Lymphopenia predicted illness severity and recovery in patients with COVID-19: A single-center, retrospective study

The outbreak of SARS-CoV-2 began in December 2019 and rapidly became a pandemic. The present study investigated the significance of lymphopenia on disease severity. A total of 115 patients with confirmed COVID-19 from a tertiary hospital in Changsha, China, were enrolled. Clinical, laboratory, treatment and outcome data were gathered and compared between patients with and without lymphopenia. The median age was 42 years (1–75). Fifty-four patients (47.0%) of the 115 patients had lymphopenia on admission. More patients in the lymphopenia group had hypertension (30.8% vs. 10.0%, P = 0.006) and coronary heart disease (3.6% vs. 0%, P = 0.029) than in the nonlymphopenia group, and more patients with leukopenia (48.1% vs 14.8%, P<0.001) and eosinopenia (92.6% vs 54.1%, P<0.001) were observed. Lymphopenia was also correlated with severity grades of pneumonia (P<0.001) and C-reactive protein (CRP) level (P = 0.0014). Lymphopenia was associated with a prolonged duration of hospitalization (17.0 days vs. 14.0 days, P = 0.002). Lymphocyte recovery appeared the earliest, prior to CRP and chest radiographs, in severe cases, which suggests its predictive value for disease improvement. Our results demonstrated the clinical significance of lymphopenia for predicting the severity of and recovery from COVID-19, which emphasizes the need to dynamically monitor lymphocyte count.

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Lymphopenia acted as an adverse factor for severity in patients with COVID-19: a single-centered, retrospective study

10.21203/rs.3.rs-22849/v1 ◽

2020 ◽

Cited By ~ 1

Author(s):

Jiheng Liu ◽

Heng Li ◽

Ming Luo ◽

Jiyang Liu ◽

Lingzhen Wu ◽

...

Keyword(s):

Coronary Heart Disease ◽

Clinical Laboratory ◽

Tertiary Hospital ◽

Outcome Data ◽

C Reactive Protein ◽

Reactive Protein ◽

Prolonged Duration ◽

Duration Of Hospitalization ◽

Severity Of The Disease ◽

Adverse Factor

Abstract Purpose: The outbreak of SARS-CoV-2 began in December and rapidly caused a pandemic. To investigate the significance of lymphopenia for the severity of the disease, this study was performed.Methods: 115 patients confirmed COVID-19 from a tertiary hospital in Changsha, China were enrolled. The clinical, laboratory, treatment and outcome data were collected and compared between patients with lymphopenia or not.Results: The median age was 42 years (1-75). 54 patients (47.0%) of the patients had lymphopenia on admission. In the group of lymphopenia, more patients had hypertension (30.8% vs 10.0%, P=0.006) and coronary heart disease (3.6% vs 0%, P=0.029) and more patients with leucopenia (48.1% vs 14.8%, P<0.001) and eosinophilia (92.6% vs 54.1%, P<0.001) were observed. Lymphopenia was also correlated with severity grades of pneumonia (P<0.001) and C-reactive protein (CRP) level (P=0.0014). Lymphopenia was associated with a prolonged duration of hospitalization (17.0 days vs 14.0 days, P=0.002). Moreover, the recovery of lymphocyte appeared the earliest before CRP and chest radiographs in severe cases, suggesting its predictive value for disease improvement. Conclusion: Our results showed the clinical significance of lymphopenia for predicting the severity of COVID-19 and the recovery of the disease, emphasizing the need to monitor the lymphocyte count dynamically.

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CHARACTERISTICS OF DENGUE INFECTION IN SAUDI CHILDREN: SINGLE CENTER RETROSPECTIVE STUDY IN A TERTIARY HOSPITAL IN JEDDAH, WESTERN SAUDI ARABIA

10.26226/morressier.58fa1764d462b80290b509b2 ◽

2017 ◽

Author(s):

Moustafa Hegazi

Keyword(s):

Saudi Arabia ◽

Retrospective Study ◽

Dengue Infection ◽

Tertiary Hospital ◽

Single Center

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Faculty Opinions recommendation of C-reactive protein as a risk factor for coronary heart disease: a systematic review and meta-analyses for the U.S. Preventive Services Task Force.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1165500.628495 ◽

2009 ◽

Author(s):

Deborah R Korenstein

Keyword(s):

Systematic Review ◽

Coronary Heart Disease ◽

Risk Factor ◽

Heart Disease ◽

Task Force ◽

Preventive Services ◽

C Reactive Protein ◽

Reactive Protein ◽

Meta Analyses ◽

The U.S

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Clinical characteristics and risk factors for mortality in COVID-19 inpatients in Birjand, Iran: a single-center retrospective study

European Journal of Medical Research ◽

10.1186/s40001-021-00553-3 ◽

2021 ◽

Vol 26 (1) ◽

Author(s):

Ghodsiyeh Azarkar ◽

Freshteh Osmani

Keyword(s):

