scholarly journals Аssociation between (rs1024611) -12518A/G CCL2 gene polymorphism and serum level of C-reactive protein with different clinical and serological phenotypes of systemic sclerosis in the Russian cohort of patients

2019 ◽  
pp. 34-39
Author(s):  
М.Ю. Крылов ◽  
Л.П. Ананьева ◽  
И.А. Гусева ◽  
Е.Ю. Самаркина ◽  
О.А. Конева ◽  
...  
Keyword(s):  
Topoisomerase I ◽  
Poor Prognosis ◽  
C Reactive Protein ◽  
Allele Polymorphism ◽  
General Group ◽  
Reactive Protein ◽  
Inflammatory Protein ◽  
Diffuse Form ◽  
High Level ◽  
Ccl2 Gene

Установлено, что полиморфизмы генов медиаторов воспаления, тканевых матричных белков и ростовых факторов вовлечены в аутоиммунные и фибротические процессы при системной склеродермии (ССД). Хемокин CCL2 является ключевым воспалительным белком, присутствующим в циркулирующей крови и в очагах повреждения кожи больных ССД. Цель настоящего исследования состояла в изучении связи полиморфизма -2518 A/G гена CCL2 с уровнем С-реактивного белка (СРБ) у больных с разными клиническими и серологическими фенотипами ССД. В общей группе пациентов носители генотипа -2518АА имели статистически значимо более высокий средний уровень СРБ по сравнению с носителями аллеля -2518G (AG+GG генотипы) (р=0,032). Сходные различия уровней СРБ были получены у пациентов с диффузной формой ССД и у пациентов с позитивными титрами антител к топоизомеразе I (р=0,041 и р=0,042 соответственно). Выводы. Носительство генотипа -2518AА ассоциировано с высоким уровнем СРБ у больных с плохим прогнозом ССД (диффузная форма и позитивные титры аутоантител к топоизомеразе I) по сравнению с носительством аллеля -2518G. Полиморфизм -2518A/G гена CCL2 может быть использован в качестве генетического маркера тяжести и неблагоприятного прогноза ССД. It has been established that polymorphisms of inflammatory mediator genes, tissue matrix proteins and growth factors are involved in autoimmune and fibrotic processes in systemic scleroderma (SSc). CCL2 chemokine is a key inflammatory protein present in the circulating blood and in the lesions of the skin of patients with SSc. The purpose of this study was to study the association of the polymorphism -2518 A / G of the CCL2 gene with C-reactive protein (CRP) levels among patients with different clinical and serological phenotypes of SJS. In the general group of patients, carriers of the genotype -2518AA had a statistically significant higher average CRP level compared to carriers of the -2518G allele (AG + GG genotypes) (p = 0.032). Similar differences in CRP levels were obtained in patients with a diffuse form of SJS and in patients with positive antibody titers to topoisomerase I (p = 0.041 and p = 0.042, respectively). Conclusions: The carriage of the -2518AA genotype was significantly associated with a high level of CRP in patients with poor prognosis of SSc (presence of a diffuse form and seropositive autoantibody titers to topoisomerase I) compared with patients carrying the -2518G allele. Polymorphism -2518A / G of the CCL2 gene can be used as a genetic marker of severity and poor prognosis for SSc.

scholarly journals Low Albumin Levels Are Associated with Poorer Outcomes in a Case Series of COVID-19 Patients in Spain: A Retrospective Cohort Study

2020 ◽  
Vol 8 (8) ◽  
pp. 1106 ◽  
Author(s):  
Roberto de la Rica ◽  
Marcio Borges ◽  
Maria Aranda ◽  
Alberto del Castillo ◽  
Antonia Socias ◽  
...  
Keyword(s):  
Retrospective Cohort ◽  
Poor Prognosis ◽  
Case Series ◽  
Hospital Length ◽  
Limited Information ◽  
C Reactive Protein ◽  
Icu Patients ◽  
Reactive Protein ◽  
Epidemiological Features ◽  
Initial Symptoms

