scholarly journals Role of Clinical Pharmacist in Promoting Patient Compliance through Assessment of Reasons for Non-Compliance and Minimum Maintenance Dose Titrations in Schizophrenic Patients

2015 ◽  
Vol 3 (1) ◽  
Author(s):  
Mounica. Bollu ◽  
Shaik Faizan Ali ◽  
Dr. Desu Brahma Srinivasa Rao ◽  
Nallani Venkataramarao ◽  
Dr. Nalluri. Murali Krishna M.D
Keyword(s):  
Medication Adherence ◽  
Paranoid Schizophrenia ◽  
Therapeutic Interventions ◽  
Dose Titration ◽  
Improve Medication Adherence ◽  
Access To Treatment ◽  
Schizophrenic Patients ◽  
Area Of Concern ◽  
Group B ◽  
The Individual

Context: Medication non-compliance is an important area of concern in schizophrenia as it contributes to relapse and re-hospitalization of the patients. Constant advancement and study of therapeutic interventions designed to improve medication adherence and the outcome of dose titrations are required to reap the most valuable benefits from the pharmacologic treatment of schizophrenia. Aim & Objective: The aim of the present study is to find out the reasons for drug non-compliance and the effectiveness of treatment outcomes after dose titrations in schizophrenic patients and the main objective is to educate the patient by counseling about the disease, drugs and the importance of medication adherence. Materials and Methods: This study was conducted over a period of six months. All male and female subjects of age group 30-40 receiving anti-psychotic medications for a minimum of 1 year before the study starts and who were noncompliant to the prescribed medications were included. Results: Females were prominent in the non-adherent group and males were found to be higher in Group-B. Most of the schizophrenic patients were suffering with paranoid schizophrenia, living in the urban environment and running their nuclear families. Majority of the Subjects in the non-adherent group were illiterates and unemployed, where as in the dose titration group many have completed their primary education and were employed. Compared to first generation antipsychotics, second generation antipsychotic drugs were most commonly prescribed. Almost 56.07% do not have the support from their families. The main reasons stated by the patients to be noncompliant were difficulty in access to treatment, financial obstacles, forgetfulness. Dose titrations were made at an interval of 1 month for four antipsychotics (haloperidol, chlorpromazine, olanzapine and risperidone) and patients were benefited by the titration which was observed through the PANSS scores at each visit. Conclusion: Findings suggest that there is a need for identification and reduction of factors responsible for noncompliance. Strategies to improve adherence have the potential to reduce these costs. Dose titration shows beneficial effect to improve patient quality of life. Hence they should be implemented in clinical practice depending upon the individual patient.

Medication adherence in schizophrenia

2016 ◽  
Vol 33 (S1) ◽  
pp. S586-S586
Author(s):  
F. Fatma ◽  
I. Baati ◽  
S. Omri ◽  
R. Sallemi ◽  
J. Masmoudi
Keyword(s):  
Substance Use ◽  
Medication Adherence ◽  
Rating Scale ◽  
Paranoid Schizophrenia ◽  
Poor Adherence ◽  
University Hospital ◽  
Cross Sectional ◽  
Stigma Scale ◽  
Need For Treatment ◽  
Schizophrenic Patients

IntroductionCompliance is a major issue in the treatment of schizophrenia. Many studies have attempted to identify factors that influence it.ObjectiveTo assess treatment adherence in patients with schizophrenia. To identify factors correlated with poor adherence.MethodsIt was a cross-sectional, descriptive and analytical study, involving 37 outpatients with DSM-IV diagnosis of schizophrenia, followed in the psychiatry department at the Hédi Chaker University Hospital of Sfax (Tunisia). The questionnaire included socio-demographic, clinical and therapeutic data. We also used the Medication Adherence Rating Scale “MARS”, the Insight Scale “IS” and the Stigma Scale (9 items).ResultsThe average age was 36.4 years. The majority of patients was male (68.8%), did not exceed the level of secondary education (89.2%) and had a low socioeconomic level (84.4%).Paranoid schizophrenia was the most frequent type of schizophrenia (54.1%). Atypical antipsychotic were prescribed in 40.5% of cases.Patients were non-adherent to treatment in 56.8% of cases. The factors correlated with poor adherence were: psychoactive substance use (P = 0.036), sexual dysfunction (P = 0.036), complexity of treatment (P = 0.036), poor insight according to the subscale “awareness of the need for treatment” of the IS (P = 0.047) and high score on the subscale “discrimination” of the Stigma Scale (P = 0.008).ConclusionTunisian schizophrenic patients have a poor adherence to treatment. Acting on risk factors (such as substance use, sexual side effects, poor insight and discrimination perception) would improve patient compliance and management of schizophrenia.Disclosure of interestThe authors have not supplied their declaration of competing interest.

