scholarly journals Low Dietary Omega-6 to Omega-3 Fatty Acid Intake Ratio Enhances Adiponectin Level in Obesity

2021 ◽  
Vol 5 (1) ◽  
pp. 30
Author(s):  
Helena Fabiani ◽  
Ninik Mudjihartini ◽  
Wiji Lestari
Keyword(s):  
Fatty Acids ◽  
Fatty Acid ◽  
Essential Fatty Acids ◽  
Acid Oxidation ◽  
Low Grade ◽  
Omega 3 ◽  
Omega 3 Fatty Acid ◽  
Omega 6 ◽  
Prevalence Of Obesity ◽  
Underlying Diseases

Every year around the world, the prevalence of obesity is increasing. Obesity and its associated diseases have become some of the most pressing health problems in developed and developing countries. In its development, adipocytes dysfunction and chronic low-grade inflammation occur in obesity will stimulate diseases at higher risk including type 2 diabetes mellitus (T2DM), atherosclerosis, hypertension, and metabolic syndrome. Western diet and sedentary lifestyle are thought to have significantly contributed to the increase in obesity recently. Diet modification is a sound method to prevent obesity and its complications. Nevertheless, the concern lies in the ratio of omega-6 towards omega-3 fatty acids intake, which in its current state indicates an imparity. Omega-3 and omega-6 are two essential fatty acids that emerge as dominant factors in obesity through adiponectin. Adiponectin refers to a protein hormone conceived by adipocytes to prevent obesity and its subsequent complications by increasing insulin sensitivity, fatty acid oxidation, anti-inflammatory, and antiaterogenic. This study aims to determine the mechanism and the role of fatty acids in omega-6 towards those within omega-3 by using adiponectin as the indicator of advancement to obesity and its underlying diseases.

STUDY OF IWASHI SARDINE LIPIDS IN THE SCOPE OF POPULATION NUTRITION OPTIMIZATION

Fisheries ◽  
2020 ◽  
Vol 2020 (5) ◽  
pp. 101-106
Author(s):  
Elena Chupikova ◽  
Konstantin Pavel ◽  
Svetlana Tkachenko
Keyword(s):  
Fatty Acids ◽  
Fatty Acid Composition ◽  
Fatty Acid ◽  
Polyunsaturated Fatty Acids ◽  
Acid Composition ◽  
Cold Storage ◽  
Human Body ◽  
Essential Fatty Acids ◽  
Omega 3 ◽  
Omega 6

The article analyzes the fatty acid composition of the frozen iwashi lipids of different shelf lives. It is established that the total amount of essential fatty acids omega-3 and omega-6 in iwashi’s fat reaches almost 90% of all polyunsaturated fatty acids and remains practically unchanged for 12 months of fish cold storage. It is shown that products from iwashi contain a significant amount of essential fatty acids, indispensable for the human body, which can be used to optimize the population nutrition and satisfy the physiological needs in eicosopentaenoic and docosahexaenoic fatty acids.

Characterization of fatty acids and nutrient composition of SAU Perilla-1 [(Perilla frutescens (L.) Britton] seeds grown with agro climatic conditions in Bangladesh

2021 ◽  
Vol 27 (02) ◽  
pp. 2307-2314
Author(s):  
M. A. K. Mojumdar ◽  
H. M. M. T. Hossain ◽  
A. F. M. J. Uddin ◽  
Meherunnessa
Keyword(s):  
Fatty Acids ◽  
Fatty Acid ◽  
Linolenic Acid ◽  
Essential Fatty Acids ◽  
Fatty Acid Analysis ◽  
Climatic Conditions ◽  
Omega 3 ◽  
Plant Seed ◽  
Omega 6 ◽  
Crop Variety

