scholarly journals Skin manifestations of a new coronovirus infection COVID-19 caused by SARS-CoV-2

2020 ◽  
Vol 96 (3) ◽  
pp. 53-62
Author(s):  
Aleksey A. Khryanin ◽  
Viktor G. Sturov ◽  
Alexander P. Nadeev ◽  
Valentina К. Bocharova
Keyword(s):  
Complement System ◽  
Primary Infection ◽  
Skin Lesions ◽  
Skin Manifestations ◽  
Skin Symptoms ◽  
Coronavirus Infection ◽  
Mechanisms Of Development ◽  
The Moment ◽  
Secondary Consequence

The review is devoted to the skin manifestations of new coronovirus infection (SARS-CoV-2), information about which is constantly updated. However, this information has not been systematized yet. The purpose of this review is to analyze the dermatological manifestations of a new coronavirus infection. On average, 12.520.4% of patients with confirmed COVID-19 have developed skin manifestations. The question of whether the skin symptoms are a secondary consequence of a respiratory infection or a primary infection of the skin itself remains open at the moment. The possible mechanisms of development of skin lesions and the role of diseases of complement system and blood hypercoagulation in the pathogenesis of the disease are discussed in the article. The review also provides descriptive and clinical examples of skin manifestations in COVID-19. Since COVID-19 tends to be asymptomatic within 14 days, skin manifestations can be an indicator of infection, which leads to the timely diagnosis. In addition, doctors' awareness about skin symptoms associated with COVID-19 infection plays a big role in preventing misdiagnosis of the disease. The authors cite their own clinical сase of a patient with COVID-19 and associated skin angiitis.

Dermatological manifestations in novel coronavirus infection COVID-19

2021 ◽  
Author(s):  
А.А. Хрянин ◽  
В.Г. Стуров ◽  
А.П. Надеев ◽  
В.К. Бочарова
Keyword(s):  
Primary Infection ◽  
Skin Lesions ◽  
The Novel ◽  
Skin Manifestations ◽  
Skin Symptoms ◽  
Coronavirus Infection ◽  
Novel Coronavirus ◽  
The Complement System ◽  
Secondary Consequence

Обзор посвящен анализу дерматологических проявлений при новой коронавирусной инфекции COVID-19, информация о которых непрерывно обновляется и дополняется. Однако до сих пор имеющиеся данные не были систематизированы. Цель обзора: проанализировать дерматологические проявления новой коронавирусной инфекции COVID-19. В среднем, у 12,5–20,4% пациентов с подтвержденным COVID-19 развились кожные проявления. Вопрос о том, являются ли кожные симптомы вторичным следствием респираторной инфекции или первичной инфекцией самой кожи, на данный момент остается открытым. Обсуждаются вероятные механизмы развития поражений кожи и роли системы комплемента и гиперкоагуляции крови в патогенезе развития дерматологических проявлений. В обзоре также приводятся клинические примеры вовлечения кожных покровов в инфекционный процесс при COVID-19. Поскольку COVID-19 имеет тенденцию к бессимптомному течению в течение 14 дней после заражения, кожные проявления могут служить индикатором инфекции, способствуя своевременной диагностике. Кроме того, осведомленность врачей о кожных симптомах, связанных с инфекцией COVID-19, имеет решающее значение для предотвращения неправильного диагноза заболевания. Review focuses on the analysis of dermatological manifestations of the novel coronovirus infection COVID-19; this information is continuously updated and supplemented. However, the available data have not been systematized until now. The purpose of this review is to analyze the dermatological manifestations of the novel coronavirus infection COVID-19. On average, 12.5–20.4% of patients with confirmed COVID-19 have developed skin manifestations. Whether the skin symptoms are a secondary consequence of a respiratory infection or a primary infection of the skin itself presently remains still open. Possible mechanisms of skin lesions development are discussed as well as the role of the complement system and blood hypercoagulation in the pathogenesis of the dermatological manifestations. The review also provides clinical examples of skin involvement in the infectious process in COVID-19. Since COVID-19 tends to be asymptomatic within 14 days of infection, so skin manifestations can serve as an indicator of infection, facilitating timely diagnosis. Moreover, physicians’ awareness of skin symptoms associated with COVID-19 is crucial for preventing misdiagnosis of the disease.