The incidence and relationship of homosexual and paranoid features in schizophrenia

1962 ◽  
Vol 108 (456) ◽  
pp. 604-615 ◽  
Author(s):  
Karel Planansky ◽  
Roy Johnston
Keyword(s):  
Paranoid Schizophrenia ◽  
Psychoanalytic Theory ◽  
Dynamic Development ◽  
Schizophrenic Patients ◽  
The Individual ◽  
Relationship Of

Through the interpretation of certain features of the schizophrenic process, psychoanalytic theory links homosexuality and paranoid schizophrenia. This theoretical link derives from a concept of the dynamic development of the individual constructed from observations about individual cases rather than from any knowledge of the frequency of the linkage in the population of schizophrenic patients.

Medication Adherence and Patients’ Characteristics in Chronic Diseases: A National Multi-Center Study

2021 ◽  
pp. 105477382110337
Author(s):  
Huda Al-Noumani ◽  
Maryam Al-Harrasi ◽  
Jimmy Jose ◽  
Zakariya Al-Naamani ◽  
Sathiya M. Panchatcharam
Keyword(s):  
Logistic Regression ◽  
Medication Adherence ◽  
Chronic Diseases ◽  
Cross Sectional Study ◽  
Improve Medication Adherence ◽  
Cross Sectional ◽  
Factors Affecting ◽  
High Adherence ◽  
Multi Center Study ◽  
The Individual

Chronic diseases constitute a significant threat to health. Worldwide, medication adherence in chronic diseases remains unsatisfactory. Understanding factors affecting adherence is essential. This study examined medication adherence by characteristics of patients with chronic diseases. This cross-sectional study included 800 patients. The Adherence to Chronic Diseases Scale was used to measure adherence. Descriptive statistics and logistic regression was used to examine factors influencing medication adherence. Low adherence was found in 19.5% of the patients, 45% had medium adherence, and 35.5% had high adherence. Logistic regression showed that retired ( OR 0.496, 95% CI [0.33–0.75]), having COPD ( OR 0.460, 95% CI [0.32–0.67]) and duration of disease ≤5 years ( OR 1.554, 95% CI [1.11–2.17]) remain independent predictors for high adherence. Mixed findings regarding the relationship between medication adherence and patients’ characteristics were noticed. Patients’ characteristics should be examined with the individual population when examining and attempting to improve medication adherence in clinical practice.

Pediatric Visual Snow Syndrome (VSS): A Case Series

2019 ◽  
pp. 249-254
Author(s):  
Kenneth J. Ciuffreda ◽  
MH Esther Han ◽  
Barry Tannen
Keyword(s):  
Visual Field ◽  
Case Series ◽  
Therapeutic Interventions ◽  
Visual Condition ◽  
Visual Phenomena ◽  
Entire Visual Field ◽  
The Individual ◽  
Vision Therapy ◽  
Abnormal Visual

Visual snow syndrome (VSS) is a relatively rare, unusual, and disturbing abnormal visual condition. The individual perceives “visual snow” (VS) throughout the entire visual field, as well as other abnormal visual phenomena (e.g., photopsia). Only relatively recently has treatment been proposed (e.g., chromatic filters) in adults with VSS, but rarely in the pediatric VSS population (i.e., medications). In this paper, we present three well-documented cases of VSS in children, including their successful neuro-optometric therapeutic interventions (i.e., chromatic filters and saccadic-based vision therapy)

The Need for Personalized Risk-Stratified Approaches to Treatment for Gestational Diabetes: A Narrative Review

2021 ◽  
Author(s):  
Shamil D. Cooray ◽  
Jacqueline A. Boyle ◽  
Georgia Soldatos ◽  
Shakila Thangaratinam ◽  
Helena J. Teede
Keyword(s):  
Gestational Diabetes ◽  
Pregnancy Outcomes ◽  
Population Based ◽  
Adverse Pregnancy Outcomes ◽  
Therapeutic Interventions ◽  
Clinical Prediction Model ◽  
Increased Risk ◽  
Adverse Pregnancy ◽  
The Individual ◽  
Personalized Risk

AbstractGestational diabetes mellitus (GDM) is common and is associated with an increased risk of adverse pregnancy outcomes. However, the prevailing one-size-fits-all approach that treats all women with GDM as having equivalent risk needs revision, given the clinical heterogeneity of GDM, the limitations of a population-based approach to risk, and the need to move beyond a glucocentric focus to address other intersecting risk factors. To address these challenges, we propose using a clinical prediction model for adverse pregnancy outcomes to guide risk-stratified approaches to treatment tailored to the individual needs of women with GDM. This will allow preventative and therapeutic interventions to be delivered to those who will maximally benefit, sparing expense, and harm for those at a lower risk.

