.71 kg/ m2. Majority 118 (65%) of them having normal BMI and 22(12%) are under weight. Only 6(3%) of them are obese. Thoughdietary diversity was medium (4-6); relationship between dietary diversity and nutritional status could not be established. Conclusion:The qualitative measurement of dietary diversity is not sufficient enough to identify women at risk of under- or over nutrition. J Dhaka Medical College, Vol. 27, No.1, April, 2018, Page 36-40


2021 ◽  
Vol 38 (5) ◽  
pp. 6-14
Author(s):  
A. O. Ovchinnikova ◽  
S. V. Mikhalchenko ◽  
M. A. Kaganova ◽  
O. E. Chernova

Objective. To assess the levels of viral load, immune status as well as labor outcome depending on the absence or presence of pregravid preparation with the partner and without the latter. Materials and methods. This cohort study included 90 women of reproductive age with stages 3 and 4A HIV infection. To compare the groups, Kruskal Wallis, Mann Whitney tests and correlation analysis were applied. Results. The pregravid preparation of HIV-infected women without a partner was detected to three-fold decrease a viral load in the I trimester of pregnancy (p = 0.001), two-fold in the II trimester (p = 0.02) and three-fold in the III trimester (p = 0.002); with a partner a two-fold decrease in the I trimester (p = 0.0018). The pregravid preparation of HIV-infected women reduces the probability of giving birth to a child with low body mass (p = 0.023); with a partner it decreases the risk for the preterm labor (p = 0.02). Conclusions. Thus, the presence of pregravid preparation in HIV-infected women, with a partner as well, decreases the probability of giving birth to a child with low body mass and preterm labor.


2018 ◽  
pp. 118-122
Author(s):  
N.V. Drohomyretska ◽  

Violation of hemomicrocirculatory processes is in the basis of the development of diseases of various organs and systems. The study of hemomicrocirculation at all levels allows us to understand the complexity and universality of these processes, as well as opens up new perspectives in the pathogenetic approach to the treatment and prevention of the diseases. The homogeneity of the reaction of all parts of the hemomicrocirculatory bed in various diseases has been proved on the basis of clinico-morphological comparisons. Study of some areas allows us to judge the state of hemomicrocirculation as an integral system. The objective: to study and compare the changes of the hemomicrocirculatory bed (HMCB) of the conjunctiva of the eyeball and adventitia of varicose veins of the small pelvis (VVSP) in women with chronic inflammatory processes of the internal genital organs (CIPIGO). Materials and methods. There were examined 54 women with chronic inflammatory processes of internal genital organs against the background of varicose veins of the small pelvis (group I); 30 – practically healthy women (control group). The age of women was between 18 and 45 years old. Bulbar microscopy was performed using the SHL-2B slit lamp. The results of microscopy were evaluated according to the system of V.S.Volkov et al. To evaluate the restructuring of the HMCB of adventitia of VVSP, the operating material of 12 women of reproductive age was used. Mainly, these were pieces of the ovarian vein. The study of HMCB in the vein wall was performed by the non-injecting method of silver impregnation according to V.V. Kupriyanov. To standardize the results, the state of the HMCB of venous wall adventitia was studied in norm in 5 women of reproductive age, who died as a result of various injuries. Results. Clinical-morphological parallels between changes in the HMCB of the conjunctiva of the eyeball and adventitia of the varicose veins of the small pelvis were revealed after the performed research. The arteriols’ architectonics was almost unchanged. Venules were dilated, twisted, somewhere varicose-enlarged, filled with formed elements. The structure of capillaries was polymorphic. The capillary net was localized and concentrated or shaped in the form of a thick planar net, the capillaries were expanded. In the micropreparations of the adventitia, there were arterio-venular anastomosis. The nuclei of the endothelial cells were shortened. In some preparations, the diameter of the arterioles corresponded to the diameter of the collection venules. Conclusions. 1. Our studies confirm both clinically and pathomorphologically that one of the links of the pathogenesis of CIPIGO, which occur against the background of VVSP, is a violation of HMCB. 2. Firstly, changes in the HMCB of the conjunctiva of the eyeball and adventitia of the varicose veins of the small pelvis in women with CIPIGO show that they are systemic. 3. The results obtained by us prove the necessity of the use of medicines that improve hemomicrocirculation in the treatment of CIPIGO against the background of VVSP. Key words: hemomicrocirculatory bed, bulbar conjunctiva, adventitia, varicose veins of the small pelvis, chronic inflammatory diseases of the small pelvic organs.


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