scholarly journals Role of therapeutic phlebotomy in management of case of porphyria cutanea tarda (PCT) admitted in tertiary care hospital Vadodara  

2020 ◽  
Vol 8 (1) ◽  
pp. 4-6
Author(s):  
Ashu Dogra
Keyword(s):  
Aminolevulinic Acid ◽  
Tertiary Care Hospital ◽  
Porphyria Cutanea Tarda ◽  
Tertiary Care ◽  
Skin Lesions ◽  
Clinical Feature ◽  
Care Hospital ◽  
Skin Symptoms ◽  
Characteristic Clinical Feature

Porphyria cutanea tarda is the most frequent type of Porphyria worldwide & presents with skin symptoms mainly. Porphyrias can affect peripheral, autonomic and central nervous system. In Porphyria conditions there is accumulation of heme precursors 5 Aminolevulinic acid, Porphobilinogen and porphyrins which are associated with characteristic clinical feature with acute neurovisceral attacks and skin lesions. This case report summarizes Case of PCT that was successfully managed with Therapeutic Phlebotomy.

scholarly journals Neurological and ENT manifestations in COVID-19

2021 ◽  
Vol 20 (4) ◽  
pp. 72-78
Author(s):  
S. M. Megrelishvili ◽  
◽  
Ya. L. Shcherbakova ◽  
S. B. Sugarova ◽  
A. D. Kanina ◽  
...  
Keyword(s):  
Hearing Loss ◽  
Sudden Hearing Loss ◽  
Neurological Complications ◽  
Viral Agent ◽  
Molecular Features ◽  
The Central Nervous System ◽  
Coronavirus Infection ◽  
Mechanisms Of Development ◽  
The Moment ◽  
Portal Of Entry

Along with the respiratory, cardiovascular, gastrointestinal, rheumatological, and neurological manifestations of the new coronavirus infection (COVID-19), the effects of this virus on the ENT organs is undeniable, as the main portal of entry of any respiratory infection. It has been proven that symptoms such as hypo- and anosmia are associated with one of the ways of the virus penetration – transnasal, through the olfactory nerves into the central nervous system. Otorhinolaryngological complaints of patients are not limited only to deterioration or loss of smell, many note the appearance of dizziness, tinnitus, worsening of the course of chronic sensorineural hearing loss, and in some cases – sudden hearing loss, which may indicate damage to the auditory and vestibular analyzer by a viral agent. The mechanisms of development of the corresponding complications at the moment are still unclear. The presented article is a review of the literature data of foreign and domestic sources, which examines the central and peripheral neurological complications, the pathways and molecular features of the penetration of the virus, as well as clinical cases of hearing impairment and the appearance of tinnitus against the background of new coronavirus infection. At the moment, information on the direct effect of the SARS-CoV-2 virus on the auditory and vestibular analyzer is insufficient and scattered, which requires further observation with subsequent detailed analysis of the results.

SKIN LESIONS IN CHILDREN WITH COVID-19-ASSOCIATED MULTISYSTEM INFLAMMATORY SYNDROME

2020 ◽  
Vol 99 (6) ◽  
pp. 259-265
Author(s):  
O.B. Tamrazova ◽  
◽  
I.M. Osmanov ◽  
A.S. Stadnikova ◽  
L.N. Mazankova ◽  
...  
Keyword(s):  
Clinical Observation ◽  
Clinical Manifestations ◽  
Chinese American ◽  
Skin Lesions ◽  
Disease Course ◽  
Skin Manifestations ◽  
Mucous Membranes ◽  
Coronavirus Infection ◽  
Inflammatory Syndrome ◽  
First Time