scholarly journals Inflammation, epigenetics, and metabolism converge to cell senescence and ageing: the regulation and intervention

2021 ◽  
Vol 6 (1) ◽  
Author(s):  
Xudong Zhu ◽  
Zhiyang Chen ◽  
Weiyan Shen ◽  
Gang Huang ◽  
John M. Sedivy ◽  
...  
Keyword(s):  
Cell Fate ◽  
Cellular Response ◽  
State Of The Art ◽  
Cell Senescence ◽  
Therapeutic Interventions ◽  
Cell Fate Decision ◽  
The Past ◽  
Fate Decision ◽  
The Individual ◽  
Remarkable Progress

AbstractRemarkable progress in ageing research has been achieved over the past decades. General perceptions and experimental evidence pinpoint that the decline of physical function often initiates by cell senescence and organ ageing. Epigenetic dynamics and immunometabolic reprogramming link to the alterations of cellular response to intrinsic and extrinsic stimuli, representing current hotspots as they not only (re-)shape the individual cell identity, but also involve in cell fate decision. This review focuses on the present findings and emerging concepts in epigenetic, inflammatory, and metabolic regulations and the consequences of the ageing process. Potential therapeutic interventions targeting cell senescence and regulatory mechanisms, using state-of-the-art techniques are also discussed.

Interventions to Improve Medication Adherence in Schizophrenia

2002 ◽  
Vol 159 (10) ◽  
pp. 1653-1664 ◽  
Author(s):  
Annette Zygmunt ◽  
Mark Olfson ◽  
Carol A. Boyer ◽  
David Mechanic
Keyword(s):  
Medication Adherence ◽  
Improve Medication Adherence

Strategies to Improve Medication Adherence in Older Persons: Consensus Statement from the Senior Italia Federanziani Advisory Board

Drugs & Aging ◽  
2016 ◽  
Vol 33 (9) ◽  
pp. 629-637 ◽  
Author(s):  
Alessandra Marengoni ◽  
Alessandro Monaco ◽  
Elisio Costa ◽  
Antonio Cherubini ◽  
Alexandra Prados-Torres ◽  
...  
Keyword(s):  
Medication Adherence ◽  
Older Persons ◽  
Consensus Statement ◽  
Advisory Board ◽  
Improve Medication Adherence

scholarly journals Could metabolomics drive the fate of COVID-19 pandemic? A narrative review on lights and shadows

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Michele Mussap ◽  
Vassilios Fanos
Keyword(s):  
Molecular Mechanisms ◽  
Vascular Dysfunction ◽  
Asymptomatic Infection ◽  
Multiple Organ ◽  
Therapeutic Interventions ◽  
Patient Specific ◽  
Wide Range ◽  
Life Threatening ◽  
The Individual ◽  
Host Metabolism

Abstract Human Severe Acute Respiratory Syndrome CoronaVirus 2 (SARS-CoV-2) infection activates a complex interaction host/virus, leading to the reprogramming of the host metabolism aimed at the energy supply for viral replication. Alterations of the host metabolic homeostasis strongly influence the immune response to SARS-CoV-2, forming the basis of a wide range of outcomes, from the asymptomatic infection to the onset of COVID-19 and up to life-threatening acute respiratory distress syndrome, vascular dysfunction, multiple organ failure, and death. Deciphering the molecular mechanisms associated with the individual susceptibility to SARS-CoV-2 infection calls for a system biology approach; this strategy can address multiple goals, including which patients will respond effectively to the therapeutic treatment. The power of metabolomics lies in the ability to recognize endogenous and exogenous metabolites within a biological sample, measuring their concentration, and identifying perturbations of biochemical pathways associated with qualitative and quantitative metabolic changes. Over the last year, a limited number of metabolomics- and lipidomics-based clinical studies in COVID-19 patients have been published and are discussed in this review. Remarkable alterations in the lipid and amino acid metabolism depict the molecular phenotype of subjects infected by SARS-CoV-2; notably, structural and functional data on the lipids-virus interaction may open new perspectives on targeted therapeutic interventions. Several limitations affect most metabolomics-based studies, slowing the routine application of metabolomics. However, moving metabolomics from bench to bedside cannot imply the mere determination of a given metabolite panel; rather, slotting metabolomics into clinical practice requires the conversion of metabolic patient-specific data into actionable clinical applications.

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