Risk Factors ◽

Platelet Count ◽

Protein Level ◽

Clinical Characteristics ◽

Single Center ◽

C Reactive Protein ◽

Reactive Protein ◽

Risk Of Death ◽

Survivor Group ◽

Epidemiological Characteristics

Abstract Background The coronavirus disease 2019(COVID-19) has affected mortality worldwide. The Cox proportional hazard (CPH) model is becoming more popular in time-to-event data analysis. This study aimed to evaluate the clinical characteristics in COVID-19 inpatients including (survivor and non-survivor); thus helping clinicians give the right treatment and assess prognosis and guide the treatment. Methods This single-center study was conducted at Hospital for COVID-19 patients in Birjand. Inpatients with confirmed COVID-19 were included. Patients were classified as the discharged or survivor group and the death or non-survivor group based on their outcome (improvement or death). Clinical, epidemiological characteristics, as well as laboratory parameters, were extracted from electronic medical records. Independent sample T test and the Chi-square test or Fisher’s exact test were used to evaluate the association of interested variables. The CPH model was used for survival analysis in the COVID-19 death patients. Significant level was set as 0.05 in all analyses. Results The results showed that the mortality rate was about (17.4%). So that, 62(17%) patients had died due to COVID-19, and 298 (83.6%) patients had recovered and discharged. Clinical parameters and comorbidities such as oxygen saturation, lymphocyte and platelet counts, hemoglobin levels, C-reactive protein, and liver and kidney function, were statistically significant between both studied groups. The results of the CPH model showed that comorbidities, hypertension, lymphocyte counts, platelet count, and C-reactive protein level, may increase the risk of death due to the COVID-19 as risk factors in inpatients cases. Conclusions Patients with, lower lymphocyte counts in hemogram, platelet count and serum albumin, and high C-reactive protein level, and also patients with comorbidities may have more risk for death. So, it should be given more attention to risk management in the progression of COVID-19 disease.

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Lipoprotein complexed C-reactive protein in patients with coronary heart disease

Thrombosis and Haemostasis ◽

10.1160/th05-05-1111 ◽

2005 ◽

Vol 94 (11) ◽

pp. 1111-1112 ◽

Cited By ~ 1

Author(s):

Thorsten Kälsch ◽

Martin Borggrefe ◽

Carl-Erik Dempfle ◽

Elif Elmas

Keyword(s):

Coronary Heart Disease ◽

Heart Disease ◽

C Reactive Protein ◽

Reactive Protein

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The Case for C-Reactive Protein as a Risk Marker for Coronary Heart Disease

Annals of Internal Medicine ◽

10.7326/0003-4819-152-6-201003160-00020 ◽

2010 ◽

Vol 152 (6) ◽

pp. 406 ◽

Cited By ~ 1

Author(s):

Nancy R. Cook

Keyword(s):

Coronary Heart Disease ◽

Heart Disease ◽

Risk Marker ◽

C Reactive Protein ◽

Reactive Protein

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Association between novel oxidative stress markers and C-reactive protein among adults without clinical coronary heart disease

Atherosclerosis ◽

10.1016/j.atherosclerosis.2004.08.007 ◽

2005 ◽

Vol 178 (1) ◽

pp. 115-121 ◽

Cited By ~ 85

Author(s):

Jerome L. Abramson ◽

W. Craig Hooper ◽

Dean P. Jones ◽

Salman Ashfaq ◽

Steven D. Rhodes ◽

...

Keyword(s):

Oxidative Stress ◽

Coronary Heart Disease ◽

Heart Disease ◽

Oxidative Stress Markers ◽

C Reactive Protein ◽

Reactive Protein ◽

Stress Markers

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C-Reactive Protein and the 10-Year Incidence of Coronary Heart Disease in Older Men and Women

ACC Current Journal Review ◽

10.1016/j.accreview.2005.10.017 ◽

2005 ◽

Vol 14 (11) ◽

pp. 16

Author(s):

M. Cushman ◽

A.M. Arnold ◽

B.M. Psaty

Keyword(s):

Coronary Heart Disease ◽

Heart Disease ◽

Older Men ◽

C Reactive Protein ◽

Men And Women ◽

Reactive Protein ◽

Older Men And Women

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Fever as a predictor of adverse outcomes in COVID-19

QJM ◽

10.1093/qjmed/hcab023 ◽

2021 ◽

Author(s):

N W Chew ◽

J N Ngiam ◽

S M Tham ◽

Z Y Lim ◽

T Y W Li ◽

...

Keyword(s):

Tertiary Hospital ◽

Adverse Outcomes ◽

C Reactive Protein ◽

Reactive Protein ◽

End Point ◽

Group 4 ◽

Group 3 ◽

Group 2 ◽

Design And Methods ◽

Group 1

Summary Background/Introduction There are little data on outcomes of COVID-19 patients with the presence of fever compared to the presence of symptoms. Aim We examined the associations between symptomology, presence of fever and outcomes of a COVID-19 cohort. Design and Methods Between 23 January and 30 April 2020, 554 COVID-19 patients were admitted to a tertiary hospital in Singapore. They were allocated into four groups based on symptomology and fever—Group 1: asymptomatic and afebrile, Group 2: symptomatic but afebrile, Group 3: febrile but asymptomatic and Group 4: symptomatic and febrile. The primary outcomes were intensive care unit (ICU) admissions and mortality. The composite end-point included ICU admissions, mortality or any COVID-19 related end-organ involvement. Results There were differences in ferritin (P=0.003), C-reactive protein (CRP) levels (P<0.001) and lymphopenia (P=0.033) across all groups, with the most favourable biochemical profile in Group 1, and the least in Group 4. Symptomatic groups (Groups 2 and 4) had higher ICU admissions (1.9% and 6.0%, respectively, P=0.003) than asymptomatic groups (Groups 1 and 3). Composite end-point was highest in Group 4 (24.0%), followed by Group 3 (8.6%), Group 2 (4.8%) and Group 1 (2.4%) (P<0.001). The presence of fever (OR 4.096, 95% CI 1.737–9.656, P=0.001) was associated with the composite end-point after adjusting for age, pulse rate, comorbidities, lymphocyte, ferritin and CRP. Presence of symptoms was not associated with the composite end-point. Discussion/Conclusion In this COVID-19 cohort, presence of fever was a predictor of adverse outcomes. This has implications on the management of febrile but asymptomatic COVID-19 patients.

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