The pandemic of the new coronavirus infection COVID-19, caused by SARS-CoV-2 coronavirus, continues to develop. The first data indicated that children tolerate this infection much easier than adults, the disease course is generally asymptomatic and mild. Chinese, American and European scientists described a variety of skin manifestations in children with COVID-19 coronavirus infection. The article presents literature data on skin manifestations in children, characteristic for COVID-19. In April 2020, the description of a new severe inflammatory syndrome in children associated with SARS-CoV-2, called multisystem inflammation syndrome (MIS), appeared for the first time. The article presents literature data on MIS clinical manifestations and its incidence. The authors describe clinical observation of MIS development in a 7-year-old child with COVID-19 and with lesions of the skin and mucous membranes.

scholarly journals The Dermatological Manifestations in the Coronavirus Infection COVID-19

2020 ◽  
Vol 10 (6) ◽  
pp. 422-429
Author(s):  
A. S. Dvornikov ◽  
A. A. Silin ◽  
T. A. Gaydina ◽  
V. N. Larina ◽  
P. A. Skripkina ◽  
...  
Keyword(s):  
Drug Treatment ◽  
Clinical Picture ◽  
Viral Infections ◽  
Skin Lesions ◽  
The Novel ◽  
Skin Manifestations ◽  
Depth Analysis ◽  
Vesicular Rash ◽  
Coronavirus Infection ◽  
Novel Coronavirus

The variety of dermatological manifestations in patients with the novel coronavirus infection COVID-19, the incidence of which depends on concomitant pathology and the characteristics of drug treatment, and their characteristics are similar to those that occur with conventional viral infections is discussed. At the present time it is proposed to distinguish several groups depending on the cause and mechanism of development: angiitis of the skin; papulo-squamous rash and pink lichen; measles rash and infectious erythema; papulo-vesicular rash; toxidermia; urticarial eruptions and artifical lesions. The variety of the clinical picture of the skin manifestations of coronavirus infection requires in-depth analysis in order to interpret correctly the skin lesions and other infectious exanthema and dermatoses in patients with COVID-19.

PINGVINAS IR PROTĖJAS. Įsivaizdavimas kaip kitybė manyje

2007 ◽  
Vol 4 ◽  
pp. 21-37
Author(s):  
Kristupas Sabolius
Keyword(s):  
Fight Club ◽  
The World ◽  
The Moment ◽  
Hollywood Movie

Kitybės klausimas dažniausiai kyla iš ego santykio su kitais arba su pasauliu. Šiame straipsnyje daroma prielaida, kad įsivaizdavimo funkcija ištirpdo subjektą ir jame pačiame atveria intersubjektyvią perspektyvą. Šiuo tikslu sugretinami Sartre’o, Husserlio bei Merleau-Ponty įsivaizdavimo funkcijos tyrimai, kuriuose išryškėja vaizdo kaip iš ego centro išslystančios ribos statusas, ir Holivudo filmo „Kovos klubas“ siužetas. Viename iš šios juostos epizodų pasirodantis pingvinas žymi egologinės schizmos akimirką ir tampa fantazijos apsireiškimu ir įsikūnijimu.Išgryninus žaidybinį, savarankišką ir multiformišką charakterį, galime konstantuoti, kad įsivaizdavimas, jei kalbėtume Kanto terminais, yra ne papildanti tarpinė funkcija, bet transcendentalinio subjekto genezėje atlieka paradoksalų „svetimos vidujybės“ arba „vidinės svetimybės“ vaidmenį. Vaizduotė yra katalizatoriaus, kuris, likdamas šalia, įgalina transcendentalinių formų išsikristalizavimą.Pagrindiniai žodžiai: vaizduotė, įsivaizdavimas, fantazija, ego, kitybė, sąmonė.PENGUIN AND PROTEUSImagination as Otherness in meKristupas Sabolius SummaryThe question of Otherness is usually taken into account while discussing the Ego’s relation with Others as well as with the World. This article is based on the premises that the function of phantasy melts the subjectivity, revealing the perspective of intersubjectivity within it. On this purpose Sartre’s, Husserl’s and Merleau-Ponty’s researches on the function of imagination, which elucidate the image as the boundary slipping from the centre of Ego, are compared to the story of Hollywood’ movie „Fight Club“. The penguin, which appears in one of the episodes, registers the moment of egological schism, thus becoming the revelation and incarnation of phantasy. While the playful, autonomous and multiform character of imaginary is cleared out, we can ascertain, speaking in Kantian terms, that it has not a complementary or intermediary function, but, in the genesis of transcendental subject, plays the paradoxical role of „allien innerness“ or „inner alienity“. Thought remaining always beside, imagination is a catalyzer which enables crystallization of transcendental forms.Keywords: imagination, imaginary, phantasy, ego, otherness, consciousness.