There is limited information available describing the clinical and epidemiological features of Spanish patients requiring hospitalization for coronavirus disease 2019 (COVID-19). In this observational study, we aimed to describe the clinical characteristics and epidemiological features of severe (non-ICU) and critically patients (ICU) with COVID-19 at triage, prior to hospitalization. Forty-eight patients (27 non-ICU and 21 ICU) with positive severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection were analyzed (mean age, 66 years, [range, 33–88 years]; 67% males). There were no differences in age or sex among groups. Initial symptoms included fever (100%), coughing (85%), dyspnea (76%), diarrhea (42%) and asthenia (21%). ICU patients had a higher prevalence of dyspnea compared to non-ICU patients (95% vs. 61%, p = 0.022). ICU-patients had lymphopenia as well as hypoalbuminemia. Lactate dehydrogenase (LDH), C-reactive protein (CRP), and procalcitonin were significantly higher in ICU patients compared to non-ICU (p < 0.001). Lower albumin levels were associated with poor prognosis measured as longer hospital length (r = −0.472, p < 0.001) and mortality (r = −0.424, p = 0.003). As of 28 April 2020, 10 patients (8 ICU and 2 non-ICU) have died (21% mortality), and while 100% of the non-ICU patients have been discharged, 33% of the ICU patients still remained hospitalized (5 in ICU and 2 had been transferred to ward). Critically ill patients with COVID-19 present lymphopenia, hypoalbuminemia and high levels of inflammation.

scholarly journals C-reactive protein: A promising biomarker for poor prognosis in COVID-19 infection

2020 ◽  
Vol 509 ◽  
pp. 91-94 ◽  
Author(s):  
Bikash R. Sahu ◽  
Raj Kishor Kampa ◽  
Archana Padhi ◽  
Aditya K. Panda
Keyword(s):  
Poor Prognosis ◽  
Protein A ◽  
C Reactive Protein ◽  
Reactive Protein

scholarly journals High Expression of C-reactive Protein Increases the Risk of Poor Prognosis in Patients with Gastric Cancer: A Meta-analysis

2019 ◽  
Vol 7 (3) ◽  
pp. 117
Author(s):  
Fulun Li ◽  
Ke Liu ◽  
Qianlong Zhao ◽  
Junyi Chen ◽  
Lingfei Liu ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Poor Prognosis ◽  
Meta Analysis ◽  
High Expression ◽  
C Reactive Protein ◽  
Reactive Protein

scholarly journals Mortality Predictors in Severe COVID-19 Patients from an East European Tertiary Center: A Never-Ending Challenge for a No Happy Ending Pandemic

2021 ◽  
Vol 11 (1) ◽  
pp. 58
Author(s):  
Amalia-Stefana Timpau ◽  
Radu-Stefan Miftode ◽  
Antoniu Octavian Petris ◽  
Irina-Iuliana Costache ◽  
Ionela-Larisa Miftode ◽  
...  
Keyword(s):  
Risk Factors ◽  
Hospital Mortality ◽  
Poor Prognosis ◽  
Survival Rates ◽  
C Reactive Protein ◽  
Happy Ending ◽  
Factors Associated ◽  
Reactive Protein ◽  
Tertiary Center ◽  
D Dimer

(1) Background: There are limited clinical data in patients from the Eastern European regions hospitalized for a severe form of Coronavirus disease 2019 (COVID-19). This study aims to identify risk factors associated with intra-hospital mortality in patients with COVID-19 severe pneumonia admitted to a tertiary center in Iasi, Romania. (2) Methods: The study is of a unicentric retrospective observational type and includes 150 patients with severe COVID-19 pneumonia divided into two subgroups, survivors and non-survivors. Demographic and clinical parameters, as well as comorbidities, laboratory and imaging investigations upon admission, treatments, and evolution during hospitalization were recorded. First, we sought to identify the risk factors associated with intra-hospital mortality using logistic regression. Secondly, we assessed the correlations between D-Dimer and C-reactive protein and predictors of poor prognosis. (3) Results: The predictors of in-hospital mortality identified in the study are D-dimers >0.5 mg/L (p = 0.002), C-reactive protein >5mg/L (p = 0.001), and heart rate above 100 beats per minute (p = 0.001). The biomarkers were also significantly correlated the need for mechanical ventilation, admission to intensive care unit, or multiple organ dysfunction syndrome. By area under the curve (AUC) analysis, we noticed that both D-Dimer (AUC 0.741) and C-reactive protein (AUC 0.707) exhibit adequate performance in predicting a poor prognosis in patients with severe viral infection. (4) Conclusions: COVID-19′s outcome is significantly influenced by several laboratory and clinical factors. As mortality induced by severe COVID-19 pneumonia is considerable, the identification of risk factors associated with negative outcome coupled with an early therapeutic approach are of paramount importance, as they may significantly improve the outcome and survival rates.