SAU Perilla-1 (Golden perilla BD) is a newly edible oil seed crop variety introduced by Sher-e-Bangla Agricultural University in Bangladesh. Its seed oil is a rich source of unsaturated fatty acid (91%), of which more than 50% is α-linolenic acid (type of omega-3 fatty acid). The estimated ratio of saturated, monounsaturated and polyunsaturated fatty acids was found 1: 2.26: 8.95. Moreover, the α-linolenic acid was detected (50.52%) as the most dominating polyunsaturated fatty acid, which was 4-four times higher than monounsaturated fatty acids in the oil of the crop variety. Fatty acid analysis of oil revealed a ratio (1:2.22) of Omega 6 to Omega 3 fatty acids, which lies within a healthy range as documented by the global scientific community. Compared to other plant seed oils, SAU Perilla-1 oil consists of Linoleic acid (Omega 6 fatty acid, 22.71%) – a component associated with obesity, which is far below the regular oils from soybean, sunflower and corn. Therefore, our findings indicated that SAU Perilla-1 seed is one of the best edible sources of plant oils rich in essential fatty acids conducive to human health.

scholarly journals Identification of Novel Acinetobacter baumannii Host Fatty Acid Stress Adaptation Strategies

mBio ◽  
2019 ◽  
Vol 10 (1) ◽  
Author(s):  
Jhih-Hang Jiang ◽  
Karl A. Hassan ◽  
Stephanie L. Begg ◽  
Thusitha W. T. Rupasinghe ◽  
Varsha Naidu ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Fatty Acid ◽  
Acinetobacter Baumannii ◽  
Bacterial Membrane ◽  
Omega 3 Fatty Acids ◽  
Omega 3 ◽  
Efflux System ◽  
Content Type ◽  
Omega 3 Fatty Acid ◽  
Omega 6

ABSTRACT Free fatty acids hold important immune-modulatory roles during infection. However, the host’s long-chain polyunsaturated fatty acids, not commonly found in the membranes of bacterial pathogens, also have significant broad-spectrum antibacterial potential. Of these, the omega-6 fatty acid arachidonic acid (AA) and the omega-3 fatty acid decosahexaenoic acid (DHA) are highly abundant; hence, we investigated their effects on the multidrug-resistant human pathogen Acinetobacter baumannii. Our analyses reveal that AA and DHA incorporate into the A. baumannii bacterial membrane and impact bacterial fitness and membrane integrity, with DHA having a more pronounced effect. Through transcriptional profiling and mutant analyses, we show that the A. baumannii β-oxidation pathway plays a protective role against AA and DHA, by limiting their incorporation into the phospholipids of the bacterial membrane. Furthermore, our study identified a second bacterial membrane protection system mediated by the AdeIJK efflux system, which modulates the lipid content of the membrane via direct efflux of lipids other than AA and DHA, thereby providing a novel function for this major efflux system in A. baumannii. This is the first study to examine the antimicrobial effects of host fatty acids on A. baumannii and highlights the potential of AA and DHA to protect against A. baumannii infections. IMPORTANCE A shift in the Western diet since the industrial revolution has resulted in a dramatic increase in the consumption of omega-6 fatty acids, with a concurrent decrease in the consumption of omega-3 fatty acids. This decrease in omega-3 fatty acid consumption has been associated with significant disease burden, including increased susceptibility to infectious diseases. Here we provide evidence that DHA, an omega-3 fatty acid, has superior antimicrobial effects upon the highly drug-resistant pathogen Acinetobacter baumannii, thereby providing insights into one of the potential health benefits of omega-3 fatty acids. The identification and characterization of two novel bacterial membrane protective mechanisms against host fatty acids provide important insights into A. baumannii adaptation during disease. Furthermore, we describe a novel role for the major multidrug efflux system AdeIJK in A. baumannii membrane maintenance and lipid transport. This core function, beyond drug efflux, increases the appeal of AdeIJK as a therapeutic target.