OBOLESCENCE AND THE DIFFUSION OF INNOVATIONS

2020 ◽  
pp. 113-130
Author(s):  
A.V. GOLUBEV ◽  
Keyword(s):  
Diffusion Of Innovations ◽  
Time Lag ◽  
Practical Implementation ◽  
Primary Role ◽  
Innovation Development ◽  
Scientific Hypothesis ◽  
Scientific Papers ◽  
The Moment ◽  
Sociological Studies

The diffusion of innovations is described as a process in a number of scientific papers. At the same time, the causes of this process have not been sufficiently studied. The author’s goal is to consider the main regularities, under which the life cycle of innovations begins, and propose measures to enhance diffusion in modern conditions. As a scientific hypothesis, the author accepts the postulate about the primary role of the obolescence of attracted innovations in this process. The analysis revealed not only the economic proportions that initiate the start of innovation promotion, but also the influence on the diffusion rate of the obsolescence degree of innovations and the market share occupied by the new product. Methodological approaches have been developed to determine economic efficiency depending on the moment of technological change-over, as well as to determine the absolute and relative speed of innovation diffusion. Sociological studies were conducted to determine the state of innovation development and the time lag between obtaining information about an innovation and its practical implementation. The author presents his “Agroopyt” information system developed to disseminate knowledge in the agricultural sphere and ensure technology transfer in agriculture. Digital methods provide for significant accelerateion of the diffusion of innovations and expand its scope.

scholarly journals Impressic Acid Ameliorates Atopic Dermatitis-Like Skin Lesions by Inhibiting ERK1/2-Mediated Phosphorylation of NF-κB and STAT1

2021 ◽  
Vol 22 (5) ◽  
pp. 2334
Author(s):  
Jae Ho Choi ◽  
Gi Ho Lee ◽  
Sun Woo Jin ◽  
Ji Yeon Kim ◽  
Yong Pil Hwang ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Skin Lesions ◽  
Histopathological Analysis ◽  
Mrna Levels ◽  
Chemokine Production ◽  
Dermal Thickness ◽  
Skin Symptoms ◽  
Tnf Α ◽  
Ifn Γ ◽  
In Cells

Impressic acid (IPA), a lupane-type triterpenoid from Acanthopanax koreanum, has many pharmacological activities, including the attenuation of vascular endothelium dysfunction, cartilage destruction, and inflammatory diseases, but its influence on atopic dermatitis (AD)-like skin lesions is unknown. Therefore, we investigated the suppressive effect of IPA on 2,4-dinitrochlorobenzene (DNCB)-induced AD-like skin symptoms in mice and the underlying mechanisms in cells. IPA attenuated the DNCB-induced increase in the serum concentrations of IgE and thymic stromal lymphopoietin (TSLP), and in the mRNA levels of thymus and activation regulated chemokine(TARC), macrophage derived chemokine (MDC), interleukin-4 (IL-4), interleukin-5 (IL-5), interleukin-13 (IL-13), tumor necrosis factor-alpha (TNF-α) and interferon-gamma (IFN-γ) in mice. Histopathological analysis showed that IPA reduced the epidermal/dermal thickness and inflammatory and mast cell infiltration of ear tissue. In addition, IPA attenuated the phosphorylation of NF-κB and IκBα, and the degradation of IκBα in ear lesions. Furthermore, IPA treatment suppressed TNF-α/IFN-γ-induced TARC expression by inhibiting the NF-κB activation in cells. Phosphorylation of extracellular signalregulated protein kinase (ERK1/2) and the signal transducer and activator of transcription 1 (STAT1), the upstream signaling proteins, was reduced by IPA treatment in HaCaT cells. In conclusion, IPA ameliorated AD-like skin symptoms by regulating cytokine and chemokine production and so has therapeutic potential for AD-like skin lesions.

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