scholarly journals C REACTIVE PROTEIN AND CARDIOVASCULAR RISK IN CASES WITH DIABETES MALLITUS TYPE II

2013 ◽  
Vol 3 (2) ◽  
pp. 10-15
Author(s):  
Munevera Bećarević ◽  
◽  
Duška Bećirović ◽  
Azijada Beganlić ◽  
Olivera Batić-Mujanović ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Blood Pressure ◽  
Cardiovascular Risk ◽  
Blood Cholesterol ◽  
Cardiovascular Risks ◽  
C Reactive Protein ◽  
Score System ◽  
Reactive Protein ◽  
Significant Difference ◽  
High Level

Introduction: Factors of cardiovascular risk (CVR) are often grouped in cases with diabetes mellitus (DM) with significant increasment of risk for CV disease . The aim of this research is to determine the frequency of CVR and and total CVR in cases with DM and to investigate connection of CRP of other factors of CVR in total cardiovascular risks. Material and methods: In 92 cases with DM weist values were taken as well as body mass index (BMI), blood pressure, sugar in blood, cholesterol, triglycerides, C reactive protein (CRP) and according to SCORE system the 10 year period of CVR were determined. Results: Out of 92 tested cases with age 55,22± 8,3 years, 63,05% were males and 36,95% were women, 81,5% were with values of sugar in blood >7mmol/l, 44,6% were with values of HbA1C>7% and 63,0% >6,5%. The value of cholesterol were >4,5mmol/l in 87%, triglycerides >1,7mmol/l in 78.3% of tested cases. 81,5% of tested cases were overweight and 49% with larger weight values. Average cardiovascular factor according to SCORE system was 3, 92± 3,7% with significant difference among sexes (M-4,86; W-2,32, p<o,05). According to height value CRP (>3mg/l) 52% of tested cases were with high cardiovascular risk. There is significant positive correlation between CRP and cholesterol level (p<0, 01), triglycerides, blood in sugar, HbA1c and upper values of blood pressure (p<0, 05). Significant correlation between CRP and total cardiovascular risk (p=0, 63) was not evident. Conclusion: Cases with diabetes mellitus have high level of non regulated cardiovascular risk factors. Even though there is significant correlation between CRP and and pressure values, sugar in blood, HbA1c, cholesterol, triglycerides, significant correlation between CRP and total cardiovascular risk in cases with diabetes mellitus is not evident.

Recurrent severe respiratory infections with low CRP secondary to autoimmune IL-6 deficiency

2021 ◽  
Vol 14 (6) ◽  
pp. e243334
Author(s):  
Alexander Hackney ◽  
Sunil James ◽  
Surendra Karanam
Keyword(s):  
Treatment Response ◽  
Clinical Presentation ◽  
Respiratory Infections ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Inflammatory Protein ◽  
Severe Infections

C reactive protein (CRP) is an inflammatory protein that is often used in conjunction with the clinical presentation of a patient to help with quantifying infection severity and measuring treatment response. We report the case of a patient who presented with severe pneumonias but had a suboptimal CRP response, later diagnosed as having an underlying immunodeficiency. This case exemplifies the need to consider immunodeficiency as an underlying pathophysiological cause in patients presenting with complicated and severe infections.

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