From Homicide to Happiness – A Commentary on Omega-3 Fatty Acids in Human Society

2007 ◽  
Vol 19 (1-2) ◽  
pp. 9-19 ◽  
Author(s):  
Joseph R. Hibbeln
Keyword(s):  
Risk Factors ◽  
Fatty Acids ◽  
Fatty Acid ◽  
American Psychiatric Association ◽  
Human Society ◽  
Omega 3 Fatty Acids ◽  
Omega 3 ◽  
Omega 3 Fatty Acid ◽  
Increased Risk ◽  
Omega 6

The field of omega-3 fatty acid deficiencies as reversible risk factors in major psychiatric disorders has flourished in the last decade. Treatment recommendations of the American Psychiatric Association may be considered for application to more normative states of psychiatric health. Considered here is the proposition that an increased risk of personality disorders, and an increased sense of despair in normative populations, might be considered as symptoms of deficiencies of omega-3 fatty acids. The major changes in the essential fatty acid composition of the food supply, including increased availability of the omega-6 linoleic acid, may be correlated not only with increased risks of homicide, but also increased risks of suicide and suboptimal social cohesion.

scholarly journals Temporal variation of fatty acid composition and pesticides in honeybees Apis mellifera and beebread

2019 ◽  
Author(s):  
Zuyi C. Gooley ◽  
Aaron C. Gooley
Keyword(s):  
Fatty Acids ◽  
Fatty Acid Composition ◽  
Fatty Acid ◽  
Acid Composition ◽  
Pesticide Exposure ◽  
Essential Fatty Acids ◽  
Omega 3 ◽  
Lethal Level ◽  
Omega 6 ◽  
Fat Bodies

AbstractA twelve-month study was conducted on changes in fatty acid composition and pesticide residues in honeybees and beebread. In honeybees, saturated fatty acid and monounsaturated fatty acid gradually increased as summer began then decreased when spring started, and polyunsaturated fatty acid had an opposite seasonal trend. Similar fluctuation was observed in the beebread collected from the same hive as those honeybees through summer to fall, especially in the essential fatty acids omega-6 and omega-3. Honeybees’ lipid metabolism can be disrupted after being exposed to a sub-lethal level of pesticide. Although three out of sixteen analyzed pesticides were detected in beebread samples summer through fall in our study, we were not able to find any negative affect of those pesticides on the honeybees’ fatty acid composition. Temporary field-realistic pesticide exposure may weaken honeybees but are unlikely to show any reflection in their fat bodies if the colony was otherwise healthy.

Supplementation of dietary long-chain polyunsaturated omega-3 fatty acids high in docosahexaenoic acid (DHA) increases plasma DHA concentration and may increase trot stride lengths in horses

2007 ◽  
Vol 4 (2) ◽  
pp. 71-78 ◽  
Author(s):  
A D Woodward ◽  
B D Nielsen ◽  
C I O'Connor ◽  
C D Skelly ◽  
S K Webel ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Fatty Acid ◽  
Docosahexaenoic Acid ◽  
Stride Length ◽  
Omega 3 Fatty Acids ◽  
Total Plasma ◽  
Omega 3 ◽  
Omega 3 Fatty Acid ◽  
Omega 6 ◽  
Long Chain

AbstractTwelve mature and six 2-year-old Arabian horses were used to determine the effect of dietary long-chain polyunsaturated omega-3 fatty acid supplementation on plasma fatty acids and lameness. Lameness scores and stride lengths were measured on day 0. Horses were striated and pair-matched according to age, gender, stride length and, for mature horses, lameness score, and each horse was fed either a treatment diet containing 5.95 g of stabilized omega-3 fatty acids plus a fat carrier (FA), for a total of 19.4 g fat, or a control diet containing 49 g of corn oil (CO) for 75 days. Horses were exercised 5 d week− 1, and blood samples were drawn and body weights recorded on days 0, 25, 50 and 75. Lameness scores and stride lengths were recorded again on day 75. Total plasma omega-3 fatty acid concentrations were higher on all days in FA horses than in CO horses. Total plasma omega-6 fatty acids increased from days 0 to 25, remained elevated through day 50 and returned to baseline on day 75 in all horses. The ratio of plasma omega-6:omega-3 fatty acids was lower in FA horses. Horses on FA had increased plasma docosahexaenoic acid (DHA) on days 25, 50 and 75. No difference in walk stride length was noted; however, FA horses tended to have a longer trot stride after supplementation when compared with CO horses. No differences were seen in prostaglandin E2 (PGE2) metabolite or tumour necrosis factor-α as measured in blood serum. In summary, supplementing omega-3 fatty acids increases plasma DHA, although there was no overall increase in omega-3 in FA horses. While a trend to increase trot stride length was seen, no differences in lameness scores between treatments were noted.

