CHARACTERISTICS OF DENGUE INFECTION IN SAUDI CHILDREN: SINGLE CENTER RETROSPECTIVE STUDY IN A TERTIARY HOSPITAL IN JEDDAH, WESTERN SAUDI ARABIA

Objective: To examine pattern of lepra reaction andmedicines used in the treatment of lepra reactions in a tertiary hospital. Material methods: In this retrospective study, prescriptions of patients treated for the lepra reactions were reviewed to find out prevalence of type 1 and type 2 reactions and medicines used in the treatment of lepra reactions. Results:A total of66 patients (male 59.1%; female 40.9%) with mean age of 36.6 (+13.1) years were included in the study. Multibacillary leprosy was present in 93.7% patients. A total of 39 (60%) patients had type 2 reaction whereas 26 (40%) had type 1 reaction. Mean number of medicines per patients was 7.5. Prednisolone was used in 62 (93.9%) patients with mean duration of 33.32 (+33.2) days whereas chloroquine was used in 52 (78.8%) patients for 36.6 (+27.9) days. Thalidomide was used in 25 (37.9%) patients. Analgesic and anti-inflammatory and anti-acidity drugs were used in 63 (95.4%) patients each whereas paracetamol was given to 41 (62.1%) patients. Antihistamine, antimicrobial agent and vitamins were given to 27 (40.9%), 27 (40.9%) and 35 (53.0%) patients respectively. Conclusion:Lepra 2 reaction is more common than lepra 1 reaction. Prednisolone and chloroquine are the two most commonly used medicines in the treatment of lepra reaction. Similarly, thalidomide, older drug has emerged as common treatment for lepra reaction.

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Outcomes of a preoperative risk-based transfusion assignment protocol in sickle cell disease patients: a single-center retrospective study from Saudi Arabia

Pediatric Hematology and Oncology ◽

10.1080/08880018.2020.1767738 ◽

2020 ◽

Vol 37 (7) ◽

pp. 599-609

Author(s):

Naif Albolowi ◽

Omima Mustafa ◽

Mohammed Almohammadi ◽

Mohammed Yasir Al-Hindi ◽

Wasil Jastaniah

Keyword(s):

Saudi Arabia ◽

Retrospective Study ◽

Sickle Cell Disease ◽

Sickle Cell ◽

Single Center ◽

Cell Disease ◽

Preoperative Risk

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A Retrospective Study of Pediatric Medication Errors in Saudi Arabia

Hospital Pharmacy ◽

10.1177/0018578719882318 ◽

2019 ◽

pp. 001857871988231

Author(s):

Oluwaseun Egunsola ◽

Sheraz Ali ◽

Dalal S. Al-Dossari ◽

Rahsid Hamoud Alnajrani

Keyword(s):

Health Care ◽

Saudi Arabia ◽

Retrospective Study ◽

Medication Errors ◽

Health Care Professionals ◽

Pediatric Population ◽

Tertiary Hospital ◽

Pediatric Care ◽

Common Drug ◽

Transcription Error

Background: The peculiarities of medication errors (MEs) among the pediatric population in the Middle East have not been adequately explored. In this study, we describe the MEs reported at the largest tertiary hospital in Saudi Arabia. Methods: This study is a retrospective analysis of MEs reported by health care professionals at a large tertiary hospital in Saudi Arabia between 2015 and 2016. Results: There were a total of 9123 MEs involving 84 different medications. In total, 109 382 drugs were ordered. Thus, 8.3 MEs per 100 prescriptions were reported during the study period. Thirty-nine errors (0.4%) reached the patient, but did not cause any harm. Transcribing errors accounted for more than half of the MEs (n = 4856, 53.2%). Physicians were the least likely to report an ME (n = 159, 1.7%), whereas pharmacists reported more MEs than any other health care professional (n = 4924, 54%). The most common drug causes of MEs were paracetamol, salbutamol, and amoxicillin, which accounted for 21.0%, 16.6%, and 12.4% of MEs, respectively, over the study period. Conclusions: Medication errors are common in pediatric care, especially for drugs such as paracetamol and amoxicillin that are frequently prescribed. Transcription error was common in this study and is more likely to be reported by pharmacists.

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Lymphopenia predicted illness severity and recovery in patients with COVID-19: A single-center, retrospective study

PLoS ONE ◽

10.1371/journal.pone.0241659 ◽

2020 ◽

Vol 15 (11) ◽

pp. e0241659

Author(s):

Jiheng Liu ◽

Heng Li ◽

Ming Luo ◽

Jiyang Liu ◽

Lingzhen Wu ◽

...

Keyword(s):

Coronary Heart Disease ◽

Retrospective Study ◽

Clinical Laboratory ◽

Tertiary Hospital ◽

Outcome Data ◽

Single Center ◽

C Reactive Protein ◽

Reactive Protein ◽

Prolonged Duration ◽

Duration Of Hospitalization

The outbreak of SARS-CoV-2 began in December 2019 and rapidly became a pandemic. The present study investigated the significance of lymphopenia on disease severity. A total of 115 patients with confirmed COVID-19 from a tertiary hospital in Changsha, China, were enrolled. Clinical, laboratory, treatment and outcome data were gathered and compared between patients with and without lymphopenia. The median age was 42 years (1–75). Fifty-four patients (47.0%) of the 115 patients had lymphopenia on admission. More patients in the lymphopenia group had hypertension (30.8% vs. 10.0%, P = 0.006) and coronary heart disease (3.6% vs. 0%, P = 0.029) than in the nonlymphopenia group, and more patients with leukopenia (48.1% vs 14.8%, P<0.001) and eosinopenia (92.6% vs 54.1%, P<0.001) were observed. Lymphopenia was also correlated with severity grades of pneumonia (P<0.001) and C-reactive protein (CRP) level (P = 0.0014). Lymphopenia was associated with a prolonged duration of hospitalization (17.0 days vs. 14.0 days, P = 0.002). Lymphocyte recovery appeared the earliest, prior to CRP and chest radiographs, in severe cases, which suggests its predictive value for disease improvement. Our results demonstrated the clinical significance of lymphopenia for predicting the severity of and recovery from COVID-19, which emphasizes the need to dynamically monitor lymphocyte count.

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