Effects of An Omega 3 Fatty Acid Supplement Consumption On Platelet Aggregation Tests in Patients Low Grade Lymphoproliferative Disorders.

Blood ◽  
2009 ◽  
Vol 114 (22) ◽  
pp. 5076-5076
Author(s):  
Gabriela Ballester ◽  
Alexander Salazar ◽  
Theodor Witte ◽  
Elaine Hardman ◽  
Doreen Griswold ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Fatty Acid ◽  
Fatty Acid Content ◽  
Lymphoproliferative Disorders ◽  
Low Grade ◽  
Base Line ◽  
Omega 3 Fatty Acids ◽  
Omega 3 ◽  
Normal Range ◽  
Omega 3 Fatty Acid

Abstract Abstract 5076 Introduction Omega 3 fatty acids, when supplemented to cell culture or in the diet of tumor bearing animals, have been shown to sensitize mouse leukemias and lymphomas or multiple human solid tumor types to chemotherapy drugs. Enhanced chemosensitivity has been associated with suppression of nuclear factor kappa B (NFkB) activation and increased susceptibility to lipid peroxidation. Some investigators have expressed concerns over a possible bleeding diathesis related to the chronic consumption of these supplements. Patients and Methods We have initiated a pilot study in patients with low grade lymphoproliferative disorders to determine omega 3 fatty acids supplements tolerance; correlation of oral supplementation with incorporation of omega 3 fatty acids in blood cell membranes and in-vitro sensitivity of leukemia cells to chemotherapy. Omega 3 capsules, containing 1250 mg total oil, 60% of which is omega 3 were administered 3 times daily. Doses were escalated after the first month to 6 capsules per day and to 9 capsules after the second month, if there was good tolerance. As part of safety monitoring, platelet aggregation studies were done at base line and at 6 months, utilizing a Siemens Dade PFA-100 analyzer. Fatty acid composition of red blood cells was assessed using gas chromatography. Results Eight patients with Chronic Lymphocytic Leukemia (Rai stage 0-1, no requiring therapy) have been accrued to date. Six of the 8 patients were also receiving aspirin at the time of study. A dose-related increase in the omega 3 fatty acid content of both red blood cells and leukocytes was documented. The total omega 3 content of red cells was about 80% over base line after 3 capsules per day for one month; after 6 capsules per day the total omega 3 content of erythrocytes was about 160% over baseline. The omega 3 content of leukocytes after supplementation was much more variable ranging from -0.5% to 280% over baseline after 3 capsules per day and 37% to 416% over baseline after 6 capsules per day. Baseline Collagen/ADP aggregation was within the normal range in all patients: mean 72.4 sec (range 59-110) (normal- 70-118), no significant changes were noted at 6 months: mean 69.2 sec (range: 59-85). Baseline Collagen/EPI aggregation was elevated in 2 patients (>300 sec), the remaining patients had normal values with a mean of 100.3 sec (normal range: 74-193). At 6 months, Collagen/EPI aggregation showed a mean value of 129.3 sec (range 110-158), representing a mean 29.6% increase over baseline. Omega3 fatty acid supplements were generally well tolerated. Currently, 6 patients are up to 6 capsules/day and 2 are at 9 capsules/day. Two patients had Grade I intermittent diarrhea (1 patient at 6 capsules/day); 1 patient noted hand bruising. Conclusions Clearly, humans can consume enough omega 3 supplements to elicit biological activity as shown by the increase in fatty acid content of erythrocytes and leukocytes. No changes in Collagen/ADP aggregation was noted after 6 months of supplementation. A mild increase in Collagen/EPI aggregation is reported, with values that remained within the normal range, even in patients also medicated with aspirin. Studies are in progress to determine effects on NFkB activity and lipid peroxidation. Disclosures No relevant conflicts of interest to declare.

scholarly journals Omega-6 and omega-3 fatty acids: Endocannabinoids, genetics and obesity

OCL ◽  
2020 ◽  
Vol 27 ◽  
pp. 7 ◽  
Author(s):  
Artemis P. Simopoulos
Keyword(s):  
Fatty Acids ◽  
Fatty Acid ◽  
Disease Risk ◽  
Receptor Expression ◽  
Fatty Acid Intake ◽  
Omega 3 Fatty Acids ◽  
Omega 3 ◽  
Omega 3 Fatty Acid ◽  
Acid Intake ◽  
Omega 6

The tissue composition of polyunsaturated fatty acids (PUFA) is important to health and depends on both dietary intake and metabolism controlled by genetic polymorphisms that should be taken into consideration in the determination of nutritional requirements, obesity and chronic disease risk. Experimental and clinical intervention studies suggest that omega-6 and omega-3 fatty acids have opposing physiological and metabolic properties and elicit divergent effects on body fat gain through mechanisms of adipogenesis, browning of adipose tissue, lipid homeostasis, systemic inflammation and an increase in the tone of the endocannabinoid system. Overweight and obese individuals have higher levels of the arachidonic acid (AA) derived endocannabinoid N-arachidonoylethanolamine (AEA) and 2-arachidonoylglycerol (2-AG) and an altered pattern of receptor expression. Since endocannabinoids are products of dietary fats, modification of the omega-6 and omega-3 fatty acid intake modulates the endocannabinoids, with eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) displacing AA from cell membranes, reducing AEA and 2-AG production, resulting in decrease in appetite and food intake leading to weight loss. Polygenic risk scores reveal susceptibility and an increase risk for obesity. Therefore, persons at risk for obesity will have to lower omega-6 and increase their omega-3 fatty acid intake in order to have a balanced ratio for health. A process needs to be established to define when genomic discoveries such as gene-nutrient-disease associations are “ready” to be evaluated as potential tools for personalized nutrition to improve public health.

scholarly journals Nutritional Analyses of Domestic and Poultry Chickens and Evaluation of the Subsequent Effects on Lowering Blood Glucose Levels in Alloxan-Induced Wister Rats

2021 ◽  
pp. 98-109
Author(s):  
Mahbuba Khatun ◽  
Md. Motiar Rahman ◽  
M. Manirujjaman ◽  
Meftah Uddin ◽  
Mst. Gulshan Ara ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Fatty Acid ◽  
Blood Glucose ◽  
Essential Fatty Acids ◽  
Gas Liquid Chromatography ◽  
Omega 3 ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Omega 6 ◽  
Macro And Micronutrients

In the recent decades, peoples concentrate more on reduced-consumption of diets containing saturated fatty acids and replace them with essential polyunsaturated ones, including omega-3 and omega-6 fatty acids, due to their promising nutritional benefits. Therefore, the production of chicken meat having lower fat compositions, and riches in pro-healthy fatty acid and other macro-and micronutrients deserves great attention in the food industry. The research aimed to characterize meat oils of two commercially available, domestic and poultry, chickens in the Northern part of Bangladesh (Rajshahi), followed by the investigation of their nutritional compositions and hypoglycemic effect in vivo. In this work, the oil was isolated from the dried meat sources by Soxhlet extractor and purified using a rotary evaporator. We subsequently characterized meat oil in terms of various parameters, such as iodine value, saponification number, unsaponifiable matter, free fatty acid (FFA) contents, peroxide value, and acid value. Besides, the nutritional parameters of chicken oil were investigated as percentages of essential fatty acids and several other micro-and macronutrients using gas-liquid chromatography and other conventional methods. Finally, Alloxan-induced Wister rats were fed with oil and chicken flesh to investigate the hypoglycemic effects. The experimental analyses show that chicken oil possesses a significant proportion of omega-3 and omega-6 fatty acid, macro-and micronutrients. Besides, oil and flesh were found to lower blood glucose levels in diabetic rats despite flesh could not significantly show hypoglycemic properties.

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